Hippocampal increase of 5-hmC in the glucocorticoid receptor gene following acute stress

Behavioural Brain Research

Volumn 286, Issue , 2015, Pages 236-240

  Li, Sisi ^a,b   Papale, Ligia A ^b   Kintner, Douglas B ^b,c   Sabat, Grzegorz ^a   Barrett Wilt, Gregory A ^a   Cengiz, Pelin ^b,c   Alisch, Reid S ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

5 hmC; Acute stress; DNA methylation; Epigenetics

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; BISULFITE; GLUCOCORTICOID RECEPTOR; 3' UNTRANSLATED REGION; 5-HYDROXYMETHYLCYTOSINE; CYTOSINE; NR3C1 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ACUTE STRESS; ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; BRAIN REGION; CELLULAR DISTRIBUTION; DENTATE GYRUS; DNA METHYLATION; EXON; GENE; GENE EXPRESSION; GENE FUNCTION; HIPPOCAMPUS; HISTONE MODIFICATION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL; NONHUMAN; NR3C1 GENE; OXIDATIVE STRESS; PREFRONTAL CORTEX; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ACUTE DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; DISEASE MODEL; EXERCISE; GENETICS; MENTAL STRESS; METABOLISM; PATHOLOGY; RANDOMIZATION;

3' UNTRANSLATED REGIONS; ACUTE DISEASE; ANIMALS; CYTOSINE; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MICE; NEURONS; RANDOM ALLOCATION; RECEPTORS, GLUCOCORTICOID; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL;

EID: 84924971913     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.03.002     Document Type: Article

References (16)

1. Abdolmaleky H.M., Cheng K.H., Faraone S.V., Wilcox M., Glatt S.J., Gao F., et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet 2006, 15(21):3132-3145.
2. Grayson D.R., Jia X., Chen Y., Sharma R.P., Mitchell C.P., Guidotti A., et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A 2005, 102(26):9341-9346.
3. Hunter R.G., McCarthy K.J., Milne T.A., Pfaff D.W., McEwen B.S. Regulation of hippocampal H3 histone methylation by acute and chronic stress. Proc Natl Acad Sci U S A 2009, 106(49):20912-20917.
4. Kuratomi G., Iwamoto K., Bundo M., Kusumi I., Kato N., Iwata N., et al. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry 2008, 13(4):429-441.
5. Poulter M.O., Du L., Weaver I.C., Palkovits M., Faludi G., Merali Z., et al. GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry 2008, 64(8):645-652.
6. Chia N., Wang L., Lu X., Senut M.C., Brenner C., Ruden D.M. Hypothesis: environmental regulation of 5-hydroxymethylcytosine by oxidative stress. Epigenetics 2011, 6(7):853-856.
7. Chopra P., Papale L.A., White A.T., Hatch A., Brown R.M., Garthwaite M.A., et al. Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics 2014, 15:131.
8. Szulwach K.E., Li X., Li Y., Song C.X., Wu H., Dai Q., et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci 2011, 14(12):1607-1616.
9. Li X., Wei W., Zhao Q.Y., Widagdo J., Baker-Andresen D., Flavell C.R., et al. Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation. Proc Natl Acad Sci U S A 2014, 111(19):7120-7125.
10. Rudenko A., Dawlaty M.M., Seo J., Cheng A.W., Meng J., Le T., et al. Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron 2013, 79(6):1109-1122.
11. Crosio C., Heitz E., Allis C.D., Borrelli E., Sassone-Corsi P. Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci 2003, 116(Pt 24):4905-4914.
12. Gray J.D., Rubin T.G., Hunter R.G., McEwen B.S. Hippocampal gene expression changes underlying stress sensitization and recovery. Mol Psychiatry 2014, 19(11):1171-1178.
13. Ferrazzano P., Chanana V., Uluc K., Fidan E., Akture E., Kintner D.B., et al. Age-dependent microglial activation in immature brains after hypoxia-ischemia. CNS Neurol Disord Drug Targets 2013, 12(3):338-349.
14. Zhang T.Y., Labonte B., Wen X.L., Turecki G., Meaney M.J. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology: Official publication of the American College of Neuropsychopharmacology 2013, 38(1):111-123.
15. McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonte B., Szyf M., et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009, 12(3):342-348.
16. Yu M., Hon G.C., Szulwach K.E., Song C.X., Zhang L., Kim A., et al. Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell 2012, 149(6):1368-1380.