-
1
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer J.R., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 2012, 366:2455-2465.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
-
2
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin J., et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 2015, 373:23-34.
-
(2015)
N. Engl. J. Med.
, vol.373
, pp. 23-34
-
-
Larkin, J.1
-
3
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow M.A., et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 2015, 372:2006-2017.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
-
4
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C., et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 2015, 372:2521-2532.
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
-
5
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian S.L., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 2012, 366:2443-2454.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
6
-
-
84895904745
-
Mitigating the toxic effects of anticancer immunotherapy
-
Gangadhar T.C., Vonderheide R.H. Mitigating the toxic effects of anticancer immunotherapy. Nat. Rev. Clin. Oncol. 2014, 11:91-99.
-
(2014)
Nat. Rev. Clin. Oncol.
, vol.11
, pp. 91-99
-
-
Gangadhar, T.C.1
Vonderheide, R.H.2
-
7
-
-
84896690513
-
Prevalence of childhood and adult obesity in the United States, 2011-2012
-
Ogden C.L., et al. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014, 311:806-814.
-
(2014)
JAMA
, vol.311
, pp. 806-814
-
-
Ogden, C.L.1
-
8
-
-
84892727198
-
What we talk about when we talk about fat
-
Rosen E.D., Spiegelman B.M. What we talk about when we talk about fat. Cell 2014, 156:20-44.
-
(2014)
Cell
, vol.156
, pp. 20-44
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
9
-
-
84888049920
-
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
-
Iida N., et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 2013, 342:967-970.
-
(2013)
Science
, vol.342
, pp. 967-970
-
-
Iida, N.1
-
10
-
-
84888059687
-
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
-
Viaud S., et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013, 342:971-976.
-
(2013)
Science
, vol.342
, pp. 971-976
-
-
Viaud, S.1
-
11
-
-
85044695622
-
Cancer and the microbiota
-
Garrett W.S. Cancer and the microbiota. Science 2015, 348:80-86.
-
(2015)
Science
, vol.348
, pp. 80-86
-
-
Garrett, W.S.1
-
12
-
-
84885783438
-
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy
-
Bouchlaka M.N., et al. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J. Exp. Med. 2013, 210:2223-2237.
-
(2013)
J. Exp. Med.
, vol.210
, pp. 2223-2237
-
-
Bouchlaka, M.N.1
-
13
-
-
84864119774
-
Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth
-
James B.R., et al. Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth. J. Immunol. 2012, 189:1311-1321.
-
(2012)
J. Immunol.
, vol.189
, pp. 1311-1321
-
-
James, B.R.1
-
14
-
-
84911904714
-
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice
-
Mirsoian A., et al. Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. J. Exp. Med. 2014, 211:2373-2383.
-
(2014)
J. Exp. Med.
, vol.211
, pp. 2373-2383
-
-
Mirsoian, A.1
-
15
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
-
Sivan A., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 2015, 350:1084-1089.
-
(2015)
Science
, vol.350
, pp. 1084-1089
-
-
Sivan, A.1
-
16
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vetizou M., et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 2015, 350:1079-1084.
-
(2015)
Science
, vol.350
, pp. 1079-1084
-
-
Vetizou, M.1
-
17
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok J.D., et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 2013, 369:122-133.
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
-
18
-
-
84969651268
-
Characterizing exposure-response (E-R) relationship of safety for nivolumab in combination with ipilimumab in patients with previously untreated advanced melanoma
-
Wang X., et al. Characterizing exposure-response (E-R) relationship of safety for nivolumab in combination with ipilimumab in patients with previously untreated advanced melanoma. In American Conference on Pharmacometrics (ACoP6) 2015.
-
(2015)
In American Conference on Pharmacometrics (ACoP6)
-
-
Wang, X.1
-
19
-
-
33744477359
-
Naive T cells in the elderly: are they still there?
-
Pfister G., et al. Naive T cells in the elderly: are they still there?. Ann. N. Y. Acad. Sci. 2006, 1067:152-157.
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1067
, pp. 152-157
-
-
Pfister, G.1
-
20
-
-
84955481171
-
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
-
Youm Y.H., et al. Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proc. Natl. Acad. Sci. U.SA. 2016, 113:1026-1031.
-
(2016)
Proc. Natl. Acad. Sci. U.SA.
, vol.113
, pp. 1026-1031
-
-
Youm, Y.H.1
-
21
-
-
84921634186
-
Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories
-
Nikolich-Zugich J. Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J. Immunol. 2014, 193:2622-2629.
-
(2014)
J. Immunol.
, vol.193
, pp. 2622-2629
-
-
Nikolich-Zugich, J.1
-
22
-
-
11144267995
-
Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes
-
Lazuardi L., et al. Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology 2005, 114:37-43.
-
(2005)
Immunology
, vol.114
, pp. 37-43
-
-
Lazuardi, L.1
-
23
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla A., et al. Macrophage-mediated inflammation in metabolic disease. Nat. Rev. Immunol. 2011, 11:738-749.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 738-749
-
-
Chawla, A.1
-
24
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg S.P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112:1796-1808.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
-
25
-
-
84860181087
-
Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice
-
Hurez V., et al. Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice. Cancer Res. 2012, 72:2089-2099.
-
(2012)
Cancer Res.
, vol.72
, pp. 2089-2099
-
-
Hurez, V.1
-
26
-
-
3142768349
-
+ T cell-mediated antitumor immunity with aging
-
+ T cell-mediated antitumor immunity with aging. J. Immunol. 2004, 173:835-844.
-
(2004)
J. Immunol.
, vol.173
, pp. 835-844
-
-
Norian, L.A.1
Allen, P.M.2
-
27
-
-
73349101903
-
Key role of T cell defects in age-related vulnerability to West Nile virus
-
Brien J.D., et al. Key role of T cell defects in age-related vulnerability to West Nile virus. J. Exp. Med. 2009, 206:2735-2745.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2735-2745
-
-
Brien, J.D.1
-
28
-
-
33846487547
-
+ recent thymic emigrants from aged mice
-
+ recent thymic emigrants from aged mice. J. Immunol. 2007, 178:1321-1331.
-
(2007)
J. Immunol.
, vol.178
, pp. 1321-1331
-
-
Clise-Dwyer, K.1
-
29
-
-
0031845411
-
Loss of resistance to a highly immunogenic tumor with age corresponds to the decline of CD8 T cell activity
-
Flood P.M., et al. Loss of resistance to a highly immunogenic tumor with age corresponds to the decline of CD8 T cell activity. J. Immunother. 1998, 21:307-316.
-
(1998)
J. Immunother.
, vol.21
, pp. 307-316
-
-
Flood, P.M.1
-
30
-
-
0034066895
-
Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice
-
Provinciali M., et al. Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice. Gene Ther. 2000, 7:624-632.
-
(2000)
Gene Ther.
, vol.7
, pp. 624-632
-
-
Provinciali, M.1
-
31
-
-
66149160389
-
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
-
Yuan R., et al. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 2009, 8:277-287.
-
(2009)
Aging Cell
, vol.8
, pp. 277-287
-
-
Yuan, R.1
-
32
-
-
70849110194
-
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
-
Tsukamoto H., et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:18333-18338.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 18333-18338
-
-
Tsukamoto, H.1
-
33
-
-
0016762055
-
Thymic involution: effect on T cell differentiation
-
Hirokawa K., Makinodan T. Thymic involution: effect on T cell differentiation. J. Immunol. 1975, 114:1659-1664.
-
(1975)
J. Immunol.
, vol.114
, pp. 1659-1664
-
-
Hirokawa, K.1
Makinodan, T.2
-
34
-
-
0015888521
-
Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis
-
Toh B.H., et al. Depression of cell-mediated immunity in old age and the immunopathic diseases, lupus erythematosus, chronic hepatitis and rheumatoid arthritis. Clin. Exp. Immunol. 1973, 14:193-202.
-
(1973)
Clin. Exp. Immunol.
, vol.14
, pp. 193-202
-
-
Toh, B.H.1
-
35
-
-
84863691378
-
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
-
Singh M., Ferrara N. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat. Biotechnol. 2012, 30:648-657.
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 648-657
-
-
Singh, M.1
Ferrara, N.2
-
36
-
-
84877028120
-
Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response
-
DuPage M., Jacks T. Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response. Curr. Opin. Immunol. 2013, 25:192-199.
-
(2013)
Curr. Opin. Immunol.
, vol.25
, pp. 192-199
-
-
DuPage, M.1
Jacks, T.2
-
37
-
-
84894098516
-
Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
-
Stromnes I.M., et al. Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Gut 2014, 63:1769-1781.
-
(2014)
Gut
, vol.63
, pp. 1769-1781
-
-
Stromnes, I.M.1
-
38
-
-
0024342545
-
Endogenous virus genomes become hypomethylated tissue-specifically during aging process of C57BL mice
-
Ono T., et al. Endogenous virus genomes become hypomethylated tissue-specifically during aging process of C57BL mice. Mech. Ageing Dev. 1989, 50:27-36.
-
(1989)
Mech. Ageing Dev.
, vol.50
, pp. 27-36
-
-
Ono, T.1
-
39
-
-
84940381273
-
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
-
Chiappinelli K.B., et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell 2015, 162:974-986.
-
(2015)
Cell
, vol.162
, pp. 974-986
-
-
Chiappinelli, K.B.1
-
40
-
-
84960194716
-
Regulatory evolution of innate immunity through co-option of endogenous retroviruses
-
Chuong E.B., et al. Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science 2016, 351:1083-1087.
-
(2016)
Science
, vol.351
, pp. 1083-1087
-
-
Chuong, E.B.1
-
41
-
-
84963612049
-
Combining epigenetic and immunotherapy to combat cancer
-
Chiappinelli K.B., et al. Combining epigenetic and immunotherapy to combat cancer. Cancer Res. 2016, 76:1683-1689.
-
(2016)
Cancer Res.
, vol.76
, pp. 1683-1689
-
-
Chiappinelli, K.B.1
-
42
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 2009, 15:930-939.
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
43
-
-
33750311697
-
Impairment of dendritic cell functionality and steady-state number in obese mice
-
Macia L., et al. Impairment of dendritic cell functionality and steady-state number in obese mice. J. Immunol. 2006, 177:5997-6006.
-
(2006)
J. Immunol.
, vol.177
, pp. 5997-6006
-
-
Macia, L.1
-
44
-
-
84883318210
-
Diet-induced obese mice exhibit altered heterologous immunity during a secondary 2009 pandemic H1N1 infection
-
Milner J.J., et al. Diet-induced obese mice exhibit altered heterologous immunity during a secondary 2009 pandemic H1N1 infection. J. Immunol. 2013, 191:2474-2485.
-
(2013)
J. Immunol.
, vol.191
, pp. 2474-2485
-
-
Milner, J.J.1
-
45
-
-
0032718690
-
Analysis of the human thymic perivascular space during aging
-
Flores K.G., et al. Analysis of the human thymic perivascular space during aging. J. Clin. Invest. 1999, 104:1031-1039.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 1031-1039
-
-
Flores, K.G.1
-
46
-
-
70349231092
-
Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
-
Yang H., et al. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J. Immunol. 2009, 183:3040-3052.
-
(2009)
J. Immunol.
, vol.183
, pp. 3040-3052
-
-
Yang, H.1
-
47
-
-
70449701826
-
Obesity accelerates thymic aging
-
Yang H., et al. Obesity accelerates thymic aging. Blood 2009, 114:3803-3812.
-
(2009)
Blood
, vol.114
, pp. 3803-3812
-
-
Yang, H.1
-
48
-
-
0015058193
-
Experimental obesity in man: cellular character of the adipose tissue
-
Salans L.B., et al. Experimental obesity in man: cellular character of the adipose tissue. J. Clin. Invest. 1971, 50:1005-1011.
-
(1971)
J. Clin. Invest.
, vol.50
, pp. 1005-1011
-
-
Salans, L.B.1
-
49
-
-
68949159760
-
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
-
Halberg N., et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol. Cell. Biol. 2009, 29:4467-4483.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4467-4483
-
-
Halberg, N.1
-
50
-
-
68349150756
-
+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 2009, 15:914-920.
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
-
51
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
Winer D.A., et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 2011, 17:610-617.
-
(2011)
Nat. Med.
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
-
52
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg S.P.R., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Invest. 2006, 116:115-124.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.R.1
-
53
-
-
84916879121
-
Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells
-
Khan S.H., et al. Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells. J. Immunol. 2014, 193:5873-5882.
-
(2014)
J. Immunol.
, vol.193
, pp. 5873-5882
-
-
Khan, S.H.1
-
54
-
-
28544431852
-
Alterations in T-cell subset frequency in peripheral blood in obesity
-
O'Rourke R.W., et al. Alterations in T-cell subset frequency in peripheral blood in obesity. Obes. Surg. 2005, 15:1463-1468.
-
(2005)
Obes. Surg.
, vol.15
, pp. 1463-1468
-
-
O'Rourke, R.W.1
-
55
-
-
84892384305
-
Is obesity a risk factor for vaccine non-responsiveness?
-
Young K.M., et al. Is obesity a risk factor for vaccine non-responsiveness?. PLoS ONE 2013, 8:e82779.
-
(2013)
PLoS ONE
, vol.8
-
-
Young, K.M.1
-
56
-
-
0037464510
-
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
-
Calle E.E., et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med. 2003, 348:1625-1638.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1625-1638
-
-
Calle, E.E.1
-
57
-
-
38949108241
-
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
-
Renehan A.G., et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008, 371:569-578.
-
(2008)
Lancet
, vol.371
, pp. 569-578
-
-
Renehan, A.G.1
-
58
-
-
84861863986
-
Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet
-
Lu Y.P., et al. Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:9065-9070.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 9065-9070
-
-
Lu, Y.P.1
-
59
-
-
77951626838
-
The predictive value of different measures of obesity for incident cardiovascular events and mortality
-
Schneider H.J., et al. The predictive value of different measures of obesity for incident cardiovascular events and mortality. J. Clin. Endocrinol. Metab. 2010, 95:1777-1785.
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 1777-1785
-
-
Schneider, H.J.1
-
60
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
61
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter M.A., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269:540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
-
62
-
-
61549102500
-
Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array
-
Fenton J.I., et al. Diet-induced adiposity alters the serum profile of inflammation in C57BL/6N mice as measured by antibody array. Diabetes Obes. Metab. 2009, 11:343-354.
-
(2009)
Diabetes Obes. Metab.
, vol.11
, pp. 343-354
-
-
Fenton, J.I.1
-
63
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 2003, 112:1821-1830.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
-
64
-
-
84863393214
-
Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents
-
Pollock N.K., et al. Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents. J. Nutr. 2012, 142:251-257.
-
(2012)
J. Nutr.
, vol.142
, pp. 251-257
-
-
Pollock, N.K.1
-
65
-
-
84924281209
-
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis
-
Griffett K., et al. The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. Mol. Metab. 2015, 4:353-357.
-
(2015)
Mol. Metab.
, vol.4
, pp. 353-357
-
-
Griffett, K.1
-
66
-
-
84872506745
-
Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants
-
Gosalbes M.J., et al. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin. Exp. Allergy 2013, 43:198-211.
-
(2013)
Clin. Exp. Allergy
, vol.43
, pp. 198-211
-
-
Gosalbes, M.J.1
-
67
-
-
85027942141
-
Gut microbial colonisation in premature neonates predicts neonatal sepsis
-
Madan J.C., et al. Gut microbial colonisation in premature neonates predicts neonatal sepsis. Arch. Dis. Child. Fetal Neonatal. Ed. 2012, 97:F456-F462.
-
(2012)
Arch. Dis. Child. Fetal Neonatal. Ed.
, vol.97
, pp. F456-F462
-
-
Madan, J.C.1
-
68
-
-
72049101608
-
Intestinal microbial ecology in premature infants assessed with non-culture-based techniques
-
Mshvildadze M., et al. Intestinal microbial ecology in premature infants assessed with non-culture-based techniques. J. Pediatr. 2010, 156:20-25.
-
(2010)
J. Pediatr.
, vol.156
, pp. 20-25
-
-
Mshvildadze, M.1
-
69
-
-
77955386857
-
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
-
Dominguez-Bello M.G., et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11971-11975.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11971-11975
-
-
Dominguez-Bello, M.G.1
-
70
-
-
84921367265
-
Modulation of immune development and function by intestinal microbiota
-
Kabat A.M., et al. Modulation of immune development and function by intestinal microbiota. Trends Immunol. 2014, 35:507-517.
-
(2014)
Trends Immunol.
, vol.35
, pp. 507-517
-
-
Kabat, A.M.1
-
71
-
-
34547686398
-
+ T cells via TLR4 signaling
-
+ T cells via TLR4 signaling. J. Clin. Invest. 2007, 117:2197-2204.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2197-2204
-
-
Paulos, C.M.1
-
72
-
-
84868613705
-
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
-
Grivennikov S.I., et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 2012, 491:254-258.
-
(2012)
Nature
, vol.491
, pp. 254-258
-
-
Grivennikov, S.I.1
-
73
-
-
78149295964
-
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
-
Wallace B.D., et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 2010, 330:831-835.
-
(2010)
Science
, vol.330
, pp. 831-835
-
-
Wallace, B.D.1
-
74
-
-
84924971514
-
The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients
-
Boleij A., et al. The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clin. Infect. Dis. 2015, 60:208-215.
-
(2015)
Clin. Infect. Dis.
, vol.60
, pp. 208-215
-
-
Boleij, A.1
-
75
-
-
33745593712
-
A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
-
Toprak N.U., et al. A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer. Clin. Microbiol. Infect. 2006, 12:782-786.
-
(2006)
Clin. Microbiol. Infect.
, vol.12
, pp. 782-786
-
-
Toprak, N.U.1
-
76
-
-
77954738601
-
+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
-
+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:12204-12209.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 12204-12209
-
-
Round, J.L.1
Mazmanian, S.K.2
-
77
-
-
84944445669
-
+ T cells and Treg function
-
+ T cells and Treg function. Gut Microbes 2015, 6:234-242.
-
(2015)
Gut Microbes
, vol.6
, pp. 234-242
-
-
Telesford, K.M.1
-
78
-
-
84904543667
-
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
-
Belcheva A., et al. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 2014, 158:288-299.
-
(2014)
Cell
, vol.158
, pp. 288-299
-
-
Belcheva, A.1
-
79
-
-
56049127918
-
Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats
-
Clarke J.M., et al. Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats. Carcinogenesis 2008, 29:2190-2194.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2190-2194
-
-
Clarke, J.M.1
-
80
-
-
84936953099
-
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
-
Spranger S., et al. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 2015, 523:231-235.
-
(2015)
Nature
, vol.523
, pp. 231-235
-
-
Spranger, S.1
-
81
-
-
84902243899
-
Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway
-
Lu R., et al. Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis 2014, 3:e105.
-
(2014)
Oncogenesis
, vol.3
, pp. e105
-
-
Lu, R.1
-
82
-
-
84869162891
-
Consistent activation of the beta-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine
-
Lu R., et al. Consistent activation of the beta-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303:G1113-G1125.
-
(2012)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.303
, pp. G1113-G1125
-
-
Lu, R.1
-
83
-
-
84947432484
-
The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation
-
Zaiss M.M., et al. The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation. Immunity 2015, 43:998-1010.
-
(2015)
Immunity
, vol.43
, pp. 998-1010
-
-
Zaiss, M.M.1
-
84
-
-
0029970242
-
Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ-free mice
-
Imaoka A., et al. Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ-free mice. Eur. J. Immunol. 1996, 26:945-948.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 945-948
-
-
Imaoka, A.1
-
85
-
-
0037438711
-
Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
-
Yamanaka T., et al. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J. Immunol. 2003, 170:816-822.
-
(2003)
J. Immunol.
, vol.170
, pp. 816-822
-
-
Yamanaka, T.1
-
86
-
-
0037371149
-
+ cell responses
-
+ cell responses. J. Immunol. 2003, 170:2727-2733.
-
(2003)
J. Immunol.
, vol.170
, pp. 2727-2733
-
-
Murphy, W.J.1
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