High-mobility group protein B1: A new biomarker of metabolic syndrome in obese children

European Journal of Endocrinology

Volumn 168, Issue 4, 2013, Pages 631-638

  Arrigo, Teresa ^a   Chirico, Valeria ^a   Salpietro, Vincenzo ^a   Munafò, Caterina ^a   Ferraù, Valeria ^a   Gitto, Eloisa ^a   Lacquaniti, Antonio ^a   Salpietro, Carmelo ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 18; INTERLEUKIN 23; INTERLEUKIN 6; LIOTHYRONINE; LIPID; RESISTIN; THYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FREE LIOTHYRONINE INDEX; HUMAN; INFLAMMATION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTIVARIATE ANALYSIS; PATIENT IDENTIFICATION; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; COHORT STUDIES; FEMALE; HMGB1 PROTEIN; HUMANS; MALE; METABOLIC SYNDROME X; OBESITY;

EID: 84875143778     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0037     Document Type: Article

References (40)

1. Kurtoglu S, Akin L, Kendirci M, Hatipoglu N, Elmali F & Mazicioglu M. The absence of insulin resistance in metabolic syndrome definition leads to underdiagnosing of metabolic risk in obese patients. European Journal of Pediatrics 2012 171 1331-1337. (doi:10.1007/s00431-012-1724-6)
2. Calcaterra V, Klersy C, Muratori T, Telli S, Caramagna C, Scaglia F, Cisternino M & Larizza D. Prevalence of metabolic syndrome (MS) in children and adolescents with varying degrees of obesity. Clinical Endocrinology 2008 68 868-872. (doi:10.1111/j.1365-2265.2007.03115.x)
3. Ciprandi G, Caimmi D, Raschetti R, Miraglia Del Giudice M, Salpietro C, Caimmi S & Castellazzi AM. Adipokines and their role in allergies. International Journal of Immunopathology and Pharmacology 2011 24 13-16.
4. Schipper HS, Nuboer R, Prop S, van den Ham HJ, de Boer FK, Kesmir C, Mombers IM, van Bekkum KA, Woudstra J, Kieft JH et al. Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14(CC) monocytes. Diabetologia 2012 55 2800-2810. (doi:10.1007/s00125-012-2641-y)
5. Jeffery AN, Murphy MJ, Metcalf BS, Hosking J, Voss LD, English P, Sattar N & Wilkin TJ. Adiponectin in childhood. International Journal of Pediatric Obesity 2008 3 130-140. (doi:10.1080/17477160801954538)
6. Greenberg AS & McDaniel ML. Identifying the links between obesity, insulin resistance and b-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes. European Journal of Clinical Investigation 2002 32 24-34. (doi:10.1046/j.1365-2362.32.s3.4.x)
7. Pervanidou P & Chrousos GP. Metabolic consequences of stress during childhood and adolescence. Metabolism 2012 61 611-619. (doi:10.1016/j.metabol. 2011.10.005)
8. Cizmecioglu FM, Etiler N, Ergen A, Gormus U, Keser A, Hekim N, Hamzaoglu O & Hatun S. Association of adiponectin, resistin and high sensitive CRP level with the metabolic syndrome in childhood and adolescence. Experimental and Clinical Endocrinology & Diabetes 2009 117 622-627. (doi:10.1055/s-0028- 1112151)
9. John BJ, Irukulla S, Abulafi AM, Kumar D &MendallMA. Systematic review: adipose tissue, obesity and gastrointestinal diseases. Alimentary Pharmacology & Therapeutics 2006 23 1511-1523. (doi:10.1111/j.1365-2036. 2006.02915.x)
10. Wilkins J, Gallimore JR, Moore EG & Pepys MB. Rapid automated high sensitivity enzyme immunoassay of C-reactive protein. Clinical Chemistry 1998 44 1358-1361.
11. Bianchi ME & Beltrame M. Upwardly mobile proteins. Workshop: the role of HMG proteins in chromatin structure, gene expression and neoplasia. EMBO Reports 2000 1 109-114. (doi:10.1093/embo-reports/kvd030)
12. Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. Journal of Experimental Medicine 2000 192 565-570. (doi:10.1084/jem.192.4.565)
13. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. American Journal of Physiology. Cell Physiology 2006 290 C917-C924. (doi:10.1152/ajpcell.00401.2005)
14. Goldstein RS, Bruchfeld A, Yang L, Qureshi AR, Gallowitsch-Puerta M, Patel NB, Huston BJ, Chavan S, Rosas-Ballina M, Gregersen PK et al. Cholinergic anti-inflammatory pathway activity and high mobility group box-1 (HMGB1) serum levels in patients with rheumatoid. Molecular Medicine 2007 13 210-215. (doi:10.2119/2006-00108.Goldstein)
15. Cole TJ, Bellizzi MC, Flegal KM & Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000 320 1-6. (doi:10.1136/bmj.320.7244.1240)
16. Tanner JM & Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Archives of Disease in Childhood 1976 51 170-179. (doi:10.1136/adc.51.3.170)
17. McCarthy HD, Jarrett KV & Crawley HF. The development of waist circumference percentiles in British children aged 5.0-16.9 y. European Journal of Clinical Nutrition 2001 55 902-907. (doi:10.1038/sj.ejcn.1601240)
18. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004 114 555-576. (doi:10.1542/peds.114.2.S2.555)
19. Cole TJ, Freeman JV & Preece MA. Body mass index reference curves for the UK, 1990. Archives of Disease in Childhood 1995 73 25-29. (doi:10.1136/adc.73.1.25)
20. Ten S & Maclaren N. Insulin resistance syndrome in children. Journal ofClinical Endocrinology andMetabolism 2004 89 2526-2539. (doi:10.1210/jc.2004- 0276)
21. Haffner FM, Gonzales C, Miettinem H, Kennedy E & Stern MP. A prospective analysis of the HOMA model. Diabetes Care 1996 19 1138-1141. (doi:10.2337/diacare.19.10.1138)
22. Gungor N, Saad R, Janosky J & Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. Journal of Pediatrics 2004 144 47-55. (doi:10.1016/j.jpeds.2003.09. 045)
23. Keskin M, Kurtoglu S, Kendirci M, Atabek ME & Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005 115 e500-e503. (doi:10.1542/peds.2004-1921)
24. Invitti C, Guzzaloni G, Gilardini L, Morabito F & Viberti G. Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabetes Care 2003 26 118-124. (doi:10.2337/diacare.26.1.118)
25. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J et al. Obesity and the metabolic syndrome in children and adolescents. New England Journal of Medicine 2004 350 2362-2374. (doi:10.1056/NEJMoa031049)
26. Siervo M, Ruggiero D, Sorice R, Nutile T, Aversano M, Iafusco M, Vetrano F, Wells JC, Stephan BC & Ciullo M. Body mass index is directly associated with biomarkers of angiogenesis and inflammation in children and adolescents. Nutrition 2012 28 262-266. (doi:10.1016/j.nut.2011.06.007)
27. Dedoussis GV, Kapiri A, Samara A, Dimitriadis D, Lambert D, Pfister M, Siest G & Visvikis-Siest S. Expression of inflammatory molecules and associations with BMI in children. European Journal of Clinical Investigation 2010 40 388-392. (doi:10.1111/j.1365-2362.2010.02277.x)
28. Garanty-Bogacka B, Syrenicz M, Goral J, Krupa B, Syrenicz J, Walczak M & Syrenicz A. Changes in inflammatory biomarkers after successful lifestyle intervention in obese children. Endokrynologia Polska 2011 62 499-505.
29. Park H, Jung Yul Park J & Yuc R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Research and Clinical Practice 2005 69 29-35. (doi:10.1016/j.diabres.2004.11. 007)
30. Scaffidi P, Misteli T & Bianchi ME. Release of chromatin protein HMGB1 by necrotic cell triggers inflammation. Nature 2002 418 191-195. (doi:10.1038/nature00858)
31. O'Connor KA, Hansen MK, Rachal Pugh C, Deak MM, Biedenkapp JC, Milligan ED, Johnson JD, Wang H, Maier SF, Tracey KJ et al. Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine 2003 24 254-265. (doi:10.1016/j.cyto.2003.08.001)
32. Brufani C, Manco M, Nobili V, Fintini D, Barbetti F & Cappa M. Thyroid function tests in obese prepubertal children: correlations with insulin sensitivity and body fat distribution. Hormone Research in Paediatrics 2012 78 100-105. (doi:10.1159/000341363)
33. Pacifico L, Anania C, Ferraro F, Andreoli GM & Chiesa C. Thyroid function in childhood obesity and metabolic comorbidity. Clinica Chimica Acta 2012 413 396-405. (doi:10.1016/j.cca.2011.11.013)
34. D'Adamo E, De Leonibus C, Giannini C, Corazzini V, De Remigis A, Chiarelli F & Mohn A. Thyroid dysfunction in obese pre-pubertal children: oxidative stress as a potential pathogenetic mechanism. Free Radical Research 2012 46 303-309. (doi:10.3109/10715762.2011.653967)
35. Gong W, Li Y, Chao F, Huang G & He F. Amino acid residues 201-205 in C-terminal acidic tail region plays a crucial role in antibacterial activity of HMGB1. Journal of Biomedical Science 2009 16 83. (doi:10.1186/1423-0127-16-83)
36. Wang H, Zhu S, Zhou R, LiW& Sama AE. Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Reviews in Molecular Medicine 2008 10 e32. (doi:10.1017/S1462399408000884)
37. Youn JH, Oh YJ, Kim ES, Choi JE & Shin JS. High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharidemediated TNF-a production in human monocytes. Journal of Immunology 2008 180 5067-5074.
38. Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, Susarla SM, Ulloa L, Wang H, DiRaimo R et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. PNAS 2004 101 296-301. (doi:10.1073/pnas.2434651100)
39. Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson MA & Fan J. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. Journal of Immunology 2009 182 572-580.
40. Papoutsakis C, Yannakoulia M, Ntalla I & Dedoussis GV. Metabolic syndrome in a Mediterranean pediatric cohort: prevalence using International Diabetes Federation-derived criteria and associations with adiponectin and leptin. Metabolism 2012 61 140-145. (doi:10.1016/j.metabol.2011.06.006)