Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Science

Volumn 313, Issue 5790, 2006, Pages 1126-1130

  Cash, Heather L ^a   Whitham, Cecilia V ^a   Behrendt, Cassie L ^a   Hooper, Lora V ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BACTERIOLOGY; CARBOHYDRATES; IMMUNOLOGY;

BACTERICIDAL LECTIN; EPITHELIAL EXPRESSION;

PROTEINS;

LECTIN;

BACTERIUM; COLONIZATION; HOST-PATHOGEN INTERACTION; MICROBIAL COMMUNITY; PROTEIN; RODENT;

ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; GERMFREE ANIMAL; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; MAMMAL CELL; MICROBIAL COLONIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; SEPSIS; SYMBIOSIS;

ANIMALS; ANTIGENS, NEOPLASM; BACTERIA; CHITIN; COLONY COUNT, MICROBIAL; GERM-FREE LIFE; GRAM-POSITIVE BACTERIA; HOMEOSTASIS; HUMANS; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; INTESTINE, SMALL; LECTINS, C-TYPE; LIGANDS; LISTERIA MONOCYTOGENES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANETH CELLS; PEPTIDOGLYCAN; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT PROTEINS; SECRETORY VESICLES; SYMBIOSIS; TUMOR MARKERS, BIOLOGICAL;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 33748039462     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1127119     Document Type: Article

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28. The authors wish to thank T. Januszewski for help with electron microscopy and D. Farrar for help with flow cytometry. This work was supported by grants from the NIH (R01 DK070855), the Crohn's and Colitis Foundation of America, and a Burroughs Wellcome Career Award in the Biomedical Sciences (to L.V.H.). H.L.C. mas supported by NIH training grant T32-AI007520. L.V.H. is on the scientific advisory board of The Dannon Company. The microarray data are held in U.S. National Center for Biotechnology Information's Gene Expression Omnibus (GEO) and the accession number is GSE5156.