Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 36, 2016, Pages E5281-E5287

  Dominguez, Laura ^a,b   Foster, Leigh ^a   Straub, John E ^a   Thirumalai, D ^c  

^a Boston University   (United States)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c The University of Texas at Austin   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; App dimer; A ; Membrane composition; Peptide

Indexed keywords

AMYLOID PRECURSOR PROTEIN; EPHRIN RECEPTOR A2; GAMMA SECRETASE; GLYCINE; HOMODIMER; MEMBRANE LIPID; MEMBRANE PROTEIN; MONOMER; APP PROTEIN, HUMAN; PEPTIDE FRAGMENT; SECRETASE;

ARTICLE; CONFORMATION; DIMERIZATION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; LIPID BILAYER; LIPID COMPOSITION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SURFACE AREA; SURFACE PROPERTY; ALZHEIMER DISEASE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; DIMERIZATION; HUMANS; MEMBRANE LIPIDS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN DOMAINS; PROTEIN STABILITY; PROTEOLYSIS; RECEPTOR, EPHA2;

EID: 84986268684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1606482113     Document Type: Article

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