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Volumn 6, Issue 8, 2011, Pages

Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CALCITRIOL; T CELL FACTOR PROTEIN; VITAMIN D RECEPTOR; WNT PROTEIN; APC PROTEIN; CALCITRIOL RECEPTOR; STEROID MONOOXYGENASE; VITAMIN D 24 HYDROXYLASE; VITAMIN D 24-HYDROXYLASE;

EID: 80051677041     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023524     Document Type: Article
Times cited : (129)

References (45)
  • 2
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde R, Smits R, Clevers H, (2001) APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1: 55-67.
    • (2001) Nat Rev Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 3
    • 44349126693 scopus 로고    scopus 로고
    • Colonic crypt organization and tumorigenesis
    • Humphries A, Wright NA, (2008) Colonic crypt organization and tumorigenesis. Nat Rev Cancer 8: 415-424.
    • (2008) Nat Rev Cancer , vol.8 , pp. 415-424
    • Humphries, A.1    Wright, N.A.2
  • 4
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256: 668-670.
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5
  • 5
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: from endoderm to cancer
    • Gregorieff A, Clevers H, (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 19: 877-890.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 6
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H, (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 7
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X, (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 8
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241-250.
    • (2002) Cell , vol.111 , pp. 241-250
    • van de Wetering, M.1    Sancho, E.2    Verweij, C.3    de Lau, W.4    Oving, I.5
  • 9
    • 8444220513 scopus 로고    scopus 로고
    • Signaling pathways in intestinal development and cancer
    • Sancho E, Batlle E, Clevers H, (2004) Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol 20: 695-723.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 695-723
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 10
    • 33749252164 scopus 로고    scopus 로고
    • The vitamin D receptor as a therapeutic target
    • Campbell MJ, Adorini L, (2006) The vitamin D receptor as a therapeutic target. Expert Opin Ther Targets 10: 735-748.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 735-748
    • Campbell, M.J.1    Adorini, L.2
  • 11
    • 34548202165 scopus 로고    scopus 로고
    • Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    • Deeb KK, Trump DL, Johnson CS, (2007) Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 7: 684-700.
    • (2007) Nat Rev Cancer , vol.7 , pp. 684-700
    • Deeb, K.K.1    Trump, D.L.2    Johnson, C.S.3
  • 12
    • 34547443879 scopus 로고    scopus 로고
    • Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs
    • Eelen G, Gysemans C, Verlinden L, Vanoirbeek E, De Clercq P, et al. (2007) Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs. Curr Med Chem 14: 1893-1910.
    • (2007) Curr Med Chem , vol.14 , pp. 1893-1910
    • Eelen, G.1    Gysemans, C.2    Verlinden, L.3    Vanoirbeek, E.4    de Clercq, P.5
  • 13
    • 18344389705 scopus 로고    scopus 로고
    • Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
    • Pálmer HG, González-Sancho JM, Espada J, Berciano MT, Puig I, et al. (2001) Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 154: 369-387.
    • (2001) J Cell Biol , vol.154 , pp. 369-387
    • Pálmer, H.G.1    González-Sancho, J.M.2    Espada, J.3    Berciano, M.T.4    Puig, I.5
  • 14
    • 34848858270 scopus 로고    scopus 로고
    • The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells
    • Aguilera O, Peña C, García JM, Larriba MJ, Ordóñez-Morán P, et al. (2007) The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis 28: 1877-1884.
    • (2007) Carcinogenesis , vol.28 , pp. 1877-1884
    • Aguilera, O.1    Peña, C.2    García, J.M.3    Larriba, M.J.4    Ordóñez-Morán, P.5
  • 15
    • 4644229397 scopus 로고    scopus 로고
    • The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
    • Pálmer HG, Larriba MJ, García JM, Ordóñez-Morán P, Peña C, et al. (2004) The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 10: 917-919.
    • (2004) Nat Med , vol.10 , pp. 917-919
    • Pálmer, H.G.1    Larriba, M.J.2    García, J.M.3    Ordóñez-Morán, P.4    Peña, C.5
  • 16
    • 69449084716 scopus 로고    scopus 로고
    • Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer
    • Larriba MJ, Martín-Villar E, García JM, Pereira F, Peña C, et al. (2009) Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30: 1459-1468.
    • (2009) Carcinogenesis , vol.30 , pp. 1459-1468
    • Larriba, M.J.1    Martín-Villar, E.2    García, J.M.3    Pereira, F.4    Peña, C.5
  • 17
    • 34249795195 scopus 로고    scopus 로고
    • The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells
    • Larriba MJ, Valle N, Pálmer HG, Ordóñez-Morán P, Álvarez-Díaz S, et al. (2007) The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. Endocr Relat Cancer 14: 141-151.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 141-151
    • Larriba, M.J.1    Valle, N.2    Pálmer, H.G.3    Ordóñez-Morán, P.4    Álvarez-Díaz, S.5
  • 18
    • 28844439793 scopus 로고    scopus 로고
    • Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?
    • Mulholland DJ, Dedhar S, Coetzee GA, Nelson CC, (2005) Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev 26: 898-915.
    • (2005) Endocr Rev , vol.26 , pp. 898-915
    • Mulholland, D.J.1    Dedhar, S.2    Coetzee, G.A.3    Nelson, C.C.4
  • 19
    • 33646134106 scopus 로고    scopus 로고
    • Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination
    • Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125: 593-605.
    • (2006) Cell , vol.125 , pp. 593-605
    • Olson, L.E.1    Tollkuhn, J.2    Scafoglio, C.3    Krones, A.4    Zhang, J.5
  • 20
    • 44649160789 scopus 로고    scopus 로고
    • The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis
    • Pálmer HG, Anjos-Afonso F, Carmeliet G, Takeda H, Watt FM, (2008) The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS One 3: e1483.
    • (2008) PLoS One , vol.3
    • Pálmer, H.G.1    Anjos-Afonso, F.2    Carmeliet, G.3    Takeda, H.4    Watt, F.M.5
  • 21
    • 33644850904 scopus 로고    scopus 로고
    • The molecular basis of vitamin D receptor and beta-catenin crossregulation
    • Shah S, Islam MN, Dakshanamurthy S, Rizvi I, Rao M, et al. (2006) The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol Cell 21: 799-809.
    • (2006) Mol Cell , vol.21 , pp. 799-809
    • Shah, S.1    Islam, M.N.2    Dakshanamurthy, S.3    Rizvi, I.4    Rao, M.5
  • 22
    • 68549126202 scopus 로고    scopus 로고
    • Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals
    • Xu H, McCann M, Zhang Z, Posner GH, Bingham V, et al. (2009) Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals. Mol Carcinog 48: 758-772.
    • (2009) Mol Carcinog , vol.48 , pp. 758-772
    • Xu, H.1    McCann, M.2    Zhang, Z.3    Posner, G.H.4    Bingham, V.5
  • 23
    • 77951661630 scopus 로고    scopus 로고
    • Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells
    • Egan JB, Thompson PA, Vitanov MV, Bartik L, Jacobs ET, et al. (2010) Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells. Mol Carcinog 49: 337-352.
    • (2010) Mol Carcinog , vol.49 , pp. 337-352
    • Egan, J.B.1    Thompson, P.A.2    Vitanov, M.V.3    Bartik, L.4    Jacobs, E.T.5
  • 24
    • 78651384347 scopus 로고    scopus 로고
    • Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    • He W, Kang YS, Dai C, Liu Y, (2011) Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22: 90-103.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 90-103
    • He, W.1    Kang, Y.S.2    Dai, C.3    Liu, Y.4
  • 25
    • 0036462480 scopus 로고    scopus 로고
    • 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apcmin Mouse
    • Huerta S, Irwin RW, Heber D, Go VL, Koeffler HP, et al. (2002) 1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apcmin Mouse. Cancer Res 62: 741-746.
    • (2002) Cancer Res , vol.62 , pp. 741-746
    • Huerta, S.1    Irwin, R.W.2    Heber, D.3    Go, V.L.4    Koeffler, H.P.5
  • 26
    • 77955387570 scopus 로고    scopus 로고
    • ApcMIN modulation of vitamin D secosteroid growth control
    • Xu H, Posner GH, Stevenson M, Campbell FC, (2010) ApcMIN modulation of vitamin D secosteroid growth control. Carcinogenesis 31: 1434-1441.
    • (2010) Carcinogenesis , vol.31 , pp. 1434-1441
    • Xu, H.1    Posner, G.H.2    Stevenson, M.3    Campbell, F.C.4
  • 27
    • 21344436821 scopus 로고    scopus 로고
    • Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
    • Silva-Vargas V, Lo Celso C, Giangreco A, Ofstad T, Prowse DM, et al. (2005) Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell 9: 121-131.
    • (2005) Dev Cell , vol.9 , pp. 121-131
    • Silva-Vargas, V.1    Lo Celso, C.2    Giangreco, A.3    Ofstad, T.4    Prowse, D.M.5
  • 28
    • 65549159598 scopus 로고    scopus 로고
    • A two-step model for colon adenoma initiation and progression caused by APC loss
    • Phelps RA, Chidester S, Dehghanizadeh S, Phelps J, Sandoval IT, et al. (2009) A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137: 623-634.
    • (2009) Cell , vol.137 , pp. 623-634
    • Phelps, R.A.1    Chidester, S.2    Dehghanizadeh, S.3    Phelps, J.4    Sandoval, I.T.5
  • 30
    • 77949587674 scopus 로고    scopus 로고
    • Lentiviral vectors to probe and manipulate the Wnt signaling pathway
    • Fuerer C, Nusse R, (2010) Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One 5: e9370.
    • (2010) PLoS One , vol.5
    • Fuerer, C.1    Nusse, R.2
  • 31
    • 58149186769 scopus 로고    scopus 로고
    • RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells
    • Ordóñez-Morán P, Larriba MJ, Pálmer HG, Valero RA, Barbáchano A, et al. (2008) RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. J Cell Biol 183: 697-710.
    • (2008) J Cell Biol , vol.183 , pp. 697-710
    • Ordóñez-Morán, P.1    Larriba, M.J.2    Pálmer, H.G.3    Valero, R.A.4    Barbáchano, A.5
  • 32
    • 33744519452 scopus 로고    scopus 로고
    • Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    • Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO, (2006) Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J Biol Chem 281: 9971-9976.
    • (2006) J Biol Chem , vol.281 , pp. 9971-9976
    • Taurin, S.1    Sandbo, N.2    Qin, Y.3    Browning, D.4    Dulin, N.O.5
  • 33
    • 34249661591 scopus 로고    scopus 로고
    • Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    • Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, et al. (2007) Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 282: 11221-11229.
    • (2007) J Biol Chem , vol.282 , pp. 11221-11229
    • Fang, D.1    Hawke, D.2    Zheng, Y.3    Xia, Y.4    Meisenhelder, J.5
  • 34
    • 33846600427 scopus 로고    scopus 로고
    • PTEN-deficient intestinal stem cells initiate intestinal polyposis
    • He XC, Yin T, Grindley JC, Tian Q, Sato T, et al. (2007) PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39: 189-198.
    • (2007) Nat Genet , vol.39 , pp. 189-198
    • He, X.C.1    Yin, T.2    Grindley, J.C.3    Tian, Q.4    Sato, T.5
  • 35
    • 33744791463 scopus 로고    scopus 로고
    • Wnt signaling: is the party in the nucleus?
    • Willert K, Jones KA, (2006) Wnt signaling: is the party in the nucleus? Genes Dev 20: 1394-1404.
    • (2006) Genes Dev , vol.20 , pp. 1394-1404
    • Willert, K.1    Jones, K.A.2
  • 36
    • 0034014831 scopus 로고    scopus 로고
    • The clonal origin and clonal evolution of epithelial tumours
    • Garcia SB, Novelli M, Wright NA, (2000) The clonal origin and clonal evolution of epithelial tumours. Int J Exp Pathol 81: 89-116.
    • (2000) Int J Exp Pathol , vol.81 , pp. 89-116
    • Garcia, S.B.1    Novelli, M.2    Wright, N.A.3
  • 37
    • 70449105185 scopus 로고    scopus 로고
    • Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
    • Kaler P, Augenlicht L, Klampfer L, (2009) Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene 28: 3892-3902.
    • (2009) Oncogene , vol.28 , pp. 3892-3902
    • Kaler, P.1    Augenlicht, L.2    Klampfer, L.3
  • 38
    • 0032780531 scopus 로고    scopus 로고
    • The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets
    • Malloy PJ, Pike JW, Feldman D, (1999) The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev 20: 156-188.
    • (1999) Endocr Rev , vol.20 , pp. 156-188
    • Malloy, P.J.1    Pike, J.W.2    Feldman, D.3
  • 39
    • 80255129256 scopus 로고    scopus 로고
    • Inactivation of the vitamin D receptor in APCmin/+ mice reveals a critical role for the vitamin D receptor in intestinal tumor growth
    • In press
    • Zheng W, Wong KE, Zhang Z, Dougherty U, Mustafi R, et al. (2011) Inactivation of the vitamin D receptor in APCmin/+ mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer. In press.
    • (2011) Int J Cancer
    • Zheng, W.1    Wong, K.E.2    Zhang, Z.3    Dougherty, U.4    Mustafi, R.5
  • 40
    • 77954760117 scopus 로고    scopus 로고
    • The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression
    • Larriba MJ, Bonilla F, Muñoz A, (2010) The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. J Steroid Biochem Mol Biol 121: 106-109.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 106-109
    • Larriba, M.J.1    Bonilla, F.2    Muñoz, A.3
  • 41
    • 9444232242 scopus 로고    scopus 로고
    • Vitamin D receptor and cytokeratin expression may be progression indicators in human colon cancer
    • Cross HS, Bajna E, Bises G, Genser D, Kallay E, et al. (1996) Vitamin D receptor and cytokeratin expression may be progression indicators in human colon cancer. Anticancer Res 16: 2333-2337.
    • (1996) Anticancer Res , vol.16 , pp. 2333-2337
    • Cross, H.S.1    Bajna, E.2    Bises, G.3    Genser, D.4    Kallay, E.5
  • 42
    • 0031799004 scopus 로고    scopus 로고
    • Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer
    • Evans SR, Nolla J, Hanfelt J, Shabahang M, Nauta RJ, et al. (1998) Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer. Clin Cancer Res 4: 1591-1595.
    • (1998) Clin Cancer Res , vol.4 , pp. 1591-1595
    • Evans, S.R.1    Nolla, J.2    Hanfelt, J.3    Shabahang, M.4    Nauta, R.J.5
  • 43
    • 27944447368 scopus 로고    scopus 로고
    • E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations
    • Peña C, García JM, Silva J, García V, Rodríguez R, et al. (2005) E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum Mol Genet 14: 3361-3370.
    • (2005) Hum Mol Genet , vol.14 , pp. 3361-3370
    • Peña, C.1    García, J.M.2    Silva, J.3    García, V.4    Rodríguez, R.5
  • 44
    • 0030610422 scopus 로고    scopus 로고
    • Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia
    • Li YC, Pirro AE, Amling M, Delling G, Baron R, et al. (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A 94: 9831-9835.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9831-9835
    • Li, Y.C.1    Pirro, A.E.2    Amling, M.3    Delling, G.4    Baron, R.5
  • 45
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    de Preter, K.2    Pattyn, F.3    Poppe, B.4    van Roy, N.5


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