The amyloid-beta forming tripeptide cleavage mechanism of γ-Secretase

eLife

Volumn 5, Issue AUGUST, 2016, Pages

  Bolduc, David M ^a   Montagna, Daniel R ^a   Seghers, Matthew C ^a   Wolfe, Michael S ^a   Selkoe, Dennis J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; PROTEIN BINDING; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IC50; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MUTATION; PROTEIN CLEAVAGE; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; CELL CULTURE; ENZYME ACTIVE SITE; KINETICS; MASS SPECTROMETRY; METABOLISM; PROTEIN DEGRADATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYTIC DOMAIN; CELLS, CULTURED; HUMANS; IMMUNOPRECIPITATION; KINETICS; MASS SPECTROMETRY; PROTEIN BINDING; PROTEOLYSIS;

EID: 84985994501     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.17578     Document Type: Article

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