Mechanisms of disease: The role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases

Nature Clinical Practice Gastroenterology and Hepatology

Volumn 2, Issue 9, 2005, Pages 416-422

  Fasano, Alessio ^a   Shea Donohue, Terez ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune; Innate immunity; Intestinal permeability tight junction; Toll like receptor

Indexed keywords

GAMMA INTERFERON; GLIADIN; INTERLEUKIN 1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNE DISEASE; CELIAC DISEASE; CYTOKINE RELEASE; DENDRITIC CELL; ENTERITIS; GASTROINTESTINAL DISEASE; GENE EXPRESSION; GENETIC PREDISPOSITION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INTESTINE FUNCTION; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; RISK FACTOR; TIGHT JUNCTION;

AUTOIMMUNE DISEASES; CELL MEMBRANE PERMEABILITY; GASTROINTESTINAL DISEASES; HUMANS; INTESTINAL MUCOSA;

EID: 27144489109     PISSN: 17434378     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncpgasthep0259     Document Type: Review

References (62)

1. Cooper GS and Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2: 119-125
2. Perl A (2004) Pathogenesis and spectrum of autoimmunity. Methods Mol Med 102: 1-8
3. Christen U and von Herrath MG (2004) Induction, acceleration or prevention of autoimmunity by molecular mimicry. Mol Immunol 40: 1113-1120
4. Miller A et al. (1991) Antigen-driven bystander suppression after oral administration of antigens. J Exp Med 174: 791-798
5. Rook GA and Brunet LR (2005) Microbes, immunoregulation, and the gut. Gut 54: 317-320
6. H2-skewed immunological memory induced by neonatal antibiotic treatment in mice. Clin Exp Allergy 32: 1112-1116
7. Weinstock JV et al. (2002) The possible link between de-worming and the emergence of immunological disease. J Lab Clin Med 139: 334-338
8. Dunne DW and Cooke A (2005) A worm's eye view of the immune system: consequences for evolution of human autoimmune disease. Nat Rev Immunol 5: 420-426
9. Shi H and Walker W (2002) T helper cell subclasses and clinical disease states. Curr Opin Gast 18: 711-716
10. Furuse M et al. (1993) Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol 123: 1777-1788
11. Furuse M et al. (1998) Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin. J Cell Biol 141: 1539-1550
12. Martin-Padura I et al. (1998) Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration. J Cell Biol 142: 117-127
13. Mitic LL et al. (2000) Molecular Physiology and Pathophysiology of Tight Junctions I. Tight junction structure and function: Lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol 279: G250-G254
14. Furuse M et al. (1999) Manner of Interaction of Heterogeneous Claudin Species Within and Between Tight Junction Strands. J Cell Biol 147: 891-903
15. Clayburgh DR et al. (2004) A porous defense: The leaky epithelial barrier in intestinal disease. Lab Invest 84: 282-291
16. Wang W et al. (2000) Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 113: 4435-4440
17. El Asmar R et al. (2002) Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology 123: 1607-1615
18. Lorenz RG and Newberry RD (2004) Isolated Lymphoid Follicles Can Function as Sites for Induction of Mucosal Immune Responses. Ann NY Acad Sci 1029: 44-57
19. Lorenz RG et al. (2003) Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin β Receptor, and TNF Receptor I Function. J Immunol 170: 5475-5482
20. Bjorkman PJ et al. (1987) The Foreign Antigen-Binding Site and T-Cell Recognition Regions of Class-I Histocompatibility Antigens. Nature 329: 512-518
21. Cuvelier C et al. (1987) Histopathology of Intestinal Inflammation Related to Reactive Arthritis. Gut 28: 394-401
22. Jang MH et al. (2004) Intestinal villous M cells: An antigen entry site in the mucosal epithelium. PNAS 101: 6110-6115
23. Hayday A and Viney JL (2000) The ins and outs of body surface immunology. Science 290: 97-100
24. Bilsborough J and Viney JL (2004) Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 127: 300-309
25. Rescigno M et al. (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2: 361-367
26. Mellman I and Steinman RM (2001) Dendritic Cells: Specialized and Regulated Antigen Processing Machines. Cell 106: 255-258
27. Alpan O et al. (2004) 'Educated' dendritic cells act as messengers from memory to naive T helper cells. Nat Immunol 5: 615-622
28. Rakoff-Nahoum S et al. (2004) Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis. Cell 118: 229-241
29. Cario E et al. (2004) Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127: 224-238
30. Rumio C et al. (2004) Degranulation of Paneth Cells via Toll-Like Receptor 9. Am J Pathol 165: 373-381
31. Otte JM et al. (2004) Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126: 1054-1070
32. Pasare C and Medzhitov R (2004) Toll-Dependent Control Mechanisms of CD4 T Cell Activation. Immunity 21: 733-741
33. Bashir ME et al. (2004) Toll-Like Receptor 4 Signaling by Intestinal Microbes Influences Susceptibility to Food Allergy. J Immunol 172: 6978-6987
34. Montalto M et al. (2004) Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells. Digestion 69: 225-228
35. Rosenfeldt V et al. (2004) Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J Pediatr 145: 612-616
36. Seehofer D et al. (2004) Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats. J Surg Res 117: 262-271
37. Madden KB et al. (2004) Enteric Nematodes Induce Stereotypic STAT6-Dependent Alterations in Intestinal Epithelial Cell Function. J Immunol 172: 5616-5621
38. Madden KB et al. (2002) Role of STAT6 and Mast Cells in IL-4- and IL-13-Induced Alterations in Murine Intestinal Epithelial Cell Function. J Immunol 169: 4417-4422
39. Shea-Donohue T et al. (2001) The Role of IL-4 in Heligmosomoides polygyrus-Induced Alterations in Murine Intestinal Epithelial Cell Function. J Immunol 167: 2234-2239
40. Ma TY et al. (2005) Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288: G422-G430
41. Wang F et al. (2005) Interferon-a and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression. Am J Pathol 166: 409-419
42. Bjarnason I et al. (2004) The G.U.T. of gut. Scand J Gastroenterol 39: 807-815
43. Wendling D (1992) Role of the intestine in the physiopathology of inflammatory rheumatism. Rev Rhum Mal Osteoartic 59: 389-392
44. Watts T et al. (2005) Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. PNAS 102: 2916-2921
45. Madara JL and Trier JS (1980) Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest 43: 254-261
46. Schulzke JD et al. (1998) Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatric Research 43: 435-441
47. Fasano A et al. (2000) Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355: 1518-1519
48. Clemente MG et al. (2003) Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 52: 218-223
49. Nikulina M et al. (2004) Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 173: 1925-1933
50. Thomas KE et al.: Gliadin Stimulation of Murine Macrophage Inflammatory Gene Expression and Intestinal Permeability are Myd88-Dependent. J Immunol, in revision
51. Danese S et al. (2004) Inflammatory bowel disease: The role of environmental factors. Autoimmun Rev 3: 394-400
52. D'Inca R et al. (1999) Intestinal permeability test as a predictor of clinical course in Crohn's disease. Am J Gastroenterol 94: 2956-2960
53. Wyatt J et al. (1993) Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341: 1437-1439
54. Barmeyer C et al. (2004) Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation. Am J Physiol Gastrointest Liver Physiol 286: G244-G252
55. Ivanov AI et al. (2004) Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment. Mol Biol Cell 15: 176-188
56. Carratu R et al. (1999) Altered intestinal permeability to mannitol in diabetes mellitus type I. J Pediatr Gastroenterol Nutr 28: 264-269
57. Cooper BT et al. (1987) Intestinal permeability in diabetic diarrhoea. Diabet Med 4: 49-52
58. Mooradian AD et al. (1986) Abnormal intestinal permeability to sugars in diabetes mellitus. Diabetologia 29: 221-224
59. Davin JC et al. (1988) Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies. Acta Paediatr Scand 77: 118-124
60. Rostoker G et al. (1993) Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability. Nephron 63: 286-290
61. Wigg AJ et al. (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of nonalcoholic steatohepatitis. Gut 48: 206-211
62. Yacyshyn B et al. (1996) Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability. Dig Dis Sci 41: 2493-2498