Nutrition, inflammation and cancer

Nature Immunology

Volumn 18, Issue 8, 2017, Pages 843-850

  Zitvogel, Laurence ^a,b,c   Pietrocola, Federico ^a,d,e,f,g   Kroemer, Guido ^{a,b,c,d,e,f,g,h,i}  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c Center of Clinical Investigations in Biotherapies of Cancer (CICBT)   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

^f INSERM   (France)

^g SORBONNE UNIVERSITÉ   (France)

^h HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

ⁱ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; COLECALCIFEROL; PYRIDOXAL KINASE; PYRIDOXINE; VITAMIN D RECEPTOR; VITAMIN;

ADAPTIVE IMMUNITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; BODY COMPOSITION; CALORIC RESTRICTION; CANCER EPIDEMIOLOGY; CANCER GROWTH; CANCER THERAPY; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CELL TRANSFORMATION; CHRONIC INFLAMMATION; DIET RESTRICTION; ENZYME PHOSPHORYLATION; FOOD INTAKE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTESTINE FLORA; LEUKOCYTE; MALIGNANT NEOPLASM; NONHUMAN; NUTRITION; PHENOTYPE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; TREATMENT RESPONSE; TUMOR MICROENVIRONMENT; DIET; IMMUNOLOGY; METABOLIC SYNDROME X; MICROFLORA; NEOPLASM; OBESITY; OVERNUTRITION; RISK FACTOR; WESTERN DIET;

DIET; DIET, WESTERN; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; MICROBIOTA; NEOPLASMS; OBESITY; OVERNUTRITION; RISK FACTORS; VITAMINS;

EID: 85025834104     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3754     Document Type: Review

References (99)

1. Schoemaker, M.J. et al. Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom. Breast Cancer Res. 18, 72 (2016).
2. Font-Burgada, J., Sun, B. &Karin, M. Obesity and cancer: the oil that feeds the flame. Cell Metab. 23, 48-62 (2016).
3. Stringhini, S. et al. Socioeconomic status and the 25×25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women. Lancet 389, 1229-1237 (2017).
4. Deng, T., Lyon, C.J., Bergin, S., Caligiuri, M.A. &Hsueh, W.A. Obesity, inflammation, and cancer. Annu. Rev. Pathol. 11, 421-449 (2016).
5. Tomasetti, C. &Vogelstein, B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78-81 (2015).
6. Tomasetti, C., Li, L. &Vogelstein, B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 355, 1330-1334 (2017).
7. López-Otín, C., Galluzzi, L., Freije, J.M., Madeo, F. &Kroemer, G. Metabolic control of longevity. Cell 166, 802-821 (2016).
8. Koene, R.J., Prizment, A.E., Blaes, A. &Konety, S.H. Shared risk factors in cardiovascular disease and cancer. Circulation 133, 1104-1114 (2016).
9. Hullar, M.A., Burnett-Hartman, A.N. &Lampe, J.W. Gut microbes, diet, and cancer. Cancer Treat. Res. 159, 377-399 (2014).
10. O'Keefe, S.J. Diet, microorganisms and their metabolites, and colon cancer. Nat. Rev. Gastroenterol. Hepatol. 13, 691-706 (2016).
11. Schäfer, M. &Werner, S. Cancer as an overhealing wound: an old hypothesis revisited. Nat. Rev. Mol. Cell Biol. 9, 628-638 (2008).
12. Palucka, A.K. &Coussens, L.M. The basis of oncoimmunology. Cell 164, 1233-1247 (2016).
13. Zitvogel, L., Kepp, O., Galluzzi, L. &Kroemer, G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat. Immunol. 13, 343-351 (2012).
14. Karki, R., Man, S.M. &Kanneganti, T.D. Inflammasomes and cancer. Cancer Immunol. Res. 5, 94-99 (2017).
15. Nathan, C. &Cunningham-Bussel, A. Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat. Rev. Immunol. 13, 349-361 (2013).
16. Elliott, L.A., Doherty, G.A., Sheahan, K. &Ryan, E.J. Human tumor-infiltrating myeloid cells: phenotypic and functional diversity. Front. Immunol. 8, 86 (2017).
17. Chen, W. &Ten Dijke, P. Immunoregulation by members of the TGFβ superfamily. Nat. Rev. Immunol. 16, 723-740 (2016).
18. Mittal, D., Gubin, M.M., Schreiber, R.D. &Smyth, M.J. New insights into cancer immunoediting and its three component phases: elimination, equilibrium and escape. Curr. Opin. Immunol. 27, 16-25 (2014).
19. Zitvogel, L., Tesniere, A. &Kroemer, G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat. Rev. Immunol. 6, 715-727 (2006).
20. Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. &Kroemer, G. Immunological effects of conventional chemotherapy and targeted anticancer agents. Cancer Cell 28, 690-714 (2015).
21. Krysko, D.V. et al. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860-875 (2012).
22. Sharma, P. &Allison, J.P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161, 205-214 (2015).
23. Pitt, J.M. et al. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and-extrinsic factors. Immunity 44, 1255-1269 (2016).
24. Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782-795 (2013).
25. Tirosh, I. et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 (2016).
26. Bougherara, H. et al. Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration. Front. Immunol. 6, 500 (2015).
27. Vacchelli, E. et al. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350, 972-978 (2015).
28. Shivappa, N., Steck, S.E., Hurley, T.G., Hussey, J.R. &Hébert, J.R. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 17, 1689-1696 (2014).
29. Prieto, I., Montemuiño, S., Luna, J., de Torres, M.V. &Amaya, E. The role of immunonutritional support in cancer treatment: current evidence. Clin. Nutr. http://dx.doi.org/0.1016/j.clnu.2016.11.015 (2016).
30. Iyengar, N.M., Gucalp, A., Dannenberg, A.J. &Hudis, C.A. Obesity and cancer mechanisms: tumor microenvironment and inflammation. J. Clin. Oncol. 34, 4270-4276 (2016).
31. Louis, P., Hold, G.L. &Flint, H.J. The gut microbiota, bacterial metabolites and colorectal cancer. Nat. Rev. Microbiol. 12, 661-672 (2014).
32. Pal, D. et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18, 1279-1285 (2012).
33. Mariño, G. et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol. Cell 53, 710-725 (2014).
34. Pietrocola, F., Galluzzi, L., Bravo-San Pedro, J.M., Madeo, F. &Kroemer, G. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 21, 805-821 (2015).
35. Yang, L., Li, P., Fu, S., Calay, E.S. &Hotamisligil, G.S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11, 467-478 (2010).
36. Umemura, A. et al. p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells. Cancer Cell 29, 935-948 (2016).
37. Zhong, Z., Sanchez-Lopez, E. &Karin, M. Autophagy, inflammation, and immunity: a troika governing cancer and its treatment. Cell 166, 288-298 (2016).
38. Doerner, S.K. et al. High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity. Mol. Cancer Res. 14, 953-965 (2016).
39. Klevorn, L.E. &Teague, R.M. Adapting cancer immunotherapy models for the real world. Trends Immunol. 37, 354-363 (2016).
40. Lamas, O., Marti, A. &Martínez, J.A. Obesity and immunocompetence. Eur. J. Clin. Nutr. 56 (Suppl. 3), S42-S45 (2002).
41. Yang, H. et al. Obesity accelerates thymic aging. Blood 114, 3803-3812 (2009).
42. Macia, L. et al. Impairment of dendritic cell functionality and steady-state number in obese mice. J. Immunol. 177, 5997-6006 (2006).
43. Conroy, M.J., Dunne, M.R., Donohoe, C.L. &Reynolds, J.V. Obesity-associated cancer: an immunological perspective. Proc. Nutr. Soc. 75, 125-138 (2016).
44. James, B.R. et al. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J. Immunol. 189, 1311-1321 (2012).
45. Mirsoian, A. et al. Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. J. Exp. Med. 211, 2373-2383 (2014).
46. Traba, J. et al. Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J. Clin. Invest. 125, 4592-4600 (2015).
47. Pietrocola, F. et al. Metabolic effects of fasting on human and mouse blood in vivo. Autophagy 13, 567-578 (2017).
48. Wang, A., Huen, S.C., Luan, H.H., Yu, S., Zhang, C. &Gallezot, J.D. et al. Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell 166, 1512-1525.e1512 (2016).
49. Dror, E. et al. Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat. Immunol. 18, 283-292 (2017).
50. van Niekerk, G., Loos, B., Nell, T. &Engelbrecht, A.M. Autophagy: a free meal in sickness-associated anorexia. Autophagy 12, 727-734 (2016).
51. Puchalska, P. &Crawford, P.A. Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metab. 25, 262-284 (2017).
52. Youm, Y.H. et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21, 263-269 (2015).
53. Hopkins, B.D., Goncalves, M.D. &Cantley, L.C. Obesity and cancer mechanisms: cancer metabolism. J. Clin. Oncol. 34, 4277-4283 (2016).
54. Moore, L.L., Chadid, S., Singer, M.R., Kreger, B.E. &Denis, G.V. Metabolic health reduces risk of obesity-related cancer in Framingham Study adults. Cancer Epidemiol. Biomarkers Prev. 23, 2057-2065 (2014).
55. Iyengar, N.M. et al. Systemic correlates of white adipose tissue inflammation in early-stage breast cancer. Clin. Cancer Res. 22, 2283-2289 (2016).
56. Kolb, R. et al. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat. Commun. 7, 13007 (2016).
57. Shivappa, N., Blair, C.K., Prizment, A.E., Jacobs, D.R. &Hebert, J.R. Prospective study of the dietary inflammatory index and risk of breast cancer in postmenopausal women. Mol. Nutr. Food Res. 61, 1600592 (2016).
58. Harmon, B.E. et al. The dietary inflammatory index is associated with colorectal cancer risk in the multiethnic cohort. J. Nutr. 147, 430-438 (2017).
59. Hodge, A.M. et al. Dietary inflammatory index, Mediterranean diet score, and lung cancer: a prospective study. Cancer Causes Control 27, 907-917 (2016).
60. Steck, S.E., Guinter, M., Zheng, J. &Thomson, C.A. Index-based dietary patterns and colorectal cancer risk: a systematic review. Adv. Nutr. 6, 763-773 (2015).
61. Mocellin, S., Briarava, M. &Pilati, P. Vitamin B6 and cancer risk: a field synopsis and meta-analysis. J. Natl. Cancer Inst. 109, 1-9 (2017).
62. Aranda, F. et al. Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer. Oncogene 34, 3053-3062 (2015).
63. Galluzzi, L. et al. Prognostic impact of vitamin B6 metabolism in lung cancer. Cell Rep. 2, 257-269 (2012).
64. Goodwin, P.J., Ennis, M., Pritchard, K.I., Koo, J. &Hood, N. Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer. J. Clin. Oncol. 27, 3757-3763 (2009).
65. Tretli, S., Hernes, E., Berg, J.P., Hestvik, U.E. &Robsahm, T.E. Association between serum 25(OH)D and death from prostate cancer. Br. J. Cancer 100, 450-454 (2009).
66. Dou, R. et al. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br. J. Nutr. 115, 1643-1660 (2016).
67. Song, M. et al. Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status. Gut 65, 296-304 (2016).
68. Giangreco, A.A. et al. Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model. J. Steroid Biochem. Mol. Biol. 148, 156-165 (2015).
69. Batai, K., Murphy, A.B., Nonn, L. &Kittles, R.A. Vitamin D and immune response: implications for prostate cancer in African Americans. Front. Immunol. 7, 53 (2016).
70. Cao, Y. et al. Regular aspirin use associates with lower risk of colorectal cancers with low numbers of tumor-infiltrating lymphocytes. Gastroenterology 151, 879-892.e4 (2016).
71. Bruce, D. &Cantorna, M.T. Intrinsic requirement for the vitamin D receptor in the development of CD8αα-expressing T cells. J. Immunol. 186, 2819-2825 (2011).
72. Larriba, M.J. et al. Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. PLoS One 6, e23524 (2011).
73. Protiva, P. et al. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial. Am. J. Clin. Nutr. 103, 1224-1231 (2016).
74. Buck, K. et al. Serum enterolactone and prognosis of postmenopausal breast cancer. J. Clin. Oncol. 29, 3730-3738 (2011).
75. Hallund, J., Tetens, I., Bügel, S., Tholstrup, T. &Bruun, J.M. The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutr. Metab. Cardiovasc. Dis. 18, 497-502 (2008).
76. Eisenberg, T. et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat. Med. 22, 1428-1438 (2016).
77. Pietrocola, F. et al. Caloric restriction mimetics enhance anticancer immunosurveillance. Cancer Cell 30, 147-160 (2016).
78. Furman, D. et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat. Med. 23, 174-184 (2017).
79. Pietrocola, F. et al. Coffee induces autophagy in vivo. Cell Cycle 13, 1987-1994 (2014).
80. Alicandro, G., Tavani, A. &La Vecchia, C. Coffee and cancer risk: a summary overview. Eur. J. Cancer Prev. http://dx.doi.org/10.1097/CEJ.0000000000000341 (2017).
81. Alisson-Silva, F., Kawanishi, K. &Varki, A. Human risk of diseases associated with red meat intake: analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid. Mol. Aspects Med. 51, 16-30 (2016).
82. Bao, Y. et al. Association of nut consumption with total and cause-specific mortality. N. Engl. J. Med. 369, 2001-2011 (2013).
83. Bonaccio, M. et al. Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study. Br. J. Nutr. 114, 804-811 (2015).
84. Siri-Tarino, P.W., Chiu, S., Bergeron, N. &Krauss, R.M. Saturated fats versus polyunsaturated fats versus carbohydrates for cardiovascular disease prevention and treatment. Annu. Rev. Nutr. 35, 517-543 (2015).
85. Flint, T.R. et al. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 24, 672-684 (2016).
86. Sjöström, L. et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 10, 653-662 (2009).
87. Rossi, E.L. et al. Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice. Cancer Prev. Res. (Phila.) 9, 339-348 (2016).
88. Lee, C. et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci. Transl. Med. 4, 124ra27 (2012).
89. Di Biase, S. et al. Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity. Cancer Cell 30, 136-146 (2016).
90. Cheng, C.W. et al. Fasting-mimicking diet promotes Ngn3-driven beta-cell regeneration to reverse diabetes. Cell 168, 775-788.e712 (2017).
91. Kreso, A. &Dick, J.E. Evolution of the cancer stem cell model. Cell Stem Cell 14, 275-291 (2014).
92. Madeo, F., Pietrocola, F., Eisenberg, T. &Kroemer, G. Caloric restriction mimetics: towards a molecular definition. Nat. Rev. Drug Discov. 13, 727-740 (2014).
93. Klement, R.J., Champ, C.E., Otto, C. &Kämmerer, U. Anti-tumor effects of ketogenic diets in mice: a meta-analysis. PLoS One 11, e0155050 (2016).
94. Woolf, E.C., Syed, N. &Scheck, A.C. Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy. Front. Mol. Neurosci. 9, 122 (2016).
95. Lussier, D.M. et al. Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet. BMC Cancer 16, 310 (2016).
96. Husain, Z., Huang, Y., Seth, P. &Sukhatme, V.P. Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J. Immunol. 191, 1486-1495 (2013).
97. Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330, 1029-1035 (1994).
98. Chen, A.C. et al. A Phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. N. Engl. J. Med. 373, 1618-1626 (2015).
99. Zhang, H. et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352, 1436-1443 (2016).