Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: Potential implications for active demethylation of CpG sites

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 35334-35338

  Maiti, Atanu ^a   Drohat, Alexander C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIRS; CATALYTIC MECHANISMS; DECARBOXYLASES; DEMETHYLATION; DNA DEMETHYLATION; DNA GLYCOSYLASE; EMBRYONIC DEVELOPMENT; GLYCOSYLASE; OXIDATION PRODUCTS; POTENTIAL MECHANISM;

DNA;

CHEMICAL REACTIONS;

5 CARBOXYLCYTOSINE; 5 FORMYLCYTOSINE; 5 METHYLCYTOSINE; CYTOSINE DERIVATIVE; DNA; GUANINE; THYMINE; THYMINE DNA GLYCOSYLASE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; CONTROLLED STUDY; CPG ISLAND; DEAMINATION; DEMETHYLATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME SPECIFICITY; EXCISION REPAIR; HUMAN; HUMAN CELL; MUTAGENESIS; NUCLEIC ACID STRUCTURE; OXIDATION; PRIORITY JOURNAL;

CPG ISLANDS; CYTIDINE; CYTOSINE; DNA METHYLATION; HUMANS; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY; THYMINE DNA GLYCOSYLASE;

EID: 80053917872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.284620     Document Type: Article

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