메뉴 건너뛰기




Volumn 454, Issue , 2017, Pages 103-111

HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity

Author keywords

Adipocyte; Alarmin; DC; HMGB1; Macrophage; Obesity; RAGE; TLRs

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; ALARMIN;

EID: 85021091181     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2017.06.012     Document Type: Review
Times cited : (75)

References (121)
  • 2
    • 3142766016 scopus 로고    scopus 로고
    • Hmgb1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis
    • xi
    • Andersson, U., Tracey, K.J., Hmgb1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis. Rheumat. Dis. Clin. N. Am. 30 (2004), 627–637 xi.
    • (2004) Rheumat. Dis. Clin. N. Am. , vol.30 , pp. 627-637
    • Andersson, U.1    Tracey, K.J.2
  • 3
    • 79953066407 scopus 로고    scopus 로고
    • Hmgb1 is a therapeutic target for sterile inflammation and infection
    • Andersson, U., Tracey, K.J., Hmgb1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 29 (2011), 139–162.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 139-162
    • Andersson, U.1    Tracey, K.J.2
  • 4
    • 84898683559 scopus 로고    scopus 로고
    • A systematic nomenclature for the redox states of high mobility group box (hmgb) proteins
    • Antoine, D.J., Harris, H.E., Andersson, U., Tracey, K.J., Bianchi, M.E., A systematic nomenclature for the redox states of high mobility group box (hmgb) proteins. Mol. Med. 20 (2014), 135–137.
    • (2014) Mol. Med. , vol.20 , pp. 135-137
    • Antoine, D.J.1    Harris, H.E.2    Andersson, U.3    Tracey, K.J.4    Bianchi, M.E.5
  • 6
    • 35948947939 scopus 로고    scopus 로고
    • Translocation of the novel cytokine hmgb1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally uv-induced lesions of cutaneous lupus erythematosus
    • Barkauskaite, V., Ek, M., Popovic, K., Harris, H.E., Wahren-Herlenius, M., Nyberg, F., Translocation of the novel cytokine hmgb1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally uv-induced lesions of cutaneous lupus erythematosus. Lupus 16 (2007), 794–802.
    • (2007) Lupus , vol.16 , pp. 794-802
    • Barkauskaite, V.1    Ek, M.2    Popovic, K.3    Harris, H.E.4    Wahren-Herlenius, M.5    Nyberg, F.6
  • 7
    • 85007557081 scopus 로고    scopus 로고
    • Hmgb1, il-1alpha, il-33 and s100 proteins: dual-function alarmins
    • Bertheloot, D., Latz, E., Hmgb1, il-1alpha, il-33 and s100 proteins: dual-function alarmins. Cell. Mol. Immunol. 14 (2017), 43–64.
    • (2017) Cell. Mol. Immunol. , vol.14 , pp. 43-64
    • Bertheloot, D.1    Latz, E.2
  • 9
    • 0024584528 scopus 로고
    • Specific recognition of cruciform DNA by nuclear protein hmg1
    • Bianchi, M.E., Beltrame, M., Paonessa, G., Specific recognition of cruciform DNA by nuclear protein hmg1. Science 243 (1989), 1056–1059.
    • (1989) Science , vol.243 , pp. 1056-1059
    • Bianchi, M.E.1    Beltrame, M.2    Paonessa, G.3
  • 11
    • 0033052037 scopus 로고    scopus 로고
    • The lack of chromosomal protein hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    • Calogero, S., Grassi, F., Aguzzi, A., Voigtlander, T., Ferrier, P., Ferrari, S., Bianchi, M.E., The lack of chromosomal protein hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat. Genet. 22 (1999), 276–280.
    • (1999) Nat. Genet. , vol.22 , pp. 276-280
    • Calogero, S.1    Grassi, F.2    Aguzzi, A.3    Voigtlander, T.4    Ferrier, P.5    Ferrari, S.6    Bianchi, M.E.7
  • 12
    • 33748742519 scopus 로고    scopus 로고
    • Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    • Cancello, R., Clement, K., Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG Int. J. Obstetr. Gynaecol. 113 (2006), 1141–1147.
    • (2006) BJOG Int. J. Obstetr. Gynaecol. , vol.113 , pp. 1141-1147
    • Cancello, R.1    Clement, K.2
  • 14
    • 84955180839 scopus 로고    scopus 로고
    • Instigation of endothelial nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of hmgb1
    • Chen, Y., Pitzer, A.L., Li, X., Li, P.L., Wang, L., Zhang, Y., Instigation of endothelial nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of hmgb1. J. Cell. Mol. Med. 19 (2015), 2715–2727.
    • (2015) J. Cell. Mol. Med. , vol.19 , pp. 2715-2727
    • Chen, Y.1    Pitzer, A.L.2    Li, X.3    Li, P.L.4    Wang, L.5    Zhang, Y.6
  • 16
    • 84881029152 scopus 로고    scopus 로고
    • Chronic adipose tissue inflammation: all immune cells on the stage
    • Cildir, G., Akincilar, S.C., Tergaonkar, V., Chronic adipose tissue inflammation: all immune cells on the stage. Trends Mol. Med. 19 (2013), 487–500.
    • (2013) Trends Mol. Med. , vol.19 , pp. 487-500
    • Cildir, G.1    Akincilar, S.C.2    Tergaonkar, V.3
  • 20
    • 84990858952 scopus 로고    scopus 로고
    • Effect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trials
    • Eichelmann, F., Schwingshackl, L., Fedirko, V., Aleksandrova, K., Effect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trials. Obes. Rev. Off. J. Int. Assoc. Study Obes. 17 (2016), 1067–1079.
    • (2016) Obes. Rev. Off. J. Int. Assoc. Study Obes. , vol.17 , pp. 1067-1079
    • Eichelmann, F.1    Schwingshackl, L.2    Fedirko, V.3    Aleksandrova, K.4
  • 21
    • 78650067155 scopus 로고    scopus 로고
    • High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity
    • Evankovich, J., Cho, S.W., Zhang, R., Cardinal, J., Dhupar, R., Zhang, L., Klune, J.R., Zlotnicki, J., Billiar, T., Tsung, A., High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. J. Biol. Chem. 285 (2010), 39888–39897.
    • (2010) J. Biol. Chem. , vol.285 , pp. 39888-39897
    • Evankovich, J.1    Cho, S.W.2    Zhang, R.3    Cardinal, J.4    Dhupar, R.5    Zhang, L.6    Klune, J.R.7    Zlotnicki, J.8    Billiar, T.9    Tsung, A.10
  • 22
    • 84994463295 scopus 로고    scopus 로고
    • Regulation of autophagy-related protein and cell differentiation by high mobility group box 1 protein in adipocytes
    • Feng, H., Yu, L., Zhang, G., Liu, G., Yang, C., Wang, H., Song, X., Regulation of autophagy-related protein and cell differentiation by high mobility group box 1 protein in adipocytes. Mediat. Inflamm., 2016, 2016, 1936386.
    • (2016) Mediat. Inflamm. , vol.2016 , pp. 1936386
    • Feng, H.1    Yu, L.2    Zhang, G.3    Liu, G.4    Yang, C.5    Wang, H.6    Song, X.7
  • 23
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: a metabolic dialogue in the language of inflammation
    • Ferrante, A.W. Jr., Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J. Intern. Med. 262 (2007), 408–414.
    • (2007) J. Intern. Med. , vol.262 , pp. 408-414
    • Ferrante, A.W.1
  • 26
    • 0036775236 scopus 로고    scopus 로고
    • The nuclear protein hmgb1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway
    • Gardella, S., Andrei, C., Ferrera, D., Lotti, L.V., Torrisi, M.R., Bianchi, M.E., Rubartelli, A., The nuclear protein hmgb1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep. 3 (2002), 995–1001.
    • (2002) EMBO Rep. , vol.3 , pp. 995-1001
    • Gardella, S.1    Andrei, C.2    Ferrera, D.3    Lotti, L.V.4    Torrisi, M.R.5    Bianchi, M.E.6    Rubartelli, A.7
  • 27
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: tracking obesity to its source
    • Gesta, S., Tseng, Y.H., Kahn, C.R., Developmental origin of fat: tracking obesity to its source. Cell 131 (2007), 242–256.
    • (2007) Cell , vol.131 , pp. 242-256
    • Gesta, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 30
    • 42949088997 scopus 로고    scopus 로고
    • The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
    • Goossens, G.H., The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol. Behav. 94 (2008), 206–218.
    • (2008) Physiol. Behav. , vol.94 , pp. 206-218
    • Goossens, G.H.1
  • 31
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (hif-1) in hypoxia induced apoptosis
    • Greijer, A.E., van der Wall, E., The role of hypoxia inducible factor 1 (hif-1) in hypoxia induced apoptosis. J. Clin. Pathol. 57 (2004), 1009–1014.
    • (2004) J. Clin. Pathol. , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    van der Wall, E.2
  • 33
    • 84883556650 scopus 로고    scopus 로고
    • Inflammation triggers high mobility group box 1 (hmgb1) secretion in adipose tissue, a potential link to obesity
    • Gunasekaran, M.K., Viranaicken, W., Girard, A.C., Festy, F., Cesari, M., Roche, R., Hoareau, L., Inflammation triggers high mobility group box 1 (hmgb1) secretion in adipose tissue, a potential link to obesity. Cytokine 64 (2013), 103–111.
    • (2013) Cytokine , vol.64 , pp. 103-111
    • Gunasekaran, M.K.1    Viranaicken, W.2    Girard, A.C.3    Festy, F.4    Cesari, M.5    Roche, R.6    Hoareau, L.7
  • 35
    • 50849096898 scopus 로고    scopus 로고
    • Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in nod mice
    • Han, J., Zhong, J., Wei, W., Wang, Y., Huang, Y., Yang, P., Purohit, S., Dong, Z., Wang, M.H., She, J.X., Gong, F., Stern, D.M., Wang, C.Y., Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in nod mice. Diabetes 57 (2008), 2118–2127.
    • (2008) Diabetes , vol.57 , pp. 2118-2127
    • Han, J.1    Zhong, J.2    Wei, W.3    Wang, Y.4    Huang, Y.5    Yang, P.6    Purohit, S.7    Dong, Z.8    Wang, M.H.9    She, J.X.10    Gong, F.11    Stern, D.M.12    Wang, C.Y.13
  • 37
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial ph and po2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation
    • Helmlinger, G., Yuan, F., Dellian, M., Jain, R.K., Interstitial ph and po2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med. 3 (1997), 177–182.
    • (1997) Nat. Med. , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 41
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993), 87–91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 43
    • 34447523457 scopus 로고    scopus 로고
    • Post-translational methylation of high mobility group box 1 (hmgb1) causes its cytoplasmic localization in neutrophils
    • Ito, I., Fukazawa, J., Yoshida, M., Post-translational methylation of high mobility group box 1 (hmgb1) causes its cytoplasmic localization in neutrophils. J. Biol. Chem. 282 (2007), 16336–16344.
    • (2007) J. Biol. Chem. , vol.282 , pp. 16336-16344
    • Ito, I.1    Fukazawa, J.2    Yoshida, M.3
  • 46
    • 0017903484 scopus 로고
    • Nonhistone proteins hmg1 and hmg2 change the DNA helical structure
    • Javaherian, K., Liu, J.F., Wang, J.C., Nonhistone proteins hmg1 and hmg2 change the DNA helical structure. Science 199 (1978), 1345–1346.
    • (1978) Science , vol.199 , pp. 1345-1346
    • Javaherian, K.1    Liu, J.F.2    Wang, J.C.3
  • 47
    • 84892167181 scopus 로고    scopus 로고
    • Toll-like receptor status in obesity and metabolic syndrome: a translational perspective
    • Jialal, I., Kaur, H., Devaraj, S., Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J. Clin. Endocrinol. Metabol. 99 (2014), 39–48.
    • (2014) J. Clin. Endocrinol. Metabol. , vol.99 , pp. 39-48
    • Jialal, I.1    Kaur, H.2    Devaraj, S.3
  • 48
    • 84878812591 scopus 로고    scopus 로고
    • Innate immune receptors: key regulators of metabolic disease progression
    • Jin, C., Henao-Mejia, J., Flavell, R.A., Innate immune receptors: key regulators of metabolic disease progression. Cell metab. 17 (2013), 873–882.
    • (2013) Cell metab. , vol.17 , pp. 873-882
    • Jin, C.1    Henao-Mejia, J.2    Flavell, R.A.3
  • 51
    • 78650472774 scopus 로고    scopus 로고
    • Toll-like receptors: linking inflammation to metabolism
    • Konner, A.C., Bruning, J.C., Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol. Metabol. TEM 22 (2011), 16–23.
    • (2011) Trends Endocrinol. Metabol. TEM , vol.22 , pp. 16-23
    • Konner, A.C.1    Bruning, J.C.2
  • 53
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase perk and phosphorylation of the translation initiation factor eif2alpha
    • Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, A., Sonenberg, N., Koromilas, A., Wouters, B.G., Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase perk and phosphorylation of the translation initiation factor eif2alpha. Mol. Cell. Biol. 22 (2002), 7405–7416.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 55
    • 27644545338 scopus 로고    scopus 로고
    • Intra-abdominal pressure in the morbidly obese
    • Lambert, D.M., Marceau, S., Forse, R.A., Intra-abdominal pressure in the morbidly obese. Obes. Surg. 15 (2005), 1225–1232.
    • (2005) Obes. Surg. , vol.15 , pp. 1225-1232
    • Lambert, D.M.1    Marceau, S.2    Forse, R.A.3
  • 56
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: from caspases to alternative mechanisms
    • Leist, M., Jaattela, M., Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2 (2001), 589–598.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 59
    • 84953431903 scopus 로고    scopus 로고
    • Damp and dic: the role of extracellular DNA and DNA-binding proteins in the pathogenesis of dic
    • Liaw, P.C., Ito, T., Iba, T., Thachil, J., Zeerleder, S., Damp and dic: the role of extracellular DNA and DNA-binding proteins in the pathogenesis of dic. Blood Rev. 30 (2016), 257–261.
    • (2016) Blood Rev. , vol.30 , pp. 257-261
    • Liaw, P.C.1    Ito, T.2    Iba, T.3    Thachil, J.4    Zeerleder, S.5
  • 60
    • 84973922637 scopus 로고    scopus 로고
    • Cellular mechanisms and consequences of glycation in atherosclerosis and obesity
    • Lopez-Diez, R., Shekhtman, A., Ramasamy, R., Schmidt, A.M., Cellular mechanisms and consequences of glycation in atherosclerosis and obesity. Biochim. Biophys. acta 1862 (2016), 2244–2252.
    • (2016) Biochim. Biophys. acta , vol.1862 , pp. 2244-2252
    • Lopez-Diez, R.1    Shekhtman, A.2    Ramasamy, R.3    Schmidt, A.M.4
  • 62
    • 84872170016 scopus 로고    scopus 로고
    • Innate immune activation in obesity
    • Lumeng, C.N., Innate immune activation in obesity. Mol. Asp. Med. 34 (2013), 12–29.
    • (2013) Mol. Asp. Med. , vol.34 , pp. 12-29
    • Lumeng, C.N.1
  • 63
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C.N., Bodzin, J.L., Saltiel, A.R., Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117 (2007), 175–184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 64
    • 84961782689 scopus 로고    scopus 로고
    • The alarmin properties of DNA and DNA-associated nuclear proteins
    • Magna, M., Pisetsky, D.S., The alarmin properties of DNA and DNA-associated nuclear proteins. Clin. Ther. 38 (2016), 1029–1041.
    • (2016) Clin. Ther. , vol.38 , pp. 1029-1041
    • Magna, M.1    Pisetsky, D.S.2
  • 66
    • 84878785347 scopus 로고    scopus 로고
    • Immunological goings-on in visceral adipose tissue
    • Mathis, D., Immunological goings-on in visceral adipose tissue. Cell metab. 17 (2013), 851–859.
    • (2013) Cell metab. , vol.17 , pp. 851-859
    • Mathis, D.1
  • 67
    • 2942700201 scopus 로고    scopus 로고
    • High mobility group box protein 1: an endogenous signal for dendritic cell maturation and th1 polarization
    • Messmer, D., Yang, H., Telusma, G., Knoll, F., Li, J., Messmer, B., Tracey, K.J., Chiorazzi, N., High mobility group box protein 1: an endogenous signal for dendritic cell maturation and th1 polarization. J. Immunol. 173 (2004), 307–313.
    • (2004) J. Immunol. , vol.173 , pp. 307-313
    • Messmer, D.1    Yang, H.2    Telusma, G.3    Knoll, F.4    Li, J.5    Messmer, B.6    Tracey, K.J.7    Chiorazzi, N.8
  • 70
    • 84867383019 scopus 로고    scopus 로고
    • Microvesicles/exosomes as potential novel biomarkers of metabolic diseases
    • Muller, G., Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes, Metabol. Syndr. Obes. Targets Ther. 5 (2012), 247–282.
    • (2012) Diabetes, Metabol. Syndr. Obes. Targets Ther. , vol.5 , pp. 247-282
    • Muller, G.1
  • 72
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and jnk-dependent pathways
    • Nguyen, M.T., Favelyukis, S., Nguyen, A.K., Reichart, D., Scott, P.A., Jenn, A., Liu-Bryan, R., Glass, C.K., Neels, J.G., Olefsky, J.M., A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via toll-like receptors 2 and 4 and jnk-dependent pathways. J. Biol. Chem. 282 (2007), 35279–35292.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6    Liu-Bryan, R.7    Glass, C.K.8    Neels, J.G.9    Olefsky, J.M.10
  • 73
    • 79751496064 scopus 로고    scopus 로고
    • Alternative macrophage activation and metabolism
    • Odegaard, J.I., Chawla, A., Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6 (2011), 275–297.
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 275-297
    • Odegaard, J.I.1    Chawla, A.2
  • 74
    • 66949144402 scopus 로고    scopus 로고
    • Hmgb1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism
    • Oh, Y.J., Youn, J.H., Ji, Y., Lee, S.E., Lim, K.J., Choi, J.E., Shin, J.S., Hmgb1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism. J. Immunol. 182 (2009), 5800–5809.
    • (2009) J. Immunol. , vol.182 , pp. 5800-5809
    • Oh, Y.J.1    Youn, J.H.2    Ji, Y.3    Lee, S.E.4    Lim, K.J.5    Choi, J.E.6    Shin, J.S.7
  • 75
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky, J.M., Glass, C.K., Macrophages, inflammation, and insulin resistance. Annu. Rev. Physiol. 72 (2010), 219–246.
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 76
    • 84868026167 scopus 로고    scopus 로고
    • Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages
    • Orr, J.S., Puglisi, M.J., Ellacott, K.L., Lumeng, C.N., Wasserman, D.H., Hasty, A.H., Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes 61 (2012), 2718–2727.
    • (2012) Diabetes , vol.61 , pp. 2718-2727
    • Orr, J.S.1    Puglisi, M.J.2    Ellacott, K.L.3    Lumeng, C.N.4    Wasserman, D.H.5    Hasty, A.H.6
  • 77
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn, O., Olefsky, J.M., The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18 (2012), 363–374.
    • (2012) Nat. Med. , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 79
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park, J.S., Svetkauskaite, D., He, Q., Kim, J.Y., Strassheim, D., Ishizaka, A., Abraham, E., Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279 (2004), 7370–7377.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 82
    • 27744461020 scopus 로고    scopus 로고
    • Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
    • Popovic, K., Ek, M., Espinosa, A., Padyukov, L., Harris, H.E., Wahren-Herlenius, M., Nyberg, F., Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis Rheumat. 52 (2005), 3639–3645.
    • (2005) Arthritis Rheumat. , vol.52 , pp. 3639-3645
    • Popovic, K.1    Ek, M.2    Espinosa, A.3    Padyukov, L.4    Harris, H.E.5    Wahren-Herlenius, M.6    Nyberg, F.7
  • 83
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in c57bl/6j mice is characterized by adipose tissue hypoxia and cytotoxic t-cell infiltration
    • Rausch, M.E., Weisberg, S., Vardhana, P., Tortoriello, D.V., Obesity in c57bl/6j mice is characterized by adipose tissue hypoxia and cytotoxic t-cell infiltration. Int. J. Obes. 32 (2008), 451–463.
    • (2008) Int. J. Obes. , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 84
    • 84983417800 scopus 로고    scopus 로고
    • Diverse macrophages polarization in tumor microenvironment
    • Rhee, I., Diverse macrophages polarization in tumor microenvironment. Archiv. Pharmacal Res. 39 (2016), 1588–1596.
    • (2016) Archiv. Pharmacal Res. , vol.39 , pp. 1588-1596
    • Rhee, I.1
  • 86
    • 70350389389 scopus 로고    scopus 로고
    • Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    • Saberi, M., Woods, N.B., de Luca, C., Schenk, S., Lu, J.C., Bandyopadhyay, G., Verma, I.M., Olefsky, J.M., Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell metab. 10 (2009), 419–429.
    • (2009) Cell metab. , vol.10 , pp. 419-429
    • Saberi, M.1    Woods, N.B.2    de Luca, C.3    Schenk, S.4    Lu, J.C.5    Bandyopadhyay, G.6    Verma, I.M.7    Olefsky, J.M.8
  • 87
    • 84892394481 scopus 로고    scopus 로고
    • Inflammation, obesity, and thrombosis
    • Samad, F., Ruf, W., Inflammation, obesity, and thrombosis. Blood 122 (2013), 3415–3422.
    • (2013) Blood , vol.122 , pp. 3415-3422
    • Samad, F.1    Ruf, W.2
  • 88
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein hmgb1 by necrotic cells triggers inflammation
    • Scaffidi, P., Misteli, T., Bianchi, M.E., Release of chromatin protein hmgb1 by necrotic cells triggers inflammation. Nature 418 (2002), 191–195.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 89
    • 85012113434 scopus 로고    scopus 로고
    • 2016 atvb plenary lecture: receptor for advanced glycation endproducts and implications for the pathogenesis an treatment of cardiometabolic disorders: spotlight on the macrophage
    • Schmidt, A.M., 2016 atvb plenary lecture: receptor for advanced glycation endproducts and implications for the pathogenesis an treatment of cardiometabolic disorders: spotlight on the macrophage. Arterioscler., Thromb., Vasc. Biol., 2017.
    • (2017) Arterioscler., Thromb., Vasc. Biol.
    • Schmidt, A.M.1
  • 90
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn, J.J., Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J. Biol. Chem. 281 (2006), 26865–26875.
    • (2006) J. Biol. Chem. , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 91
    • 85009959468 scopus 로고    scopus 로고
    • Glycation & the rage axis: targeting signal transduction through diaph1
    • Shekhtman, A., Ramasamy, R., Schmidt, A.M., Glycation & the rage axis: targeting signal transduction through diaph1. Expert Rev. Proteom. 14 (2017), 147–156.
    • (2017) Expert Rev. Proteom. , vol.14 , pp. 147-156
    • Shekhtman, A.1    Ramasamy, R.2    Schmidt, A.M.3
  • 92
    • 84983754943 scopus 로고    scopus 로고
    • Hmgb1 is secreted by 3t3-l1 adipocytes through jnk signaling and the secretion is partially inhibited by adiponectin
    • Shimizu, T., Yamakuchi, M., Biswas, K.K., Aryal, B., Yamada, S., Hashiguchi, T., Maruyama, I., Hmgb1 is secreted by 3t3-l1 adipocytes through jnk signaling and the secretion is partially inhibited by adiponectin. Obesity 24 (2016), 1913–1921.
    • (2016) Obesity , vol.24 , pp. 1913-1921
    • Shimizu, T.1    Yamakuchi, M.2    Biswas, K.K.3    Aryal, B.4    Yamada, S.5    Hashiguchi, T.6    Maruyama, I.7
  • 93
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica, A., Mantovani, A., Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122 (2012), 787–795.
    • (2012) J. Clin. Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 95
    • 66149098965 scopus 로고    scopus 로고
    • Obesity, inflammation, and macrophages. Nestle Nutrition workshop series. Paediatric programme 63, 151–159; discussion 159-162, 259-168.
    • Subramanian V., Ferrante, A.W., Jr., 2009, Obesity, inflammation, and macrophages. Nestle Nutrition workshop series. Paediatric programme 63, 151–159; discussion 159-162, 259-168.
    • (2009)
    • Subramanian, V.1    Ferrante, A.W.2
  • 96
    • 33846302361 scopus 로고    scopus 로고
    • Attenuation of obesity-induced adipose tissue inflammation in c3h/hej mice carrying a toll-like receptor 4 mutation
    • Suganami, T., Mieda, T., Itoh, M., Shimoda, Y., Kamei, Y., Ogawa, Y., Attenuation of obesity-induced adipose tissue inflammation in c3h/hej mice carrying a toll-like receptor 4 mutation. Biochem. Biophys. Res. Commun. 354 (2007), 45–49.
    • (2007) Biochem. Biophys. Res. Commun. , vol.354 , pp. 45-49
    • Suganami, T.1    Mieda, T.2    Itoh, M.3    Shimoda, Y.4    Kamei, Y.5    Ogawa, Y.6
  • 101
    • 36548999695 scopus 로고    scopus 로고
    • Hmgb1 release induced by liver ischemia involves toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling
    • Tsung, A., Klune, J.R., Zhang, X., Jeyabalan, G., Cao, Z., Peng, X., Stolz, D.B., Geller, D.A., Rosengart, M.R., Billiar, T.R., Hmgb1 release induced by liver ischemia involves toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J. Exp. Med. 204 (2007), 2913–2923.
    • (2007) J. Exp. Med. , vol.204 , pp. 2913-2923
    • Tsung, A.1    Klune, J.R.2    Zhang, X.3    Jeyabalan, G.4    Cao, Z.5    Peng, X.6    Stolz, D.B.7    Geller, D.A.8    Rosengart, M.R.9    Billiar, T.R.10
  • 102
    • 41049117932 scopus 로고    scopus 로고
    • Convergence and amplification of toll-like receptor (tlr) and receptor for advanced glycation end products (rage) signaling pathways via high mobility group b1 (hmgb1)
    • van Beijnum, J.R., Buurman, W.A., Griffioen, A.W., Convergence and amplification of toll-like receptor (tlr) and receptor for advanced glycation end products (rage) signaling pathways via high mobility group b1 (hmgb1). Angiogenesis 11 (2008), 91–99.
    • (2008) Angiogenesis , vol.11 , pp. 91-99
    • van Beijnum, J.R.1    Buurman, W.A.2    Griffioen, A.W.3
  • 105
    • 84875631644 scopus 로고    scopus 로고
    • Hmgb1 and leukocyte migration during trauma and sterile inflammation
    • Venereau, E., Schiraldi, M., Uguccioni, M., Bianchi, M.E., Hmgb1 and leukocyte migration during trauma and sterile inflammation. Mol. Immunol. 55 (2013), 76–82.
    • (2013) Mol. Immunol. , vol.55 , pp. 76-82
    • Venereau, E.1    Schiraldi, M.2    Uguccioni, M.3    Bianchi, M.E.4
  • 106
    • 10044265209 scopus 로고    scopus 로고
    • Jnk potentiates tnf-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
    • Ventura, J.J., Cogswell, P., Flavell, R.A., Baldwin, A.S. Jr., Davis, R.J., Jnk potentiates tnf-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes & Dev. 18 (2004), 2905–2915.
    • (2004) Genes & Dev. , vol.18 , pp. 2905-2915
    • Ventura, J.J.1    Cogswell, P.2    Flavell, R.A.3    Baldwin, A.S.4    Davis, R.J.5
  • 107
    • 84902087184 scopus 로고    scopus 로고
    • A dangerous duo in adipose tissue: high-mobility group box 1 protein and macrophages
    • Wagner, M., A dangerous duo in adipose tissue: high-mobility group box 1 protein and macrophages. Yale J. Biol. Med. 87 (2014), 127–133.
    • (2014) Yale J. Biol. Med. , vol.87 , pp. 127-133
    • Wagner, M.1
  • 109
    • 84943231922 scopus 로고    scopus 로고
    • Plasma hmgb-1 levels in subjects with obesity and type 2 diabetes: a cross-sectional study in China
    • Wang, H., Qu, H., Deng, H., Plasma hmgb-1 levels in subjects with obesity and type 2 diabetes: a cross-sectional study in China. PloS One, 10, 2015, e0136564.
    • (2015) PloS One , vol.10 , pp. e0136564
    • Wang, H.1    Qu, H.2    Deng, H.3
  • 110
    • 84995743402 scopus 로고    scopus 로고
    • Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin b-mediated nlrp3 inflammasome activation
    • Wang, L., Chen, Y., Li, X., Zhang, Y., Gulbins, E., Zhang, Y., Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin b-mediated nlrp3 inflammasome activation. Oncotarget 7 (2016), 73229–73241.
    • (2016) Oncotarget , vol.7 , pp. 73229-73241
    • Wang, L.1    Chen, Y.2    Li, X.3    Zhang, Y.4    Gulbins, E.5    Zhang, Y.6
  • 113
    • 68249135718 scopus 로고    scopus 로고
    • Adipose tissue: the new endocrine organ? A review article
    • Wozniak, S.E., Gee, L.L., Wachtel, M.S., Frezza, E.E., Adipose tissue: the new endocrine organ? A review article. Dig. Dis. Sci. 54 (2009), 1847–1856.
    • (2009) Dig. Dis. Sci. , vol.54 , pp. 1847-1856
    • Wozniak, S.E.1    Gee, L.L.2    Wachtel, M.S.3    Frezza, E.E.4
  • 115
    • 0028304625 scopus 로고
    • Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins
    • Yan, S.D., Schmidt, A.M., Anderson, G.M., Zhang, J., Brett, J., Zou, Y.S., Pinsky, D., Stern, D., Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 269 (1994), 9889–9897.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9889-9897
    • Yan, S.D.1    Schmidt, A.M.2    Anderson, G.M.3    Zhang, J.4    Brett, J.5    Zou, Y.S.6    Pinsky, D.7    Stern, D.8
  • 117
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye, J., Gao, Z., Yin, J., He, Q., Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metabol. 293 (2007), E1118–E1128.
    • (2007) Am. J. Physiol. Endocrinol. Metabol. , vol.293 , pp. E1118-E1128
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 118
    • 33751584837 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of hmgb1 is regulated by phosphorylation that redirects it toward secretion
    • Youn, J.H., Shin, J.S., Nucleocytoplasmic shuttling of hmgb1 is regulated by phosphorylation that redirects it toward secretion. J. Immunol. 177 (2006), 7889–7897.
    • (2006) J. Immunol. , vol.177 , pp. 7889-7897
    • Youn, J.H.1    Shin, J.S.2
  • 119
    • 58149308833 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase (camk) iv mediates nucleocytoplasmic shuttling and release of hmgb1 during lipopolysaccharide stimulation of macrophages
    • Zhang, X., Wheeler, D., Tang, Y., Guo, L., Shapiro, R.A., Ribar, T.J., Means, A.R., Billiar, T.R., Angus, D.C., Rosengart, M.R., Calcium/calmodulin-dependent protein kinase (camk) iv mediates nucleocytoplasmic shuttling and release of hmgb1 during lipopolysaccharide stimulation of macrophages. J. Immunol. 181 (2008), 5015–5023.
    • (2008) J. Immunol. , vol.181 , pp. 5015-5023
    • Zhang, X.1    Wheeler, D.2    Tang, Y.3    Guo, L.4    Shapiro, R.A.5    Ribar, T.J.6    Means, A.R.7    Billiar, T.R.8    Angus, D.C.9    Rosengart, M.R.10
  • 120
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994), 425–432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.