Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation

Oncotarget

Volumn 7, Issue 45, 2016, Pages 73229-73241

  Wang, Lei ^a,b   Chen, Yang ^b   Li, Xiang ^b,c   Zhang, Youzhi ^c   Gulbins, Erich ^d   Zhang, Yang ^b,c  

^a SUN YAT SEN UNIVERSITY   (China)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Cathepsin B; Free fatty acid; Inflammasome; Obesity; Tight junction

Indexed keywords

CA 074ME; CATHEPSIN B; CATHEPSIN B INHIBITOR; CRYOPYRIN; FATTY ACID; GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; PALMITIC ACID; PROTEIN ZO1; PROTEIN ZO2; TYROSYLVALYLALANYLASPARTATE CHLOROMETHYL KETONE; UNCLASSIFIED DRUG; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIAL CELL; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DELETION; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LYSOSOME; MALE; MOUSE; NLRP3 GENE; NONHUMAN; OBESITY; TIGHT JUNCTION; ANIMAL; CAPILLARY PERMEABILITY; CARDIAC MUSCLE; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PERMEABILITY;

ANIMALS; CAPILLARY PERMEABILITY; CASPASE 1; CATHEPSIN B; CELLS, CULTURED; DIET, HIGH-FAT; ENDOTHELIAL CELLS; FATTY ACIDS, NONESTERIFIED; GENE DELETION; HMGB1 PROTEIN; INFLAMMASOMES; LYSOSOMES; MALE; MICE; MICE, KNOCKOUT; MYOCARDIUM; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PALMITATES; PERMEABILITY; TIGHT JUNCTIONS;

EID: 84995743402     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.12302     Document Type: Article

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