Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production

Molecular Therapy

Volumn 24, Issue 5, 2016, Pages 915-925

  Yao, Yingying ^a,b   Wang, Yi ^a,b   Zhang, Zhijun ^a   He, Long ^a   Zhu, Jianghui ^a   Zhang, Meng ^a   He, Xiaoyu ^a   Cheng, Zhenshun ^c   Ao, Qilin ^b   Cao, Yong ^a,b   Yang, Ping ^a   Su, Yunchao ^d   Zhao, Jianping ^b   Zhang, Shu ^a   Yu, Qilin ^a   Ning, Qin ^b   Xiang, Xudong ^e   Xiong, Weining ^a,b   Wang, Cong Yi ^a   Xu, Yongjian ^a,b  

^a Tongji Hospital   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c WUHAN UNIVERSITY   (China)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; BLEOMYCIN; CCAAT ENHANCER BINDING PROTEIN; COLLAGEN TYPE 1; FIBRONECTIN; INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA; DDIT3 PROTEIN, HUMAN; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ADULT; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; HUMAN TISSUE; LUNG FIBROSIS; MACROPHAGE; MALE; MIDDLE AGED; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; AGED; ANIMAL; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; GENETICS; METABOLISM; MOUSE; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION;

AGED; ANIMALS; BLEOMYCIN; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; MACROPHAGES; MALE; MICE; MIDDLE AGED; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSFORMING GROWTH FACTOR BETA;

EID: 84961219525     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2016.36     Document Type: Article

References (39)

1. Kolb M and Collard HR (2014). Staging of idiopathic pulmonary fibrosis: past, present and future. Eur Respir Rev 23: 220-224.
2. Raghu G, Behr J, Brown KK, Egan JJ, Kawut SM, Flaherty KR, et al.; ARTEMIS-IPF Investigators (2013). Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med 158: 641-649.
3. Shulgina L, Cahn AP, Chilvers ER, Parfrey H, Clark AB, Wilson EC, et al. (2013). Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: a randomised controlled trial. Thorax 68: 155-162.
4. Wynn TA (2011). Integrating mechanisms of pulmonary fibrosis. J Exp Med 208: 1339-1350.
5. Sica A and Mantovani A (2012). Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122: 787-795.
6. Lawrence T and Natoli G (2011). Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 11: 750-761.
7. Ji WJ, Ma YQ, Zhou X, Zhang YD, Lu RY, Sun HY, et al. (2014). Temporal and spatial characterization of mononuclear phagocytes in circulating, lung alveolar and interstitial compartments in a mouse model of bleomycin-induced pulmonary injury. J Immunol Methods 403: 7-16.
8. Murray LA, Rosada R, Moreira AP, Joshi A, Kramer MS, Hesson DP, et al. (2010). Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages. PLoS One 5: e9683.
9. Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, et al. (2014). Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. J Immunol 193: 2801-2811.
10. Gharib SA, Johnston LK, Huizar I, Birkland TP, Hanson J, Wang Y, et al. (2014). MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis. J Leukoc Biol 95: 9-18.
11. Song E, Ouyang N, Horbelt M, Antus B, Wang M and Exton MS (2000). Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol 204: 19-28.
12. Hengstermann A and Müller T (2008). Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-proteinresponse-dependent PERK pathway of cell survival. Free Radic Biol Med 44: 1097-1107.
13. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, et al. (2002). Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532.
14. Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, et al. (2005). CHOP/ GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem 95: 974-986.
15. Yang JR, Yao FH, Zhang JG, Ji ZY, Li KL, Zhan J, et al. (2014). Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway. Am J Physiol Renal Physiol 306: F75-F84.
16. Namba T, Tanaka K, Ito Y, Ishihara T, Hoshino T, Gotoh T, et al. (2009). Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol 174: 1786-1798.
17. Oh J, Riek AE, Weng S, Petty M, Kim D, Colonna M, et al. (2012). Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem 287: 11629-11641.
18. Gordon S and Martinez FO (2010). Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604.
19. Stevenson NJ, Addley MR, Ryan EJ, Boyd CR, Carroll HP, Paunovic V, et al. (2009). CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J Leukoc Biol 85: 289-297.
20. Whyte CS, Bishop ET, Rückerl D, Gaspar-Pereira S, Barker RN, Allen JE, et al. (2011). Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol 90: 845-854.
21. Korfei M, Ruppert C, Mahavadi P, Henneke I, Markart P, Koch M, et al. (2008). Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 178: 838-846.
22. Bloom JW (1987). The interaction of rDNA factor VIII, factor VIIIdes-797-1562 and factor VIIIdes-797-1562-derived peptides with phospholipid. Thromb Res 48: 439-448.
23. Belperio JA, Dy M, Murray L, Burdick MD, Xue YY, Strieter RM, et al. (2004). The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis. J Immunol 173: 4692-4698.
24. Pechkovsky DV, Prasse A, Kollert F, Engel KM, Dentler J, Luttmann W, et al. (2010). Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin Immunol 137: 89-101.
25. Wei Q, Sha Y, Bhattacharya A, Abdel Fattah E, Bonilla D, Jyothula SS, et al. (2014). Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. Am J Respir Crit Care Med 189: 16-29.
26. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, et al. (2007). Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447: 1116-1120.
27. Dickensheets H, Vazquez N, Sheikh F, Gingras S, Murray PJ, Ryan JJ, et al. (2007). Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling. Genes Immun 8: 21-27.
28. Batchvarova N, Wang XZ and Ron D (1995). Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J 14: 4654-4661.
29. Cui TX, Lin G, LaPensee CR, Calinescu AA, Rathore M, Streeter C, et al. (2011). C/EBP-mediates growth hormone-regulated expression of multiple target genes. Mol Endocrinol 25: 681-693.
30. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, et al.; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis (2011). An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 183: 788-824.
31. Gong S, Li J, Ma L, Li K, Zhang L, Wang G, et al. (2013). Blockade of dopamine D1-like receptor signalling protects mice against OVA-induced acute asthma by inhibiting B-cell activating transcription factor signalling and Th17 function. FEBS J 280: 6262-6273.
32. Zou R, He Y, Li YQ, Han M, Ma ZF, Liu XC, et al. (2014). Telmisartan protects 5/6 Nx rats against renal injury by enhancing nNOS-derived NO generation via regulation of PPAR-signaling. Am J Transl Res 6: 517-527.
33. Ashcroft T, Simpson JM and Timbrell V (1988). Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41: 467-470.
34. Zhong J, Yu Q, Yang P, Rao X, He L, Fang J, et al. (2014). MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis. J Autoimmun 53: 95-104.
35. Schwegmann A, Guler R, Cutler AJ, Arendse B, Horsnell WG, Flemming A, et al. (2007). Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proc Natl Acad Sci USA 104: 16251-16256.
36. Yang P, Zhang Y, Pang J, Zhang S, Yu Q, He L, et al. (2013). Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities. Am J Pathol 183: 617-625.
37. Ran L, Yu Q, Zhang S, Xiong F, Cheng J, Yang P, et al. (2015). Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages. Dis Model Mech 8: 691-700.
38. Zhang S, Lv JW, Yang P, Yu Q, Pang J, Wang Z, et al. (2012). Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling. Am J Pathol 181: 937-946.
39. Zhong J, Yang P, Muta K, Dong R, Marrero M, Gong F, et al. (2010). Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock. PLoS One 5: e9593.