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Volumn 8, Issue JUL, 2017, Pages

New insights into 5hmC DNA modification: Generation, distribution and function

Author keywords

5 hydroxymethylcytosine; DNA demethylation; DNA hydroxylation; Epigenetics; TET proteins

Indexed keywords

5 HYDROXYMETHYL CYTOSINE; CHROMOMETHYLASE 3; CYTOSINE DERIVATIVE; DNA METHYLTRANSFERASE 1; GENOMIC DNA; METHYLTRANSFERASE; METHYLTRANSFERASE 2; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 85026406234     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2017.00100     Document Type: Review
Times cited : (167)

References (122)
  • 1
    • 84883424925 scopus 로고    scopus 로고
    • Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus
    • Al-Mahdawi, S., Sandi, C., Mouro Pinto, R., and Pook, M. A. (2013). Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus. PLoS ONE 8:e74956. doi: 10.1371/journal.pone.0074956.
    • (2013) PLoS ONE , vol.8
    • Al-Mahdawi, S.1    Sandi, C.2    Mouro Pinto, R.3    Pook, M.A.4
  • 2
    • 84857147244 scopus 로고    scopus 로고
    • Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals
    • Almeida, R. D., Sottile, V., Loose, M., De Sousa, P. A., Johnson, A. D., and Ruzov, A. (2012). Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammals. Epigenetics 7, 137-140. doi: 10.4161/epi.7.2.18949.
    • (2012) Epigenetics , vol.7 , pp. 137-140
    • Almeida, R.D.1    Sottile, V.2    Loose, M.3    De Sousa, P.A.4    Johnson, A.D.5    Ruzov, A.6
  • 3
    • 84923169323 scopus 로고    scopus 로고
    • Global DNA cytosine methylation as an evolving trait: phylogenetic signal and correlated evolution with genome size in angiosperms
    • Alonso, C., Pérez, R., Bazaga, P., and Herrera, C. M. (2015). Global DNA cytosine methylation as an evolving trait: phylogenetic signal and correlated evolution with genome size in angiosperms. Front. Genet. 6:4. doi: 10.3389/fgene.2015.00004.
    • (2015) Front. Genet , vol.6 , pp. 4
    • Alonso, C.1    Pérez, R.2    Bazaga, P.3    Herrera, C.M.4
  • 4
    • 84956699513 scopus 로고    scopus 로고
    • De novo DNA methylation drives 5hmC accumulation in mouse zygotes
    • Amouroux, R., Nashun, B., Shirane, K., Nakagawa, S., Hill, P. W., D'Souza, Z., et al. (2016). De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat. Cell Biol. 18, 225-233. doi: 10.1038/ncb3296.
    • (2016) Nat. Cell Biol , vol.18 , pp. 225-233
    • Amouroux, R.1    Nashun, B.2    Shirane, K.3    Nakagawa, S.4    Hill, P.W.5    D'Souza, Z.6
  • 5
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., et al. (2006). A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326. doi: 10.1016/j.cell.2006.02.041.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5    Cuff, J.6
  • 6
    • 0024021747 scopus 로고
    • Splice site selection, rate of splicing, and alternative splicing on nascent transcripts
    • Beyer, A. L., and Osheim, Y. N. (1988). Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev. 2, 754-765. doi: 10.1101/gad.2.6.754.
    • (1988) Genes Dev , vol.2 , pp. 754-765
    • Beyer, A.L.1    Osheim, Y.N.2
  • 7
    • 83855163995 scopus 로고    scopus 로고
    • Uncovering the role of 5-hydroxymethylcytosine in the epigenome
    • Branco, M. R., Ficz, G., and Reik, W. (2012). Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat. Rev. Genet 13, 7-13. doi: 10.1038/nrg3080.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 7-13
    • Branco, M.R.1    Ficz, G.2    Reik, W.3
  • 8
    • 84898871225 scopus 로고    scopus 로고
    • Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species
    • Capuano, F., Mülleder, M., Kok, R., Blom, H. J., and Ralser, M. (2014). Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and other yeast species. Anal. Chem. 86, 3697-3702. doi: 10.1021/ac500447w.
    • (2014) Anal. Chem , vol.86 , pp. 3697-3702
    • Capuano, F.1    Mülleder, M.2    Kok, R.3    Blom, H.J.4    Ralser, M.5
  • 9
    • 79956294973 scopus 로고    scopus 로고
    • DNA methylation and demethylation in mammals
    • Chen, Z. X., and Riggs, A. D. (2011). DNA methylation and demethylation in mammals. J. Biol. Chem. 286, 18347-18353. doi: 10.1074/jbc.R110.205286.
    • (2011) J. Biol. Chem , vol.286 , pp. 18347-18353
    • Chen, Z.X.1    Riggs, A.D.2
  • 10
    • 84878944565 scopus 로고    scopus 로고
    • Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
    • Chouliaras, L., Mastroeni, D., Delvaux, E., Grove, A., Kenis, G., Hof, P. R., et al. (2013). Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol. Aging 34, 2091-2099. doi: 10.1016/j.neurobiolaging.2013.02.021.
    • (2013) Neurobiol. Aging , vol.34 , pp. 2091-2099
    • Chouliaras, L.1    Mastroeni, D.2    Delvaux, E.3    Grove, A.4    Kenis, G.5    Hof, P.R.6
  • 11
    • 63249106600 scopus 로고    scopus 로고
    • JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes
    • Cliffe, L. J., Kieft, R., Southern, T., Birkeland, S. R., Marshall, M., Sweeney, K., et al. (2009). JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes. Nucleic Acids Res. 37, 1452-1462. doi: 10.1093/nar/gkn1067.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1452-1462
    • Cliffe, L.J.1    Kieft, R.2    Southern, T.3    Birkeland, S.R.4    Marshall, M.5    Sweeney, K.6
  • 12
    • 84954349048 scopus 로고    scopus 로고
    • RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine
    • Delatte, B., Wang, F., Ngoc, L. V., Collignon, E., Bonvin, E., Deplus, R., et al. (2016). RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine. Science 351, 282-285. doi: 10.1126/science.aac5253.
    • (2016) Science , vol.351 , pp. 282-285
    • Delatte, B.1    Wang, F.2    Ngoc, L.V.3    Collignon, E.4    Bonvin, E.5    Deplus, R.6
  • 13
    • 84979593589 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system
    • Diotel, N., Mérot, Y., Coumailleau, P., Gueguen, M. M., Sérandour, A. A., Salbert, G., et al. (2017). 5-Hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system. J. Comp. Neurol. 525, 478-497. doi: 10.1002/cne.24077.
    • (2017) J. Comp. Neurol , vol.525 , pp. 478-497
    • Diotel, N.1    Mérot, Y.2    Coumailleau, P.3    Gueguen, M.M.4    Sérandour, A.A.5    Salbert, G.6
  • 14
    • 84866104895 scopus 로고    scopus 로고
    • Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients
    • Dong, E., Gavin, D. P., Chen, Y., and Davis, J. (2012). Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients. Transl. Psychiatry 2, e159. doi: 10.1038/tp.2012.86.
    • (2012) Transl. Psychiatry , vol.2
    • Dong, E.1    Gavin, D.P.2    Chen, Y.3    Davis, J.4
  • 15
    • 8944233789 scopus 로고
    • The Cs2SO4 equilibbrium density gradient and its application for the study of T-even phage DNA: glucosylation and replication
    • Erikson, R. L., and Szybalski, W. (1964). The Cs2SO4 equilibbrium density gradient and its application for the study of T-even phage DNA: glucosylation and replication. Virology 22, 111-124. doi: 10.1016/0042-6822(64)90053-4.
    • (1964) Virology , vol.22 , pp. 111-124
    • Erikson, R.L.1    Szybalski, W.2
  • 16
    • 84961218734 scopus 로고    scopus 로고
    • Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
    • Feinberg, A. P., Koldobskiy, M. A., and Göndör, A. (2016). Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat. Rev. Genet. 17, 284-299. doi: 10.1038/nrg.2016.13.
    • (2016) Nat. Rev. Genet , vol.17 , pp. 284-299
    • Feinberg, A.P.1    Koldobskiy, M.A.2    Göndör, A.3
  • 17
    • 79956323623 scopus 로고    scopus 로고
    • Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
    • Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., et al. (2011). Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 473, 398-402. doi: 10.1038/nature10008.
    • (2011) Nature , vol.473 , pp. 398-402
    • Ficz, G.1    Branco, M.R.2    Seisenberger, S.3    Santos, F.4    Krueger, F.5    Hore, T.A.6
  • 18
    • 8944259725 scopus 로고
    • Virus-induced acquisition of metabolic function. 1. Enzymatic formation of 5-hydroxymethyldeoxycytidylate
    • Flaks, J. G., and Cohen, S. S. (1959). Virus-induced acquisition of metabolic function. 1. Enzymatic formation of 5-hydroxymethyldeoxycytidylate. J. Biol. Chem. 234, 1501-1506.
    • (1959) J. Biol. Chem , vol.234 , pp. 1501-1506
    • Flaks, J.G.1    Cohen, S.S.2
  • 19
    • 84872268888 scopus 로고    scopus 로고
    • Nucleic acid modifications with epigenetic significance
    • Fu, Y., and He, C. (2012). Nucleic acid modifications with epigenetic significance. Curr. Opin. Chem. Biol. 16, 516-524. doi: 10.1016/j.cbpa.2012.10.002.
    • (2012) Curr. Opin. Chem. Biol , vol.16 , pp. 516-524
    • Fu, Y.1    He, C.2
  • 20
    • 32044470027 scopus 로고    scopus 로고
    • DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation
    • Gehring, M., Huh, J. H., Hsieh, T. F., Penterman, J., Choi, Y., Harada, J. J., et al. (2006). DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation. Cell 124, 495-506. doi: 10.1016/j.cell.2005.12.034.
    • (2006) Cell , vol.124 , pp. 495-506
    • Gehring, M.1    Huh, J.H.2    Hsieh, T.F.3    Penterman, J.4    Choi, Y.5    Harada, J.J.6
  • 21
    • 78650826181 scopus 로고    scopus 로고
    • Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    • Globisch, D., Münzel, M., Müller, M., Michalakis, S., Wagner, M., Koch, S., et al. (2010). Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS ONE 5:e15367. doi: 10.1371/journal.pone.0015367.
    • (2010) PLoS ONE , vol.5
    • Globisch, D.1    Münzel, M.2    Müller, M.3    Michalakis, S.4    Wagner, M.5    Koch, S.6
  • 22
    • 84860388901 scopus 로고    scopus 로고
    • Active DNA demethylation by oxidation and repair
    • Gong, Z., and Zhu, J. K. (2011). Active DNA demethylation by oxidation and repair. Cell Res. 21, 1649-1651. doi: 10.1038/cr.2011.140.
    • (2011) Cell Res , vol.21 , pp. 1649-1651
    • Gong, Z.1    Zhu, J.K.2
  • 23
    • 84901583781 scopus 로고    scopus 로고
    • Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product
    • Grand, A., Jorge, N., Morell, C., Cadet, J., and Eriksson, L. A. (2014). Deamination features of 5-hydroxymethylcytosine, a radical and enzymatic DNA oxidation product. J. Mol. Model. 20, 2290-2299. doi: 10.1007/s00894-014-2290-9.
    • (2014) J. Mol. Model , vol.20 , pp. 2290-2299
    • Grand, A.1    Jorge, N.2    Morell, C.3    Cadet, J.4    Eriksson, L.A.5
  • 24
    • 84954540490 scopus 로고    scopus 로고
    • Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells
    • Grosser, C., Wagner, N., Grothaus, K., and Horsthemke, B. (2015). Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells. Epigenetics 10, 819-833. doi: 10.1080/15592294.2015.1073879.
    • (2015) Epigenetics , vol.10 , pp. 819-833
    • Grosser, C.1    Wagner, N.2    Grothaus, K.3    Horsthemke, B.4
  • 25
    • 80053348585 scopus 로고    scopus 로고
    • The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
    • Gu, T. P., Guo, F., Yang, H., Wu, H. P., Xu, G. F., Liu, W., et al. (2011). The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477, 606-610. doi: 10.1038/nature10443.
    • (2011) Nature , vol.477 , pp. 606-610
    • Gu, T.P.1    Guo, F.2    Yang, H.3    Wu, H.P.4    Xu, G.F.5    Liu, W.6
  • 26
    • 84905911865 scopus 로고    scopus 로고
    • Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis
    • Hammoud, S. S., Low, D. H., Yi, C., Carrell, D. T., Guccione, E., and Cairns, B. R. (2014). Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis. Cell Stem Cell 15, 239-253. doi: 10.1016/j.stem.2014.04.006.
    • (2014) Cell Stem Cell , vol.15 , pp. 239-253
    • Hammoud, S.S.1    Low, D.H.2    Yi, C.3    Carrell, D.T.4    Guccione, E.5    Cairns, B.R.6
  • 27
    • 84979784066 scopus 로고    scopus 로고
    • A highly sensitive and robust method for genome-wide 5hmc profiling of rare cell populations
    • Han, D., Lu, X., Shih, A. H., Nie, J., You, Q., Xu, M. M., et al. (2016). A highly sensitive and robust method for genome-wide 5hmc profiling of rare cell populations. Mol. Cell 63, 711-719. doi: 10.1016/j.molcel.2016.06.028.
    • (2016) Mol. Cell , vol.63 , pp. 711-719
    • Han, D.1    Lu, X.2    Shih, A.H.3    Nie, J.4    You, Q.5    Xu, M.M.6
  • 28
    • 78651138418 scopus 로고
    • Host-induced modification of T-even phages due to defective glucosylation of their DNA
    • Hattman, S., and Fukasawa, T. (1963). Host-induced modification of T-even phages due to defective glucosylation of their DNA. Proc. Nat. Acad. Sci. U.S.A. 50, 297-300. doi: 10.1073/pnas.50.2.297.
    • (1963) Proc. Nat. Acad. Sci. U.S.A , vol.50 , pp. 297-300
    • Hattman, S.1    Fukasawa, T.2
  • 29
    • 79952535972 scopus 로고    scopus 로고
    • Regulation and function of DNA methylation in plants and animals
    • He, X. J., Chen, T., and Zhu, J. K. (2011). Regulation and function of DNA methylation in plants and animals. Cell Res. 21, 442-465. doi: 10.1038/cr.2011.23.
    • (2011) Cell Res , vol.21 , pp. 442-465
    • He, X.J.1    Chen, T.2    Zhu, J.K.3
  • 30
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He, Y. F., Li, B. Z., Li, Z., Liu, P., Wang, Y., Tang, Q., et al. (2011). Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303-1307. doi: 10.1126/science.1210944.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6
  • 31
    • 0033575886 scopus 로고    scopus 로고
    • The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
    • Hendrich, B., Hardeland, U., Ng, H. H., Jiricny, J., and Bird, A. (1999). The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 401, 301-304. doi: 10.1038/4584.
    • (1999) Nature , vol.401 , pp. 301-304
    • Hendrich, B.1    Hardeland, U.2    Ng, H.H.3    Jiricny, J.4    Bird, A.5
  • 32
    • 0014274573 scopus 로고
    • Protein synthesis by E. coli infected with bacteriophage T4D
    • Hosoda, J., and Levinthal, C. (1968). Protein synthesis by E. coli infected with bacteriophage T4D. Virology 34, 709-727. doi: 10.1016/0042-6822(68)90092-5.
    • (1968) Virology , vol.34 , pp. 709-727
    • Hosoda, J.1    Levinthal, C.2
  • 33
    • 84957846754 scopus 로고
    • The quantitative separation of purines, pyrimidines and nucleosides by paper chromatography
    • Hotchkiss, R. D. (1948). The quantitative separation of purines, pyrimidines and nucleosides by paper chromatography. J. Biol. Chem. 175, 315-332.
    • (1948) J. Biol. Chem , vol.175 , pp. 315-332
    • Hotchkiss, R.D.1
  • 34
    • 84946217906 scopus 로고    scopus 로고
    • Structural insight into substrate preference for TET-mediated oxidation
    • Hu, L., Lu, J., Cheng, J., Rao, Q., Li, Z., Hou, H., et al. (2015). Structural insight into substrate preference for TET-mediated oxidation. Nature 527, 118-122. doi: 10.1038/nature15713.
    • (2015) Nature , vol.527 , pp. 118-122
    • Hu, L.1    Lu, J.2    Cheng, J.3    Rao, Q.4    Li, Z.5    Hou, H.6
  • 35
    • 84893373754 scopus 로고    scopus 로고
    • Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells
    • Huang, Y., Chavez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., et al. (2014). Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc. Nat. Acad. Sci. U.S.A. 111, 1361-1366. doi: 10.1073/pnas.1322921111.
    • (2014) Proc. Nat. Acad. Sci. U.S.A , vol.111 , pp. 1361-1366
    • Huang, Y.1    Chavez, L.2    Chang, X.3    Wang, X.4    Pastor, W.A.5    Kang, J.6
  • 36
    • 84889081371 scopus 로고    scopus 로고
    • Chromatin's thread to alternative splicing regulation
    • Iannone, C., and Valcarcel, J. (2013). Chromatin's thread to alternative splicing regulation. Chromosoma 122, 465-474. doi: 10.1007/s00412-013-0425-x.
    • (2013) Chromosoma , vol.122 , pp. 465-474
    • Iannone, C.1    Valcarcel, J.2
  • 37
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito, S., D'Alessio, A. C., Taranova, O. V., Hong, K., Sowers, L. C., and Zhang, Y. (2010). Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129-1133. doi: 10.1038/nature09303.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 38
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., et al. (2011). Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303. doi: 10.1126/science.1210597.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6
  • 39
    • 84899483043 scopus 로고    scopus 로고
    • Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases
    • Jang, H., Shin, H., Eichman, B. F., and Huh, J. H. (2014). Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases. Biochem. Biophys. Res. Commun. 446, 1067-1072. doi: 10.1016/j.bbrc.2014.03.060.
    • (2014) Biochem. Biophys. Res. Commun , vol.446 , pp. 1067-1072
    • Jang, H.1    Shin, H.2    Eichman, B.F.3    Huh, J.H.4
  • 40
    • 84901828175 scopus 로고    scopus 로고
    • Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1-and DNMT3a-mediated cytosine methylation
    • Ji, D., Lin, K., Song, J., and Wang, Y. (2014). Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1-and DNMT3a-mediated cytosine methylation. Mol. Biosyst. 10, 1749-1752. doi: 10.1039/c4mb00150h.
    • (2014) Mol. Biosyst , vol.10 , pp. 1749-1752
    • Ji, D.1    Lin, K.2    Song, J.3    Wang, Y.4
  • 41
    • 84949532719 scopus 로고    scopus 로고
    • Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency
    • Jiang, D., Zhang, Y., Hart, R. P., Chen, J., Herrup, K., and Li, J. (2015). Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain 138, 3520-3536. doi: 10.1093/brain/awv284.
    • (2015) Brain , vol.138 , pp. 3520-3536
    • Jiang, D.1    Zhang, Y.2    Hart, R.P.3    Chen, J.4    Herrup, K.5    Li, J.6
  • 42
    • 84255200412 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
    • Jin, S. G., Jiang, Y., Qiu, R., Rauch, T. A., Wang, Y., Schackert, G., et al. (2011). 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res. 71, 7360-7365. doi: 10.1158/0008-5472.CAN-11-2023.
    • (2011) Cancer Res , vol.71 , pp. 7360-7365
    • Jin, S.G.1    Jiang, Y.2    Qiu, R.3    Rauch, T.A.4    Wang, Y.5    Schackert, G.6
  • 43
    • 84953313336 scopus 로고    scopus 로고
    • Tet3 reads 5-carboxylcytosine through Its CXXC domain and is a potential guardian against neurodegeneration
    • Jin, S. G., Zhang, Z. M., Dunwell, T. L., Harter, M. R., Wu, X., Johnson, J., et al. (2016). Tet3 reads 5-carboxylcytosine through Its CXXC domain and is a potential guardian against neurodegeneration. Cell Rep. 14, 493-505. doi: 10.1016/j.celrep.2015.12.044.
    • (2016) Cell Rep , vol.14 , pp. 493-505
    • Jin, S.G.1    Zhang, Z.M.2    Dunwell, T.L.3    Harter, M.R.4    Wu, X.5    Johnson, J.6
  • 44
    • 84867230056 scopus 로고    scopus 로고
    • 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
    • Khare, T., Pai, S., Koncevicius, K., Pal, M., Kriukiene, E., Liutkeviciute, Z., et al. (2012). 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat. Struct. Mol. Biol. 19, 1037-1043. doi: 10.1038/nsmb.2372.
    • (2012) Nat. Struct. Mol. Biol , vol.19 , pp. 1037-1043
    • Khare, T.1    Pai, S.2    Koncevicius, K.3    Pal, M.4    Kriukiene, E.5    Liutkeviciute, Z.6
  • 45
    • 4444237887 scopus 로고
    • Deoxycytidine triphosphatase, an enzyme induced by bacteriophage infection
    • Koerner, J. F., Smith, M. S., and Buchanan, J. M. (1960). Deoxycytidine triphosphatase, an enzyme induced by bacteriophage infection. J. Biol. Chem. 235, 2691-2697.
    • (1960) J. Biol. Chem , vol.235 , pp. 2691-2697
    • Koerner, J.F.1    Smith, M.S.2    Buchanan, J.M.3
  • 46
    • 84992322851 scopus 로고    scopus 로고
    • A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG Islands
    • Kong, L., Tan, L., Lv, R., Shi, Z., Xiong, L., Wu, F., et al. (2016). A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG Islands. Nucleic Acids Res. 44, 8682-8692. doi: 10.1093/nar/gkw529.
    • (2016) Nucleic Acids Res , vol.44 , pp. 8682-8692
    • Kong, L.1    Tan, L.2    Lv, R.3    Shi, Z.4    Xiong, L.5    Wu, F.6
  • 47
    • 0642329601 scopus 로고
    • Enzymatic synthesis of deoxyribonucleic acid. VI. Influence of bacteriophage T2 on the synthetic pathway in host cells
    • Kornberg, A., Zimmerman, S. B., Kornberg, S. R., and Josse, J. (1959). Enzymatic synthesis of deoxyribonucleic acid. VI. Influence of bacteriophage T2 on the synthetic pathway in host cells. Proc. Nat. Acad. Sci. U.S.A. 45, 772-785. doi: 10.1073/pnas.45.6.772.
    • (1959) Proc. Nat. Acad. Sci. U.S.A , vol.45 , pp. 772-785
    • Kornberg, A.1    Zimmerman, S.B.2    Kornberg, S.R.3    Josse, J.4
  • 48
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis, S., and Heintz, N. (2009). The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324, 929-930. doi: 10.1126/science.1169786.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 49
    • 84875878011 scopus 로고    scopus 로고
    • Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells
    • Kubiura, M., Okano, M., Kimura, H., Kawamura, F., and Tada, M. (2012). Chromosome-wide regulation of euchromatin-specific 5mC to 5hmC conversion in mouse ES cells and female human somatic cells. Chromosome Res. 20, 837-848. doi: 10.1007/s10577-012-9317-9.
    • (2012) Chromosome Res , vol.20 , pp. 837-848
    • Kubiura, M.1    Okano, M.2    Kimura, H.3    Kawamura, F.4    Tada, M.5
  • 50
    • 0014590111 scopus 로고
    • Biological effects of substituting cytosine for 5-hydroxymethylcytosine in the deoxyribonucleic acid of bacteriophage T4
    • Kutter, E. M., and Wiberg, J. S. (1969). Biological effects of substituting cytosine for 5-hydroxymethylcytosine in the deoxyribonucleic acid of bacteriophage T4. J. Virol. 4, 439-453.
    • (1969) J. Virol , vol.4 , pp. 439-453
    • Kutter, E.M.1    Wiberg, J.S.2
  • 51
    • 85022223640 scopus 로고    scopus 로고
    • Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
    • Landfors, M., Johansen, J., Aronsen, J. M., Vågbø, C. B., Doré, L. C., He, C., et al. (2017). Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discov. 3:17013. doi: 10.1038/celldisc.2017.13.
    • (2017) Cell Discov , vol.3 , pp. 17013
    • Landfors, M.1    Johansen, J.2    Aronsen, J.M.3    Vågbø, C.B.4    Doré, L.C.5    He, C.6
  • 52
    • 84928761297 scopus 로고    scopus 로고
    • The alternative role of DNA methylation in splicing regulation
    • Lev Maor, G., Yearim, A., and Ast, G. (2015). The alternative role of DNA methylation in splicing regulation. Trends Genet. 31, 274-280. doi: 10.1016/j.tig.2015.03.002.
    • (2015) Trends Genet , vol.31 , pp. 274-280
    • Lev Maor, G.1    Yearim, A.2    Ast, G.3
  • 53
    • 84924971913 scopus 로고    scopus 로고
    • Hippocampal increase of 5hmC in the glucocorticoid receptor gene following acute stress
    • Li, S., Papale, L. A., Zhang, Q., Madrid, A., Chen, L., Chopra, P., et al. (2015). Hippocampal increase of 5hmC in the glucocorticoid receptor gene following acute stress. Behav. Brain Res. 286, 236-240. doi: 10.1016/j.bbr.2015.03.002.
    • (2015) Behav. Brain Res , vol.286 , pp. 236-240
    • Li, S.1    Papale, L.A.2    Zhang, Q.3    Madrid, A.4    Chen, L.5    Chopra, P.6
  • 54
    • 84948973859 scopus 로고    scopus 로고
    • Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress
    • Li, S., Papale, L. A., Zhang, Q., Madrid, A., Chen, L., Chopra, P., et al. (2016). Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress. Neurobiol. Dis. 86, 99-108. doi: 10.1016/j.nbd.2015.11.010.
    • (2016) Neurobiol. Dis , vol.86 , pp. 99-108
    • Li, S.1    Papale, L.A.2    Zhang, Q.3    Madrid, A.4    Chen, L.5    Chopra, P.6
  • 55
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian, C. G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., et al. (2012). Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150, 1135-1146. doi: 10.1016/j.cell.2012.07.033.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3    Wu, F.4    Larson, A.5    Dresser, K.6
  • 56
    • 42749087226 scopus 로고    scopus 로고
    • Highly integrated single-base resolution maps of the epigenome in Arabidopsis
    • Lister, R., O'Malley, R. C., Tonti-Filippini, J., Gregory, B. D., Berry, C. C., Millar, A. H., et al. (2008). Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell 133, 523-536. doi: 10.1016/j.cell.2008.03.029.
    • (2008) Cell , vol.133 , pp. 523-536
    • Lister, R.1    O'Malley, R.C.2    Tonti-Filippini, J.3    Gregory, B.D.4    Berry, C.C.5    Millar, A.H.6
  • 57
    • 84990211830 scopus 로고    scopus 로고
    • Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
    • Liu, J., Zhu, Y., Luo, G. Z., Wang, X., Yue, Y., Wang, X., et al. (2016). Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nat. Commun. 7:13052. doi: 10.1038/ncomms13052.
    • (2016) Nat. Commun , vol.7 , pp. 13052
    • Liu, J.1    Zhu, Y.2    Luo, G.Z.3    Wang, X.4    Yue, Y.5    Wang, X.6
  • 58
    • 84894216161 scopus 로고    scopus 로고
    • Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA
    • Liu, S., Dunwell, T. L., Pfeifer, G. P., Dunwell, J. M., Ullah, I., and Wang, Y. (2013). Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. PLoS ONE 8:e84620. doi: 10.1371/journal.pone.0084620.
    • (2013) PLoS ONE , vol.8
    • Liu, S.1    Dunwell, T.L.2    Pfeifer, G.P.3    Dunwell, J.M.4    Ullah, I.5    Wang, Y.6
  • 59
    • 85019448438 scopus 로고    scopus 로고
    • The role of 5-hydroxymethylcytosine in development, aging and age-related diseases
    • López, V., Fernández, A. F., and Fraga, M. F. (2017). The role of 5-hydroxymethylcytosine in development, aging and age-related diseases. Ageing Res. Rev. 37, 28-38. doi: 10.1016/j.arr.2017.05.002.
    • (2017) Ageing Res. Rev , vol.37 , pp. 28-38
    • López, V.1    Fernández, A.F.2    Fraga, M.F.3
  • 60
    • 84925762489 scopus 로고    scopus 로고
    • TET family proteins: oxidation activity, interacting molecules, and functions in diseases
    • Lu, X., Zhao, B. S., and He, C. (2015). TET family proteins: oxidation activity, interacting molecules, and functions in diseases. Chem. Rev. 115, 2225-2239. doi: 10.1021/cr500470n.
    • (2015) Chem. Rev , vol.115 , pp. 2225-2239
    • Lu, X.1    Zhao, B.S.2    He, C.3
  • 61
    • 78650961149 scopus 로고    scopus 로고
    • Epigenetics in alternative pre-mRNA splicing
    • Luco, R. F., Allo, M., Schor, I. E., Kornblihtt, A. R., and Misteli, T. (2011). Epigenetics in alternative pre-mRNA splicing. Cell 144, 16-26. doi: 10.1016/j.cell.2010.11.056.
    • (2011) Cell , vol.144 , pp. 16-26
    • Luco, R.F.1    Allo, M.2    Schor, I.E.3    Kornblihtt, A.R.4    Misteli, T.5
  • 62
    • 80053917872 scopus 로고    scopus 로고
    • Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
    • Maiti, A., and Drohat, A. C. (2011). Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J. Biol. Chem. 286, 35334-35338. doi: 10.1074/jbc.C111.284620.
    • (2011) J. Biol. Chem , vol.286 , pp. 35334-35338
    • Maiti, A.1    Drohat, A.C.2
  • 63
    • 84875221641 scopus 로고    scopus 로고
    • Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice
    • Matrisciano, F., Tueting, P., Dalal, I., Kadriu, B., Grayson, D. R., Davis, J. M., et al. (2013). Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology 68, 184-194. doi: 10.1016/j.neuropharm.2012.04.013.
    • (2013) Neuropharmacology , vol.68 , pp. 184-194
    • Matrisciano, F.1    Tueting, P.2    Dalal, I.3    Kadriu, B.4    Grayson, D.R.5    Davis, J.M.6
  • 64
    • 84887214395 scopus 로고    scopus 로고
    • Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
    • Maunakea, A. K., Chepelev, I., Cui, K., and Zhao, K. (2013). Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 23, 1256-1269. doi: 10.1038/cr.2013.110.
    • (2013) Cell Res , vol.23 , pp. 1256-1269
    • Maunakea, A.K.1    Chepelev, I.2    Cui, K.3    Zhao, K.4
  • 65
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • Mellén, M., Ayata, P., Dewell, S., Kriaucionis, S., and Heintz, N. (2012). MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151, 1417-1430. doi: 10.1016/j.cell.2012.11.022.
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellén, M.1    Ayata, P.2    Dewell, S.3    Kriaucionis, S.4    Heintz, N.5
  • 67
    • 0345588683 scopus 로고    scopus 로고
    • T4 phage beta-glucosyltransferase: substrate binding and proposed catalytic mechanism
    • Moréra, S., Imberty, A., Aschke-Sonnenborn, U., Rüger, W., and Freemont, P. S. (1999). T4 phage beta-glucosyltransferase: substrate binding and proposed catalytic mechanism. J. Mol. Biol. 292, 717-730. doi: 10.1006/jmbi.1999.3094.
    • (1999) J. Mol. Biol , vol.292 , pp. 717-730
    • Moréra, S.1    Imberty, A.2    Aschke-Sonnenborn, U.3    Rüger, W.4    Freemont, P.S.5
  • 68
    • 84877810203 scopus 로고    scopus 로고
    • Changes of DNA methylation and hydroxymethylation in plant protoplast cultures
    • Moricová, P., Ondrej, V., Navrátilová, B., and Luhová, L. (2013). Changes of DNA methylation and hydroxymethylation in plant protoplast cultures. Acta Biochim. Pol. 60, 33-36.
    • (2013) Acta Biochim. Pol , vol.60 , pp. 33-36
    • Moricová, P.1    Ondrej, V.2    Navrátilová, B.3    Luhová, L.4
  • 69
    • 84905582980 scopus 로고    scopus 로고
    • TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
    • Müller, U., Bauer, C., Siegl, M., Rottach, A., and Leonhardt, H. (2014). TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation. Nucleic Acids Res. 42, 8592-8604. doi: 10.1093/nar/gku552.
    • (2014) Nucleic Acids Res , vol.42 , pp. 8592-8604
    • Müller, U.1    Bauer, C.2    Siegl, M.3    Rottach, A.4    Leonhardt, H.5
  • 71
    • 84865329141 scopus 로고    scopus 로고
    • AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
    • Nabel, C. S., Jia, H., Ye, Y., Shen, L., Goldschmidt, H. L., Stivers, J. T., et al. (2012). AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation. Nat. Chem. Biol. 8, 751-758. doi: 10.1038/nchembio.1042.
    • (2012) Nat. Chem. Biol , vol.8 , pp. 751-758
    • Nabel, C.S.1    Jia, H.2    Ye, Y.3    Shen, L.4    Goldschmidt, H.L.5    Stivers, J.T.6
  • 72
    • 84883064448 scopus 로고    scopus 로고
    • Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells
    • Neri, F., Incarnato, D., Krepelova, A., Rapelli, S., Pagnani, A., Zecchina, R., et al. (2013). Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome Biol. 14:R91. doi: 10.1186/gb-2013-14-8-r91.
    • (2013) Genome Biol , vol.14
    • Neri, F.1    Incarnato, D.2    Krepelova, A.3    Rapelli, S.4    Pagnani, A.5    Zecchina, R.6
  • 73
    • 84857891830 scopus 로고    scopus 로고
    • Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes
    • Nestor, C. E., Ottaviano, R., Reddington, J., Sproul, D., Reinhardt, D., Dunican, D., et al. (2012). Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. Genome Res. 22, 467-477. doi: 10.1101/gr.126417.111.
    • (2012) Genome Res , vol.22 , pp. 467-477
    • Nestor, C.E.1    Ottaviano, R.2    Reddington, J.3    Sproul, D.4    Reinhardt, D.5    Dunican, D.6
  • 74
    • 84992127763 scopus 로고    scopus 로고
    • Widespread natural variation of DNA methylation within angiosperms
    • Niederhuth, C. E., Bewick, A. J., Ji, L., Alabady, M. S., Kim, K. D., Li, Q., et al. (2016). Widespread natural variation of DNA methylation within angiosperms. Genome Biol. 17, 194-212. doi: 10.1186/s13059-016-1059-0.
    • (2016) Genome Biol , vol.17 , pp. 194-212
    • Niederhuth, C.E.1    Bewick, A.J.2    Ji, L.3    Alabady, M.S.4    Kim, K.D.5    Li, Q.6
  • 75
    • 0037099537 scopus 로고    scopus 로고
    • LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t (10;11) (q22;q23)
    • Ono, R., Taki, T., Taketani, T., Taniwaki, M., Kobayashi, H., and Hayashi, Y. (2002). LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t (10;11) (q22;q23). Cancer Res. 62, 4075-4080.
    • (2002) Cancer Res , vol.62 , pp. 4075-4080
    • Ono, R.1    Taki, T.2    Taketani, T.3    Taniwaki, M.4    Kobayashi, H.5    Hayashi, Y.6
  • 76
    • 85015689347 scopus 로고    scopus 로고
    • Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors
    • Papale, L. A., Madrid, A., Li, S., and Alisch, R. S. (2017). Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors. Epigenetics 12, 264-276. doi: 10.1080/15592294.2017.1285986.
    • (2017) Epigenetics , vol.12 , pp. 264-276
    • Papale, L.A.1    Madrid, A.2    Li, S.3    Alisch, R.S.4
  • 77
    • 79956308473 scopus 로고    scopus 로고
    • Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
    • Pastor, W. A., Pape, U. J., Huang, Y., Henderson, H. R., Lister, R., Ko, M., et al. (2011). Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473, 394-397. doi: 10.1038/nature10102.
    • (2011) Nature , vol.473 , pp. 394-397
    • Pastor, W.A.1    Pape, U.J.2    Huang, Y.3    Henderson, H.R.4    Lister, R.5    Ko, M.6
  • 78
    • 80053540965 scopus 로고    scopus 로고
    • Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    • Penagarikano, O., Abrahams, B. S., Herman, E. I., Winden, K. D., Gdalyahu, A., Dong, H., et al. (2011). Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell 147, 235-246. doi: 10.1016/j.cell.2011.08.040.
    • (2011) Cell , vol.147 , pp. 235-246
    • Penagarikano, O.1    Abrahams, B.S.2    Herman, E.I.3    Winden, K.D.4    Gdalyahu, A.5    Dong, H.6
  • 79
    • 0015298215 scopus 로고
    • The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
    • Penn, N. W., Suwalski, R., O'Riley, C., Bojanowski, K., and Yura, R. (1972). The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem. J. 126, 781-790. doi: 10.1042/bj1260781.
    • (1972) Biochem. J , vol.126 , pp. 781-790
    • Penn, N.W.1    Suwalski, R.2    O'Riley, C.3    Bojanowski, K.4    Yura, R.5
  • 81
    • 84892824761 scopus 로고    scopus 로고
    • Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing
    • Prakash, A., Carroll, B. L., Sweasy, J. B., Wallace, S. S., and Doublié, S. (2014). Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. DNA Repair. 14, 17-26. doi: 10.1016/j.dnarep.2013.12.003.
    • (2014) DNA Repair , vol.14 , pp. 17-26
    • Prakash, A.1    Carroll, B.L.2    Sweasy, J.B.3    Wallace, S.S.4    Doublié, S.5
  • 82
  • 83
    • 78651132012 scopus 로고
    • A chemical basis for the host-induced modification of T-even bacteriophages
    • Shedlovsky, A., and Brenner, S. (1963). A chemical basis for the host-induced modification of T-even bacteriophages. Proc. Nat. Acad. Sci. U.S.A. 50, 300-305. doi: 10.1073/pnas.50.2.300.
    • (1963) Proc. Nat. Acad. Sci. U.S.A , vol.50 , pp. 300-305
    • Shedlovsky, A.1    Brenner, S.2
  • 84
    • 84974602567 scopus 로고    scopus 로고
    • Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease
    • Shu, L., Sun, W., Li, L., Xu, Z., Lin, L., Xie, P., et al. (2016). Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease. BMC Genomics 17:381. doi: 10.1186/s12864-016-2731-1.
    • (2016) BMC Genomics , vol.17 , pp. 381
    • Shu, L.1    Sun, W.2    Li, L.3    Xu, Z.4    Lin, L.5    Xie, P.6
  • 85
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: roles in mammalian development
    • Smith, Z. D., and Meissner, A. (2013). DNA methylation: roles in mammalian development. Nat. Rev. Genet. 14, 204-220. doi: 10.1038/nrg3354.
    • (2013) Nat. Rev. Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 86
    • 84964407520 scopus 로고    scopus 로고
    • Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation
    • Song, C. X., Diao, J., Brunger, A. T., and Quake, S. R. (2016). Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation. Proc. Nat. Acad. Sci. U.S.A. 113, 4338-4343. doi: 10.1073/pnas.1600223113.
    • (2016) Proc. Nat. Acad. Sci. U.S.A , vol.113 , pp. 4338-4343
    • Song, C.X.1    Diao, J.2    Brunger, A.T.3    Quake, S.R.4
  • 87
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song, C. X., Szulwach, K. E., Fu, Y., Dai, Q., Yi, C., Li, X., et al. (2011). Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 29, 68-72. doi: 10.1038/nbt.1732.
    • (2011) Nat. Biotechnol , vol.29 , pp. 68-72
    • Song, C.X.1    Szulwach, K.E.2    Fu, Y.3    Dai, Q.4    Yi, C.5    Li, X.6
  • 88
    • 84869392308 scopus 로고    scopus 로고
    • Mapping recently identified nucleotide variants in the genome and transcriptome
    • Song, C. X., Yi, C., and He, C. (2012). Mapping recently identified nucleotide variants in the genome and transcriptome. Nat. Biotechnol. 30, 1107-1116. doi: 10.1038/nbt.2398.
    • (2012) Nat. Biotechnol , vol.30 , pp. 1107-1116
    • Song, C.X.1    Yi, C.2    He, C.3
  • 89
    • 84874771985 scopus 로고    scopus 로고
    • Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
    • Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W., Bauer, C., et al. (2013). Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152, 1146-1159. doi: 10.1016/j.cell.2013.02.004.
    • (2013) Cell , vol.152 , pp. 1146-1159
    • Spruijt, C.G.1    Gnerlich, F.2    Smits, A.H.3    Pfaffeneder, T.4    Jansen, P.W.5    Bauer, C.6
  • 90
    • 84999008873 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human
    • Sun, M., Song, M. M., Wei, B., Gao, Q., Li, L., Yao, B., et al. (2016). 5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human. Hum. Mol. Genet. 25, 2208-2219. doi: 10.1093/hmg/ddw089.
    • (2016) Hum. Mol. Genet , vol.25 , pp. 2208-2219
    • Sun, M.1    Song, M.M.2    Wei, B.3    Gao, Q.4    Li, L.5    Yao, B.6
  • 91
    • 79959859654 scopus 로고    scopus 로고
    • Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells
    • Szulwach, K. E., Li, X., Li, Y., Song, C. X., Han, J. W., Kim, S., et al. (2011a). Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet. 7:e1002154. doi: 10.1371/journal.pgen.1002154.
    • (2011) PLoS Genet , vol.7
    • Szulwach, K.E.1    Li, X.2    Li, Y.3    Song, C.X.4    Han, J.W.5    Kim, S.6
  • 92
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    • Szulwach, K. E., Li, X., Li, Y., Song, C. X., Wu, H., Dai, Q., et al. (2011b). 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat. Neurosci. 14, 1607-1616. doi: 10.1038/nn.2959.
    • (2011) Nat. Neurosci , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1    Li, X.2    Li, Y.3    Song, C.X.4    Wu, H.5    Dai, Q.6
  • 93
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., et al. (2009). Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935. doi: 10.1126/science.1170116.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 94
    • 84953402739 scopus 로고    scopus 로고
    • Blurred boundaries: the RNA binding protein Lin28A is also an epigenetic regulator
    • Tan, F. E., and Yeo, G. W. (2016). Blurred boundaries: the RNA binding protein Lin28A is also an epigenetic regulator. Mol. Cell 61, 1-2. doi: 10.1016/j.molcel.2015.12.018.
    • (2016) Mol. Cell , vol.61 , pp. 1-2
    • Tan, F.E.1    Yeo, G.W.2
  • 95
    • 84876580885 scopus 로고    scopus 로고
    • Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method
    • Tan, L., Xiong, L., Xu, W., Wu, F., Huang, N., Xu, Y., et al. (2013). Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method. Nucleic Acids Res. 41:e84. doi: 10.1093/nar/gkt091.
    • (2013) Nucleic Acids Res , vol.41
    • Tan, L.1    Xiong, L.2    Xu, W.3    Wu, F.4    Huang, N.5    Xu, Y.6
  • 96
    • 84961246642 scopus 로고    scopus 로고
    • Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains
    • Tang, Y., Han, S., Asakawa, T., Luo, Y., Han, X., Xiao, B., et al. (2016). Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains. Neuropsychiatr. Dis. Treat. 12, 617-624. doi: 10.2147/NDT.S97456.
    • (2016) Neuropsychiatr. Dis. Treat , vol.12 , pp. 617-624
    • Tang, Y.1    Han, S.2    Asakawa, T.3    Luo, Y.4    Han, X.5    Xiao, B.6
  • 97
    • 84863042219 scopus 로고    scopus 로고
    • Biochemical characterization of recombinant β-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes
    • Terragni, J., Bitinaite, J., Zheng, Y., and Pradhan, S. (2012). Biochemical characterization of recombinant β-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes. Biochemistry 51, 1009-1019. doi: 10.1021/bi2014739.
    • (2012) Biochemistry , vol.51 , pp. 1009-1019
    • Terragni, J.1    Bitinaite, J.2    Zheng, Y.3    Pradhan, S.4
  • 98
    • 85009078232 scopus 로고    scopus 로고
    • The application of genome-wide 5-hydroxymethylcytosine studies in cancer research
    • Thomson, J. P., and Meehan, R. R. (2017). The application of genome-wide 5-hydroxymethylcytosine studies in cancer research. Epigenetics 9, 77-91. doi: 10.2217/epi-2016-0122.
    • (2017) Epigenetics , vol.9 , pp. 77-91
    • Thomson, J.P.1    Meehan, R.R.2
  • 99
    • 84864677516 scopus 로고    scopus 로고
    • Epigenetics: judge, jury and executioner of stem cell fate
    • Tollervey, J. R., and Lunyak, V. V. (2012). Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics 7, 823-840. doi: 10.4161/epi.21141.
    • (2012) Epigenetics , vol.7 , pp. 823-840
    • Tollervey, J.R.1    Lunyak, V.V.2
  • 100
    • 84944751601 scopus 로고    scopus 로고
    • Functional coupling between writers, erasers and readers of histone and DNA methylation
    • Torres, I. O., and Fujimori, D. G. (2015). Functional coupling between writers, erasers and readers of histone and DNA methylation. Curr. Opin. Struct. Biol. 35, 68-75. doi: 10.1016/j.sbi.2015.09.007.
    • (2015) Curr. Opin. Struct. Biol , vol.35 , pp. 68-75
    • Torres, I.O.1    Fujimori, D.G.2
  • 101
    • 84910090768 scopus 로고    scopus 로고
    • Age-associated decrease in global DNA methylation in patients with major depression
    • Tseng, P. T., Lin, P. Y., Lee, Y., Hung, C. F., Lung, F. W., Chen, C. S., et al. (2014). Age-associated decrease in global DNA methylation in patients with major depression. Neuropsychiatr. Dis. Treat. 10, 2105-2114. doi: 10.2147/NDT.S71997.
    • (2014) Neuropsychiatr. Dis. Treat , vol.10 , pp. 2105-2114
    • Tseng, P.T.1    Lin, P.Y.2    Lee, Y.3    Hung, C.F.4    Lung, F.W.5    Chen, C.S.6
  • 102
    • 84942251301 scopus 로고    scopus 로고
    • MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells
    • Tu, J., Ng, S. H., Luk, A. C., Liao, J., Jiang, X., Feng, B., et al. (2015). MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res. 43, 7805-7822. doi: 10.1093/nar/gkv653.
    • (2015) Nucleic Acids Res , vol.43 , pp. 7805-7822
    • Tu, J.1    Ng, S.H.2    Luk, A.C.3    Liao, J.4    Jiang, X.5    Feng, B.6
  • 103
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA Maintenance methyltransferase DNMT1
    • Valinluck, V., and Sowers, L. C. (2007). Endogenous cytosine damage products alter the site selectivity of human DNA Maintenance methyltransferase DNMT1. Cancer Res. 67, 946-950. doi: 10.1158/0008-5472.CAN-06-3123.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 105
    • 84877744385 scopus 로고    scopus 로고
    • Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease
    • Villar-Menéndez, I., Blanch, M., Tyebji, S., Pereira-Veiga, T., Albasanz, J. L., Martín, M., et al. (2013). Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease. Neuromolecular. Med. 15, 295-309. doi: 10.1007/s12017-013-8219-0.
    • (2013) Neuromolecular. Med , vol.15 , pp. 295-309
    • Villar-Menéndez, I.1    Blanch, M.2    Tyebji, S.3    Pereira-Veiga, T.4    Albasanz, J.L.5    Martín, M.6
  • 106
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., et al. (2008). Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470-476. doi: 10.1038/nature07509.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3    Khrebtukova, I.4    Zhang, L.5    Mayr, C.6
  • 107
    • 84883012277 scopus 로고    scopus 로고
    • Genome-wide loss of 5hmC is a novel epigenetic feature of Huntington's disease
    • Wang, F., Yang, Y., Lin, X., Wang, J. Q., Wu, Y. S., Xie, W., et al. (2013). Genome-wide loss of 5hmC is a novel epigenetic feature of Huntington's disease. Hum. Mol. Genet. 22, 3641-3653. doi: 10.1093/hmg/ddt214.
    • (2013) Hum. Mol. Genet , vol.22 , pp. 3641-3653
    • Wang, F.1    Yang, Y.2    Lin, X.3    Wang, J.Q.4    Wu, Y.S.5    Xie, W.6
  • 108
    • 84948407931 scopus 로고    scopus 로고
    • Genome-wide mapping of 5-hydroxymethylcytosine in three rice cultivars reveals its preferential localization in transcriptionally silent transposable element genes
    • Wang, X. L., Song, S. H., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., et al. (2015). Genome-wide mapping of 5-hydroxymethylcytosine in three rice cultivars reveals its preferential localization in transcriptionally silent transposable element genes. J. Exp. Bot. 66, 6651-6663. doi: 10.1093/jxb/erv372.
    • (2015) J. Exp. Bot , vol.66 , pp. 6651-6663
    • Wang, X.L.1    Song, S.H.2    Luo, S.3    Khrebtukova, I.4    Zhang, L.5    Mayr, C.6
  • 109
    • 80051556380 scopus 로고    scopus 로고
    • Epigenetics in C. elegans: facts and challenges
    • Wenzel, D., Palladino, F., and Jedrusik-Bode, M. (2011). Epigenetics in C. elegans: facts and challenges. Genesis 49, 647-661. doi: 10.1002/dvg.20762.
    • (2011) Genesis , vol.49 , pp. 647-661
    • Wenzel, D.1    Palladino, F.2    Jedrusik-Bode, M.3
  • 110
    • 33646008874 scopus 로고    scopus 로고
    • N6-methyl-adenine: an epigenetic signal for DNA-protein interactions
    • Wion, D., and Casadesus, J. (2006). N6-methyl-adenine: an epigenetic signal for DNA-protein interactions. Nat. Rev. Microbiol. 4, 183-192. doi: 10.1038/nrmicro1350.
    • (2006) Nat. Rev. Microbiol , vol.4 , pp. 183-192
    • Wion, D.1    Casadesus, J.2
  • 111
    • 77953596050 scopus 로고    scopus 로고
    • Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes
    • Wossidlo, M., Arand, J., Sebastiano, V., Lepikhov, K., Boiani, M., Reinhardt, R., et al. (2010). Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. EMBO J. 29, 1877-1888. doi: 10.1038/emboj.2010.80.
    • (2010) EMBO J , vol.29 , pp. 1877-1888
    • Wossidlo, M.1    Arand, J.2    Sebastiano, V.3    Lepikhov, K.4    Boiani, M.5    Reinhardt, R.6
  • 112
    • 79954457998 scopus 로고    scopus 로고
    • Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
    • Wu, H., D'Alessio, A. C., Ito, S., Wang, Z., Cui, K., Zhao, K., et al. (2011). Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes Dev. 25, 679-684. doi: 10.1101/gad.2036011.
    • (2011) Genes Dev , vol.25 , pp. 679-684
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3    Wang, Z.4    Cui, K.5    Zhao, K.6
  • 113
    • 34250317798 scopus 로고
    • A new pyrimidine base from bacteriophage nucleic acids
    • Wyatt, G. R., and Cohen, S. S. (1952). A new pyrimidine base from bacteriophage nucleic acids. Nature 170, 1072-1073. doi: 10.1038/1701072a0.
    • (1952) Nature , vol.170 , pp. 1072-1073
    • Wyatt, G.R.1    Cohen, S.S.2
  • 114
    • 0001129080 scopus 로고
    • The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine
    • Wyatt, G. R., and Cohen, S. S. (1953). The bases of the nucleic acids of some bacterial and animal viruses: the occurrence of 5-hydroxymethylcytosine. Biochem. J. 55, 774-782. doi: 10.1042/bj0550774.
    • (1953) Biochem. J , vol.55 , pp. 774-782
    • Wyatt, G.R.1    Cohen, S.S.2
  • 115
    • 84893015285 scopus 로고    scopus 로고
    • Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome
    • Yao, B., Lin, L., Street, R. C., Zalewski, Z. A., Galloway, J. N., Wu, H., et al. (2014). Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome. Hum. Mol. Genet. 23, 1095-1107. doi: 10.1093/hmg/ddt504.
    • (2014) Hum. Mol. Genet , vol.23 , pp. 1095-1107
    • Yao, B.1    Lin, L.2    Street, R.C.3    Zalewski, Z.A.4    Galloway, J.N.5    Wu, H.6
  • 116
    • 84859387765 scopus 로고    scopus 로고
    • Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA
    • Yao, Q., Song, C. X., He, C., Kumaran, D., and Dunn, J. J. (2012). Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA. Protein Expr. Purif. 83, 104-111. doi: 10.1016/j.pep.2012.03.003.
    • (2012) Protein Expr. Purif , vol.83 , pp. 104-111
    • Yao, Q.1    Song, C.X.2    He, C.3    Kumaran, D.4    Dunn, J.J.5
  • 117
    • 84924578243 scopus 로고    scopus 로고
    • HP1 is involved in regulating the global impact of DNA methylation on alternative splicing
    • Yearim, A., Gelfman, S., Shayevitch, R., Melcer, S., Glaich, O., Mallm, J. P., et al. (2015). HP1 is involved in regulating the global impact of DNA methylation on alternative splicing. Cell Rep. 10, 1122-1134. doi: 10.1016/j.celrep.2015.01.038.
    • (2015) Cell Rep , vol.10 , pp. 1122-1134
    • Yearim, A.1    Gelfman, S.2    Shayevitch, R.3    Melcer, S.4    Glaich, O.5    Mallm, J.P.6
  • 118
    • 84870620786 scopus 로고    scopus 로고
    • Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine
    • Yu, M., Hon, G. C., Szulwach, K. E., Song, C. X., Jin, P., Ren, B., et al. (2012). Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine. Nat. Protoc. 7, 2159-2170. doi: 10.1038/nprot.2012.137.
    • (2012) Nat. Protoc , vol.7 , pp. 2159-2170
    • Yu, M.1    Hon, G.C.2    Szulwach, K.E.3    Song, C.X.4    Jin, P.5    Ren, B.6
  • 119
    • 34249845812 scopus 로고    scopus 로고
    • The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase
    • Yu, Z., Genest, P. A., ter Riet, B., Sweeney, K., DiPaolo, C., Kieft, R., et al. (2007). The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. Nucleic Acids Res. 35, 2107-2115. doi: 10.1093/nar/gkm049.
    • (2007) Nucleic Acids Res , vol.35 , pp. 2107-2115
    • Yu, Z.1    Genest, P.A.2    ter Riet, B.3    Sweeney, K.4    DiPaolo, C.5    Kieft, R.6
  • 120
    • 84953410774 scopus 로고    scopus 로고
    • Lin28A binds active promoters and recruits Tet1 to regulate gene expression
    • Zeng, Y., Yao, B., Shin, J., Lin, L., Kim, N., Song, Q., et al. (2016). Lin28A binds active promoters and recruits Tet1 to regulate gene expression. Mol. Cell. 61, 153-160. doi: 10.1016/j.molcel.2015.11.020.
    • (2016) Mol. Cell , vol.61 , pp. 153-160
    • Zeng, Y.1    Yao, B.2    Shin, J.3    Lin, L.4    Kim, N.5    Song, Q.6
  • 121
    • 84901950311 scopus 로고    scopus 로고
    • Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2
    • Zhou, T., Xiong, J., Wang, M., Yang, N., Wong, J., Zhu, B., et al. (2014). Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. Mol. Cell. 54, 879-886. doi: 10.1016/j.molcel.2014.04.003.
    • (2014) Mol. Cell , vol.54 , pp. 879-886
    • Zhou, T.1    Xiong, J.2    Wang, M.3    Yang, N.4    Wong, J.5    Zhu, B.6
  • 122
    • 73349104113 scopus 로고    scopus 로고
    • Active DNA demethylation mediated by DNA glycosylases
    • Zhu, J. K. (2009). Active DNA demethylation mediated by DNA glycosylases. Annu. Rev. Genet. 43, 143-166. doi: 10.1146/annurev-genet-102108-134205.
    • (2009) Annu. Rev. Genet , vol.43 , pp. 143-166
    • Zhu, J.K.1


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