The Asp 299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF

Journal of Immunology

Volumn 188, Issue 9, 2012, Pages 4506-4515

  Figueroa, Leandra ^a,b   Xiong, Yanbao ^a   Song, Chang ^a   Piao, Wenji ^a   Vogel, Stefanie N ^a   Medvedev, Andrei E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; BETA INTERFERON; CD14 ANTIGEN; GLYCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; YELLOW FLUORESCENT PROTEIN; LY96 PROTEIN, HUMAN; LY96 PROTEIN, MOUSE; MYD88 PROTEIN, HUMAN; MYD88 PROTEIN, MOUSE; PROTEIN KINASE; PROTEIN MD 2; TICAM 1 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; TICAM1 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DIMERIZATION; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOPRECIPITATION; MACROPHAGE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; WILD TYPE; ANIMAL; CELL CULTURE; CELL STRAIN HEK293; CYTOLOGY; DRUG EFFECT; GENETIC POLYMORPHISM; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELLS, CULTURED; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHOSPHORYLATION; POLYMORPHISM, GENETIC; PROTEIN KINASES; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84860340474     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200202     Document Type: Article

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