Initial Substrate Binding of γ-Secretase: The Role of Substrate Flexibility

ACS Chemical Neuroscience

Volumn 8, Issue 6, 2017, Pages 1279-1290

  Li, Shu ^a   Zhang, Wan ^a   Han, Wei ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

amyloid precursor protein; amyloid peptide; intramembrane protease; notch signal; substrate recognition; Secretase

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; AMYLOID BETA PROTEIN; PROTEIN BINDING; SECRETASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DIMERIZATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; LIPID BILAYER; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STATIC ELECTRICITY; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 85021095942     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00425     Document Type: Article

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