Fecal microbiota transplant restores mucosal integrity in a murine model of burn injury

Shock

Volumn 45, Issue 6, 2016, Pages 647-652

  Kuethe, Joshua W ^a   Armocida, Stephanie M ^a   Midura, Emily F ^a   Rice, Teresa C ^a   Hildeman, David A ^b,c   Healy, Daniel P ^c,d   Caldwell, Charles C ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c Department of Orthopaedic Surgery   (United States)

^d UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER   (United States)

Author keywords

Burn injury; Gut permeability; Microbiome

Indexed keywords

BUTYRIC ACID;

AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BURN; COLON PERMEABILITY; CONTROLLED STUDY; FECAL MICROBIOTA TRANSPLANTATION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; MALE; MICROBIAL COMMUNITY; MOUSE; MURINE MODEL; NONHUMAN; PHYLOGENY; ANIMAL; COLON; DISEASE MODEL; INTESTINE; MICROBIOLOGY; MICROFLORA; PATHOLOGY; PERMEABILITY; PROCEDURES;

ANIMALS; BURNS; COLON; DISEASE MODELS, ANIMAL; FECAL MICROBIOTA TRANSPLANTATION; GASTROINTESTINAL MICROBIOME; INTESTINES; MICE; MICROBIOTA; PERMEABILITY;

EID: 84950142722     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000551     Document Type: Article

References (36)

1. Savage DC: Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31:107-133, 1977.
2. Barcenilla A, Pryde SE, Martin JC, Duncan SH, Stewart CS, Henderson C, Flint HJ: Phylogenetic relationships of butyrate-producing bacteria from the human gut. Appl Environ Microbiol 66:1654-1661, 2000.
3. Cummings JH, Macfarlane GT: Colonic microflora: nutrition and health. Nutrition 13:476-478, 1997.
4. Bien J, Palagani V, Bozko P: The intestinal microbiota dysbiosis and Clostri-dium difficile infection: is there a relationship with inflammatory bowel disease? Therap Adv Gastroenterol 6:53-68, 2013.
5. Guarner F, Malagelada JR: Gut flora in health and disease. Lancet 361:512-519, 2003.
6. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE: Metagenomic analysis of the human distal gut microbiome. Science 312:1355-1359, 2006.
7. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI: The human microbiome project. Nature 449:804-810, 2007.
8. Madigan MT: Brock Biology of Microorganisms. San Francisco: Benjamin Cummings; 2012. p. xxviii, 1043, 1077 p.
9. Cummings JH, Macfarlane GT: Role of intestinal bacteria in nutrient metabolism. JPEN J Parenter Enteral Nutr 21:357-365, 1997.
10. Frankel WL, Zhang W, Singh A, Klurfeld DM, Don S, Sakata T, Modlin I, Rombeau JL: Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology 106:375-380, 1994.
11. Gibson PR, Moeller I, Kagelari O, Folino M, Young GP: Contrasting effects of butyrate on the expression of phenotypic markers of differentiation in neoplastic and non-neoplastic colonic epithelial cells in vitro. J Gastroenterol Hepatol 7:165-172, 1992.
12. Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, et al.: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446-450, 2013.
13. Hanschen M, Tajima G, O'Leary F, Ikeda K, Lederer JA: Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells. Shock 35:252-257, 2011.
14. MacConmara MP, Tajima G, O'Leary F, Delisle AJ, McKenna AM, Stallwood CG, Mannick JA, Lederer JA: Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. J Leukoc Biol 89:137-147, 2011.
15. Magnotti LJ, Deitch EA: Burns, bacterial translocation, gut barrier function, and failure. J Burn Care Rehabil 26:383-391, 2005.
16. Lichtman SM: Bacterial [correction of baterial] translocation in humans. J Pediatr Gastroenterol Nutr 33:1-10, 2001.
17. Van Leeuwen PA, Boermeester MA, Houdijk AP, Ferwerda CC, Cuesta MA, Meyer S, Wesdorp RI: Clinical significance of translocation. Gut 35:S28-S34, 1994.
18. Bagdasarian N, Rao K, Malani PN: Diagnosis and treatment of Clostridium difficile in adults: a systematic review. JAMA 313:398-408, 2015.
19. Hirsch BE, Saraiya N, Poeth K, Schwartz RM, Epstein ME, Honig G: Effectiveness of fecal-derived microbiota transfer using orally administered capsules for recurrent Clostridium difficile infection. BMC Infect Dis 15:191, 2015.
20. Tschop J, Martignoni A, Reid MD, Adediran SG, Gardner J, Noel GJ, Ogle CK, Neely AN, Caldwell CC: Differential immunological phenotypes are exhibited after scald and flame burns. Shock 31:157-163, 2009.
21. Croswell A, Amir E, Teggatz P, Barman M, Salzman NH: Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. Infect Immun 77:2741-2753, 2009.
22. Martignoni A, Tschop J, Goetzman HS, Choi LG, Reid MD, Johannigman JA, Lentsch AB, Caldwell CC: CD4-expressing cells are early mediators of the innate immune system during sepsis. Shock 29:591-597, 2008.
23. Huda-Faujan N, Abdulamir AS, Fatimah AB, Anas OM, Shuhaimi M, Yazid AM, Loong YY: The impact ofthe levelof the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. Open Biochem J 4:53-58, 2010.
24. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, et al.: Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 20:159-166, 2014.
25. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI: Human nutrition, the gut microbiome and the immune system. Nature 474:327-336, 2011.
26. Roediger WE: Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21:793-798, 1980.
27. Pinkus LM, Windmueller HG: Phosphate-dependent glutaminase of small intestine: localization and role in intestinal glutamine metabolism. Arch Biochem Biophys 182:506-517, 1977.
28. Di Bella S, Gouliouris T, Petrosillo N: Fecal microbiota transplantation (FMT) for Clostridium difficile infection: focus on immunocompromised patients. J Infect Chemother 21:230-237, 2015.
29. Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB: Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 298:531-534, 1978.
30. Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, Guyatt GH: Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med 157:878-888, 2012.
31. Drekonja DM, Butler M, MacDonald R, Bliss D, Filice GA, Rector TS, Wilt TJ: Comparative effectiveness of Clostridium difficile treatments: a systematic review. Ann Intern Med 155:839-847, 2011.
32. Ohashi Y, Sumitani K, Tokunaga M, Ishihara N, Okubo T, Fujisawa T: Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrateproducing bacteria in the human large intestine. Benef Microbes 6:451-455, 2015.
33. Eiseman B, Silen W, Bascom GS, Kauvar AJ: Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 44:854-859, 1958.
34. Hamilton MJ, Weingarden AR, Unno T, Khoruts A, Sadowsky MJ: High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes 4:125-135, 2013.
35. Shimizu K, Ogura H, Asahara T, Nomoto K, Matsushima A, Hayakawa K, Ikegawa H, Tasaki O, Kuwagata Y, Shimazu T: Gut microbiota and environment in patients with major burns: a preliminary report. Burns 41:e28-e33, 2015.
36. Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, Hammer AM, Morris NL, Li X, Eberhardt JM, et al.: Burn injury alters the intestinal micro-biome and increases gut permeability and bacterial translocation. PLoS One 10:e0129996, 2015.