Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation

Biochemical and Biophysical Research Communications

Volumn 354, Issue 1, 2007, Pages 45-49

  Suganami, Takayoshi ^a   Mieda, Tae ^a   Itoh, Michiko ^a   Shimoda, Yuri ^a   Kamei, Yasutomi ^a   Ogawa, Yoshihiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adipocytes; C3H HeJ mice; Fatty acids; Inflammation; Macrophages; Obesity; Toll like receptor 4 (TLR4); Tumor necrosis factor (TNF )

Indexed keywords

MESSENGER RNA; MUTANT PROTEIN; SATURATED FATTY ACID; TOLL LIKE RECEPTOR 4;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C3H MOUSE; CELL STRAIN 3T3; COCULTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MUTATION; HYPERTROPHY; INFLAMMATION; LIPID DIET; LIPOLYSIS; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR GENE; TLR4 GENE;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; MALE; MICE; MICE, INBRED C3H; MUTATION; OBESITY; PANNICULITIS; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 33846302361     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.190     Document Type: Article

References (20)

1. Montague C.T., and O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49 (2000) 883-888
2. Matsuzawa Y., Funahashi T., and Nakamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann. N. Y. Acad. Sci. 892 (1999) 146-154
3. Lyon C.J., Law R.E., and Hsueh W.A. Minireview: adiposity, inflammation, and atherogenesis. Endocrinology 144 (2003) 2195-2200
4. Berg A.H., and Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ. Res. 96 (2005) 939-949
5. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., and Ferrante Jr. A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112 (2003) 1796-1808
6. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., Sole J., Nichols A., Ross J.S., Tartaglia L.A., and Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112 (2003) 1821-1830
7. Suganami T., Nishida J., and Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2062-2068
8. Dresner A., Laurent D., Marcucci M., Griffin M.E., Dufour S., Cline G.W., Slezak L.A., Andersen D.K., Hundal R.S., Rothman D.L., Petersen K.F., and Shulman G.I. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103 (1999) 253-259
9. Boden G., She P., Mozzoli M., Cheung P., Gumireddy K., Reddy P., Xiang X., Luo Z., and Ruderman N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54 (2005) 3458-3465
10. Nguyen M.T., Satoh H., Favelyukis S., Babendure J.L., Imamura T., Sbodio J.I., Zalevsky J., Dahiyat B.I., Chi N.W., and Olefsky J.M. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J. Biol. Chem. 280 (2005) 35361-35371
11. Park J., Choe S.S., Choi A.H., Kim K.H., Yoon M.J., Suganami T., Ogawa Y., and Kim J.B. Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals. Diabetes 55 (2006) 2939-2949
12. Lee J.Y., Sohn K.H., Rhee S.H., and Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276 (2001) 16683-16689
13. Suganami T., Tanimoto-Koyama K., Nishida J., Itoh M., Yuan X., Mizuarai S., Kotani H., Yamaoka S., Miyake K., Aoe S., Kamei Y., and Ogawa Y. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 84-91
14. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 282 (1998) 2085-2088
15. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
16. Kitagawa K., Wada T., Furuichi K., Hashimoto H., Ishiwata Y., Asano M., Takeya M., Kuziel W.A., Matsushima K., Mukaida N., and Yokoyama H. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am. J. Pathol. 165 (2004) 237-246
17. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., and Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 116 (2006) 1784-1792
18. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., Furuyama N., Kondo H., Takahashi M., Arita Y., Komuro R., Ouchi N., Kihara S., Tochino Y., Okutomi K., Horie M., Takeda S., Aoyama T., Funahashi T., and Matsuzawa Y. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 8 (2002) 731-737
19. Song M.J., Kim K.H., Yoon J.M., and Kim J.B. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem. Biophys. Res. Commun. 346 (2006) 739-745
20. Shi H., Kokoeva M.V., Inouye K., Tzameli I., Yin H., and Flier J.S. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116 (2006) 3015-3025