A component of innate immunity prevents bacterial biofilm development

Nature

Volumn 417, Issue 6888, 2002, Pages 552-555

  Singh, Pradeep K ^a   Parsek, Matthew R ^b   Greenberg, E Peter ^c   Welsh, Michael J ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Northwestern University   (United States)

^c W M Keck Foundation Microbial Communities   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOFILMS; DISEASES; IMMUNOLOGY;

IMMUNE SYSTEM;

MICROBIOLOGY;

LACTOFERRIN; TOBRAMYCIN;

DISEASE;

ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BACTERIUM; BIOFILM; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; DEFENSE MECHANISM; IMMUNE SYSTEM; IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

BIOFILMS; CHRONIC DISEASE; CONALBUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN PEROXIDE; IMMUNITY, NATURAL; IRON; IRON CHELATING AGENTS; LACTOFERRIN; PSEUDOMONAS AERUGINOSA; TOBRAMYCIN;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0037198693     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/417552a     Document Type: Article

References (30)

1. The role of extracellular bactericidal factors in pulmonary host defenses
2. Innate antimicrobial activity of nasal secretions
3. Antimicrobial proteins and peptides in host defense
4. Innate antimicrobial peptide protects the skin from invasive bacterial infection
5. Bacterial biofilms: A common cause of persistent infections
6. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth
7. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
8. Biofilm resistance to antimicrobial agents
9. Clinical manifestations and treatment of pulmonary infections in cystic fibrosis
10. Phylogenetic perspectives in innate immunity
11. Iron and infection: New developments and their implications
12. Decreased tear lactoferrin concentration in patients with chronic hepatitis C
13. Lysozyme and lactoferrin in sputum from patients with chronic obstructive lung disease
14. Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis
15. Concentrations of lactoferrin and iron in human milk at different stages of lactation
16. Secretory IgA does not enhance the bacteriostatic effects of iron-binding or vitamin B12-binding proteins in human colostrum
17. The zinc-reversible antimicrobial activity of neutrophil lysates and abscess fluid supernatants
18. The effects of lactoferrin on Gram-negative bacteria
19. Lactoferrin increases the susceptibility of S. epidermidis biofilms to lysozyme and vancomycin
20. One for all and all for one
21. Development and dynamics of Pseudomonas sp. biofilms
22. The biochemistry of deferrioxamine and its relation to iron metabolism
23. Iron acquisition from transferrin and lactoferrin by Pseudomonas aeruginosa pyoverdin
24. Characterization of a five-gene cluster required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa
25. Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fibrosis
26. Increased concentrations of iron and isoferritins in the lower respiratory tract of patients with stable cystic fibrosis
27. Increased iron and ferritin content of sputum from patients with cystic fibrosis or chronic bronchitis
28. The involvement of cell-to-cell signals in the development of a bacterial biofilm
29. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function
30. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development