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Volumn 9, Issue NOV2016, 2016, Pages

Tumor metabolism, the ketogenic diet and β-hydroxybutyrate: Novel approaches to adjuvant brain tumor therapy

Author keywords

Beta hydroxybutyrate; Cancer; Glioblastoma; Glioma; Ketogenic diet; Ketones; Metabolism

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; EPIDERMAL GROWTH FACTOR; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; NEUROPROTECTIVE AGENT; PLATELET DERIVED GROWTH FACTOR; POLYUNSATURATED FATTY ACID; SOMATOMEDIN; TEMOZOLOMIDE; VASCULOTROPIN;

EID: 84995897363     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2016.00122     Document Type: Article
Times cited : (88)

References (150)
  • 1
    • 84860521413 scopus 로고    scopus 로고
    • The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma
    • Abdelwahab, M. G., Fenton, K. E., Preul, M. C., Rho, J. M., Lynch, A., Stafford, P., et al. (2012). The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS One 7:e36197. doi: 10.1371/journal.pone.0036197
    • (2012) Plos One , vol.7
    • Abdelwahab, M.G.1    Fenton, K.E.2    Preul, M.C.3    Rho, J.M.4    Lynch, A.5    Stafford, P.6
  • 2
    • 84904562699 scopus 로고    scopus 로고
    • Dietary PUFA and cancer
    • Abel, S., Riedel, S., and Gelderblom, W. C. A. (2014). Dietary PUFA and cancer. Proc. Nutr. Soc. 73, 361-367. doi: 10.1017/s0029665114000585
    • (2014) Proc. Nutr. Soc , vol.73 , pp. 361-367
    • Abel, S.1    Riedel, S.2    Gelderblom, W.C.A.3
  • 4
    • 84881135707 scopus 로고    scopus 로고
    • Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts
    • Allen, B. G., Bhatia, S. K., Buatti, J. M., Brandt, K. E., Lindholm, K. E., Button, A. M., et al. (2013). Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clin. Cancer Res. 19, 3905-3913. doi: 10.1158/1078-0432.CCR-12-0287
    • (2013) Clin. Cancer Res , vol.19 , pp. 3905-3913
    • Allen, B.G.1    Bhatia, S.K.2    Buatti, J.M.3    Brandt, K.E.4    Lindholm, K.E.5    Button, A.M.6
  • 5
    • 84941773651 scopus 로고    scopus 로고
    • MYC disrupts the circadian clock and metabolism in cancer cells
    • Altman, B. J., Hsieh, A. L., Sengupta, A., Krishnanaiah, S. Y., Stine, Z. E., Walton, Z. E., et al. (2015). MYC disrupts the circadian clock and metabolism in cancer cells. Cell Metab. 22, 1009-1019. doi: 10.1016/j.cmet.2015.09.003
    • (2015) Cell Metab , vol.22 , pp. 1009-1019
    • Altman, B.J.1    Hsieh, A.L.2    Sengupta, A.3    Krishnanaiah, S.Y.4    Stine, Z.E.5    Walton, Z.E.6
  • 6
    • 65649115060 scopus 로고    scopus 로고
    • Hypoxia helps glioma to fight therapy
    • Amberger-Murphy, V. (2009). Hypoxia helps glioma to fight therapy. Curr. Cancer Drug Targets 9, 381-390. doi: 10.2174/156800909788166637
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 381-390
    • Amberger-Murphy, V.1
  • 8
    • 84955287687 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
    • Asati, V., Mahapatra, D. K., and Bharti, S. K. (2016). PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives. Eur. J. Med. Chem. 109, 314-341. doi: 10.1016/j.ejmech.2016.01.012
    • (2016) Eur. J. Med. Chem , vol.109 , pp. 314-341
    • Asati, V.1    Mahapatra, D.K.2    Bharti, S.K.3
  • 9
    • 84959463734 scopus 로고    scopus 로고
    • Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment
    • Barron, C. C., Bilan, P. J., Tsakiridis, T., and Tsiani, E. (2016). Facilitative glucose transporters: implications for cancer detection, prognosis and treatment. Metabolism 65, 124-139. doi: 10.1016/j.metabol.2015.10.007
    • (2016) Metabolism , vol.65 , pp. 124-139
    • Barron, C.C.1    Bilan, P.J.2    Tsakiridis, T.3    Tsiani, E.4
  • 10
    • 84961288801 scopus 로고    scopus 로고
    • The interaction between epigenetics, nutrition and the development of cancer
    • Bishop, K. S., and Ferguson, L. R. (2015). The interaction between epigenetics, nutrition and the development of cancer. Nutrients 7, 922-947. doi: 10.3390/nu7020922
    • (2015) Nutrients , vol.7 , pp. 922-947
    • Bishop, K.S.1    Ferguson, L.R.2
  • 11
    • 84885472358 scopus 로고    scopus 로고
    • Health-related quality of life of significant others of patients with malignant CNS versus non-CNS tumors: A comparative study
    • Boele, F. W., Heimans, J. J., Aaronson, N. K., Taphoorn, M. J., Postma, T. J., Reijneveld, J. C., et al. (2013). Health-related quality of life of significant others of patients with malignant CNS versus non-CNS tumors: a comparative study. J. Neurooncol. 115, 87-94. doi: 10.1007/s11060-013-1198-z
    • (2013) J. Neurooncol , vol.115 , pp. 87-94
    • Boele, F.W.1    Heimans, J.J.2    Aaronson, N.K.3    Taphoorn, M.J.4    Postma, T.J.5    Reijneveld, J.C.6
  • 12
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth. Nat
    • Boroughs, L. K., and DeBerardinis, R. J. (2015). Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol. 17, 351-359. doi: 10.1038/ncb3124
    • (2015) Cell Biol , vol.17 , pp. 351-359
    • Boroughs, L.K.1    Deberardinis, R.J.2
  • 13
    • 85121351214 scopus 로고    scopus 로고
    • Energy disruptors: Rising stars in anticancer therapy?
    • Bost, F., Decoux-Poullot, A. G., Tanti, J. F., and Clavel, S. (2016). Energy disruptors: rising stars in anticancer therapy? Oncogenesis 5:e188. doi: 10.1038/oncsis.2015.46
    • (2016) Oncogenesis , vol.5
    • Bost, F.1    Decoux-Poullot, A.G.2    Tanti, J.F.3    Clavel, S.4
  • 15
    • 84868019043 scopus 로고    scopus 로고
    • Cancer cell metabolism: One hallmark, many faces
    • Cantor, J. R., and Sabatini, D. M. (2012). Cancer cell metabolism: one hallmark, many faces. Cancer Discov. 2, 881-898. doi: 10.1158/2159-8290.CD-12-0345
    • (2012) Cancer Discov , vol.2 , pp. 881-898
    • Cantor, J.R.1    Sabatini, D.M.2
  • 16
    • 84926430176 scopus 로고    scopus 로고
    • Cancer prevention and therapy through the modulation of the tumor microenvironment
    • Casey, S. C., Amedei, A., Aquilano, K., Azmi, A. S., Benencia, F., Bhakta, D., et al. (2015). Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin. Cancer Biol. 35, S199-S223. doi: 10.1016/j.semcancer.2015.02.007
    • (2015) Semin. Cancer Biol , vol.35 , pp. S199-S223
    • Casey, S.C.1    Amedei, A.2    Aquilano, K.3    Azmi, A.S.4    Benencia, F.5    Bhakta, D.6
  • 17
    • 84875208817 scopus 로고    scopus 로고
    • The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model
    • Caso, J., Masko, E. M., Ii, J. A., Poulton, S. H., Dewhirst, M., Pizzo, S. V., et al. (2013). The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. Prostate 73, 449-454. doi: 10.1002/pros.22586
    • (2013) Prostate , vol.73 , pp. 449-454
    • Caso, J.1    Masko, E.M.2    Ii, J.A.3    Poulton, S.H.4    Dewhirst, M.5    Pizzo, S.V.6
  • 18
    • 84873037371 scopus 로고    scopus 로고
    • Nutrient restriction and radiation therapy for cancer treatment: When less is more
    • Champ, C. E., Baserga, R., Mishra, M. V., Jin, L., Sotgia, F., Lisanti, M. P., et al. (2013). Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist 18, 97-103. doi: 10.1634/theoncologist.2012-0164
    • (2013) Oncologist , vol.18 , pp. 97-103
    • Champ, C.E.1    Baserga, R.2    Mishra, M.V.3    Jin, L.4    Sotgia, F.5    Lisanti, M.P.6
  • 19
    • 84901625233 scopus 로고    scopus 로고
    • Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme
    • Champ, C. E., Palmer, J. D., Volek, J. S., Werner-Wasik, M., Andrews, D. W., Evans, J. J., et al. (2014). Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. J. Neurooncol. 117, 125-131. doi: 10.1007/s11060-014-1362-0
    • (2014) J. Neurooncol , vol.117 , pp. 125-131
    • Champ, C.E.1    Palmer, J.D.2    Volek, J.S.3    Werner-Wasik, M.4    Andrews, D.W.5    Evans, J.J.6
  • 20
    • 84920059831 scopus 로고    scopus 로고
    • The emerging roles of microRNAs in cancer metabolism
    • Chan, B., Manley, J., Lee, J., and Singh, S. R. (2015). The emerging roles of microRNAs in cancer metabolism. Cancer Lett. 356, 301-308. doi: 10.1016/j.canlet.2014.10.011
    • (2015) Cancer Lett , vol.356 , pp. 301-308
    • Chan, B.1    Manley, J.2    Lee, J.3    Singh, S.R.4
  • 21
    • 84973494141 scopus 로고    scopus 로고
    • Emerging approaches for targeting metabolic vulnerabilities in malignant glioma
    • Clark, P. M., Mai, W. X., Cloughesy, T. F., and Nathanson, D. A. (2016). Emerging approaches for targeting metabolic vulnerabilities in malignant glioma. Curr. Neurol. Neurosci. Rep. 16:17. doi: 10.1007/s11910-015-0613-6
    • (2016) Curr. Neurol. Neurosci. Rep , vol.16 , pp. 17
    • Clark, P.M.1    Mai, W.X.2    Cloughesy, T.F.3    Nathanson, D.A.4
  • 22
    • 84942786804 scopus 로고    scopus 로고
    • Metabolic and mind shifts: From glucose to glutamine and acetate addictions in cancer
    • Corbet, C., and Feron, O. (2015). Metabolic and mind shifts: from glucose to glutamine and acetate addictions in cancer. Curr. Opin. Clin. Nutr. Metab. Care 18, 346-353. doi: 10.1097/MCO.0000000000000178
    • (2015) Curr. Opin. Clin. Nutr. Metab. Care , vol.18 , pp. 346-353
    • Corbet, C.1    Feron, O.2
  • 24
    • 84880826654 scopus 로고    scopus 로고
    • New research with diets and epilepsy
    • Cross, J. H. (2013). New research with diets and epilepsy. J. Child Neurol. 28, 970-974. doi: 10.1177/0883073813487593
    • (2013) J. Child Neurol , vol.28 , pp. 970-974
    • Cross, J.H.1
  • 25
    • 84883508982 scopus 로고    scopus 로고
    • Optimization of tumor radiotherapy with modulators of cell metabolism: Toward clinical applications
    • Danhier, P., De Saedeleer, C. J., Karroum, O., De Preter, G., Porporato, P. E., Jordan, B. F., et al. (2013). Optimization of tumor radiotherapy with modulators of cell metabolism: toward clinical applications. Semin. Radiat. Oncol. 23, 262-272. doi: 10.1016/j.semradonc.2013.05.008
    • (2013) Semin. Radiat. Oncol , vol.23 , pp. 262-272
    • Danhier, P.1    De Saedeleer, C.J.2    Karroum, O.3    De Preter, G.4    Porporato, P.E.5    Jordan, B.F.6
  • 26
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • Dewhirst, M. W. (2009). Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat. Res. 172, 653-665. doi: 10.1667/RR1926.1
    • (2009) Radiat. Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 27
    • 84940467267 scopus 로고    scopus 로고
    • Regulation of mTORC1 by PI3K signaling
    • Dibble, C. C., and Cantley, L. C. (2015). Regulation of mTORC1 by PI3K signaling. Trends Cell Biol. 25, 545-555. doi: 10.1016/j.tcb.2015.06.002
    • (2015) Trends Cell Biol , vol.25 , pp. 545-555
    • Dibble, C.C.1    Cantley, L.C.2
  • 28
    • 84922268466 scopus 로고    scopus 로고
    • The level of patient-reported outcome reporting in randomised controlled trials of brain tumour patients: A systematic review
    • Dirven, L., Taphoorn, M. J., Reijneveld, J. C., Blazeby, J., Jacobs, M., Pusic, A., et al. (2014). The level of patient-reported outcome reporting in randomised controlled trials of brain tumour patients: a systematic review. Eur. J. Cancer 50, 2432-2448. doi: 10.1016/j.ejca.2014.06.016
    • (2014) Eur. J. Cancer , vol.50 , pp. 2432-2448
    • Dirven, L.1    Taphoorn, M.J.2    Reijneveld, J.C.3    Blazeby, J.4    Jacobs, M.5    Pusic, A.6
  • 29
    • 0023877369 scopus 로고
    • Cancer cachexia: Influence of systemic ketosis on substrate levels and nitrogen metabolism
    • Fearon, K. C., Borland, W., Preston, T., Tisdale, M. J., Shenkin, A., and Calman, K. C. (1988). Cancer cachexia: influence of systemic ketosis on substrate levels and nitrogen metabolism. Am. J. Clin. Nutr. 47, 42-48.
    • (1988) Am. J. Clin. Nutr , vol.47 , pp. 42-48
    • Fearon, K.C.1    Borland, W.2    Preston, T.3    Tisdale, M.J.4    Shenkin, A.5    Calman, K.C.6
  • 30
    • 0036354737 scopus 로고    scopus 로고
    • Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1
    • Fischer, S., Wobben, M., Marti, H. H., Renz, D., and Schaper, W. (2002). Hypoxia-induced hyperpermeability in brain microvessel endothelial cells involves VEGF-mediated changes in the expression of zonula occludens-1. Microvasc. Res. 63, 70-80. doi: 10.1006/mvre.2001.2367
    • (2002) Microvasc. Res , vol.63 , pp. 70-80
    • Fischer, S.1    Wobben, M.2    Marti, H.H.3    Renz, D.4    Schaper, W.5
  • 31
    • 37449034484 scopus 로고    scopus 로고
    • Carbohydrate restriction, prostate cancer growth and the insulin-like growth factor axis
    • Freedland, S. J., Mavropoulos, J., Wang, A., Darshan, M., Demark-Wahnefried, W., Aronson, W. J., et al. (2008). Carbohydrate restriction, prostate cancer growth and the insulin-like growth factor axis. Prostate 68, 11-19. doi: 10.1002/pros.20683
    • (2008) Prostate , vol.68 , pp. 11-19
    • Freedland, S.J.1    Mavropoulos, J.2    Wang, A.3    Darshan, M.4    Demark-Wahnefried, W.5    Aronson, W.J.6
  • 32
    • 34247847903 scopus 로고    scopus 로고
    • Silencing hypoxia-inducible factor-1α inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    • Fujiwara, S., Nakagawa, K., Harada, H., Nagato, S., Furukawa, K., Teraoka, M., et al. (2007). Silencing hypoxia-inducible factor-1α inhibits cell migration and invasion under hypoxic environment in malignant gliomas. Int. J. Oncol. 30, 793-802. doi: 10.3892/ijo.30.4.793
    • (2007) Int. J. Oncol , vol.30 , pp. 793-802
    • Fujiwara, S.1    Nakagawa, K.2    Harada, H.3    Nagato, S.4    Furukawa, K.5    Teraoka, M.6
  • 33
    • 84965191205 scopus 로고    scopus 로고
    • Ketogenic diets, mitochondria and neurological diseases
    • Gano, L. B., Patel, M., and Rho, J. M. (2014). Ketogenic diets, mitochondria and neurological diseases. J. Lipid Res. 55, 2211-2228. doi: 10.1194/jlr.r048975
    • (2014) J. Lipid Res , vol.55 , pp. 2211-2228
    • Gano, L.B.1    Patel, M.2    Rho, J.M.3
  • 34
    • 33748298884 scopus 로고    scopus 로고
    • Neuroprotective and disease-modifying effects of the ketogenic diet
    • Gasior, M., Rogawski, M. A., and Hartman, A. L. (2006). Neuroprotective and disease-modifying effects of the ketogenic diet. Behav. Pharmacol. 17, 431-439. doi: 10.1097/00008877-200609000-00009
    • (2006) Behav. Pharmacol , vol.17 , pp. 431-439
    • Gasior, M.1    Rogawski, M.A.2    Hartman, A.L.3
  • 35
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R. A., and Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4, 891-899. doi: 10.1038/nrc1478
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 36
    • 85069238576 scopus 로고    scopus 로고
    • Defects in mitochondrial metabolism and cancer
    • Gaude, E., and Frezza, C. (2014). Defects in mitochondrial metabolism and cancer. Cancer Metab. 2:10. doi: 10.1186/2049-3002-2-10
    • (2014) Cancer Metab , vol.2 , pp. 10
    • Gaude, E.1    Frezza, C.2
  • 37
    • 84917710704 scopus 로고    scopus 로고
    • Long-chain Fatty Acid analogues suppress breast tumorigenesis and progression
    • Gluschnaider, U., Hertz, R., Ohayon, S., Smeir, E., Smets, M., Pikarsky, E., et al. (2014). Long-chain Fatty Acid analogues suppress breast tumorigenesis and progression. Cancer Res. 74, 6991-7002. doi: 10.1158/0008-5472.CAN-14-0385
    • (2014) Cancer Res , vol.74 , pp. 6991-7002
    • Gluschnaider, U.1    Hertz, R.2    Ohayon, S.3    Smeir, E.4    Smets, M.5    Pikarsky, E.6
  • 38
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 39
    • 84928574381 scopus 로고    scopus 로고
    • Growth of human colon cancer cells in nude mice is delayed by ketogenic diet with or without omega-3 fatty acids and medium-chain triglycerides. Asian Pac
    • Hao, G. W., Chen, Y. S., He, D. M., Wang, H. Y., Wu, G. H., and Zhang, B. (2015). Growth of human colon cancer cells in nude mice is delayed by ketogenic diet with or without omega-3 fatty acids and medium-chain triglycerides. Asian Pac. J. Cancer Prev. 16, 2061-2068. doi: 10.7314/apjcp.2015.16.5.2061
    • (2015) J. Cancer Prev , vol.16 , pp. 2061-2068
    • Hao, G.W.1    Chen, Y.S.2    He, D.M.3    Wang, H.Y.4    Wu, G.H.5    Zhang, B.6
  • 40
    • 84864080763 scopus 로고    scopus 로고
    • Neuroprotection in metabolism-based therapy
    • Hartman, A. L. (2012). Neuroprotection in metabolism-based therapy. Epilepsy Res. 100, 286-294. doi: 10.1016/j.eplepsyres.2011.04.016
    • (2012) Epilepsy Res , vol.100 , pp. 286-294
    • Hartman, A.L.1
  • 41
    • 84856302564 scopus 로고    scopus 로고
    • Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: A 31P/1H MRSI and quantitative magnetic resonance imaging study
    • Hattingen, E., Jurcoane, A., Bähr, O., Rieger, J., Magerkurth, J., Anti, S., et al. (2011). Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study. Neuro Oncol. 13, 1349-1363. doi: 10.1093/neuonc/nor132
    • (2011) Neuro Oncol , vol.13 , pp. 1349-1363
    • Hattingen, E.1    Jurcoane, A.2    Bähr, O.3    Rieger, J.4    Magerkurth, J.5    Anti, S.6
  • 44
    • 84875356074 scopus 로고    scopus 로고
    • Regulation of the metabolism of polyunsaturated Fatty acids and butyrate in colon cancer cells
    • Hofmanova, J., Hyrslova Vaculova, A., and Kozubik, A. (2013). Regulation of the metabolism of polyunsaturated Fatty acids and butyrate in colon cancer cells. Curr. Pharm. Biotechnol. 14, 274-288. doi: 10.2174/1389201011314030004
    • (2013) Curr. Pharm. Biotechnol , vol.14 , pp. 274-288
    • Hofmanova, J.1    Hyrslova Vaculova, A.2    Kozubik, A.3
  • 47
    • 84880648196 scopus 로고    scopus 로고
    • Tumor-derived lactate modifies antitumor immune response: Effect on myeloid-derived suppressor cells and NK cells
    • Husain, Z., Huang, Y., Seth, P., and Sukhatme, V. P. (2013). Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J. Immunol. 191, 1486-1495. doi: 10.4049/jimmunol.1202702
    • (2013) J. Immunol , vol.191 , pp. 1486-1495
    • Husain, Z.1    Huang, Y.2    Seth, P.3    Sukhatme, V.P.4
  • 48
    • 84901428396 scopus 로고    scopus 로고
    • Regulation of cancer metabolism by oncogenes and tumor suppressors
    • Iurlaro, R., León-Annicchiarico, C. L., and Muñoz-Pinedo, C. (2014). Regulation of cancer metabolism by oncogenes and tumor suppressors. Methods Enzymol. 542, 59-80. doi: 10.1016/B978-0-12-416618-9.00003-0
    • (2014) Methods Enzymol , vol.542 , pp. 59-80
    • Iurlaro, R.1    León-Annicchiarico, C.L.2    Muñoz-Pinedo, C.3
  • 49
    • 84955321102 scopus 로고    scopus 로고
    • Acetate as a metabolic and epigenetic modifier of cancer therapy
    • Jaworski, D. M., Namboodiri, A. M., and Moffett, J. R. (2016). Acetate as a metabolic and epigenetic modifier of cancer therapy. J. Cell. Biochem. 117, 574-588. doi: 10.1002/jcb.25305
    • (2016) J. Cell. Biochem , vol.117 , pp. 574-588
    • Jaworski, D.M.1    Namboodiri, A.M.2    Moffett, J.R.3
  • 50
    • 84881171944 scopus 로고    scopus 로고
    • Caloric restriction reduces edema and prolongs survival in a mouse glioma model
    • Jiang, Y.-S., and Wang, F.-R. (2013). Caloric restriction reduces edema and prolongs survival in a mouse glioma model. J. Neurooncol. 114, 25-32. doi: 10.1007/s11060-013-1154-y
    • (2013) J. Neurooncol , vol.114 , pp. 25-32
    • Jiang, Y.-S.1    Wang, F.-R.2
  • 51
    • 3242811307 scopus 로고    scopus 로고
    • Tumors may modulate host immunity partly through hypoxia-induced sympathetic bias
    • Joon, Y. A., Bazar, K. A., and Lee, P. Y. (2004). Tumors may modulate host immunity partly through hypoxia-induced sympathetic bias. Med. Hypotheses 63, 352-356. doi: 10.1016/j.mehy.2004.02.026
    • (2004) Med. Hypotheses , vol.63 , pp. 352-356
    • Joon, Y.A.1    Bazar, K.A.2    Lee, P.Y.3
  • 52
    • 84929353032 scopus 로고    scopus 로고
    • Molecular connections between cancer cell metabolism and the tumor microenvironment
    • Justus, C. R., Sanderlin, E. J., and Yang, L. V. (2015). Molecular connections between cancer cell metabolism and the tumor microenvironment. Int. J. Mol. Sci. 16, 11055-11086. doi: 10.3390/ijms160511055
    • (2015) Int. J. Mol. Sci , vol.16 , pp. 11055-11086
    • Justus, C.R.1    Sanderlin, E.J.2    Yang, L.V.3
  • 53
    • 84875253158 scopus 로고    scopus 로고
    • A ketone ester diet exhibits anxiolytic and cognition-sparing properties and lessens amyloid and tau pathologies in a mouse model of Alzheimer’s disease
    • Kashiwaya, Y., Bergman, C., Lee, J. H., Wan, R., King, M. T., Mughal, M. R., et al. (2013). A ketone ester diet exhibits anxiolytic and cognition-sparing properties and lessens amyloid and tau pathologies in a mouse model of Alzheimer’s disease. Neurobiol. Aging 34, 1530-1539. doi: 10.1016/j.neurobiolaging.2012.11.023
    • (2013) Neurobiol. Aging , vol.34 , pp. 1530-1539
    • Kashiwaya, Y.1    Bergman, C.2    Lee, J.H.3    Wan, R.4    King, M.T.5    Mughal, M.R.6
  • 54
    • 17844371306 scopus 로고    scopus 로고
    • Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
    • Kaur, B., Khwaja, F. W., Severson, E. A., Matheny, S. L., Brat, D. J., and Van Meir, E. G. (2005). Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol. 7, 134-153. doi: 10.1215/s1152851704001115
    • (2005) Neuro Oncol , vol.7 , pp. 134-153
    • Kaur, B.1    Khwaja, F.W.2    Severson, E.A.3    Matheny, S.L.4    Brat, D.J.5    Van Meir, E.G.6
  • 55
    • 84860494814 scopus 로고    scopus 로고
    • Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis
    • Kim, D. Y., Hao, J., Liu, R., Turner, G., Shi, F.-D., and Rho, J. M. (2012). Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS One 7:e35476. doi: 10.1371/journal.pone.0035476
    • (2012) Plos One , vol.7
    • Kim, D.Y.1    Hao, J.2    Liu, R.3    Turner, G.4    Shi, F.-D.5    Rho, J.M.6
  • 56
    • 84871706742 scopus 로고    scopus 로고
    • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer
    • Kim, H. S., Masko, E. M., Poulton, S. L., Kennedy, K. M., Pizzo, S. V., Dewhirst, M. W., et al. (2012). Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. BJU Int. 110, 1062-1069. doi: 10.1111/j.1464-410x.2012.10971.x
    • (2012) BJU Int , vol.110 , pp. 1062-1069
    • Kim, H.S.1    Masko, E.M.2    Poulton, S.L.3    Kennedy, K.M.4    Pizzo, S.V.5    Dewhirst, M.W.6
  • 57
    • 84930652884 scopus 로고    scopus 로고
    • Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells
    • Kim, M. H., and Kim, H. (2013). Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells. J. Cancer Prev. 18, 221-226. doi: 10.15430/jcp.2013.18.3.221
    • (2013) J. Cancer Prev , vol.18 , pp. 221-226
    • Kim, M.H.1    Kim, H.2
  • 58
    • 40049107581 scopus 로고    scopus 로고
    • The ketogenic diet and epilepsy
    • Kim, D. Y., and Rho, J. M. (2008). The ketogenic diet and epilepsy. Curr. Opin. Clin. Nutr. Metab. Care 11, 113-120. doi: 10.1097/MCO.0b013e3282f44c06
    • (2008) Curr. Opin. Clin. Nutr. Metab. Care , vol.11 , pp. 113-120
    • Kim, D.Y.1    Rho, J.M.2
  • 59
    • 84899977976 scopus 로고    scopus 로고
    • Calories, carbohydrates and cancer therapy with radiation: Exploiting the five R’s through dietary manipulation
    • Klement, R. J., and Champ, C. E. (2014). Calories, carbohydrates and cancer therapy with radiation: exploiting the five R’s through dietary manipulation. Cancer Metastasis Rev. 33, 217-229. doi: 10.1007/s10555-014-9495-3
    • (2014) Cancer Metastasis Rev , vol.33 , pp. 217-229
    • Klement, R.J.1    Champ, C.E.2
  • 60
    • 84863229916 scopus 로고    scopus 로고
    • Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
    • Lee, C., Raffaghello, L., Brandhorst, S., Safdie, F. M., Bianchi, G., Martin-Montalvo, A., et al. (2012). Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci. Transl. Med. 4:124ra127. doi: 10.1126/scitranslmed.3003293
    • (2012) Sci. Transl. Med
    • Lee, C.1    Raffaghello, L.2    Brandhorst, S.3    Safdie, F.M.4    Bianchi, G.5    Martin-Montalvo, A.6
  • 61
    • 76749169812 scopus 로고    scopus 로고
    • Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    • Lee, C., Safdie, F. M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., et al. (2010). Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 70, 1564-1572. doi: 10.1158/0008-5472.CAN-09-3228
    • (2010) Cancer Res , vol.70 , pp. 1564-1572
    • Lee, C.1    Safdie, F.M.2    Raffaghello, L.3    Wei, M.4    Madia, F.5    Parrella, E.6
  • 62
    • 84884565153 scopus 로고    scopus 로고
    • The evolution of genome-scale models of cancer metabolism. Front
    • Lewis, N. E., and Abdel-Haleem, A. M. (2013). The evolution of genome-scale models of cancer metabolism. Front. Physiol. 4:237. doi: 10.3389/fphys.2013.00237
    • (2013) Physiol , vol.4 , pp. 237
    • Lewis, N.E.1    Abdel-Haleem, A.M.2
  • 63
    • 67449116585 scopus 로고    scopus 로고
    • Availability of neurotransmitter glutamate is diminished when β-hydroxybutyrate replaces glucose in cultured neurons
    • Lund, T. M., Risa, O., Sonnewald, U., Schousboe, A., and Waagepetersen, H. S. (2009). Availability of neurotransmitter glutamate is diminished when β-hydroxybutyrate replaces glucose in cultured neurons. J. Neurochem. 110, 80-91. doi: 10.1111/j.1471-4159.2009.06115.x
    • (2009) J. Neurochem , vol.110 , pp. 80-91
    • Lund, T.M.1    Risa, O.2    Sonnewald, U.3    Schousboe, A.4    Waagepetersen, H.S.5
  • 64
    • 85007454066 scopus 로고    scopus 로고
    • Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet
    • Lussier, D. M., Woolf, E. C., Johnson, J. L., Brooks, K. S., Blattman, J. N., and Scheck, A. C. (2016). Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet. BMC Cancer 16:310. doi: 10.1186/s12885-016-2337-7
    • (2016) BMC Cancer , vol.16 , pp. 310
    • Lussier, D.M.1    Woolf, E.C.2    Johnson, J.L.3    Brooks, K.S.4    Blattman, J.N.5    Scheck, A.C.6
  • 65
    • 84918531944 scopus 로고    scopus 로고
    • Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: A systematic review and meta-analysis
    • Lv, M., Zhu, X., Wang, H., Wang, F., and Guan, W. (2014). Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis. PLoS One 9:e115147. doi: 10.1371/journal.pone.0115147
    • (2014) Plos One , vol.9
    • Lv, M.1    Zhu, X.2    Wang, H.3    Wang, F.4    Guan, W.5
  • 66
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet and ketone bodies
    • Maalouf, M., Rho, J. M., and Mattson, M. P. (2009). The neuroprotective properties of calorie restriction, the ketogenic diet and ketone bodies. Brain Res. Rev. 59, 293-315. doi: 10.1016/j.brainresrev.2008.09.002
    • (2009) Brain Res. Rev , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 67
    • 84862977182 scopus 로고    scopus 로고
    • Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor
    • Madan, E., Gogna, R., Bhatt, M., Pati, U., Kuppusamy, P., and Mahdi, A. A. (2011). Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor. Oncotarget 2, 948-957. doi: 10.18632/oncotarget.389
    • (2011) Oncotarget , vol.2 , pp. 948-957
    • Madan, E.1    Gogna, R.2    Bhatt, M.3    Pati, U.4    Kuppusamy, P.5    Mahdi, A.A.6
  • 68
    • 79960858482 scopus 로고    scopus 로고
    • Metabolism and brain cancer
    • Marie, S. K., and Shinjo, S. M. (2011). Metabolism and brain cancer. Clinics 66, 33-43. doi: 10.1590/s1807-59322011001300005
    • (2011) Clinics , vol.66 , pp. 33-43
    • Marie, S.K.1    Shinjo, S.M.2
  • 69
    • 58149161852 scopus 로고    scopus 로고
    • Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet
    • Marsh, J., Mukherjee, P., and Seyfried, T. N. (2008). Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr. Metab. (Lond) 5:33. doi: 10.1186/1743-7075-5-33
    • (2008) Nutr. Metab. (Lond) , vol.5 , pp. 33
    • Marsh, J.1    Mukherjee, P.2    Seyfried, T.N.3
  • 70
    • 84907063686 scopus 로고    scopus 로고
    • PI3K/AKT signaling pathway and cancer: An updated review
    • Martini, M., De Santis, M. C., Braccini, L., Gulluni, F., and Hirsch, E. (2014). PI3K/AKT signaling pathway and cancer: an updated review. Ann. Med. 46, 372-383. doi: 10.3109/07853890.2014.912836
    • (2014) Ann. Med , vol.46 , pp. 372-383
    • Martini, M.1    De Santis, M.C.2    Braccini, L.3    Gulluni, F.4    Hirsch, E.5
  • 71
    • 84968735483 scopus 로고    scopus 로고
    • A supplemented high-fat low-carbohydrate diet for the treatment of glioblastoma
    • Martuscello, R. T., Vedam-Mai, V., McCarthy, D. J., Schmoll, M. E., Jundi, M. A., Louviere, C. D., et al. (2016). A supplemented high-fat low-carbohydrate diet for the treatment of glioblastoma. Clin. Cancer Res. 22, 2482-2495. doi: 10.1158/1078-0432.CCR-15-0916
    • (2016) Clin. Cancer Res , vol.22 , pp. 2482-2495
    • Martuscello, R.T.1    Vedam-Mai, V.2    McCarthy, D.J.3    Schmoll, M.E.4    Jundi, M.A.5    Louviere, C.D.6
  • 72
    • 84880842042 scopus 로고    scopus 로고
    • Ketogenic diets and pain
    • Masino, S. A., and Ruskin, D. N. (2013). Ketogenic diets and pain. J. Child Neurol. 28, 993-1001. doi: 10.1177/0883073813487595
    • (2013) J. Child Neurol , vol.28 , pp. 993-1001
    • Masino, S.A.1    Ruskin, D.N.2
  • 73
    • 84970919297 scopus 로고    scopus 로고
    • Hypoxia signaling pathways in cancer metabolism: The importance of co-selecting interconnected physiological pathways
    • Masson, N., and Ratcliffe, P. J. (2014). Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab. 2:3. doi: 10.1186/2049-3002-2-3
    • (2014) Cancer Metab , vol.2 , pp. 3
    • Masson, N.1    Ratcliffe, P.J.2
  • 74
    • 79960661966 scopus 로고    scopus 로고
    • Differential utilization of ketone bodies by neurons and glioma cell lines: A rationale for ketogenic diet as experimental glioma therapy
    • Maurer, G. D., Brucker, D. P., Bähr, O., Harter, P. N., Hattingen, E., Walenta, S., et al. (2011). Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer 11:315. doi: 10.1186/1471-2407-11-315
    • (2011) BMC Cancer , vol.11 , pp. 315
    • Maurer, G.D.1    Brucker, D.P.2    Bähr, O.3    Harter, P.N.4    Hattingen, E.5    Walenta, S.6
  • 75
    • 68949183226 scopus 로고    scopus 로고
    • The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model
    • Mavropoulos, J. C., Buschemeyer, W. C. III, Tewari, A. K., Rokhfeld, D., Pollak, M., Zhao, Y., et al. (2009). The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev. Res. (Phila) 2, 557-565. doi: 10.1158/1940-6207.capr-08-0188
    • (2009) Cancer Prev. Res. (Phila) , vol.2 , pp. 557-565
    • Mavropoulos, J.C.1    Buschemeyer, W.2    Tewari, A.K.3    Rokhfeld, D.4    Pollak, M.5    Zhao, Y.6
  • 76
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., et al. (2011). Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481, 380-384. doi: 10.1038/nature10602
    • (2011) Nature , vol.481 , pp. 380-384
    • Metallo, C.M.1    Gameiro, P.A.2    Bell, E.L.3    Mattaini, K.R.4    Yang, J.5    Hiller, K.6
  • 77
    • 84864084943 scopus 로고    scopus 로고
    • Modulation of oxidative stress and mitochondrial function by the ketogenic diet
    • Milder, J., and Patel, M. (2012). Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res. 100, 295-303. doi: 10.1016/j.eplepsyres.2011.09.021
    • (2012) Epilepsy Res , vol.100 , pp. 295-303
    • Milder, J.1    Patel, M.2
  • 79
    • 84961677958 scopus 로고    scopus 로고
    • T cells and cancer: How metabolism shapes immunity. Front
    • Molon, B., Cali, B., and Viola, A. (2016). T cells and cancer: how metabolism shapes immunity. Front. Immunol. 7:20. doi: 10.3389/fimmu.2016.00020
    • (2016) Immunol , vol.7 , pp. 20
    • Molon, B.1    Cali, B.2    Viola, A.3
  • 80
    • 19444376784 scopus 로고    scopus 로고
    • Cerebral ketone body metabolism
    • Morris, A. A. M. (2005). Cerebral ketone body metabolism. J. Inherit. Metab. Dis. 28, 109-121. doi: 10.1007/s10545-005-5518-0
    • (2005) J. Inherit. Metab. Dis , vol.28 , pp. 109-121
    • Morris, A.A.M.1
  • 81
    • 78449278861 scopus 로고    scopus 로고
    • AQP-4 in peritumoral edematous tissue is correlated with the degree of glioma and with expression of VEGF and HIF-alpha
    • Mou, K., Chen, M., Mao, Q., Wang, P., Ni, R., Xia, X., et al. (2010). AQP-4 in peritumoral edematous tissue is correlated with the degree of glioma and with expression of VEGF and HIF-alpha. J. Neurooncol. 100, 375-383. doi: 10.1007/s11060-010-0205-x
    • (2010) J. Neurooncol , vol.100 , pp. 375-383
    • Mou, K.1    Chen, M.2    Mao, Q.3    Wang, P.4    Ni, R.5    Xia, X.6
  • 82
    • 0029009816 scopus 로고
    • Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer
    • Nebeling, L. C., and Lerner, E. (1995). Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer. J. Am. Diet. Assoc. 95, 693-697. doi: 10.1016/s0002-8223(95)00189-1
    • (1995) J. Am. Diet. Assoc , vol.95 , pp. 693-697
    • Nebeling, L.C.1    Lerner, E.2
  • 83
    • 0028946933 scopus 로고
    • Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: Two case reports
    • Nebeling, L. C., Miraldi, F., Shurin, S. B., and Lerner, E. (1995). Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. J. Am. Coll. Nutr. 14, 202-208. doi: 10.1080/07315724.1995.10718495
    • (1995) J. Am. Coll. Nutr , vol.14 , pp. 202-208
    • Nebeling, L.C.1    Miraldi, F.2    Shurin, S.B.3    Lerner, E.4
  • 84
    • 84890978770 scopus 로고    scopus 로고
    • Ketone bodies as signaling metabolites
    • Newman, J. C., and Verdin, E. (2014). Ketone bodies as signaling metabolites. Trends Endocrinol. Metab. 25, 42-52. doi: 10.1016/j.tem.2013.09.002
    • (2014) Trends Endocrinol. Metab , vol.25 , pp. 42-52
    • Newman, J.C.1    Verdin, E.2
  • 85
    • 84922709891 scopus 로고    scopus 로고
    • A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer’s disease
    • Newport, M. T., Vanitallie, T. B., Kashiwaya, Y., King, M. T., and Veech, R. L. (2015). A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease. Alzheimers Dement. 11, 99-103. doi: 10.1016/j.jalz.2014.01.006
    • (2015) Alzheimers Dement , vol.11 , pp. 99-103
    • Newport, M.T.1    Vanitallie, T.B.2    Kashiwaya, Y.3    King, M.T.4    Veech, R.L.5
  • 86
    • 79952947661 scopus 로고    scopus 로고
    • Molecular heterogeneity in glioblastoma: Therapeutic opportunities and challenges
    • Nicholas, M. K., Lukas, R. V., Chmura, S., Yamini, B., Lesniak, M., and Pytel, P. (2011). Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges. Semin. Oncol. 38, 243-253. doi: 10.1053/j.seminoncol.2011.01.009
    • (2011) Semin. Oncol , vol.38 , pp. 243-253
    • Nicholas, M.K.1    Lukas, R.V.2    Chmura, S.3    Yamini, B.4    Lesniak, M.5    Pytel, P.6
  • 88
    • 84920814046 scopus 로고    scopus 로고
    • Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy
    • Obre, E., and Rossignol, R. (2015). Emerging concepts in bioenergetics and cancer research: metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy. Int. J. Biochem. Cell Biol. 59C, 167-181. doi: 10.1016/j.biocel.2014.12.008
    • (2015) Int. J. Biochem. Cell Biol , vol.59 , pp. 167-181
    • Obre, E.1    Rossignol, R.2
  • 89
    • 60249088344 scopus 로고    scopus 로고
    • Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense
    • Olovnikov, I. A., Kravchenko, J. E., and Chumakov, P. M. (2009). Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense. Semin. Cancer Biol. 19, 32-41. doi: 10.1016/j.semcancer.2008.11.005
    • (2009) Semin. Cancer Biol , vol.19 , pp. 32-41
    • Olovnikov, I.A.1    Kravchenko, J.E.2    Chumakov, P.M.3
  • 90
    • 44649088303 scopus 로고    scopus 로고
    • Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
    • Otto, C., Kaemmerer, U., Illert, B., Muehling, B., Pfetzer, N., Wittig, R., et al. (2008). Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides. BMC Cancer 8:122. doi: 10.1186/1471-2407-8-122
    • (2008) BMC Cancer , vol.8 , pp. 122
    • Otto, C.1    Kaemmerer, U.2    Illert, B.3    Muehling, B.4    Pfetzer, N.5    Wittig, R.6
  • 91
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova, N. N., and Thompson, C. B. (2016). The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27-47. doi: 10.1016/j.cmet.2015.12.006
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 92
    • 85015692306 scopus 로고    scopus 로고
    • Abstract 240: The ketogenic diet alters the expression of microRNAs that play key roles in tumor development
    • Pazmandi, J., O’Neill, K. S., Scheck, A. C., Szlosarek, P. W., Woolf, E. C., Brooks, K. S., et al. (2015). Abstract 240: the ketogenic diet alters the expression of microRNAs that play key roles in tumor development. Cancer Res. 75, 240-240. doi: 10.1158/1538-7445.am2015-240
    • (2015) Cancer Res , vol.75 , pp. 240-240
    • Pazmandi, J.1    O’Neill, K.S.2    Scheck, A.C.3    Szlosarek, P.W.4    Woolf, E.C.5    Brooks, K.S.6
  • 93
  • 94
    • 55349122964 scopus 로고    scopus 로고
    • Ketones and brain function: Possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate
    • Pifferi, F., Tremblay, S., Plourde, M., Tremblay-Mercier, J., Bentourkia, M., and Cunnane, S. C. (2008). Ketones and brain function: possible link to polyunsaturated fatty acids and availability of a new brain PET tracer, 11C-acetoacetate. Epilepsia 49, 76-79. doi: 10.1111/j.1528-1167.2008.01842.x
    • (2008) Epilepsia , vol.49 , pp. 76-79
    • Pifferi, F.1    Tremblay, S.2    Plourde, M.3    Tremblay-Mercier, J.4    Bentourkia, M.5    Cunnane, S.C.6
  • 95
    • 84904438541 scopus 로고    scopus 로고
    • Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer
    • Poff, A. M., Ari, C., Arnold, P., Seyfried, T. N., and D’Agostino, D. P. (2014). Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. Int. J. Cancer 135, 1711-1720. doi: 10.1002/ijc.28809
    • (2014) Int. J. Cancer , vol.135 , pp. 1711-1720
    • Poff, A.M.1    Ari, C.2    Arnold, P.3    Seyfried, T.N.4    D’Agostino, D.P.5
  • 96
    • 84878758801 scopus 로고    scopus 로고
    • The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer
    • Poff, A. M., Ari, C., Seyfried, T. N., and D’Agostino, D. P. (2013). The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One 8:e65522. doi: 10.1371/journal.pone.0065522
    • (2013) Plos One , vol.8
    • Poff, A.M.1    Ari, C.2    Seyfried, T.N.3    D’Agostino, D.P.4
  • 97
    • 84936976775 scopus 로고    scopus 로고
    • Non-toxic metabolic management of metastatic cancer in vm mice: Novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy
    • Poff, A. M., Ward, N., Seyfried, T. N., Arnold, P., and D’Agostino, D. P. (2015). Non-toxic metabolic management of metastatic cancer in vm mice: novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy. PLoS One 10:e0127407. doi: 10.1371/journal.pone.0127407
    • (2015) Plos One , vol.10
    • Poff, A.M.1    Ward, N.2    Seyfried, T.N.3    Arnold, P.4    D’Agostino, D.P.5
  • 98
    • 33746899015 scopus 로고    scopus 로고
    • Akt1 activation can augment hypoxia-inducible factor-1α expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
    • Pore, N., Jiang, Z., Shu, H. K., Bernhard, E., Kao, G. D., and Maity, A. (2006). Akt1 activation can augment hypoxia-inducible factor-1α expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol. Cancer Res. 4, 471-479. doi: 10.1158/1541-7786.mcr-05-0234
    • (2006) Mol. Cancer Res , vol.4 , pp. 471-479
    • Pore, N.1    Jiang, Z.2    Shu, H.K.3    Bernhard, E.4    Kao, G.D.5    Maity, A.6
  • 101
    • 80053036165 scopus 로고    scopus 로고
    • The role of p53 in metabolic regulation
    • Puzio-Kuter, A. M. (2011). The role of p53 in metabolic regulation. Genes Cancer 2, 385-391. doi: 10.1177/1947601911409738
    • (2011) Genes Cancer , vol.2 , pp. 385-391
    • Puzio-Kuter, A.M.1
  • 102
    • 46149107882 scopus 로고    scopus 로고
    • Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
    • Raffaghello, L., Lee, C., Safdie, F. M., Wei, M., Madia, F., Bianchi, G., et al. (2008). Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc. Natl. Acad. Sci. U S A 105, 8215-8220. doi: 10.1073/pnas.0708100105
    • (2008) Proc. Natl. Acad. Sci. U S A , vol.105 , pp. 8215-8220
    • Raffaghello, L.1    Lee, C.2    Safdie, F.M.3    Wei, M.4    Madia, F.5    Bianchi, G.6
  • 103
    • 78649882284 scopus 로고    scopus 로고
    • Fasting and differential chemotherapy protection in patients
    • Raffaghello, L., Safdie, F., Bianchi, G., Dorff, T., Fontana, L., and Longo, V. D. (2010). Fasting and differential chemotherapy protection in patients. Cell Cycle 9, 4474-4476. doi: 10.4161/cc.9.22.13954
    • (2010) Cell Cycle , vol.9 , pp. 4474-4476
    • Raffaghello, L.1    Safdie, F.2    Bianchi, G.3    Dorff, T.4    Fontana, L.5    Longo, V.D.6
  • 104
    • 84901325457 scopus 로고    scopus 로고
    • The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat
    • Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller-Fielitz, H., et al. (2014). The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nat. Commun. 5:3944. doi: 10.1038/ncomms4944
    • (2014) Commun , vol.5 , pp. 3944
    • Rahman, M.1    Muhammad, S.2    Khan, M.A.3    Chen, H.4    Ridder, D.A.5    Müller-Fielitz, H.6
  • 105
    • 84921887492 scopus 로고    scopus 로고
    • Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
    • Roberts, D. J., and Miyamoto, S. (2015). Hexokinase II integrates energy metabolism and cellular protection: akting on mitochondria and TORCing to autophagy. Cell Death Differ. 22, 248-257. doi: 10.1038/cdd.2014.173
    • (2015) Cell Death Differ , vol.22 , pp. 248-257
    • Roberts, D.J.1    Miyamoto, S.2
  • 106
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the “Warburg kinase”?-Akt-energy metabolism interactions and oncogenesis
    • Robey, R. B., and Hay, N. (2009). Is Akt the “Warburg kinase”?-Akt-energy metabolism interactions and oncogenesis. Semin. Cancer Biol. 19, 25-31. doi: 10.1016/j.semcancer.2008.11.010
    • (2009) Semin. Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 107
    • 84937720481 scopus 로고    scopus 로고
    • Metabolic reprogramming and dysregulated metabolism: Cause, consequence and/or enabler of environmental carcinogenesis?
    • Robey, R. B., Weisz, J., Kuemmerle, N. B., Salzberg, A. C., Berg, A., Brown, D. G., et al. (2015). Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis 36, S203-S231. doi: 10.1093/carcin/bgv037
    • (2015) Carcinogenesis , vol.36 , pp. S203-S231
    • Robey, R.B.1    Weisz, J.2    Kuemmerle, N.B.3    Salzberg, A.C.4    Berg, A.5    Brown, D.G.6
  • 109
    • 84995975577 scopus 로고    scopus 로고
    • Abstract 3346: The ketone body β-hydroxybutyrate increases radiosensitivity in glioma cell lines in vitro
    • Rossi, A. P., Woolf, E. C., Brooks, K. S., Fairres, M. J., and Scheck, A. C. (2015). Abstract 3346: the ketone body β-hydroxybutyrate increases radiosensitivity in glioma cell lines in vitro. Cancer Res. 75:3346. doi: 10.1158/1538-7445.am2015-3346
    • (2015) Cancer Res , vol.75 , pp. 3346
    • Rossi, A.P.1    Woolf, E.C.2    Brooks, K.S.3    Fairres, M.J.4    Scheck, A.C.5
  • 110
    • 84866274799 scopus 로고    scopus 로고
    • Fasting enhances the response of glioma to chemo-and radiotherapy
    • Safdie, F., Brandhorst, S., Wei, M., Wang, W., Lee, C., Hwang, S., et al. (2012). Fasting enhances the response of glioma to chemo-and radiotherapy. PLoS One 7:e44603. doi: 10.1371/journal.pone.0044603
    • (2012) Plos One , vol.7
    • Safdie, F.1    Brandhorst, S.2    Wei, M.3    Wang, W.4    Lee, C.5    Hwang, S.6
  • 111
    • 84879390182 scopus 로고    scopus 로고
    • Caloric restriction augments radiation efficacy in breast cancer
    • Saleh, A. D., Simone, B. A., Palazzo, J., Savage, J. E., Sano, Y., Dan, T., et al. (2013). Caloric restriction augments radiation efficacy in breast cancer. Cell Cycle 12, 1955-1963. doi: 10.4161/cc.25016
    • (2013) Cell Cycle , vol.12 , pp. 1955-1963
    • Saleh, A.D.1    Simone, B.A.2    Palazzo, J.3    Savage, J.E.4    Sano, Y.5    Dan, T.6
  • 112
    • 84902505887 scopus 로고    scopus 로고
    • Ionizing radiation-induced DNA damage, response and repair
    • Santivasi, W. L., and Xia, F. (2014). Ionizing radiation-induced DNA damage, response and repair. Antioxid. Redox Signal. 21, 251-259. doi: 10.1089/ars.2013.5668
    • (2014) Antioxid. Redox Signal , vol.21 , pp. 251-259
    • Santivasi, W.L.1    Xia, F.2
  • 113
    • 34548539093 scopus 로고    scopus 로고
    • Dietary factors and growth and metabolism in experimental tumors
    • Sauer, L. A., Blask, D. E., and Dauchy, R. T. (2007). Dietary factors and growth and metabolism in experimental tumors. J. Nutr. Biochem. 18, 637-649. doi: 10.1016/j.jnutbio.2006.12.009
    • (2007) J. Nutr. Biochem , vol.18 , pp. 637-649
    • Sauer, L.A.1    Blask, D.E.2    Dauchy, R.T.3
  • 114
    • 84864108226 scopus 로고    scopus 로고
    • The ketogenic diet for the treatment of glioma: Insights from genetic profiling
    • Scheck, A. C., Abdelwahab, M. G., Fenton, K., and Stafford, P. (2012). The ketogenic diet for the treatment of glioma: insights from genetic profiling. Epilepsy Res. 100, 327-337. doi: 10.1016/j.eplepsyres.2011.09.022
    • (2012) Epilepsy Res , vol.100 , pp. 327-337
    • Scheck, A.C.1    Abdelwahab, M.G.2    Fenton, K.3    Stafford, P.4
  • 115
    • 84920519675 scopus 로고    scopus 로고
    • Abstract 638: Mechanistic studies of the ketogenic diet as an adjuvant therapy for malignant gliomas
    • Scheck, A. C., Abdelwahab, M. G., Stafford, P., Kim, D. Y., Iwai, S., Preul, M. C., et al. (2011). Abstract 638: mechanistic studies of the ketogenic diet as an adjuvant therapy for malignant gliomas. Cancer Res. 70, 638-638. doi: 10.1158/1538-7445.am10-638
    • (2011) Cancer Res , vol.70 , pp. 638-638
    • Scheck, A.C.1    Abdelwahab, M.G.2    Stafford, P.3    Kim, D.Y.4    Iwai, S.5    Preul, M.C.6
  • 116
    • 79960688044 scopus 로고    scopus 로고
    • Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial
    • Schmidt, M., Pfetzer, N., Schwab, M., Strauss, I., and Kammerer, U. (2011). Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: a pilot trial. Nutr. Metab. (Lond) 8:54. doi: 10.1186/1743-7075-8-54
    • (2011) Nutr. Metab. (Lond) , vol.8 , pp. 54
    • Schmidt, M.1    Pfetzer, N.2    Schwab, M.3    Strauss, I.4    Kammerer, U.5
  • 117
    • 84930937889 scopus 로고    scopus 로고
    • Treatment of glioma patients with ketogenic diets: Report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature
    • Schwartz, K., Chang, H. T., Nikolai, M., Pernicone, J., Rhee, S., Olson, K., et al. (2015). Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab. 3:3. doi: 10.1186/s40170-015-0129-1
    • (2015) Cancer Metab , vol.3 , pp. 3
    • Schwartz, K.1    Chang, H.T.2    Nikolai, M.3    Pernicone, J.4    Rhee, S.5    Olson, K.6
  • 118
    • 84883501150 scopus 로고    scopus 로고
    • HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
    • Semenza, G. L. (2013). HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J. Clin. Invest 123, 3664-3671. doi: 10.1172/JCI67230
    • (2013) J. Clin. Invest , vol.123 , pp. 3664-3671
    • Semenza, G.L.1
  • 119
    • 84891585156 scopus 로고    scopus 로고
    • Management and Prevention of Cancer. Hoboken, NJ: John Wiley and Sons, Inc
    • Seyfried, T. N. (2012). Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer. Hoboken, NJ: John Wiley and Sons, Inc.
    • (2012) Cancer as a Metabolic Disease: On the Origin
    • Seyfried, T.N.1
  • 121
    • 27744502691 scopus 로고    scopus 로고
    • Targeting energy metabolism in brain cancer: Review and hypothesis. Nutr
    • Seyfried, T. N., and Mukherjee, P. (2005). Targeting energy metabolism in brain cancer: review and hypothesis. Nutr. Metab. (Lond) 2:30. doi: 10.1186/1743-7075-2-30
    • (2005) Metab. (Lond) , vol.2 , pp. 30
    • Seyfried, T.N.1    Mukherjee, P.2
  • 122
    • 77956249320 scopus 로고    scopus 로고
    • Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse
    • Shelton, L. M., Huysentruyt, L. C., Mukherjee, P., and Seyfried, T. N. (2010). Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. ASN Neuro 2:e00038. doi: 10.1042/AN20100002
    • (2010) ASN Neuro , vol.2
    • Shelton, L.M.1    Huysentruyt, L.C.2    Mukherjee, P.3    Seyfried, T.N.4
  • 123
    • 84872166360 scopus 로고    scopus 로고
    • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
    • Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., et al. (2013). Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339, 211-214. doi: 10.1126/science.1227166
    • (2013) Science , vol.339 , pp. 211-214
    • Shimazu, T.1    Hirschey, M.D.2    Newman, J.3    He, W.4    Shirakawa, K.5    Le Moan, N.6
  • 124
    • 84923207192 scopus 로고    scopus 로고
    • Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
    • Shukla, S. K., Gebregiworgis, T., Purohit, V., Chaika, N. V., Gunda, V., Radhakrishnan, P., et al. (2014). Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2:18. doi: 10.1186/2049-3002-2-18
    • (2014) Cancer Metab , vol.2 , pp. 18
    • Shukla, S.K.1    Gebregiworgis, T.2    Purohit, V.3    Chaika, N.V.4    Gunda, V.5    Radhakrishnan, P.6
  • 125
    • 84995974498 scopus 로고    scopus 로고
    • The ketone body β-hydroxybutyrate radiosensitizes glioblastoma multiforme stem cells
    • Silva-Nichols, H. B., Woolf, E. C., Deleyrolle, L. P., Reynolds, B. A., and Scheck, A. C. (2015). The ketone body β-hydroxybutyrate radiosensitizes glioblastoma multiforme stem cells. Neuro Oncol. 17:v35. doi: 10.1093/neuonc/nov204.77
    • (2015) Neuro Oncol , pp. 17
    • Silva-Nichols, H.B.1    Woolf, E.C.2    Deleyrolle, L.P.3    Reynolds, B.A.4    Scheck, A.C.5
  • 126
    • 84880231512 scopus 로고    scopus 로고
    • Selectively starving cancer cells through dietary manipulation: Methods and clinical implications
    • Simone, B. A., Champ, C. E., Rosenberg, A. L., Berger, A. C., Monti, D. A., Dicker, A. P., et al. (2013). Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol. 9, 959-976. doi: 10.2217/fon.13.31
    • (2013) Future Oncol , vol.9 , pp. 959-976
    • Simone, B.A.1    Champ, C.E.2    Rosenberg, A.L.3    Berger, A.C.4    Monti, D.A.5    Dicker, A.P.6
  • 127
    • 58149514084 scopus 로고    scopus 로고
    • Ketone bodies inhibit the viability of human neuroblastoma cells
    • Skinner, R., Trujillo, A., Ma, X., and Beierle, E. A. (2009). Ketone bodies inhibit the viability of human neuroblastoma cells. J. Pediatr. Surg. 44, 212-216. doi: 10.1016/j.jpedsurg.2008.10.042
    • (2009) J. Pediatr. Surg , vol.44 , pp. 212-216
    • Skinner, R.1    Trujillo, A.2    Ma, X.3    Beierle, E.A.4
  • 128
    • 77956465178 scopus 로고    scopus 로고
    • The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
    • Stafford, P., Abdelwahab, M. G., Kim, D. Y., Preul, M. C., Rho, J. M., and Scheck, A. C. (2010). The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr. Metab. (Lond) 7:74. doi: 10.1186/1743-7075-7-74
    • (2010) Nutr. Metab. (Lond) , vol.7 , pp. 74
    • Stafford, P.1    Abdelwahab, M.G.2    Kim, D.Y.3    Preul, M.C.4    Rho, J.M.5    Scheck, A.C.6
  • 130
    • 0020674992 scopus 로고
    • Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues
    • Tisdale, M. J., and Brennan, R. A. (1983). Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues. Br. J. Cancer 47, 293-297. doi: 10.1038/bjc.1983.38
    • (1983) Br. J. Cancer , vol.47 , pp. 293-297
    • Tisdale, M.J.1    Brennan, R.A.2
  • 131
    • 0023270392 scopus 로고
    • Reduction of weight loss and tumour size in a cachexia model by a high fat diet
    • Tisdale, M. J., Brennan, R. A., and Fearon, K. C. (1987). Reduction of weight loss and tumour size in a cachexia model by a high fat diet. Br. J. Cancer 56, 39-43. doi: 10.1038/bjc.1987.149
    • (1987) Br. J. Cancer , vol.56 , pp. 39-43
    • Tisdale, M.J.1    Brennan, R.A.2    Fearon, K.C.3
  • 132
    • 79957516708 scopus 로고    scopus 로고
    • Response assessment in neuro-oncology (A report of the RANO group): Assessment of outcome in trials of diffuse low-grade gliomas
    • van den Bent, M. J., Wefel, J. S., Schiff, D., Taphoorn, M. J., Jaeckle, K., Junck, L., et al. (2011). Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas. Lancet Oncol. 12, 583-593. doi: 10.1016/s1470-2045(11)70057-2
    • (2011) Lancet Oncol , vol.12 , pp. 583-593
    • Van Den Bent, M.J.1    Wefel, J.S.2    Schiff, D.3    Taphoorn, M.J.4    Jaeckle, K.5    Junck, L.6
  • 133
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C., and Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033. doi: 10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 134
    • 0141919698 scopus 로고    scopus 로고
    • Ketones: Metabolism’s ugly duckling
    • Vanitallie, T. B., and Nufert, T. H. (2003). Ketones: metabolism’s ugly duckling. Nutr. Rev. 61, 327-341. doi: 10.1301/nr.2003.oct.327-341
    • (2003) Nutr. Rev , vol.61 , pp. 327-341
    • Vanitallie, T.B.1    Nufert, T.H.2
  • 135
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance and mitochondrial metabolism. Prostaglandins Leukot
    • Veech, R. L. (2004). The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids 70, 309-319. doi: 10.1016/j.plefa.2003.09.007
    • (2004) Essent. Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 136
    • 84904384275 scopus 로고    scopus 로고
    • Ketone ester effects on metabolism and transcription
    • Veech, R. L. (2014). Ketone ester effects on metabolism and transcription. J. Lipid Res. 55, 2004-2006. doi: 10.1194/jlr.r046292
    • (2014) J. Lipid Res , vol.55 , pp. 2004-2006
    • Veech, R.L.1
  • 137
    • 0034844219 scopus 로고    scopus 로고
    • Ketone bodies, potential therapeutic uses
    • Veech, R. L., Chance, B., Kashiwaya, Y., Lardy, H. A., and Cahill, G. F. Jr. (2001). Ketone bodies, potential therapeutic uses. IUBMB Life 51, 241-247. doi: 10.1080/152165401753311780
    • (2001) IUBMB Life , vol.51 , pp. 241-247
    • Veech, R.L.1    Chance, B.2    Kashiwaya, Y.3    Lardy, H.A.4    Cahill, G.F.5
  • 138
    • 84973598699 scopus 로고    scopus 로고
    • Anti-inflammatory and pro-resolving effects of N-3 PUFA in cancers: Structures and mechanisms
    • Wang, Q., Hu, M., Xu, H., and Yang, X. (2016). Anti-inflammatory and pro-resolving effects of N-3 PUFA in cancers: structures and mechanisms. Curr. Top. Med. Chem. 16, 888-894. doi: 10.2174/1568026615666150827101602
    • (2016) Curr. Top. Med. Chem , vol.16 , pp. 888-894
    • Wang, Q.1    Hu, M.2    Xu, H.3    Yang, X.4
  • 139
    • 84255167386 scopus 로고    scopus 로고
    • The powerful applications of polyunsaturated fatty acids in improving the therapeutic efficacy of anticancer drugs
    • Wang, J., Luo, T., Li, S., and Zhao, J. (2012). The powerful applications of polyunsaturated fatty acids in improving the therapeutic efficacy of anticancer drugs. Expert Opin. Drug Deliv. 9, 1-7. doi: 10.1517/17425247.2011.618183
    • (2012) Expert Opin. Drug Deliv , vol.9 , pp. 1-7
    • Wang, J.1    Luo, T.2    Li, S.3    Zhao, J.4
  • 140
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg, O., Wind, F., and Negelein, E. (1927). The metabolism of tumors in the body. J. Gen. Physiol. 8, 519-530. doi: 10.1085/jgp.8.6.519
    • (1927) J. Gen. Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 141
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • Ward, P. S., and Thompson, C. B. (2012). Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 21, 297-308. doi: 10.1016/j.ccr.2012.02.014
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 142
    • 84876029468 scopus 로고    scopus 로고
    • Hypoxia induces a phase transition within a kinase signaling network in cancer cells
    • Wei, W., Shi, Q., Remacle, F., Qin, L., Shackelford, D. B., Shin, Y. S., et al. (2013). Hypoxia induces a phase transition within a kinase signaling network in cancer cells. Proc. Natl. Acad. Sci. U S A 110, E1352-E1360. doi: 10.1073/pnas.1303060110
    • (2013) Proc. Natl. Acad. Sci. U S A , vol.110 , pp. E1352-E1360
    • Wei, W.1    Shi, Q.2    Remacle, F.3    Qin, L.4    Shackelford, D.B.5    Shin, Y.S.6
  • 143
    • 84939123198 scopus 로고    scopus 로고
    • The ketogenic diet alters the hypoxic response and affects expression of proteins associated with angiogenesis, invasive potential and vascular permeability in a mouse glioma model
    • Woolf, E. C., Curley, K. L., Liu, Q., Turner, G. H., Charlton, J. A., Preul, M. C., et al. (2015). The ketogenic diet alters the hypoxic response and affects expression of proteins associated with angiogenesis, invasive potential and vascular permeability in a mouse glioma model. PLoS One 10:e0130357. doi: 10.1371/journal.pone.0130357
    • (2015) Plos One , vol.10
    • Woolf, E.C.1    Curley, K.L.2    Liu, Q.3    Turner, G.H.4    Charlton, J.A.5    Preul, M.C.6
  • 144
    • 0032992249 scopus 로고    scopus 로고
    • Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress
    • Yamada, M., Tomida, A., Yun, J., Cai, B., Yoshikawa, H., Taketani, Y., et al. (1999). Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress. Cancer Chemother. Pharmacol. 44, 59-64. doi: 10.1007/s002800050945
    • (1999) Cancer Chemother. Pharmacol , vol.44 , pp. 59-64
    • Yamada, M.1    Tomida, A.2    Yun, J.3    Cai, B.4    Yoshikawa, H.5    Taketani, Y.6
  • 145
    • 84866340817 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
    • Yang, L., Lin, C., Wang, L., Guo, H., and Wang, X. (2012). Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp. Cell Res. 318, 2417-2426. doi: 10.1016/j.yexcr.2012.07.017
    • (2012) Exp. Cell Res , vol.318 , pp. 2417-2426
    • Yang, L.1    Lin, C.2    Wang, L.3    Guo, H.4    Wang, X.5
  • 146
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • Yang, C., Sudderth, J., Dang, T., Bachoo, R. G., McDonald, J. G., and DeBerardinis, R. J. (2009). Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 69, 7986-7993. doi: 10.1158/0008-5472.CAN-09-2266
    • (2009) Cancer Res , vol.69 , pp. 7986-7993
    • Yang, C.1    Sudderth, J.2    Dang, T.3    Bachoo, R.G.4    McDonald, J.G.5    Deberardinis, R.J.6
  • 147
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm, Y. H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., et al. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21, 263-269. doi: 10.1038/nm.3804
    • (2015) Nat. Med , vol.21 , pp. 263-269
    • Youm, Y.H.1    Nguyen, K.Y.2    Grant, R.W.3    Goldberg, E.L.4    Bodogai, M.5    Kim, D.6
  • 148
    • 33847780073 scopus 로고    scopus 로고
    • The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
    • Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., and Seyfried, T. N. (2007). The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr. Metab. (Lond) 4:5. doi: 10.1186/1743-7075-4-5
    • (2007) Nutr. Metab. (Lond) , vol.4 , pp. 5
    • Zhou, W.1    Mukherjee, P.2    Kiebish, M.A.3    Markis, W.T.4    Mantis, J.G.5    Seyfried, T.N.6
  • 149
    • 77951028897 scopus 로고    scopus 로고
    • Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case report
    • Zuccoli, G., Marcello, N., Pisanello, A., Servadei, F., Vaccaro, S., Mukherjee, P., et al. (2010). Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: case report. Nutr. Metab. (Lond) 7:33. doi: 10.1186/1743-7075-7-33
    • (2010) Nutr. Metab. (Lond) , vol.7 , pp. 33
    • Zuccoli, G.1    Marcello, N.2    Pisanello, A.3    Servadei, F.4    Vaccaro, S.5    Mukherjee, P.6
  • 150
    • 84907202296 scopus 로고    scopus 로고
    • Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
    • Zwaans, B. M., and Lombard, D. B. (2014). Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis. Model. Mech. 7, 1023-1032. doi: 10.1242/dmm.016287
    • (2014) Dis. Model. Mech , vol.7 , pp. 1023-1032
    • Zwaans, B.M.1    Lombard, D.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.