Fatty acids trigger mitochondrion-dependent necrosis

Cell Cycle

Volumn 9, Issue 14, 2010, Pages 2908-2914

  Rockenfeller, Patrick ^a   Ring, Julia ^a   Muschett, Vera ^a   Beranek, Andreas ^b   Buettner, Sabrina ^a   Carmona Gutierrez, Didac ^a   Eisenberg, Tobias ^a   Khoury, Chamel ^a   Rechberger, Gerald ^a   Kohlwein, Sepp D ^a   Kroemer, Guido ^c   Madeo, Frank ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c INSERM   (France)

Author keywords

Cell death; Fatty acid stress; Lipotoxicity; Necrosis; Nutrition

Indexed keywords

COOKING FAT; FATTY ACID; HIGH MOBILITY GROUP B1 PROTEIN; MITOCHONDRIAL DNA; OIL; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL FUNCTION; CELL MEMBRANE; CONTROLLED STUDY; FATTY ACID DESATURATION; MICROENVIRONMENT; MITOCHONDRION; NECROSIS; NONHUMAN; NUTRITION; SMALL INTESTINE; YEAST CELL;

EID: 77956839027     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.14.12346     Document Type: Article

References (59)

1. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000; 894:1-12.
2. Kopelman PG. Obesity as a medical problem. Nature 2000; 404:20-2.
3. Lopez S, Bermudez B, Pacheco YM, Villar J, Abia R, Muriana FJ. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 2008; 88:638-44.
4. Rockenfeller P, Madeo F. Ageing and eating. Biochim Biophys Acta 1803:499-506.
5. Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat- and obesity-induced insulin resistance. Cell Metab 2007; 5:167-79.
6. Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 2001; 276:14890-5.
7. de Pablo MA, Susin SA, Jacotot E, Larochette N, Costantini P, Ravagnan L, et al. Palmitate induces apoptosis via a direct effect on mitochondria. Apoptosis 1999; 4:81-7.
8. Sparagna GC, Hickson-Bick DL, Buja LM, McMillin JB. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 2000; 279:2124-32.
9. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S. ROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS. Mol Interv 2005; 5:94-111.
10. Kagan VE, Borisenko GG, Tyurina YY, Tyurin VA, Jiang J, Potapovich AI, et al. Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine. Free Radic Biol Med 2004; 37:1963-85.
11. Ostrander DB, Sparagna GC, Amoscato AA, McMillin JB, Dowhan W. Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis. J Biol Chem 2001; 276:38061-7.
12. Scorrano L, Penzo D, Petronilli V, Pagano F, Bernardi P. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling. J Biol Chem 2001; 276:12035-40.
13. Garbarino J, Padamsee M, Wilcox L, Oelkers PM, D'Ambrosio D, Ruggles KV, et al. Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem 2009; 284:30994-1005.
14. Pineau L, Colas J, Dupont S, Beney L, Fleurat-Lessard P, Berjeaud JM, et al. Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids. Traffic 2009; 10:673-90.
15. Zhang Q, Chieu HK, Low CP, Zhang S, Heng CK, Yang H. Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase. J Biol Chem 2003; 278:47145-55.
16. Walker NI, Harmon BV, Gobe GC, Kerr JF. Patterns of cell death. Methods Achiev Exp Pathol 1988; 13:18-54.
17. Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol 2009.
18. Vanlangenakker N, Vanden Berghe T, Krysko DV, Festjens N, Vandenabeele P. Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med 2008; 8:207-20.
19. Galluzzi L, Kepp O, Kroemer G. RIP kinases initiate programmed necrosis. J Mol Cell Biol 2009; 1:8-10.
20. Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 2006; 1757:1371-87.
21. Kalai M, Van Loo G, Vanden Berghe T, Meeus A, Burm W, Saelens X, et al. Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ 2002; 9:981-94.
22. Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J Biol Chem 1992; 267:5317-23.
23. Zong WX, Thompson CB. Necrotic death as a cell fate. Genes Dev 2006; 20:1-15.
24. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000; 21:383-421.
25. Golstein P, Kroemer G. Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 2007; 32:37-43.
26. Syntichaki P, Tavernarakis N. The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci 2003; 4:672-84.
27. Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 2009; 11:1305-14.
28. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, et al. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 2004; 166:1055-67.
29. Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, Wissing S, et al. Chronological aging leads to apoptosis in yeast. J Cell Biol 2004; 164:501-7.
30. Rockenfeller P, Madeo F. Apoptotic death of ageing yeast. Exp Gerontol 2008; 43:876-81.
31. Madeo F, Eisenberg T, Buttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy 6:160-2.
32. Carmona-Gutierrez D, Ruckenstuhl C, Bauer MA, Eisenberg T, Buttner S, Madeo F. Cell death in yeast: growing applications of a dying buddy. Cell Death Differ 17:733-4.
33. Galluzzi L, Blomgren K, Kroemer G. Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 2009; 10:481-94.
34. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87:99-163. (Pubitemid 46209992)
35. Madeo F, Carmona-Gutierrez D, Ring J, Buttner S, Eisenberg T, Kroemer G. Caspase-dependent and caspase-independent cell death pathways in yeast. Biochem Biophys Res Commun 2009; 382:227-31.
36. Proskuryakov SY, Konoplyannikov AG, Gabai VL. Necrosis: a specific form of programmed cell death? Exp Cell Res 2003; 283:1-16.
37. Vanden Berghe T, Kalai M, van Loo G, Declercq W, Vandenabeele P. Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. J Biol Chem 2003; 278:5622-9.
38. Black PN, DiRusso CC. Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim Biophys Acta 2007; 1771:286-98.
39. Petschnigg J, Wolinski H, Kolb D, Zellnig G, Kurat CF, Natter K, et al. Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast. J Biol Chem 2009; 284:30981-93.
40. Brownlee IA, Forster DJ, Wilcox MD, Dettmar PW, Seal CJ, Pearson JP. Physiological parameters governing the action of pancreatic lipase. Nutr Res Rev 1-9.
41. Eisenberg T, Carmona-Gutierrez D, Buttner S, Tavernarakis N, Madeo F. Necrosis in yeast. Apoptosis.
42. Mathieu P, Lemieux I, Despres JP. Obesity, inflammation and cardiovascular risk. Clin Pharmacol Ther 87:407-16.
43. Proskuryakov SY, Gabai VL, Konoplyannikov AG. Necrosis is an active and controlled form of programmed cell death. Biochemistry (Mosc) 2002; 67:387-408.
44. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, et al. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005; 434:652-8.
45. Temkin V, Huang Q, Liu H, Osada H, Pope RM. Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol 2006; 26:2215-25.
46. Carneiro LA, Travassos LH, Soares F, Tattoli I, Magalhaes JG, Bozza MT, et al. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe 2009; 5:123-36.
47. Galluzzi L, Kroemer G. Shigella targets the mitochondrial checkpoint of programmed necrosis. Cell Host Microbe 2009; 5:107-9.
48. Skulachev VP. Bioenergetic aspects of apoptosis, necrosis and mitoptosis. Apoptosis 2006; 11:473-85.
49. Jungwirth H, Ring J, Mayer T, Schauer A, Buttner S, Eisenberg T, et al. Loss of peroxisome function triggers necrosis. FEBS Lett 2008; 582:2882-6.
50. Sripriya P, Vedantam LV, Podile AR. Involvement of mitochondria and metacaspase elevation in harpin Pss-induced cell death of Saccharomyces cerevisiae. J Cell Biochem 2009; 107:1150-9.
51. Bener Aksam E, Jungwirth H, Kohlwein SD, Ring J, Madeo F, Veenhuis M, et al. Absence of the peroxiredoxin Pmp20 causes peroxisomal protein leakage and necrotic cell death. Free Radic Biol Med 2008; 45:1115-24.
52. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci USA 2003; 100:3077-82.
53. Evans MV, Turton HE, Grant CM, Dawes IW. Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response. J Bacteriol 1998; 180:483-90.
54. Cipak A, Hasslacher M, Tehlivets O, Collinson EJ, Zivkovic M, Matijevic T, et al. Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. Free Radic Biol Med 2006; 40:897-906.
55. Madeo F, Frohlich E, Frohlich KU. A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 1997; 139:729-34.
56. Wissing S, Ludovico P, Herker E, Buttner S, Engelhardt SM, Decker T, et al. An AIF orthologue regulates apoptosis in yeast. J Cell Biol 2004; 166:969-74.
57. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957; 226:497-509.
58. Schneiter R, Daum G. Analysis of yeast lipids. Methods Mol Biol 2006; 313:75-84.
59. Morrison WR, Smith LM. Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride - Methanol. J Lipid Res 1964; 5:600-8.