TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Akbarshahi, Hamid ^a   Axelsson, Jakob B F ^a   Said, Katarzyna ^a   Malmström, Anders ^b   Fischer, Hans ^b   Andersson, Roland ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Heparan sulphate; Inflammation; Interferon regulatory factor 3; Pancreas; Toll like receptor 4

Indexed keywords

HEPARAN SULFATE; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; MYELOPEROXIDASE; PHOSPHATE BUFFERED SALINE; RANTES; TOLL LIKE RECEPTOR 4; 3 O DECYL 2 DEOXY 6 O (2 DEOXY 3 O (3 METHOXYDECYL) 6 O METHYL 2 ((1 OXO 11 OCTADECENYL)AMINO) 4 O PHOSPHONOGLUCOPYRANOSYL) 2 ((1,3 DIOXOTETRADECYL)AMINO) 1 (DIHYDROXY PHOSPHATE)GLUCOPYRANOSE; 3-O-DECYL-2-DEOXY-6-O-(2-DEOXY-3-O-(3-METHOXYDECYL)-6-O-METHYL-2-((1-OXO-11-OCTADECENYL)AMINO)-4-O-PHOSPHONOGLUCOPYRANOSYL)-2-((1,3-DIOXOTETRADECYL)AMINO)-1-(DIHYDROXY PHOSPHATE)GLUCOPYRANOSE; CHEMOTACTIC FACTOR; CYTOKINE; DISACCHARIDE; IRF3 PROTEIN, MOUSE; PEROXIDASE; SUGAR PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENETIC ENGINEERING; INNATE IMMUNITY; KNOCKOUT MOUSE; MALE; MOUSE; MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PANCREAS DUCT; PANCREATITIS; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; DRUG EFFECT; INFLAMMATION; METABOLISM; MOUSE MUTANT; PANCREAS; PATHOLOGY; TIME;

ANIMALS; CHEMOKINE CCL5; CHEMOTACTIC FACTORS; CYTOKINES; DISACCHARIDES; HEPARITIN SULFATE; INFLAMMATION; INTERFERON REGULATORY FACTOR-3; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; PANCREAS; PEROXIDASE; SUGAR PHOSPHATES; TIME FACTORS; TOLL-LIKE RECEPTOR 4;

EID: 83755173986     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-219     Document Type: Article

References (26)

1. Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 2007, 446:1030-1037. 10.1038/nature05817, 17460664.
2. Sasisekharan R, Shriver Z, Venkataraman G, Narayanasami U. Roles of heparan-sulphate glycosaminoglycans in cancer. Nat Rev Cancer 2002, 2:521-528. 10.1038/nrc842, 12094238.
3. Bernfield M, Gotte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, Zako M. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 1999, 68:729-777. 10.1146/annurev.biochem.68.1.729, 10872465.
4. Juuti A, Nordling S, Lundin J, Louhimo J, Haglund C. Syndecan-1 expression--a novel prognostic marker in pancreatic cancer. Oncology 2005, 68:97-106. 10.1159/000085702, 15886501.
5. Ledin J, Staatz W, Li JP, Gotte M, Selleck S, Kjellen L, Spillmann D. Heparan sulfate structure in mice with genetically modified heparan sulfate production. J Biol Chem 2004, 279:42732-42741. 10.1074/jbc.M405382200, 15292174.
6. Axelsson JB, Akbarshahi H, Said K, Malmstrom A, Andersson R. Proposed protective mechanism of the pancreas in the rat. J Inflamm (Lond) 2010, 7:24.
7. Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010, 2010.
8. Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002, 168:5233-5239.
9. Fransson LA, Sjoberg I, Havsmark B. Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination. Eur J Biochem 1980, 106:59-69.
10. Westergren-Thorsson G, Onnervik PO, Fransson LA, Malmstrom A. Proliferation of cultured fibroblasts is inhibited by L-iduronate-containing glycosaminoglycans. J Cell Physiol 1991, 147:523-530. 10.1002/jcp.1041470319, 2066370.
11. Ekman-Ordeberg G, Malmstrom A. Use of sulfated glycosaminoglycans for establishing effective labor in women. International Patent. SEO200005-7 2003,
12. Gorbet MB, Sefton MV. Endotoxin: the uninvited guest. Biomaterials 2005, 26:6811-6817. 10.1016/j.biomaterials.2005.04.063, 16019062.
13. Axelsson J, Norrman G, Malmstrom A, Westrom B, Andersson R. Initiation of acute pancreatitis by heparan sulphate in the rat. Scand J Gastroenterol 2008, 43:480-489. 10.1080/00365520701733814, 18365914.
14. Koike K, Moore FA, Moore EE, Poggetti RS, Tuder RM, Banerjee A. Endotoxin after gut ischemia/reperfusion causes irreversible lung injury. J Surg Res 1992, 52:656-662. 10.1016/0022-4804(92)90145-P, 1326681.
15. Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007, 130:906-917. 10.1016/j.cell.2007.08.002, 17803912.
16. Fischer H, Lutay N, Ragnarsdottir B, Yadav M, Jonsson K, Urbano A, Al Hadad A, Ramisch S, Storm P, Dobrindt U, et al. Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection. PLoS Pathog 2010, 6.
17. Fischer H, Ellstrom P, Ekstrom K, Gustafsson L, Gustafsson M, Svanborg C. Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4. Cell Microbiol 2007, 9:1239-1251. 10.1111/j.1462-5822.2006.00867.x, 17223929.
18. Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, Marsche G, Young MF, Mihalik D, Gotte M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005, 115:2223-2233. 10.1172/JCI23755, 1174916, 16025156.
19. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simon JC. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002, 195:99-111. 10.1084/jem.20001858, 2196009, 11781369.
20. Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S, Przetak M, Chow J, Gusovsky F, Christ WJ, Rossignol DP. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 2003, 304:1093-1102.
21. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003, 301:640-643. 10.1126/science.1087262, 12855817.
22. Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 2003, 198:1043-1055. 10.1084/jem.20031023, 2194210, 14517278.
23. Johnston B, Burns AR, Suematsu M, Issekutz TB, Woodman RC, Kubes P. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. J Clin Invest 1999, 103:1269-1276. 10.1172/JCI5208, 408354, 10225970.
24. Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol 2004, 287:G919-928. 10.1152/ajpgi.00372.2003, 15205118.
25. Hui KP, Lee SM, Cheung CY, Ng IH, Poon LL, Guan Y, Ip NY, Lau AS, Peiris JS. Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J Immunol 2009, 182:1088-1098.
26. Pan ZZ, Parkyn L, Ray A, Ray P. Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils. Am J Physiol Lung Cell Mol Physiol 2000, 279:L658-666.