Allelic variation in the toll-like receptor adaptor protein Ticam2 contributes to SARS-coronavirus pathogenesis in mice

G3: Genes, Genomes, Genetics

Volumn 7, Issue 6, 2017, Pages 1653-1663

  Gralinski, E ^a   Menachery, Vineet D ^a   Morgan, Andrew P ^b   Totura, Allison L ^b   Beall, Anne ^b   Kocher, Jacob ^a   Plante, Jessica ^a   Harrison Shostak, D Corinne ^b   Schäfer, Alexandra ^a   Villena, Fernando Pardo Manuel ^b,c   Ferris, Martin T ^b   Baric, Ralph S ^a,b,c  

^a IL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Collaborative Cross; F2; Host susceptibility genes; MPP; Multi parent Advanced Generation Inter Cross (MAGIC); Multiparental populations; SARS CoV; Ticam2

Indexed keywords

TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 12; CHROMOSOME 15; CHROMOSOME 18; CHROMOSOME 7; CHROMOSOME 9; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC VARIATION; LUNG HEMORRHAGE; MALE; MOUSE; NONHUMAN; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SIGNAL TRANSDUCTION; TICAM2 GENE; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS TITRATION; WEIGHT REDUCTION; ANIMAL; CELL LINE; CHROMOSOMAL MAPPING; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOST PATHOGEN INTERACTION; KNOCKOUT MOUSE; PHYSIOLOGY; VIROLOGY;

ALLELES; ANIMALS; CELL LINE; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HOST-PATHOGEN INTERACTIONS; MALE; MICE; MICE, KNOCKOUT; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL LOAD;

EID: 85020271369     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.117.041434     Document Type: Article

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