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Volumn 11, Issue , 2016, Pages 421-449

Obesity, Inflammation, and Cancer

Author keywords

Adipokine; Adipose tissue; Body mass index; Cancer risk; Cytokine; Metabolic dysregulation; Weight loss

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CHEMOKINE; CYTOKINE; ESTROGEN; HORMONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; NEU DIFFERENTIATION FACTOR; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84971310275     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-012615-044359     Document Type: Article
Times cited : (586)

References (186)
  • 1
    • 84964740709 scopus 로고    scopus 로고
    • Geneva: WHO Media Centre
    • World Health Organ. 2015. Obesity and Overweight. Geneva: WHO Media Centre. http://who.int/mediacentre/factsheets/fs311/en/
    • (2015) Obesity and Overweight
  • 2
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011-2012
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. 2014. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311:806-14
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 3
    • 59449085264 scopus 로고    scopus 로고
    • Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe
    • Aggarwal BB, Vijayalekshmi RV, Sung B. 2009. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin. Cancer. Res. 15:425-30
    • (2009) Clin. Cancer. Res. , vol.15 , pp. 425-430
    • Aggarwal, B.B.1    Vijayalekshmi, R.V.2    Sung, B.3
  • 4
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. S. Adults
    • Calle EE, RodriguezC,Walker-Thurmond K,ThunMJ. 2003. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 348(17):1625-38
    • (2003) N. Engl. J. Med. , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 5
    • 84924910144 scopus 로고    scopus 로고
    • Global burden of cancer attributable to high body-mass index in 2012: A population-based study
    • Arnold M, Pandeya N, Byrnes G, Renehan AG, Stevens GA, et al. 2015. Global burden of cancer attributable to high body-mass index in 2012: A population-based study. Lancet Oncol. 16:36-46
    • (2015) Lancet Oncol. , vol.16 , pp. 36-46
    • Arnold, M.1    Pandeya, N.2    Byrnes, G.3    Renehan, A.G.4    Stevens, G.A.5
  • 7
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. 2012. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21:309-22
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 8
    • 79251586865 scopus 로고    scopus 로고
    • Role of TLR2-dependent inflammation in metastatic progression
    • Kim S, Karin M. 2011. Role of TLR2-dependent inflammation in metastatic progression. Ann. N. Y. Acad. Sci. 1217:191-206
    • (2011) Ann. N. Y. Acad. Sci. , vol.1217 , pp. 191-206
    • Kim, S.1    Karin, M.2
  • 10
    • 34548247242 scopus 로고    scopus 로고
    • The rapidly expanding family of adipokines
    • MacDougald OA, Burant CF. 2007. The rapidly expanding family of adipokines. Cell Metab. 6:159-61
    • (2007) Cell Metab. , vol.6 , pp. 159-161
    • MacDougald, O.A.1    Burant, C.F.2
  • 12
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, et al. 2008. Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance. Cell Metab. 7:496-507
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Red Eagle, A.3    Vats, D.4    Morel, C.R.5
  • 13
    • 78651073627 scopus 로고    scopus 로고
    • IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
    • Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, et al. 2010. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. PNAS 107:22617-22
    • (2010) PNAS , vol.107 , pp. 22617-22622
    • Ricardo-Gonzalez, R.R.1    Red Eagle, A.2    Odegaard, J.I.3    Jouihan, H.4    Morel, C.R.5
  • 14
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, et al. 2011. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332:243-47
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5
  • 15
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, et al. 2013. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210:535-49
    • (2013) J. Exp. Med. , vol.210 , pp. 535-549
    • Molofsky, A.B.1    Nussbaum, J.C.2    Liang, H.E.3    Van Dyken, S.J.4    Cheng, L.E.5
  • 16
    • 84877582160 scopus 로고    scopus 로고
    • Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue
    • Zeyda M,Wernly B, Demyanets S, Kaun C, Hammerle M, et al. 2013. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int. J. Obes. (Lond.) 37:658-65
    • (2013) Int. J. Obes. (Lond.) , vol.37 , pp. 658-665
    • Zeyda, M.1    Wernly, B.2    Demyanets, S.3    Kaun, C.4    Hammerle, M.5
  • 17
    • 84888346690 scopus 로고    scopus 로고
    • Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice
    • Hams E, Locksley RM, McKenzie AN, Fallon PG. 2013. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 191:5349-53
    • (2013) J. Immunol. , vol.191 , pp. 5349-5353
    • Hams, E.1    Locksley, R.M.2    McKenzie, A.N.3    Fallon, P.G.4
  • 18
    • 84940768022 scopus 로고    scopus 로고
    • IL-25 elicits innate lymphoid cells and multipotent progenitor type 2 cells that reduce renal ischemic/reperfusion injury
    • Huang Q, Niu Z, Tan J, Yang J, Liu Y, et al. 2015. IL-25 elicits innate lymphoid cells and multipotent progenitor type 2 cells that reduce renal ischemic/reperfusion injury. J. Am. Soc. Nephrol. 26:2199-211
    • (2015) J. Am. Soc. Nephrol. , vol.26 , pp. 2199-2211
    • Huang, Q.1    Niu, Z.2    Tan, J.3    Yang, J.4    Liu, Y.5
  • 19
    • 84904035279 scopus 로고    scopus 로고
    • Adipose tissue-resident regulatory T cells: Phenotypic specialization, functions and therapeutic potential
    • Cipolletta D. 2014. Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential. Immunology 142:517-25
    • (2014) Immunology , vol.142 , pp. 517-525
    • Cipolletta, D.1
  • 20
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15:930-39
    • (2009) Nat. Med. , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5
  • 21
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, Truong D, TsuiH, et al. 2009. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15:921-29
    • (2009) Nat. Med. , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5
  • 22
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γis amajor driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta D, FeuererM, Li A, Kamei N, Lee J, et al. 2012. PPAR-γis amajor driver of the accumulation and phenotype of adipose tissue Treg cells. Nature 486:549-53
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3    Kamei, N.4    Lee, J.5
  • 23
    • 84923607143 scopus 로고    scopus 로고
    • The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatoryTcells
    • Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, et al. 2015. The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatoryTcells. Nat. Immunol. 16:276-85
    • (2015) Nat. Immunol. , vol.16 , pp. 276-285
    • Vasanthakumar, A.1    Moro, K.2    Xin, A.3    Liao, Y.4    Gloury, R.5
  • 24
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, et al. 2009. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58:2574-82
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1    Usui, I.2    Bukhari, A.3    Ikutani, M.4    Oya, T.5
  • 25
    • 84866141957 scopus 로고    scopus 로고
    • Immunological functions of leptin and adiponectin
    • Carbone F, La Rocca C, Matarese G. 2012. Immunological functions of leptin and adiponectin. Biochimie 94:2082-88
    • (2012) Biochimie , vol.94 , pp. 2082-2088
    • Carbone, F.1    La Rocca, C.2    Matarese, G.3
  • 26
    • 77954844177 scopus 로고    scopus 로고
    • Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity
    • OuchiN,Higuchi A, Ohashi K, Oshima Y,Gokce N, et al. 2010. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329:454-57
    • (2010) Science , vol.329 , pp. 454-457
    • Ouchi, N.1    Higuchi, A.2    Ohashi, K.3    Oshima, Y.4    Gokce, N.5
  • 27
    • 84904392112 scopus 로고    scopus 로고
    • Macrophages, immunity, and metabolic disease
    • McNelis JC, Olefsky JM. 2014. Macrophages, immunity, and metabolic disease. Immunity 41:36-48
    • (2014) Immunity , vol.41 , pp. 36-48
    • McNelis, J.C.1    Olefsky, J.M.2
  • 28
    • 84878785347 scopus 로고    scopus 로고
    • Immunological goings-on in visceral adipose tissue
    • Mathis D. 2013. Immunological goings-on in visceral adipose tissue. Cell Metab. 17:851-59
    • (2013) Cell Metab. , vol.17 , pp. 851-859
    • Mathis, D.1
  • 29
    • 84907991703 scopus 로고    scopus 로고
    • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
    • Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, et al. 2014. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab. 20:614-25
    • (2014) Cell Metab. , vol.20 , pp. 614-625
    • Kratz, M.1    Coats, B.R.2    Hisert, K.B.3    Hagman, D.4    Mutskov, V.5
  • 30
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • Deng T, Lyon CJ, Minze LJ, Lin J, Zou J, et al. 2013. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 17:411-22
    • (2013) Cell Metab. , vol.17 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3    Lin, J.4    Zou, J.5
  • 31
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas SK, Mantovani A. 2010. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 11:889-96
    • (2010) Nat. Immunol. , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 32
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S,Manabe I, NagasakiM, Eto K, Yamashita H, et al. 2009. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15:914-20
    • (2009) Nat. Med. , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5
  • 33
    • 84925627014 scopus 로고    scopus 로고
    • NK cells link obesityinduced adipose stress to inflammation and insulin resistance
    • Wensveen FM, Jelencic V, Valentic S, Sestan M, Wensveen TT, et al. 2015. NK cells link obesityinduced adipose stress to inflammation and insulin resistance. Nat. Immunol. 16:376-85
    • (2015) Nat. Immunol. , vol.16 , pp. 376-385
    • Wensveen, F.M.1    Jelencic, V.2    Valentic, S.3    Sestan, M.4    Wensveen, T.T.5
  • 34
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Investig. 112:1821-30
    • (2003) J. Clin. Investig. , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5
  • 35
    • 34347354309 scopus 로고    scopus 로고
    • Macrophagespecific PPARγcontrols alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, GoforthMH, Morel CR, Subramanian V, et al. 2007. Macrophagespecific PPARγcontrols alternative activation and improves insulin resistance. Nature 447:1116-20
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3    Morel, C.R.4    Subramanian, V.5
  • 36
    • 20044387026 scopus 로고    scopus 로고
    • IKK-βlinks inflammation to obesityinduced insulin resistance
    • ArkanMC, Hevener AL, Greten FR,Maeda S, Li ZW, et al. 2005. IKK-βlinks inflammation to obesityinduced insulin resistance. Nat. Med. 11:191-98
    • (2005) Nat. Med. , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3    Maeda, S.4    Li, Z.W.5
  • 37
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • HanMS, Jung DY, MorelC, Lakhani SA, Kim JK, et al. 2013. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339:218-22
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5
  • 38
    • 84888131271 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization
    • Eguchi J, Kong X, Tenta M, Wang X, Kang S, Rosen ED. 2013. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes 62:3394-403
    • (2013) Diabetes , vol.62 , pp. 3394-3403
    • Eguchi, J.1    Kong, X.2    Tenta, M.3    Wang, X.4    Kang, S.5    Rosen, E.D.6
  • 39
    • 84921467844 scopus 로고    scopus 로고
    • Macrophage recruitment in obese adipose tissue
    • Bai Y, Sun Q. 2015. Macrophage recruitment in obese adipose tissue. Obes. Rev. 16:127-36
    • (2015) Obes. Rev. , vol.16 , pp. 127-136
    • Bai, Y.1    Sun, Q.2
  • 40
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D,Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144:646-74
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 41
    • 84928749945 scopus 로고    scopus 로고
    • New horizons in tumormicroenvironment biology: Challenges and opportunities
    • Chen F, Zhuang X, Lin L, Yu P,Wang Y, et al. 2015. New horizons in tumormicroenvironment biology: challenges and opportunities. BMC Med. 13:45
    • (2015) BMC Med. , vol.13 , pp. 45
    • Chen, F.1    Zhuang, X.2    Lin, L.3    Yu, P.4    Wang, Y.5
  • 42
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. 2001. Inflammation and cancer: back to Virchow? Lancet 357:539-45
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 43
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. 2010. Immunity, inflammation, and cancer. Cell 140:883-99
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 44
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • Noy R, Pollard JW. 2014. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41:49-61
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 45
    • 80053159303 scopus 로고    scopus 로고
    • The parallel lives of angiogenesis and immunosuppression: Cancer and other tales
    • Motz GT, Coukos G. 2011. The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat. Rev. Immunol. 11:702-11
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 702-711
    • Motz, G.T.1    Coukos, G.2
  • 46
    • 84866079242 scopus 로고    scopus 로고
    • The role of adiponectin in cancer: A review of current evidence
    • Dalamaga M, Diakopoulos KN, Mantzoros CS. 2012. The role of adiponectin in cancer: A review of current evidence. Endocr. Rev. 33:547-94
    • (2012) Endocr. Rev. , vol.33 , pp. 547-594
    • Dalamaga, M.1    Diakopoulos, K.N.2    Mantzoros, C.S.3
  • 47
    • 84877090947 scopus 로고    scopus 로고
    • Molecular pathways: Adiponectin and leptin signaling in cancer
    • Vansaun MN. 2013. Molecular pathways: adiponectin and leptin signaling in cancer. Clin. Cancer Res. 19:1926-32
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1926-1932
    • Vansaun, M.N.1
  • 48
    • 84938975246 scopus 로고    scopus 로고
    • Circulating adiponectin, leptin and adiponectin-leptin ratio and endometrial cancer risk: Evidence from a meta-analysis of epidemiologic studies
    • Gong TT, Wu QJ, Wang YL, Ma XX. 2015. Circulating adiponectin, leptin and adiponectin-leptin ratio and endometrial cancer risk: evidence from a meta-analysis of epidemiologic studies. Int. J. Cancer 137(8):1967-78
    • (2015) Int. J. Cancer , vol.137 , Issue.8 , pp. 1967-1978
    • Gong, T.T.1    Wu, Q.J.2    Wang, Y.L.3    Ma, X.X.4
  • 50
    • 40649109728 scopus 로고    scopus 로고
    • The Wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
    • Naugler WE, Karin M. 2008. The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 14:109-19
    • (2008) Trends Mol. Med. , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 52
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. 2009. Tumour necrosis factor and cancer. Nat. Rev. Cancer 9:361-71
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 53
    • 79952996039 scopus 로고    scopus 로고
    • Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage
    • Grivennikov SI, Karin M. 2010. Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage. Ann. Rheum. Dis. 70(Suppl. 1):i104-8
    • (2010) Ann. Rheum. Dis. , vol.70 , pp. i104-i108
    • Grivennikov, S.I.1    Karin, M.2
  • 54
    • 84877977924 scopus 로고    scopus 로고
    • Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk
    • Xu J, Yin Z, Cao S, Gao W, Liu L, et al. 2013. Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. PLOS ONE 8:e63654
    • (2013) PLOS ONE , vol.8 , pp. e63654
    • Xu, J.1    Yin, Z.2    Cao, S.3    Gao, W.4    Liu, L.5
  • 55
    • 33845212729 scopus 로고    scopus 로고
    • Interleukin-1 and cancer progression: The emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment
    • Lewis AM, Varghese S, XuH, Alexander HR. 2006. Interleukin-1 and cancer progression: The emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment. J. Transl.Med. 4:48
    • (2006) J. Transl.Med. , vol.4 , pp. 48
    • Lewis, A.M.1    Varghese, S.2    Xu, H.3    Alexander, H.R.4
  • 57
    • 34948813665 scopus 로고    scopus 로고
    • Osteopontin mediates obesityinduced adipose tissue macrophage infiltration and insulin resistance in mice
    • Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, et al. 2007. Osteopontin mediates obesityinduced adipose tissue macrophage infiltration and insulin resistance in mice. J. Clin. Investig. 117:2877-88
    • (2007) J. Clin. Investig. , vol.117 , pp. 2877-2888
    • Nomiyama, T.1    Perez-Tilve, D.2    Ogawa, D.3    Gizard, F.4    Zhao, Y.5
  • 58
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: Role in cell signaling and cancer progression
    • Rangaswami H, Bulbule A, Kundu GC. 2006. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol. 16:79-87
    • (2006) Trends Cell Biol. , vol.16 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 60
    • 33646842919 scopus 로고    scopus 로고
    • Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer
    • Johansen JS. 2006. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan. Med. Bull. 53:172-209
    • (2006) Dan. Med. Bull. , vol.53 , pp. 172-209
    • Johansen, J.S.1
  • 61
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6:772-83
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 62
    • 84868611621 scopus 로고    scopus 로고
    • Adipocyte-derived endotrophin promotes malignant tumor progression
    • Park J, Scherer PE. 2012. Adipocyte-derived endotrophin promotes malignant tumor progression. J. Clin. Investig. 122(11):4243-56
    • (2012) J. Clin. Investig. , vol.122 , Issue.11 , pp. 4243-4256
    • Park, J.1    Scherer, P.E.2
  • 64
    • 79953305102 scopus 로고    scopus 로고
    • Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion
    • Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, et al. 2011. Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71:2455-65
    • (2011) Cancer Res. , vol.71 , pp. 2455-2465
    • Dirat, B.1    Bochet, L.2    Dabek, M.3    Daviaud, D.4    Dauvillier, S.5
  • 65
    • 84929877740 scopus 로고    scopus 로고
    • Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: A systematic review
    • Freese KE, Kokai L, Edwards RP, Philips BJ, Sheikh MA, Kelley J, et al. 2015. Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: A systematic review. Cancer Res. 75:1161-68
    • (2015) Cancer Res. , vol.75 , pp. 1161-1168
    • Freese, K.E.1    Kokai, L.2    Edwards, R.P.3    Philips, B.J.4    Sheikh, M.A.5    Kelley, J.6
  • 67
    • 84921684494 scopus 로고    scopus 로고
    • Concise review: The obesity cancer paradigm: Exploration of the interactions and crosstalk with adipose stem cells
    • Strong AL, Burow ME, Gimble JM, Bunnell BA. 2015. Concise review: The obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells. Stem Cells 33:318-26
    • (2015) Stem Cells , vol.33 , pp. 318-326
    • Strong, A.L.1    Burow, M.E.2    Gimble, J.M.3    Bunnell, B.A.4
  • 69
    • 0033573326 scopus 로고    scopus 로고
    • Waist circumference, waist:hip ratio, and risk of breast cancer in the Nurses' Health Study
    • Huang Z,Willett WC, Colditz GA, Hunter DJ, Manson JE, et al. 1999. Waist circumference, waist:hip ratio, and risk of breast cancer in the Nurses' Health Study. Am. J. Epidemiol. 150:1316-24
    • (1999) Am. J. Epidemiol. , vol.150 , pp. 1316-1324
    • Huang, Z.1    Willett, W.C.2    Colditz, G.A.3    Hunter, D.J.4    Manson, J.E.5
  • 70
    • 70450250235 scopus 로고    scopus 로고
    • Gene expression patterns in visceral and subcutaneous adipose depots in rats are linked to their morphologic features
    • Palou M, Priego T, Sanchez J, Rodriguez AM, Palou A, Pico C. 2009. Gene expression patterns in visceral and subcutaneous adipose depots in rats are linked to their morphologic features. Cell Physiol. Biochem. 24:547-56
    • (2009) Cell Physiol. Biochem. , vol.24 , pp. 547-556
    • Palou, M.1    Priego, T.2    Sanchez, J.3    Rodriguez, A.M.4    Palou, A.5    Pico, C.6
  • 72
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. 2008. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 8:915-28
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 73
    • 79959466358 scopus 로고    scopus 로고
    • Minireview: IGF, insulin, and cancer
    • Gallagher EJ, LeRoith D. 2011. Minireview: IGF, insulin, and cancer. Endocrinology 152:2546-51
    • (2011) Endocrinology , vol.152 , pp. 2546-2551
    • Gallagher, E.J.1    LeRoith, D.2
  • 74
    • 77953199006 scopus 로고    scopus 로고
    • Insulin resistance and cancer: Epidemiological evidence
    • Tsugane S, Inoue M. 2010. Insulin resistance and cancer: epidemiological evidence. Cancer Sci. 101:1073-79
    • (2010) Cancer Sci. , vol.101 , pp. 1073-1079
    • Tsugane, S.1    Inoue, M.2
  • 75
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, Czech MP. 2008. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9:367-77
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 76
    • 84926148241 scopus 로고    scopus 로고
    • Obesity as a cause of hepatocellular carcinoma
    • Kew MC. 2015. Obesity as a cause of hepatocellular carcinoma. Ann. Hepatol. 14:299-303
    • (2015) Ann. Hepatol. , vol.14 , pp. 299-303
    • Kew, M.C.1
  • 77
    • 84869436442 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review
    • White DL, Kanwal F, El-Serag HB. 2012. Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. Clin. Gastroenterol. Hepatol. 10:1342-59.e2
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 1342e2-1359e2
    • White, D.L.1    Kanwal, F.2    El-Serag, H.B.3
  • 80
    • 84895488200 scopus 로고    scopus 로고
    • Plasma level of LDLcholesterol at diagnosis is a predictor factor of breast tumor progression
    • Rodrigues Dos Santos C, Fonseca I, Dias S, Mendes de Almeida JC. 2014. Plasma level of LDLcholesterol at diagnosis is a predictor factor of breast tumor progression. BMC Cancer 14:132
    • (2014) BMC Cancer , vol.14 , pp. 132
    • Rodrigues Dos Santos, C.1    Fonseca, I.2    Dias, S.3    Mendes De Almeida, J.C.4
  • 81
    • 84888791736 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    • Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, et al. 2012. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342:1094-98
    • (2012) Science , vol.342 , pp. 1094-1098
    • Nelson, E.R.1    Wardell, S.E.2    Jasper, J.S.3    Park, S.4    Suchindran, S.5
  • 82
    • 84872493396 scopus 로고    scopus 로고
    • Cholesterolmetabolism and the pathogenesis of non-alcoholic steatohepatitis
    • Musso G, Gambino R, CassaderM. 2013. Cholesterolmetabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog. Lipid Res. 52:175-91
    • (2013) Prog. Lipid Res. , vol.52 , pp. 175-191
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 83
    • 73149109062 scopus 로고    scopus 로고
    • Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    • Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. 2010. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140:49-61
    • (2010) Cell , vol.140 , pp. 49-61
    • Nomura, D.K.1    Long, J.Z.2    Niessen, S.3    Hoover, H.S.4    Ng, S.W.5    Cravatt, B.F.6
  • 84
    • 11844259994 scopus 로고    scopus 로고
    • Fasting serum glucose level and cancer risk in Korean men and women
    • Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM. 2005. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293:194-202
    • (2005) JAMA , vol.293 , pp. 194-202
    • Jee, S.H.1    Ohrr, H.2    Sull, J.W.3    Yun, J.E.4    Ji, M.5    Samet, J.M.6
  • 86
    • 84908891835 scopus 로고    scopus 로고
    • Hyperglycemia as a risk factor for cancer progression
    • Ryu TY, Park J, Scherer PE. 2014. Hyperglycemia as a risk factor for cancer progression. Diabetes Metab. J. 38:330-36
    • (2014) Diabetes Metab. J. , vol.38 , pp. 330-336
    • Ryu, T.Y.1    Park, J.2    Scherer, P.E.3
  • 87
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-20
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 88
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, et al. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-90
    • (2000) Nature , vol.404 , pp. 787-790
    • Nishikawa, T.1    Edelstein, D.2    Du, X.L.3    Yamagishi, S.4    Matsumura, T.5
  • 89
    • 0037109184 scopus 로고    scopus 로고
    • Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: Role of oxidative stress
    • Esposito K,Nappo F, Marfella R, GiuglianoG,Giugliano F, et al. 2002. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106:2067-72
    • (2002) Circulation , vol.106 , pp. 2067-2072
    • Esposito, K.1    Nappo, F.2    Marfella, R.3    Giugliano, G.4    Giugliano, F.5
  • 90
    • 84871361983 scopus 로고    scopus 로고
    • Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer
    • Park J, Sarode VR, Euhus D, Kittler R, Scherer PE. 2012. Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer. PNAS 109:21058-63
    • (2012) PNAS , vol.109 , pp. 21058-21063
    • Park, J.1    Sarode, V.R.2    Euhus, D.3    Kittler, R.4    Scherer, P.E.5
  • 91
    • 84908213474 scopus 로고    scopus 로고
    • Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles' heel?
    • Sabharwal SS, Schumacker PT. 2014. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nat. Rev. Cancer 14:709-21
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 709-721
    • Sabharwal, S.S.1    Schumacker, P.T.2
  • 92
    • 84884194246 scopus 로고    scopus 로고
    • Angiotensin II-induced production of mitochondrial reactive oxygen species: Potential mechanisms and relevance for cardiovascular disease
    • Dikalov SI, Nazarewicz RR. 2014. Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxid. Redox Signal. 19:1085-94
    • (2014) Antioxid. Redox Signal. , vol.19 , pp. 1085-1094
    • Dikalov, S.I.1    Nazarewicz, R.R.2
  • 94
    • 85027951435 scopus 로고    scopus 로고
    • Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5. 24 million UK adults
    • Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. 2014. Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5.24 million UK adults. Lancet 384:755-65
    • (2014) Lancet , vol.384 , pp. 755-765
    • Bhaskaran, K.1    Douglas, I.2    Forbes, H.3    Dos-Santos-Silva, I.4    Leon, D.A.5    Smeeth, L.6
  • 95
    • 78650969715 scopus 로고    scopus 로고
    • Effect of obesity on survival of women with breast cancer: Systematic review and meta-analysis
    • Protani M, Coory M, Martin JH. 2010. Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res. Treat. 123:627-35
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 627-635
    • Protani, M.1    Coory, M.2    Martin, J.H.3
  • 96
    • 19944404432 scopus 로고    scopus 로고
    • Roles for neuregulins in human cancer
    • Stove C, Bracke M. 2004. Roles for neuregulins in human cancer. Clin. Exp. Metastasis 21:665-84
    • (2004) Clin. Exp. Metastasis , vol.21 , pp. 665-684
    • Stove, C.1    Bracke, M.2
  • 97
    • 84887617570 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth
    • Wu Q, Ishikawa T, Sirianni R, Tang H, McDonald JG, et al. 2013. 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep. 5:637-45
    • (2013) Cell Rep. , vol.5 , pp. 637-645
    • Wu, Q.1    Ishikawa, T.2    Sirianni, R.3    Tang, H.4    McDonald, J.G.5
  • 98
    • 84888791736 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology
    • Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, et al. 2013. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342:1094-98
    • (2013) Science , vol.342 , pp. 1094-1098
    • Nelson, E.R.1    Wardell, S.E.2    Jasper, J.S.3    Park, S.4    Suchindran, S.5
  • 99
    • 0023210536 scopus 로고
    • Adipose tissue as a source of hormones
    • Siiteri PK. 1987. Adipose tissue as a source of hormones. Am. J. Clin. Nutr. 45:277-82
    • (1987) Am. J. Clin. Nutr. , vol.45 , pp. 277-282
    • Siiteri, P.K.1
  • 100
    • 83755229569 scopus 로고    scopus 로고
    • The possible impact of obesity on androgen, progesterone and estrogen receptors (ERαand ERβ) gene expression in breast cancer patients
    • Esfahlan RJ, Zarghami N, Esfahlan AJ, Mollazadeh M, Nejati K, Nasiri M. 2011. The possible impact of obesity on androgen, progesterone and estrogen receptors (ERαand ERβ) gene expression in breast cancer patients. Breast Cancer (Auckl.) 5:227-37
    • (2011) Breast Cancer (Auckl.) , vol.5 , pp. 227-237
    • Esfahlan, R.J.1    Zarghami, N.2    Esfahlan, A.J.3    Mollazadeh, M.4    Nejati, K.5    Nasiri, M.6
  • 102
    • 84862819412 scopus 로고    scopus 로고
    • Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells
    • Guo S, Liu M, Wang G, Torroella-KouriM,Gonzalez-Perez RR. 2012. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. Biochim. Biophys. Acta 1825:207-22
    • (2012) Biochim. Biophys. Acta , vol.1825 , pp. 207-222
    • Guo, S.1    Liu, M.2    Wang, G.3    Torroella-Kouri, M.4    Gonzalez-Perez, R.R.5
  • 103
    • 84915773887 scopus 로고    scopus 로고
    • The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression
    • Ando S, Barone I, Giordano C, Bonofiglio D, Catalano S. 2014. The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression. Front. Oncol. 4:340
    • (2014) Front. Oncol. , vol.4 , pp. 340
    • Ando, S.1    Barone, I.2    Giordano, C.3    Bonofiglio, D.4    Catalano, S.5
  • 104
    • 58249106120 scopus 로고    scopus 로고
    • IL-1 family in breast cancer: Potential interplay with leptin and other adipocytokines
    • Perrier S, Caldefie-Chezet F, Vasson MP. 2009. IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines. FEBS Lett. 583:259-65
    • (2009) FEBS Lett. , vol.583 , pp. 259-265
    • Perrier, S.1    Caldefie-Chezet, F.2    Vasson, M.P.3
  • 105
  • 106
    • 84899447215 scopus 로고    scopus 로고
    • Obesity-associated mechanisms of hepatocarcinogenesis
    • Karagozian R, Derdak Z, Baffy G. 2014. Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism 63:607-17
    • (2014) Metabolism , vol.63 , pp. 607-617
    • Karagozian, R.1    Derdak, Z.2    Baffy, G.3
  • 108
    • 84923597485 scopus 로고    scopus 로고
    • Leptin in nonalcoholic fatty liver disease: A narrative review
    • Polyzos SA, Kountouras J, Mantzoros CS. 2015. Leptin in nonalcoholic fatty liver disease: A narrative review. Metabolism 64:60-78
    • (2015) Metabolism , vol.64 , pp. 60-78
    • Polyzos, S.A.1    Kountouras, J.2    Mantzoros, C.S.3
  • 109
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg H, Moschen AR. 2010. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology 52:1836-46
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 110
    • 21244472975 scopus 로고    scopus 로고
    • IKKβcouples hepatocyte death to cytokinedriven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. 2005. IKKβcouples hepatocyte death to cytokinedriven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-90
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 111
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH,YuGY,HeG, Ali SR, et al. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140:197-208
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5
  • 112
    • 33746032571 scopus 로고    scopus 로고
    • Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    • Sakurai T, Maeda S, Chang L, Karin M. 2006. Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. PNAS 103:10544-51
    • (2006) PNAS , vol.103 , pp. 10544-10551
    • Sakurai, T.1    Maeda, S.2    Chang, L.3    Karin, M.4
  • 113
    • 0037382797 scopus 로고    scopus 로고
    • C-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration
    • Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, et al. 2003. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 37:824-32
    • (2003) Hepatology , vol.37 , pp. 824-832
    • Schwabe, R.F.1    Bradham, C.A.2    Uehara, T.3    Hatano, E.4    Bennett, B.L.5
  • 114
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V, Ogata H, Kuntzen C, et al. 2010. Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 17:286-97
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5
  • 115
    • 84874642641 scopus 로고    scopus 로고
    • The inflammatory microenvironment in hepatocellular carcinoma: A pivotal role for tumor-associated macrophages
    • Capece D, Fischietti M, Verzella D, Gaggiano A, Cicciarelli G, et al. 2013. The inflammatory microenvironment in hepatocellular carcinoma: A pivotal role for tumor-associated macrophages. Biomed. Res. Int. 2013:187204
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 187204
    • Capece, D.1    Fischietti, M.2    Verzella, D.3    Gaggiano, A.4    Cicciarelli, G.5
  • 116
    • 34250005419 scopus 로고    scopus 로고
    • Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients
    • Fu J, Xu D, Liu Z, Shi M, Zhao P, et al. 2007. Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132:2328-39
    • (2007) Gastroenterology , vol.132 , pp. 2328-2339
    • Fu, J.1    Xu, D.2    Liu, Z.3    Shi, M.4    Zhao, P.5
  • 117
    • 75149155674 scopus 로고    scopus 로고
    • Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis
    • Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, et al. 2010. Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res. 70:57-67
    • (2010) Cancer Res. , vol.70 , pp. 57-67
    • Wu, Y.1    Brodt, P.2    Sun, H.3    Mejia, W.4    Novosyadlyy, R.5
  • 119
  • 120
    • 75149167913 scopus 로고    scopus 로고
    • AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease
    • Farraye FA, Odze RD, Eaden J, Itzkowitz SH. 2010. AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology 138:746-74
    • (2010) Gastroenterology , vol.138 , pp. 746-774
    • Farraye, F.A.1    Odze, R.D.2    Eaden, J.3    Itzkowitz, S.H.4
  • 121
    • 58149340659 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer
    • Ogino S, Kirkner GJ, Nosho K, Irahara N, Kure S, et al. 2008. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. Clin. Cancer Res. 14:8221-27
    • (2008) Clin. Cancer Res. , vol.14 , pp. 8221-8227
    • Ogino, S.1    Kirkner, G.J.2    Nosho, K.3    Irahara, N.4    Kure, S.5
  • 122
    • 34248157118 scopus 로고    scopus 로고
    • Effect of aspirin on long-term risk of colorectal cancer: Consistent evidence from randomised and observational studies
    • Flossmann E, Rothwell PM. 2007. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369:1603-13
    • (2007) Lancet , vol.369 , pp. 1603-1613
    • Flossmann, E.1    Rothwell, P.M.2
  • 123
    • 84929390853 scopus 로고    scopus 로고
    • Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants
    • Nan H, Hutter CM, Lin Y, Jacobs EJ, Ulrich CM, et al. 2015. Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. JAMA 313:1133-42
    • (2015) JAMA , vol.313 , pp. 1133-1142
    • Nan, H.1    Hutter, C.M.2    Lin, Y.3    Jacobs, E.J.4    Ulrich, C.M.5
  • 124
    • 84874927068 scopus 로고    scopus 로고
    • Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status
    • Morikawa T, Kuchiba A, Lochhead P, Nishihara R, Yamauchi M, et al. 2013. Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status. Cancer Res. 73:1600-10
    • (2013) Cancer Res. , vol.73 , pp. 1600-1610
    • Morikawa, T.1    Kuchiba, A.2    Lochhead, P.3    Nishihara, R.4    Yamauchi, M.5
  • 125
    • 0034710915 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin
    • Playford MP, Bicknell D, Bodmer WF, Macaulay VM. 2000. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin. PNAS 97:12103-8
    • (2000) PNAS , vol.97 , pp. 12103-12108
    • Playford, M.P.1    Bicknell, D.2    Bodmer, W.F.3    Macaulay, V.M.4
  • 126
    • 84856241235 scopus 로고    scopus 로고
    • Molecular mechanisms linking adipokines to obesity-related colon cancer: Focus on leptin
    • Drew JE. 2012. Molecular mechanisms linking adipokines to obesity-related colon cancer: focus on leptin. Proc. Nutr. Soc. 71:175-80
    • (2012) Proc. Nutr. Soc. , vol.71 , pp. 175-180
    • Drew, J.E.1
  • 128
    • 80054724598 scopus 로고    scopus 로고
    • Increased soluble leptin receptor levels are associated with advanced tumor stage in colorectal cancer patients
    • Tutino V, Notarnicola M, Guerra V, Lorusso D, Caruso MG. 2011. Increased soluble leptin receptor levels are associated with advanced tumor stage in colorectal cancer patients. Anticancer Res. 31:3381-83
    • (2011) Anticancer Res. , vol.31 , pp. 3381-3383
    • Tutino, V.1    Notarnicola, M.2    Guerra, V.3    Lorusso, D.4    Caruso, M.G.5
  • 130
    • 80052580981 scopus 로고    scopus 로고
    • Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis
    • Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, et al. 2011. Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut 60:1363-71
    • (2011) Gut , vol.60 , pp. 1363-1371
    • Endo, H.1    Hosono, K.2    Uchiyama, T.3    Sakai, E.4    Sugiyama, M.5
  • 131
    • 69249142193 scopus 로고    scopus 로고
    • Epigenetic repression of DNAmismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    • Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, et al. 2009. Epigenetic repression of DNAmismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 69:6423-29
    • (2009) Cancer Res. , vol.69 , pp. 6423-6429
    • Edwards, R.A.1    Witherspoon, M.2    Wang, K.3    Afrasiabi, K.4    Pham, T.5
  • 132
    • 84874594105 scopus 로고    scopus 로고
    • Salutary effects of adiponectin on colon cancer: In vivo and in vitro studies in mice
    • Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, et al. 2013. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut 62:561-70
    • (2013) Gut , vol.62 , pp. 561-570
    • Moon, H.S.1    Liu, X.2    Nagel, J.M.3    Chamberland, J.P.4    Diakopoulos, K.N.5
  • 135
    • 77954506093 scopus 로고    scopus 로고
    • Adipokine regulation of colon cancer: Adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3
    • Fenton JI, Birmingham JM. 2010. Adipokine regulation of colon cancer: Adiponectin attenuates interleukin-6-induced colon carcinoma cell proliferation via STAT-3. Mol. Carcinog. 49:700-9
    • (2010) Mol. Carcinog. , vol.49 , pp. 700-709
    • Fenton, J.I.1    Birmingham, J.M.2
  • 136
    • 84906933692 scopus 로고    scopus 로고
    • Tumour microenvironment of both early-and late-stage colorectal cancer is equally immunosuppressive
    • O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, et al. 2014. Tumour microenvironment of both early-and late-stage colorectal cancer is equally immunosuppressive. Br. J. Cancer 111:927-32
    • (2014) Br. J. Cancer , vol.111 , pp. 927-932
    • O'Toole, A.1    Michielsen, A.J.2    Nolan, B.3    Tosetto, M.4    Sheahan, K.5
  • 137
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • Salama P, PhillipsM,Grieu F, Morris M, Zeps N, et al. 2009. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J. Clin. Oncol. 27:186-92
    • (2009) J. Clin. Oncol. , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3    Morris, M.4    Zeps, N.5
  • 138
    • 84895168217 scopus 로고    scopus 로고
    • Highly prevalent colorectal cancerinfiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells
    • Scurr M, Ladell K, Besneux M, Christian A, Hockey T, et al. 2014. Highly prevalent colorectal cancerinfiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunol. 7:428-39
    • (2014) Mucosal Immunol. , vol.7 , pp. 428-439
    • Scurr, M.1    Ladell, K.2    Besneux, M.3    Christian, A.4    Hockey, T.5
  • 139
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. 2007. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 67:10019-26
    • (2007) Cancer Res. , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 140
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
    • Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, et al. 2010. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185:1836-45
    • (2010) J. Immunol. , vol.185 , pp. 1836-1845
    • Yang, H.1    Youm, Y.H.2    Vandanmagsar, B.3    Ravussin, A.4    Gimble, J.M.5
  • 141
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. 2008. Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet 371:569-78
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 142
    • 80052665281 scopus 로고    scopus 로고
    • Metabolic syndrome and pancreatic cancer risk: A case-control study in Italy and meta-analysis
    • Rosato V, Tavani A, Bosetti C, Pelucchi C, Talamini R, et al. 2011. Metabolic syndrome and pancreatic cancer risk: A case-control study in Italy and meta-analysis. Metabolism 60:1372-78
    • (2011) Metabolism , vol.60 , pp. 1372-1378
    • Rosato, V.1    Tavani, A.2    Bosetti, C.3    Pelucchi, C.4    Talamini, R.5
  • 143
    • 82455192294 scopus 로고    scopus 로고
    • Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: A study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
    • Grote VA, Rohrmann S, Nieters A, Dossus L, Tjonneland A, et al. 2011. Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: A study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia 54:3037-46
    • (2011) Diabetologia , vol.54 , pp. 3037-3046
    • Grote, V.A.1    Rohrmann, S.2    Nieters, A.3    Dossus, L.4    Tjonneland, A.5
  • 144
    • 84864883249 scopus 로고    scopus 로고
    • AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway
    • KangR,TangD,Lotze MT,Zeh HJ 3rd. 2012. AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway. Autophagy 8:989-91
    • (2012) Autophagy , vol.8 , pp. 989-991
    • Kang, R.1    Tang, D.2    Lotze, M.T.3    Zeh, H.J.4
  • 146
    • 84871770725 scopus 로고    scopus 로고
    • Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium
    • Elena JW, Steplowski E, Yu K, Hartge P, Tobias GS, et al. 2013. Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium. Cancer Causes Control 24:13-25
    • (2013) Cancer Causes Control , vol.24 , pp. 13-25
    • Elena, J.W.1    Steplowski, E.2    Yu, K.3    Hartge, P.4    Tobias, G.S.5
  • 147
    • 84872590843 scopus 로고    scopus 로고
    • A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts
    • Bao Y, Giovannucci EL, Kraft P, Stampfer MJ, Ogino S, et al. 2013. A prospective study of plasma adiponectin and pancreatic cancer risk in five US cohorts. J. Natl. Cancer Inst. 105:95-103
    • (2013) J. Natl. Cancer Inst. , vol.105 , pp. 95-103
    • Bao, Y.1    Giovannucci, E.L.2    Kraft, P.3    Stampfer, M.J.4    Ogino, S.5
  • 148
    • 84905020159 scopus 로고    scopus 로고
    • Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
    • Huang B, Cheng X, Wang D, Peng M, Xue Z, et al. 2014. Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling. Oncotarget 5:4732-45
    • (2014) Oncotarget , vol.5 , pp. 4732-4745
    • Huang, B.1    Cheng, X.2    Wang, D.3    Peng, M.4    Xue, Z.5
  • 149
    • 77649188501 scopus 로고    scopus 로고
    • A genomewide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22. 1, 1q32.1 and 5p15.33
    • Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, et al. 2010. A genomewide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat. Genet. 42:224-28
    • (2010) Nat. Genet. , vol.42 , pp. 224-228
    • Petersen, G.M.1    Amundadottir, L.2    Fuchs, C.S.3    Kraft, P.4    Stolzenberg-Solomon, R.Z.5
  • 150
  • 152
    • 67650561470 scopus 로고    scopus 로고
    • Obesity potentiates the growth and dissemination of pancreatic cancer
    • Zyromski NJ, Mathur A, Pitt HA, Wade TE, Wang S, et al. 2009. Obesity potentiates the growth and dissemination of pancreatic cancer. Surgery 146:258-63
    • (2009) Surgery , vol.146 , pp. 258-263
    • Zyromski, N.J.1    Mathur, A.2    Pitt, H.A.3    Wade, T.E.4    Wang, S.5
  • 153
    • 84928644441 scopus 로고    scopus 로고
    • Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells
    • Mendonsa AM, Chalfant MC, Gorden LD, VanSaun MN. 2015. Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. PLOS ONE 10:e0126686
    • (2015) PLOS ONE , vol.10 , pp. e0126686
    • Mendonsa, A.M.1    Chalfant, M.C.2    Gorden, L.D.3    VanSaun, M.N.4
  • 154
  • 155
    • 10044261013 scopus 로고    scopus 로고
    • Cytokines in pancreatic carcinoma: Correlation with phenotypic characteristics and prognosis
    • Ebrahimi B, Tucker SL, Li D, Abbruzzese JL, Kurzrock R. 2004. Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer 101:2727-36
    • (2004) Cancer , vol.101 , pp. 2727-2736
    • Ebrahimi, B.1    Tucker, S.L.2    Li, D.3    Abbruzzese, J.L.4    Kurzrock, R.5
  • 156
    • 45049085722 scopus 로고    scopus 로고
    • Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2
    • Angst E, Reber HA, Hines OJ, Eibl G. 2008. Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. Surgery 144:57-65
    • (2008) Surgery , vol.144 , pp. 57-65
    • Angst, E.1    Reber, H.A.2    Hines, O.J.3    Eibl, G.4
  • 157
    • 10744221950 scopus 로고    scopus 로고
    • Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1β
    • Muerkoster S, Wegehenkel K, Arlt A, Witt M, Sipos B, et al. 2004. Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1β. Cancer Res. 64:1331-37
    • (2004) Cancer Res. , vol.64 , pp. 1331-1337
    • Muerkoster, S.1    Wegehenkel, K.2    Arlt, A.3    Witt, M.4    Sipos, B.5
  • 158
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, et al. 2012. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491:399-405
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1    Waddell, N.2    Kassahn, K.S.3    Gingras, M.C.4    Muthuswamy, L.B.5
  • 159
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta Y, Lee KE,Hajdu CH,MillerG, Bar-SagiD. 2012. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21:836-47
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 160
    • 62549089788 scopus 로고    scopus 로고
    • Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion
    • Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, et al. 2009. Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion. PNAS 106:3354-59
    • (2009) PNAS , vol.106 , pp. 3354-3359
    • Khasawneh, J.1    Schulz, M.D.2    Walch, A.3    Rozman, J.4    Hrabe De Angelis, M.5
  • 161
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • Ben-Neriah Y, Karin M. 2011. Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol. 12:715-23
    • (2011) Nat. Immunol. , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 163
    • 84877848590 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner
    • Mace TA, Ameen Z, Collins A,Wojcik S, Mair M, et al. 2013. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res. 73:3007-18
    • (2013) Cancer Res. , vol.73 , pp. 3007-3018
    • Mace, T.A.1    Ameen, Z.2    Collins, A.3    Wojcik, S.4    Mair, M.5
  • 164
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne LJ, Beatty GL, Jhala N, ClarkCE, Rhim AD, et al. 2012. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21:822-35
    • (2012) Cancer Cell , vol.21 , pp. 822-835
    • Bayne, L.J.1    Beatty, G.L.2    Jhala, N.3    Clark, C.E.4    Rhim, A.D.5
  • 165
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I, Ishikawa J,Matsuyama A, et al. 2000. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723-32
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5
  • 166
    • 7744226149 scopus 로고    scopus 로고
    • Weight loss regulates inflammationrelated genes in white adipose tissue of obese subjects
    • Clement K, ViguerieN, PoitouC, Carette C, Pelloux V, et al. 2004. Weight loss regulates inflammationrelated genes in white adipose tissue of obese subjects. FASEB. J. 18:1657-69
    • (2004) FASEB. J. , vol.18 , pp. 1657-1669
    • Clement, K.1    Viguerie, N.2    Poitou, C.3    Carette, C.4    Pelloux, V.5
  • 167
    • 2142817993 scopus 로고    scopus 로고
    • Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: A randomized controlled clinical trial
    • Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, et al. 2004. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: A randomized controlled clinical trial. Am. J. Clin. Nutr. 79:544-51
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 544-551
    • Nicklas, B.J.1    Ambrosius, W.2    Messier, S.P.3    Miller, G.D.4    Penninx, B.W.5
  • 168
    • 84888203688 scopus 로고    scopus 로고
    • Diet and diet combined with chronic aerobic exercise decreases body fat mass and alters plasma and adipose tissue inflammatory markers in obese women
    • Lakhdar N, Denguezli M, Zaouali M, Zbidi A, Tabka Z, Bouassida A. 2013. Diet and diet combined with chronic aerobic exercise decreases body fat mass and alters plasma and adipose tissue inflammatory markers in obese women. Inflammation 36:1239-47
    • (2013) Inflammation , vol.36 , pp. 1239-1247
    • Lakhdar, N.1    Denguezli, M.2    Zaouali, M.3    Zbidi, A.4    Tabka, Z.5    Bouassida, A.6
  • 169
    • 84888215040 scopus 로고    scopus 로고
    • Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach
    • Kong LC, Wuillemin PH, Bastard JP, Sokolovska N, Gougis S, et al. 2013. Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach. Am. J. Clin. Nutr. 98:1385-94
    • (2013) Am. J. Clin. Nutr. , vol.98 , pp. 1385-1394
    • Kong, L.C.1    Wuillemin, P.H.2    Bastard, J.P.3    Sokolovska, N.4    Gougis, S.5
  • 170
    • 79251479402 scopus 로고    scopus 로고
    • Diet-induced weight loss reduces colorectal inflammation: Implications for colorectal carcinogenesis
    • Pendyala S, Neff LM, Suarez-Farinas M, Holt PR. 2011. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Am. J. Clin. Nutr. 93:234-42
    • (2011) Am. J. Clin. Nutr. , vol.93 , pp. 234-242
    • Pendyala, S.1    Neff, L.M.2    Suarez-Farinas, M.3    Holt, P.R.4
  • 171
    • 0142157708 scopus 로고    scopus 로고
    • Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factorβand cyclooxygenase isoforms in Zucker obese (fa/fa) rats
    • Raju J, Bird RP. 2003. Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factorβand cyclooxygenase isoforms in Zucker obese (fa/fa) rats. Cancer Res. 63:6595-601
    • (2003) Cancer Res. , vol.63 , pp. 6595-6601
    • Raju, J.1    Bird, R.P.2
  • 172
    • 84888222805 scopus 로고    scopus 로고
    • Favorablemodulation of benign breast tissue and serum risk biomarkers is associated with >10% weight loss in postmenopausal women
    • Fabian CJ, Kimler BF, Donnelly JE, Sullivan DK, Klemp JR, et al. 2013. Favorablemodulation of benign breast tissue and serum risk biomarkers is associated with >10% weight loss in postmenopausal women. Breast Cancer Res. Treat. 142:119-32
    • (2013) Breast Cancer Res. Treat. , vol.142 , pp. 119-132
    • Fabian, C.J.1    Kimler, B.F.2    Donnelly, J.E.3    Sullivan, D.K.4    Klemp, J.R.5
  • 173
    • 41549088287 scopus 로고    scopus 로고
    • Weight change and cancer risk in a cohort of more than 65,000 adults in Austria
    • Rapp K, Klenk J, Ulmer H, Concin H, Diem G, et al. 2008. Weight change and cancer risk in a cohort of more than 65,000 adults in Austria. Ann. Oncol. 19:641-48
    • (2008) Ann. Oncol. , vol.19 , pp. 641-648
    • Rapp, K.1    Klenk, J.2    Ulmer, H.3    Concin, H.4    Diem, G.5
  • 174
    • 18044381512 scopus 로고    scopus 로고
    • Loss of insulin resistance after Roux-en-Y gastric bypass surgery: A time course study
    • Wickremesekera K, Miller G, Naotunne TD, Knowles G, Stubbs RS. 2005. Loss of insulin resistance after Roux-en-Y gastric bypass surgery: A time course study. Obes. Surg. 15:474-81
    • (2005) Obes. Surg. , vol.15 , pp. 474-481
    • Wickremesekera, K.1    Miller, G.2    Naotunne, T.D.3    Knowles, G.4    Stubbs, R.S.5
  • 176
    • 84907379847 scopus 로고    scopus 로고
    • Bariatric surgery for obesity and metabolic conditions in adults
    • Arterburn DE, Courcoulas AP. 2014. Bariatric surgery for obesity and metabolic conditions in adults. BMJ 349:g3961
    • (2014) BMJ , vol.349 , pp. g3961
    • Arterburn, D.E.1    Courcoulas, A.P.2
  • 177
    • 84923437382 scopus 로고    scopus 로고
    • Does bariatric surgery reduce cancer risk? A review of the literature
    • Maestro A, Rigla M, Caixas A. 2015. Does bariatric surgery reduce cancer risk? A review of the literature. Endocrinol. Nutr. 62:138-43
    • (2015) Endocrinol. Nutr. , vol.62 , pp. 138-143
    • Maestro, A.1    Rigla, M.2    Caixas, A.3
  • 178
    • 67649344115 scopus 로고    scopus 로고
    • Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): A prospective, controlled intervention trial
    • Sjöström L, Gummesson A, Sjöström CD, Narbro K, Peltonen M, et al. 2009. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): A prospective, controlled intervention trial. Lancet Oncol. 10:653-62
    • (2009) Lancet Oncol. , vol.10 , pp. 653-662
    • Sjöström, L.1    Gummesson, A.2    Sjöström, C.D.3    Narbro, K.4    Peltonen, M.5
  • 180
    • 84938204297 scopus 로고    scopus 로고
    • Bariatric surgery and risk of postoperative endometrial cancer: A systematic review and meta-analysis
    • Upala S, Anawin S. 2015. Bariatric surgery and risk of postoperative endometrial cancer: A systematic review and meta-analysis. Surg. Obes. Relat. Dis. 11(4):949-55
    • (2015) Surg. Obes. Relat. Dis. , vol.11 , Issue.4 , pp. 949-955
    • Upala, S.1    Anawin, S.2
  • 181
    • 84939891983 scopus 로고    scopus 로고
    • The effects of bariatric surgery on colorectal cancer risk: Systematic review and meta-analysis
    • Afshar S, Kelly SB, Seymour K, Lara J, Woodcock S, Mathers JC. 2014. The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis. Obes. Surg. 24:1793-99
    • (2014) Obes. Surg. , vol.24 , pp. 1793-1799
    • Afshar, S.1    Kelly, S.B.2    Seymour, K.3    Lara, J.4    Woodcock, S.5    Mathers, J.C.6
  • 183
    • 84938918533 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity in theUnited States, 2007-2012
    • Yang L, Colditz GA. 2015. Prevalence of overweight and obesity in theUnited States, 2007-2012. JAMA Intern. Med. 175(8):1412-13
    • (2015) JAMA Intern. Med. , vol.175 , Issue.8 , pp. 1412-1413
    • Yang, L.1    Colditz, G.A.2
  • 184
    • 84905982814 scopus 로고    scopus 로고
    • NSAID use reduces breast cancer recurrence in overweight and obese women: Role of prostaglandin-aromatase interactions
    • Bowers LW, Maximo IX, Brenner AJ, Beeram M, Hursting SD, et al. 2014. NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions. Cancer Res. 74:4446-57
    • (2014) Cancer Res. , vol.74 , pp. 4446-4457
    • Bowers, L.W.1    Maximo, I.X.2    Brenner, A.J.3    Beeram, M.4    Hursting, S.D.5
  • 186
    • 84928568621 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study
    • Shebl FM, Hsing AW, Park Y, Hollenbeck AR, Chu LW, et al. 2014. Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study. PLOS ONE 9:e114633
    • (2014) PLOS ONE , vol.9 , pp. e114633
    • Shebl, F.M.1    Hsing, A.W.2    Park, Y.3    Hollenbeck, A.R.4    Chu, L.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.