Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Nature Medicine

Volumn 23, Issue 2, 2017, Pages 174-184

  Furman, David ^a,b   Chang, Junlei ^a   Lartigue, Lydia ^c   Bolen, Christopher R ^a,f   Haddad, François ^a   Gaudilliere, Brice ^a   Ganio, Edward A ^a   Fragiadakis, Gabriela K ^a   Spitzer, Matthew H ^a   Douchet, Isabelle ^d   Daburon, Sophie ^d   Moreau, Jean François ^d   Nolan, Garry P ^a   Blanco, Patrick ^d   Déchanet Merville, Julie ^d   Dekker, Cornelia L ^a   Jojic, Vladimir ^e   Kuo, Calvin J ^a   Davis, Mark M ^a   Faustin, Benjamin ^d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^c INSTITUT BERGONIÉ   (France)

^d CNRS Bordeaux Segalen University   (France)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; INFLAMMASOME; INFLAMMASOME MODULE HIGH; INFLAMMASOME MODULE LOW; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; CALCIUM BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CYTIDINE; CYTOKINE; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE; IL1RN PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; N-ACETYLCYTIDINE; NLRC4 PROTEIN, HUMAN; NLRC5 PROTEIN, HUMAN; NUCLEOTIDE; SIGNAL PEPTIDE; TLR5 PROTEIN, HUMAN; TLR6 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 8; TRANSCRIPTOME;

AGING; ARTERIAL STIFFNESS; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HEALTH STATUS; HUMAN; HYPERTENSION; LONGEVITY; METABOLIC DISORDER; NUCLEOTIDE METABOLISM; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; REGRESSION ANALYSIS; STABLE EXPRESSION; ADULT; AGED; ANALOGS AND DERIVATIVES; ANIMAL; ARTERIAL WALL THICKNESS; BLOOD PRESSURE; CELL LINE; DRUG EFFECTS; FEMALE; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE ACTIVATION; MACROPHAGE; MALE; METABOLISM; METABOLOMICS; MIDDLE AGED; MONOCYTE; MORTALITY; MOUSE; NEUTROPHIL; PULSE WAVE; THROMBOCYTE; THROMBOCYTE ACTIVATION; VERY ELDERLY; YOUNG ADULT;

ADENINE; ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; BLOOD PLATELETS; BLOOD PRESSURE; CAFFEINE; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CAROTID INTIMA-MEDIA THICKNESS; CELL LINE; CYTIDINE; CYTOKINES; FEMALE; HUMANS; HYPERTENSION; IMMUNOBLOTTING; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MALE; METABOLOMICS; MICE; MIDDLE AGED; MONOCYTES; MORTALITY; NEUTROPHIL ACTIVATION; NEUTROPHILS; NUCLEOTIDES; OXIDATIVE STRESS; PHENOTYPE; PLATELET ACTIVATION; PULSE WAVE ANALYSIS; PURINERGIC P1 RECEPTOR ANTAGONISTS; REGRESSION ANALYSIS; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTOR 6; TOLL-LIKE RECEPTOR 8; TRANSCRIPTOME; VASCULAR STIFFNESS; YOUNG ADULT;

EID: 85009785723     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4267     Document Type: Article

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