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Volumn 14, Issue 3, 2016, Pages 493-505

Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration

Author keywords

[No Author keywords available]

Indexed keywords

5 CARBOXYLCYTOSINE; CYTOSINE; MESSENGER RNA; OXIDOREDUCTASE; PROTEIN TET3; UNCLASSIFIED DRUG; 5-CARBOXYLCYTOSINE; DNA BINDING PROTEIN; HISTONE; ISOPROTEIN; ONCOPROTEIN; TET3 PROTEIN, MOUSE;

EID: 84953313336     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.12.044     Document Type: Article
Times cited : (100)

References (73)
  • 2
    • 84901705539 scopus 로고    scopus 로고
    • E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex
    • Coey C.T., Fitzgerald M.E., Maiti A., Reiter K.H., Guzzo C.M., Matunis M.J., Drohat A.C. E2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex. J. Biol. Chem. 2014, 289:15810-15819.
    • (2014) J. Biol. Chem. , vol.289 , pp. 15810-15819
    • Coey, C.T.1    Fitzgerald, M.E.2    Maiti, A.3    Reiter, K.H.4    Guzzo, C.M.5    Matunis, M.J.6    Drohat, A.C.7
  • 6
    • 84947745064 scopus 로고    scopus 로고
    • Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease
    • Gan-Or Z., Dion P.A., Rouleau G.A. Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease. Autophagy 2015, 11:1443-1457.
    • (2015) Autophagy , vol.11 , pp. 1443-1457
    • Gan-Or, Z.1    Dion, P.A.2    Rouleau, G.A.3
  • 8
    • 35549003626 scopus 로고    scopus 로고
    • The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase
    • Guan X., Madabushi A., Chang D.Y., Fitzgerald M.E., Shi G., Drohat A.C., Lu A.L. The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase. Nucleic Acids Res. 2007, 35:6207-6218.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 6207-6218
    • Guan, X.1    Madabushi, A.2    Chang, D.Y.3    Fitzgerald, M.E.4    Shi, G.5    Drohat, A.C.6    Lu, A.L.7
  • 9
    • 84914817563 scopus 로고    scopus 로고
    • Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote
    • Guo F., Li X., Liang D., Li T., Zhu P., Guo H., Wu X., Wen L., Gu T.P., Hu B., et al. Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote. Cell Stem Cell 2014, 15:447-458.
    • (2014) Cell Stem Cell , vol.15 , pp. 447-458
    • Guo, F.1    Li, X.2    Liang, D.3    Li, T.4    Zhu, P.5    Guo, H.6    Wu, X.7    Wen, L.8    Gu, T.P.9    Hu, B.10
  • 10
  • 12
    • 84927696607 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine: a stable or transient DNA modification?
    • Hahn M.A., Szabó P.E., Pfeifer G.P. 5-Hydroxymethylcytosine: a stable or transient DNA modification?. Genomics 2014, 104:314-323.
    • (2014) Genomics , vol.104 , pp. 314-323
    • Hahn, M.A.1    Szabó, P.E.2    Pfeifer, G.P.3
  • 14
    • 0037086643 scopus 로고    scopus 로고
    • Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover
    • Hardeland U., Steinacher R., Jiricny J., Schär P. Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J. 2002, 21:1456-1464.
    • (2002) EMBO J. , vol.21 , pp. 1456-1464
    • Hardeland, U.1    Steinacher, R.2    Jiricny, J.3    Schär, P.4
  • 16
    • 84878667424 scopus 로고    scopus 로고
    • Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH
    • Hashimoto H., Zhang X., Cheng X. Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst.) 2013, 12:535-540.
    • (2013) DNA Repair (Amst.) , vol.12 , pp. 535-540
    • Hashimoto, H.1    Zhang, X.2    Cheng, X.3
  • 18
    • 0036847620 scopus 로고    scopus 로고
    • Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes
    • Hassan A.H., Prochasson P., Neely K.E., Galasinski S.C., Chandy M., Carrozza M.J., Workman J.L. Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Cell 2002, 111:369-379.
    • (2002) Cell , vol.111 , pp. 369-379
    • Hassan, A.H.1    Prochasson, P.2    Neely, K.E.3    Galasinski, S.C.4    Chandy, M.5    Carrozza, M.J.6    Workman, J.L.7
  • 19
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He Y.F., Li B.Z., Li Z., Liu P., Wang Y., Tang Q., Ding J., Jia Y., Chen Z., Li L., et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011, 333:1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6    Ding, J.7    Jia, Y.8    Chen, Z.9    Li, L.10
  • 20
    • 84894560490 scopus 로고    scopus 로고
    • Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation
    • Hu L., Li Z., Cheng J., Rao Q., Gong W., Liu M., Shi Y.G., Zhu J., Wang P., Xu Y. Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell 2013, 155:1545-1555.
    • (2013) Cell , vol.155 , pp. 1545-1555
    • Hu, L.1    Li, Z.2    Cheng, J.3    Rao, Q.4    Gong, W.5    Liu, M.6    Shi, Y.G.7    Zhu, J.8    Wang, P.9    Xu, Y.10
  • 21
    • 84897989106 scopus 로고    scopus 로고
    • Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming
    • Hu X., Zhang L., Mao S.Q., Li Z., Chen J., Zhang R.R., Wu H.P., Gao J., Guo F., Liu W., et al. Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming. Cell Stem Cell 2014, 14:512-522.
    • (2014) Cell Stem Cell , vol.14 , pp. 512-522
    • Hu, X.1    Zhang, L.2    Mao, S.Q.3    Li, Z.4    Chen, J.5    Zhang, R.R.6    Wu, H.P.7    Gao, J.8    Guo, F.9    Liu, W.10
  • 23
    • 79952763586 scopus 로고    scopus 로고
    • Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
    • Iqbal K., Jin S.G., Pfeifer G.P., Szabó P.E. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc. Natl. Acad. Sci. USA 2011, 108:3642-3647.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 3642-3647
    • Iqbal, K.1    Jin, S.G.2    Pfeifer, G.P.3    Szabó, P.E.4
  • 24
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito S., D'Alessio A.C., Taranova O.V., Hong K., Sowers L.C., Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010, 466:1129-1133.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 25
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S., Shen L., Dai Q., Wu S.C., Collins L.B., Swenberg J.A., He C., Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011, 333:1300-1303.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 28
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: the mark and its mediators
    • Klose R.J., Bird A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 2006, 31:89-97.
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 31
    • 84877930005 scopus 로고    scopus 로고
    • DNA methylation and methylcytosine oxidation in cell fate decisions
    • Koh K.P., Rao A. DNA methylation and methylcytosine oxidation in cell fate decisions. Curr. Opin. Cell Biol. 2013, 25:152-161.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 152-161
    • Koh, K.P.1    Rao, A.2
  • 32
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S., Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009, 324:929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 34
    • 84877778628 scopus 로고    scopus 로고
    • Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules
    • Liu N., Wang M., Deng W., Schmidt C.S., Qin W., Leonhardt H., Spada F. Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules. PLoS ONE 2013, 8:e62755.
    • (2013) PLoS ONE , vol.8 , pp. e62755
    • Liu, N.1    Wang, M.2    Deng, W.3    Schmidt, C.S.4    Qin, W.5    Leonhardt, H.6    Spada, F.7
  • 36
    • 85005843352 scopus 로고    scopus 로고
    • Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability
    • Liu N., Zhang Z., Wu H., Jiang Y., Meng L., Xiong J., Zhao Z., Zhou X., Li J., Li H., et al. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 2015, 29:379-393.
    • (2015) Genes Dev. , vol.29 , pp. 379-393
    • Liu, N.1    Zhang, Z.2    Wu, H.3    Jiang, Y.4    Meng, L.5    Xiong, J.6    Zhao, Z.7    Zhou, X.8    Li, J.9    Li, H.10
  • 37
    • 84924441282 scopus 로고    scopus 로고
    • Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics
    • Lu X., Han D., Zhao B.S., Song C.X., Zhang L.S., Doré L.C., He C. Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics. Cell Res. 2015, 25:386-389.
    • (2015) Cell Res. , vol.25 , pp. 386-389
    • Lu, X.1    Han, D.2    Zhao, B.S.3    Song, C.X.4    Zhang, L.S.5    Doré, L.C.6    He, C.7
  • 38
    • 80053917872 scopus 로고    scopus 로고
    • Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
    • Maiti A., Drohat A.C. Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. J. Biol. Chem. 2011, 286:35334-35338.
    • (2011) J. Biol. Chem. , vol.286 , pp. 35334-35338
    • Maiti, A.1    Drohat, A.C.2
  • 41
    • 84877693964 scopus 로고    scopus 로고
    • Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
    • Minor E.A., Court B.L., Young J.I., Wang G. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J. Biol. Chem. 2013, 288:13669-13674.
    • (2013) J. Biol. Chem. , vol.288 , pp. 13669-13674
    • Minor, E.A.1    Court, B.L.2    Young, J.I.3    Wang, G.4
  • 43
    • 80052716148 scopus 로고    scopus 로고
    • Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
    • Palmieri M., Impey S., Kang H., di Ronza A., Pelz C., Sardiello M., Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum. Mol. Genet. 2011, 20:3852-3866.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3852-3866
    • Palmieri, M.1    Impey, S.2    Kang, H.3    di Ronza, A.4    Pelz, C.5    Sardiello, M.6    Ballabio, A.7
  • 44
    • 39549106043 scopus 로고    scopus 로고
    • CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins
    • Parsons J.L., Tait P.S., Finch D., Dianova I.I., Allinson S.L., Dianov G.L. CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. Mol. Cell 2008, 29:477-487.
    • (2008) Mol. Cell , vol.29 , pp. 477-487
    • Parsons, J.L.1    Tait, P.S.2    Finch, D.3    Dianova, I.I.4    Allinson, S.L.5    Dianov, G.L.6
  • 47
    • 84876794613 scopus 로고    scopus 로고
    • 5-hydroxymethylcytosine and its potential roles in development and cancer
    • Pfeifer G.P., Kadam S., Jin S.G. 5-hydroxymethylcytosine and its potential roles in development and cancer. Epigenetics Chromatin 2013, 6:10.
    • (2013) Epigenetics Chromatin , vol.6 , pp. 10
    • Pfeifer, G.P.1    Kadam, S.2    Jin, S.G.3
  • 49
    • 77950672979 scopus 로고    scopus 로고
    • Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease
    • Schneider L., Zhang J. Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease. Mol. Neurodegener. 2010, 5:14.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 14
    • Schneider, L.1    Zhang, J.2
  • 52
    • 84860441181 scopus 로고    scopus 로고
    • Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics
    • Shacka J.J. Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics. Brain Res. Bull. 2012, 88:43-57.
    • (2012) Brain Res. Bull. , vol.88 , pp. 43-57
    • Shacka, J.J.1
  • 53
    • 84876946045 scopus 로고    scopus 로고
    • Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics
    • Shen L., Wu H., Diep D., Yamaguchi S., D'Alessio A.C., Fung H.L., Zhang K., Zhang Y. Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics. Cell 2013, 153:692-706.
    • (2013) Cell , vol.153 , pp. 692-706
    • Shen, L.1    Wu, H.2    Diep, D.3    Yamaguchi, S.4    D'Alessio, A.C.5    Fung, H.L.6    Zhang, K.7    Zhang, Y.8
  • 54
    • 84914818905 scopus 로고    scopus 로고
    • Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes
    • Shen L., Inoue A., He J., Liu Y., Lu F., Zhang Y. Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell 2014, 15:459-470.
    • (2014) Cell Stem Cell , vol.15 , pp. 459-470
    • Shen, L.1    Inoue, A.2    He, J.3    Liu, Y.4    Lu, F.5    Zhang, Y.6
  • 56
    • 39549095122 scopus 로고    scopus 로고
    • CHIPping away at base excision repair
    • Sobol R.W. CHIPping away at base excision repair. Mol. Cell 2008, 29:413-415.
    • (2008) Mol. Cell , vol.29 , pp. 413-415
    • Sobol, R.W.1
  • 57
    • 79952053850 scopus 로고    scopus 로고
    • Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation
    • Song J., Rechkoblit O., Bestor T.H., Patel D.J. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science 2011, 331:1036-1040.
    • (2011) Science , vol.331 , pp. 1036-1040
    • Song, J.1    Rechkoblit, O.2    Bestor, T.H.3    Patel, D.J.4
  • 62
    • 44849099551 scopus 로고    scopus 로고
    • Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse
    • Tsunemoto K., Anzai M., Matsuoka T., Tokoro M., Shin S.W., Amano T., Mitani T., Kato H., Hosoi Y., Saeki K., et al. Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse. Mol. Reprod. Dev. 2008, 75:1104-1108.
    • (2008) Mol. Reprod. Dev. , vol.75 , pp. 1104-1108
    • Tsunemoto, K.1    Anzai, M.2    Matsuoka, T.3    Tokoro, M.4    Shin, S.W.5    Amano, T.6    Mitani, T.7    Kato, H.8    Hosoi, Y.9    Saeki, K.10
  • 63
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
    • Valinluck V., Sowers L.C. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res. 2007, 67:946-950.
    • (2007) Cancer Res. , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 64
    • 84899091504 scopus 로고    scopus 로고
    • Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
    • Wen L., Li X., Yan L., Tan Y., Li R., Zhao Y., Wang Y., Xie J., Zhang Y., Song C., et al. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biol. 2014, 15:R49.
    • (2014) Genome Biol. , vol.15 , pp. R49
    • Wen, L.1    Li, X.2    Yan, L.3    Tan, Y.4    Li, R.5    Zhao, Y.6    Wang, Y.7    Xie, J.8    Zhang, Y.9    Song, C.10
  • 67
    • 84892763878 scopus 로고    scopus 로고
    • Reversing DNA methylation: mechanisms, genomics, and biological functions
    • Wu H., Zhang Y. Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell 2014, 156:45-68.
    • (2014) Cell , vol.156 , pp. 45-68
    • Wu, H.1    Zhang, Y.2
  • 68
    • 79955948324 scopus 로고    scopus 로고
    • Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
    • Xu Y., Wu F., Tan L., Kong L., Xiong L., Deng J., Barbera A.J., Zheng L., Zhang H., Huang S., et al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol. Cell 2011, 42:451-464.
    • (2011) Mol. Cell , vol.42 , pp. 451-464
    • Xu, Y.1    Wu, F.2    Tan, L.3    Kong, L.4    Xiong, L.5    Deng, J.6    Barbera, A.J.7    Zheng, L.8    Zhang, H.9    Huang, S.10
  • 69
    • 84870883633 scopus 로고    scopus 로고
    • Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development
    • Xu Y., Xu C., Kato A., Tempel W., Abreu J.G., Bian C., Hu Y., Hu D., Zhao B., Cerovina T., et al. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell 2012, 151:1200-1213.
    • (2012) Cell , vol.151 , pp. 1200-1213
    • Xu, Y.1    Xu, C.2    Kato, A.3    Tempel, W.4    Abreu, J.G.5    Bian, C.6    Hu, Y.7    Hu, D.8    Zhao, B.9    Cerovina, T.10
  • 70
    • 84890568163 scopus 로고    scopus 로고
    • Role of Tet1 in erasure of genomic imprinting
    • Yamaguchi S., Shen L., Liu Y., Sendler D., Zhang Y. Role of Tet1 in erasure of genomic imprinting. Nature 2013, 504:460-464.
    • (2013) Nature , vol.504 , pp. 460-464
    • Yamaguchi, S.1    Shen, L.2    Liu, Y.3    Sendler, D.4    Zhang, Y.5
  • 71
    • 84880344660 scopus 로고    scopus 로고
    • Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
    • Yin R., Mao S.Q., Zhao B., Chong Z., Yang Y., Zhao C., Zhang D., Huang H., Gao J., Li Z., et al. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J. Am. Chem. Soc. 2013, 135:10396-10403.
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 10396-10403
    • Yin, R.1    Mao, S.Q.2    Zhao, B.3    Chong, Z.4    Yang, Y.5    Zhao, C.6    Zhang, D.7    Huang, H.8    Gao, J.9    Li, Z.10
  • 72
    • 41649092299 scopus 로고    scopus 로고
    • Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin
    • Zhang K., Mosch K., Fischle W., Grewal S.I. Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin. Nat. Struct. Mol. Biol. 2008, 15:381-388.
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 381-388
    • Zhang, K.1    Mosch, K.2    Fischle, W.3    Grewal, S.I.4


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