Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Journal of Experimental Medicine

Volumn 211, Issue 12, 2014, Pages 2373-2383

  Mirsoian, Annie ^a   Bouchlaka, Myriam N ^a   Sckisel, Gail D ^a   Chen, Mingyi ^a   Pai, Chien Chun Steven ^a   Maverakis, Emanuel ^a   Spencer, Richard G ^c   Fishbein, Kenneth W ^c   Siddiqui, Sana ^c   Monjazeb, Arta M ^a   Martin, Bronwen ^c   Maudsley, Stuart ^c   Hesdorffer, Charles ^c   Ferrucci, Luigi ^c   Longo, Dan L ^c   Blazar, Bruce R ^d   Wiltrout, Robert H ^e   Taub, Dennis D ^b,f   Murphy, William J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD40 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; ETANERCEPT; RECOMBINANT INTERLEUKIN 2; TUMOR NECROSIS FACTOR; AUTACOID;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; CYTOKINE STORM; DIET; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; INFLAMMATION; INTESTINE INJURY; INTRAABDOMINAL FAT; LETHALITY; LIVER INJURY; LOW DRUG DOSE; MACROPHAGE; MIDDLE AGED; MOUSE; NONHUMAN; OBESITY; PERITONEUM; ANIMAL; BLOOD; C57BL MOUSE; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NEOPLASMS; PROCEDURES;

ADIPOSITY; AGING; ANIMALS; CALORIC RESTRICTION; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOTHERAPY; INFLAMMATION MEDIATORS; INTRA-ABDOMINAL FAT; MACROPHAGES; MICE, INBRED C57BL; MICE, OBESE; NEOPLASMS; OBESITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84911904714     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20140116     Document Type: Article

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