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Volumn 73, Issue 12, 2005, Pages 7844-7852

Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; CLAUDIN; CLAUDIN 4; CLAUDIN 5; CYTOTOXIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; OCCLUDIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 28444489667     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.12.7844-7852.2005     Document Type: Article
Times cited : (119)

References (57)
  • 1
    • 0038780624 scopus 로고    scopus 로고
    • Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    • Amieva, M. R., R. Vogetmann, A. Covacci, L. S. Tompkins, W. J. Nelson, and S. Falkow. 2003. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300:1430-1434.
    • (2003) Science , vol.300 , pp. 1430-1434
    • Amieva, M.R.1    Vogetmann, R.2    Covacci, A.3    Tompkins, L.S.4    Nelson, W.J.5    Falkow, S.6
  • 2
    • 0031926408 scopus 로고    scopus 로고
    • Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability
    • Borch, K., C. Sjostedt, U. Hannestad, J. D. Soderholm, L. Franzen, and S. Mardh. 1998. Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability. Dig. Dis. Sci. 43:749-753.
    • (1998) Dig. Dis. Sci. , vol.43 , pp. 749-753
    • Borch, K.1    Sjostedt, C.2    Hannestad, U.3    Soderholm, J.D.4    Franzen, L.5    Mardh, S.6
  • 3
    • 0027749278 scopus 로고
    • Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens
    • Boren, T., P. Falk, K. A. Roth, G. Larson, and S. Normark. 1993. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262:1892-1895.
    • (1993) Science , vol.262 , pp. 1892-1895
    • Boren, T.1    Falk, P.2    Roth, K.A.3    Larson, G.4    Normark, S.5
  • 5
    • 0035150809 scopus 로고    scopus 로고
    • Cellular responses induced after contact with Helicobacter pylori
    • Censlni, S., M. Stein, and A. Covacci. 2001. Cellular responses induced after contact with Helicobacter pylori. Curr. Opin. Microbiol. 4:41-46.
    • (2001) Curr. Opin. Microbiol. , vol.4 , pp. 41-46
    • Censlni, S.1    Stein, M.2    Covacci, A.3
  • 6
    • 0036084962 scopus 로고    scopus 로고
    • Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner
    • Chin, A. C., D. A. Teoh, K. G.-E. Scott, J. B. Weddings, W. K. Macnaughton, and A. G. Buret. 2002. Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in a caspase-3-dependent manner. Infect. Immun. 70:3673-3680.
    • (2002) Infect. Immun. , vol.70 , pp. 3673-3680
    • Chin, A.C.1    Teoh, D.A.2    Scott, K.G.-E.3    Weddings, J.B.4    Macnaughton, W.K.5    Buret, A.G.6
  • 9
    • 0033052552 scopus 로고    scopus 로고
    • Helicobacter pylori factors associated with disease
    • Cover, T. L., and M. J. Blaser. 1999. Helicobacter pylori factors associated with disease. Gastroenterology 117:257-260.
    • (1999) Gastroenterology , vol.117 , pp. 257-260
    • Cover, T.L.1    Blaser, M.J.2
  • 10
    • 0034849908 scopus 로고    scopus 로고
    • Characterization of virulence factors of mouse-adapted Helicobacter pylori strain SS1 and effects on gastric hydrophobicity
    • Day, A. S., N. L. Jones, Z. Policova, H. A. Jennings, E. K. Yau, P. Shannon, A. W. Neumann, and P. M. Sherman. 2001. Characterization of virulence factors of mouse-adapted Helicobacter pylori strain SS1 and effects on gastric hydrophobicity. Dig. Dis. Sci. 46:1943-1951.
    • (2001) Dig. Dis. Sci. , vol.46 , pp. 1943-1951
    • Day, A.S.1    Jones, N.L.2    Policova, Z.3    Jennings, H.A.4    Yau, E.K.5    Shannon, P.6    Neumann, A.W.7    Sherman, P.M.8
  • 12
    • 0013575179 scopus 로고    scopus 로고
    • Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994
    • Dixon, M. F., R. M. Genta, J. H. Yardley, and P. Correa. 1996. Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol. 20:1161-1181.
    • (1996) Am. J. Surg. Pathol. , vol.20 , pp. 1161-1181
    • Dixon, M.F.1    Genta, R.M.2    Yardley, J.H.3    Correa, P.4
  • 13
    • 0027512558 scopus 로고
    • An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium
    • Falk, P., K. A. Roth, T. Boren, T. U. Westblom, and J. I. Gordon. 1993. An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc. Natl. Acad. Sci. USA 90:2035-2039.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2035-2039
    • Falk, P.1    Roth, K.A.2    Boren, T.3    Westblom, T.U.4    Gordon, J.I.5
  • 14
    • 0031051849 scopus 로고    scopus 로고
    • The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway
    • Fasano, A., S. Uzzau, C. Fiore, and K. Margaretten. 1997. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology 112:839-846.
    • (1997) Gastroenterology , vol.112 , pp. 839-846
    • Fasano, A.1    Uzzau, S.2    Fiore, C.3    Margaretten, K.4
  • 16
    • 0025156110 scopus 로고
    • Salmonella interactions with polarized human intestinal Caco-2 epithelial cells
    • Finlay, B. B., and S. Falkow. 1990. Salmonella interactions with polarized human intestinal Caco-2 epithelial cells. J. Infect. Dis. 162:1096-1106.
    • (1990) J. Infect. Dis. , vol.162 , pp. 1096-1106
    • Finlay, B.B.1    Falkow, S.2
  • 17
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse, M., K. Fujita, T. Hiiragi, K. Fujimoto, and S. Tsukita. 1998. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141:1539-1550.
    • (1998) J. Cell Biol. , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 18
  • 19
    • 0031082887 scopus 로고    scopus 로고
    • Decrease in gastric permeability to sucrose following cure of Helicobacter pylon infection
    • Goodgame, R. W., H. M. Malaty, H. M. El-Zimaity, and D. Y. Graham. 1997. Decrease in gastric permeability to sucrose following cure of Helicobacter pylon infection. Helicobacter 2:44-47.
    • (1997) Helicobacter , vol.2 , pp. 44-47
    • Goodgame, R.W.1    Malaty, H.M.2    El-Zimaity, H.M.3    Graham, D.Y.4
  • 21
    • 0022634633 scopus 로고
    • Campylobacter pyloridis and gastritis: Association with intercellular spaces and adaptation to an environment of mucus as important factors in the colonization of the gastric epithelium
    • Hazell, S. L., A. Lee, L. Brady, and W. Hennessy. 1986. Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in the colonization of the gastric epithelium. J. Infect. Dis. 153:658-663.
    • (1986) J. Infect. Dis. , vol.153 , pp. 658-663
    • Hazell, S.L.1    Lee, A.2    Brady, L.3    Hennessy, W.4
  • 22
    • 0035102580 scopus 로고    scopus 로고
    • The roles of claudin superfamily proteins in paracellular transport
    • Heiskala, M., P. A. Peterson, and Y. Yang. 2001. The roles of claudin superfamily proteins in paracellular transport. Traffic 2:93-98.
    • (2001) Traffic , vol.2 , pp. 93-98
    • Heiskala, M.1    Peterson, P.A.2    Yang, Y.3
  • 23
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi, H., R. Tsutsumi, S. Muto, T. Sugiyama, T. Azuma, M. Asaka, and M. Hatakeyama. 2002. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683-686.
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1    Tsutsumi, R.2    Muto, S.3    Sugiyama, T.4    Azuma, T.5    Asaka, M.6    Hatakeyama, M.7
  • 24
    • 0023917890 scopus 로고
    • ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation
    • Ishikawa, T., T. Chijiwa, M. Hagiwara, S. Mamiya, M. Saitoh, and H. Hidaka. 1988. ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation. Mol. Pharmacol. 33:598-603.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 598-603
    • Ishikawa, T.1    Chijiwa, T.2    Hagiwara, M.3    Mamiya, S.4    Saitoh, M.5    Hidaka, H.6
  • 25
    • 0032783147 scopus 로고    scopus 로고
    • Helicobacter pylon induces gastric epithelial cell apoptosis in association with increased Fas receptor expression
    • Jones, N. L., A. S. Day, H. A. Jennings, and P. M. Sherman. 1999. Helicobacter pylon induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect. Immun. 67:4237-4242.
    • (1999) Infect. Immun. , vol.67 , pp. 4237-4242
    • Jones, N.L.1    Day, A.S.2    Jennings, H.A.3    Sherman, P.M.4
  • 26
    • 0037417428 scopus 로고    scopus 로고
    • Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast
    • Kominsky, S. L., P. Argani, D. Korz, E. Evron, V. Raman, E. Garrett, A. Rein, G. Sauter, O. P. Kallioniemi, and S. Sukumar. 2003. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22:2021-2033.
    • (2003) Oncogene , vol.22 , pp. 2021-2033
    • Kominsky, S.L.1    Argani, P.2    Korz, D.3    Evron, E.4    Raman, V.5    Garrett, E.6    Rein, A.7    Sauter, G.8    Kallioniemi, O.P.9    Sukumar, S.10
  • 28
    • 16244421730 scopus 로고    scopus 로고
    • Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma
    • Lee, S. K., J. Moon, S. W. Park, S. Y. Song, J. B. Chung, and J. K. Kang. 2005. Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma. Oncol. Rep. 13:193-199.
    • (2005) Oncol. Rep. , vol.13 , pp. 193-199
    • Lee, S.K.1    Moon, J.2    Park, S.W.3    Song, S.Y.4    Chung, J.B.5    Kang, J.K.6
  • 30
    • 0024292731 scopus 로고
    • Tight junction dynamics: Is paracellular transport regulated?
    • Madara, J. L. 1988. Tight junction dynamics: is paracellular transport regulated? Cell 53:497-498.
    • (1988) Cell , vol.53 , pp. 497-498
    • Madara, J.L.1
  • 31
    • 0023510866 scopus 로고
    • Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
    • Madara, J. L., and J. R. Pappenheimer. 1987. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100:149-164.
    • (1987) J. Membr. Biol. , vol.100 , pp. 149-164
    • Madara, J.L.1    Pappenheimer, J.R.2
  • 32
    • 0037336565 scopus 로고    scopus 로고
    • Signalling to and from tight junctions
    • Matter, K., and M. S. Balda. 2003. Signalling to and from tight junctions. Nat. Rev. Mol. Cell Biol. 4:225-236.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 225-236
    • Matter, K.1    Balda, M.S.2
  • 37
    • 0347511901 scopus 로고    scopus 로고
    • Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells
    • Mitchell, D. J., H. Q. Huynh, P. J. M. Ceponis, N. L. Jones, and P. M. Sherman. 2004. Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells. Infect. Immun. 72:537-545.
    • (2004) Infect. Immun. , vol.72 , pp. 537-545
    • Mitchell, D.J.1    Huynh, H.Q.2    Ceponis, P.J.M.3    Jones, N.L.4    Sherman, P.M.5
  • 38
    • 0023546355 scopus 로고
    • Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers
    • Nash, S., J. Stafford, and J. L. Madara. 1987. Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers. J. Clin. Investig. 80:1104-1113.
    • (1987) J. Clin. Investig. , vol.80 , pp. 1104-1113
    • Nash, S.1    Stafford, J.2    Madara, J.L.3
  • 39
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit, S., J. Puls, B. Sedlmaier, E. Gerland, W. Fischer, and R. Haas. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287:1497-1500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3    Gerland, E.4    Fischer, W.5    Haas, R.6
  • 40
    • 0029934888 scopus 로고    scopus 로고
    • Immunologic, functional, and morphological characterization of three new human small intestinal epithelial cell lines
    • Pang, G., A. Buret, E. O'Loughlin, A. Smith, R. Batey, and R. Clancy. 1996. Immunologic, functional, and morphological characterization of three new human small intestinal epithelial cell lines. Gastroenterology 111:8-18.
    • (1996) Gastroenterology , vol.111 , pp. 8-18
    • Pang, G.1    Buret, A.2    O'Loughlin, E.3    Smith, A.4    Batey, R.5    Clancy, R.6
  • 41
    • 0032528956 scopus 로고    scopus 로고
    • Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin
    • Papini, E., B. Satin, N. Norais, M. de Bernard, J. L. Telford, R. Rappuoli, and C. Montecucco. 1998. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J. Clin. Investig. 102:813-820.
    • (1998) J. Clin. Investig. , vol.102 , pp. 813-820
    • Papini, E.1    Satin, B.2    Norais, N.3    De Bernard, M.4    Telford, J.L.5    Rappuoli, R.6    Montecucco, C.7
  • 42
    • 0032842774 scopus 로고    scopus 로고
    • Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity
    • Pelicic, V., J. M. Reyrat, L. Sartori, C. Pagliaccia, R. Rappuoli, J. L. Telford, C. Montecncco, and E. Papini. 1999. Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity. Microbiology 145:2043-2050.
    • (1999) Microbiology , vol.145 , pp. 2043-2050
    • Pelicic, V.1    Reyrat, J.M.2    Sartori, L.3    Pagliaccia, C.4    Rappuoli, R.5    Telford, J.L.6    Montecncco, C.7    Papini, E.8
  • 44
    • 0029815921 scopus 로고    scopus 로고
    • Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose
    • Rabassa, A. A., R. Goodgame, F. M. Sutton, C. N, Ou, C. Rognerud, and D. Y. Graham. 1996. Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose. Gut 39:159-163.
    • (1996) Gut , vol.39 , pp. 159-163
    • Rabassa, A.A.1    Goodgame, R.2    Sutton, F.M.3    Ou, C.N.4    Rognerud, C.5    Graham, D.Y.6
  • 45
    • 0032550221 scopus 로고    scopus 로고
    • Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions
    • Saitou, M., K. Fujimoto, Y. Doi, M. Itoh, T. Fujimoto, M. Furuse, H. Takano, T. Noda, and S. Tsukita. 1998. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J. Cell Biol. 141:397-408.
    • (1998) J. Cell Biol. , vol.141 , pp. 397-408
    • Saitou, M.1    Fujimoto, K.2    Doi, Y.3    Itoh, M.4    Fujimoto, T.5    Furuse, M.6    Takano, H.7    Noda, T.8    Tsukita, S.9
  • 46
    • 0036300466 scopus 로고    scopus 로고
    • Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells
    • Sakaguchi, T., H. Kohler, X. Gu, B. A. McCormick, and H. C. Reinecker. 2002. Shigella flexneri regulates tight junction-associated proteins in human intestinal epithelial cells. Cell Microbiol. 4:367-381.
    • (2002) Cell Microbiol. , vol.4 , pp. 367-381
    • Sakaguchi, T.1    Kohler, H.2    Gu, X.3    McCormick, B.A.4    Reinecker, H.C.5
  • 48
    • 0036789132 scopus 로고    scopus 로고
    • Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion
    • Scott, K. G. E., J. B. Meddings, D. R. Kirk, S. P. Lees-Miller, and A. G. Buret. 2002. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology 123:1179-1190.
    • (2002) Gastroenterology , vol.123 , pp. 1179-1190
    • Scott, K.G.E.1    Meddings, J.B.2    Kirk, D.R.3    Lees-Miller, S.P.4    Buret, A.G.5
  • 49
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal, E. D., J. Cha, J. Lo, S. Falkow, and L. S. Tompkins. 1999. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc. Natl. Acad. Sci. USA 96:14559-14564.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3    Falkow, S.4    Tompkins, L.S.5
  • 50
    • 0033853899 scopus 로고    scopus 로고
    • Enteropa thogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions
    • Simonovic, I., J. Rosenberg, A. Koutsouris, and G. Hecht. 2000. Enteropa thogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell. Microbiol. 2:305-315.
    • (2000) Cell. Microbiol. , vol.2 , pp. 305-315
    • Simonovic, I.1    Rosenberg, J.2    Koutsouris, A.3    Hecht, G.4
  • 51
    • 0033523773 scopus 로고    scopus 로고
    • Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
    • Sonoda, N., M. Furuse, H. Sasaki, S. Yonemura, J. Katahira, Y. Horiguchi, and S. Tsukita. 1999. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147:195-204.
    • (1999) J. Cell Biol. , vol.147 , pp. 195-204
    • Sonoda, N.1    Furuse, M.2    Sasaki, H.3    Yonemura, S.4    Katahira, J.5    Horiguchi, Y.6    Tsukita, S.7
  • 53
    • 0031812341 scopus 로고    scopus 로고
    • Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators
    • Terrés, A. M., J. M. Pajares, A. M. Hopkins, A. Murphy, A. Moran, A. W. Baird, and D. Kelleher. 1998. Helicobacter pylori disrupts epithelial barrier function in a process inhibited by protein kinase C activators. Infect. Immun. 66:2943-2950.
    • (1998) Infect. Immun. , vol.66 , pp. 2943-2950
    • Terrés, A.M.1    Pajares, J.M.2    Hopkins, A.M.3    Murphy, A.4    Moran, A.5    Baird, A.W.6    Kelleher, D.7
  • 55
    • 0030669302 scopus 로고    scopus 로고
    • Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
    • Turner, J. R., B. K. Rill, S. L. Carlson, D. Carnes, R. Kerner, R. J. Mrsny, and J. L. Madara. 1997. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am. J. Physiol. 273: C1378-C1385.
    • (1997) Am. J. Physiol. , vol.273
    • Turner, J.R.1    Rill, B.K.2    Carlson, S.L.3    Carnes, D.4    Kerner, R.5    Mrsny, R.J.6    Madara, J.L.7
  • 56
    • 84920247287 scopus 로고
    • Unidentified curved bacilli on gastric epithelium in active chronic gastritis
    • Warren, J. R., and B. Marshall. 1983. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet i:1273-1275.
    • (1983) Lancet , vol.1 , pp. 1273-1275
    • Warren, J.R.1    Marshall, B.2
  • 57
    • 0030775148 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability
    • Yuhan, R., A. Koutsouris, S. D, Savkovic, and G. Hecht. 1997. Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability. Gastroenterology 113:1873-1882.
    • (1997) Gastroenterology , vol.113 , pp. 1873-1882
    • Yuhan, R.1    Koutsouris, A.2    Savkovic, S.D.3    Hecht, G.4


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