Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 5, 2015, Pages 5153-5160

  Lin, Rui ^a   Zhou, Lu ^a   Zhang, Jie ^a   Wang, Bangmao ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Autoimmune hepatitis; Bacterial; Intestinal permeability; Microbiota; Translocation

Indexed keywords

BACTERIAL DNA; LIPOPOLYSACCHARIDE; OCCLUDIN; OCLN PROTEIN, HUMAN; PROTEIN ZO1; RNA 16S; TJP1 PROTEIN, HUMAN;

ADULT; AGED; BACTERIAL TRANSLOCATION; BLOOD; CASE CONTROL STUDY; DUODENUM; DYSBIOSIS; FEMALE; GENETICS; HEPATITIS, AUTOIMMUNE; HOST PATHOGEN INTERACTION; HUMAN; INTESTINE FLORA; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PERMEABILITY; RIBOTYPING; TIGHT JUNCTION;

ADULT; AGED; BACTERIAL TRANSLOCATION; CASE-CONTROL STUDIES; DNA, BACTERIAL; DUODENUM; DYSBIOSIS; FEMALE; GASTROINTESTINAL MICROBIOME; HEPATITIS, AUTOIMMUNE; HOST-PATHOGEN INTERACTIONS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; OCCLUDIN; PERMEABILITY; RIBOTYPING; RNA, RIBOSOMAL, 16S; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84937924335     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Gossard AA and Lindor KD. Autoimmune hepatitis: a review. J Gastroenterol 2012; 47: 498-503.
2. Mackay IR. Autoimmune hepatitis: what must be said. Exp Mol Pathol 2012; 93: 350-353.
3. Zeuzem S. Gut-liver axis. Int J Colorectal Dis 2000; 15: 59-82.
4. Bilzer M, Roggel F and Gerbes AL. Role of Kupffer cells in host defense and liver disease. Liver Int 2006; 26: 1175-1186.
5. Seki E and Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 2008; 48: 322-335.
6. Szabo G, Bala S, Petrasek J and Gattu A. Gut-liver axis and sensing microbes. Dig Dis 2010; 28: 737-744.
7. Gabbard SL, Lacy BE, Levine GM and Crowell MD. The impact of alcohol consumption and cholecystectomy on small intestinal bacterial overgrowth. Dig Dis Sci 2014; 59: 638-644.
8. Crispe IN. The liver as a lymphoid organ. Annu Rev Immunol 2009; 27: 147-163.
9. Pradere JP, Troeger JS, Dapito DH, Mencin AA and Schwabe RF. Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis 2010; 30: 232-244.
10. Szabo G, Mandrekar P, Petrasek J, Catalano D. The unfolding web of innate immune dysregulation in alcoholic liver injury. Alcohol Clin Exp Res 2011; 35: 782-786.
11. Fouts DE, Torralba M, Nelson KE and Catalano D. Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease. J Hepatol 2012; 56: 1283-1292.
12. Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, Lippai D, Catalano D, Mandrekar P, Dolganiuc A, Kurt-Jones E and Szabo G. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol 2011; 300: G433-441.
13. Chen Y, Yang F, Lu H, Wang B, Chen Y, Lei D, Wang Y, Zhu B, Li L. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 2011; 54: 562-572.
14. Lu H, Wu Z, Xu W, Wang B, Chen Y, Lei D, Wang Y, Zhu B and Li L. Intestinal microbiota was assessed in cirrhotic patients with hepatitis B virus infection. Intestinal microbiota of HBV cirrhotic patients. Microb Ecol 2011; 61: 693-703.
15. Hennes EM, Zeniya M, Czaja AJ, Inui A and Fujisawa T. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology 2008; 48: 169-176.
16. Shimizu M, Saitoh Y and Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues. Hum Pathol 1990; 21: 607-612.
17. Skrivanova E, Worgan HJ, Pinloche E, Marounek M, Newbold CJ and McEwan NR. Changes in the bacterial population of the caecum and stomach of the rabbit in response to addition of dietary caprylic acid. Vet Microbiol 2010; 144: 334-339.
18. Gong CY, Zhou AL, Mao JH, Hu YE and Geng JS. The role of Toll-like receptor 4 on inflammation and Abeta formation in cortex astrocytes. Sheng Li Xue Bao 2014; 66: 631-638.
19. Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 2008; 8: 411-420.
20. Arrieta MC, Bistritz L and Meddings JB. Alterations in intestinal permeability. Gut 2006; 55: 1512-1520.
21. Barrett KE. New ways of thinking about (and teaching about) intestinal epithelial function. Adv Physiol Educ 2008; 32: 25-34.
22. Marshall JC. The gut as a potential trigger of exercise-induced inflammatory responses. Can J Physiol Pharmacol 1998; 76: 479-484.
23. Wiest R and Garcia-Tsao G. Bacterial translocation (BT) in cirrhosis. Hepatology 2005; 41: 422-433.
24. Mandrekar P, Bala S, Catalano D, Kodys K and Szabo G. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. J Immunol 2009; 183: 1320-1327.
25. Wu D and Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis 2009; 29: 141-154.
26. Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, Mascianà R, Forgione A, Gabrieli ML, Perotti G, Vecchio FM, Rapaccini G, Gasbarrini G and Day CP. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49: 1877-1887.
27. Rao RK, Seth A and Sheth P. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2004; 286: G881-884.
28. Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J Hepatol 2009; 50: 538-547.
29. Kavanaugh MJ, Clark C, Goto M, Rangan J, Jakate S, Shaikh M, Banan A and Fields JZ. Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns 2005; 31: 290-296.
30. Thakur V, McMullen MR, Pritchard MT and Nagy LE. Regulation of macrophage activation in alcoholic liver disease. J Gastroenterol Hepatol 2007; 22 Suppl 1: S53-56.
31. Almeida J, Galhenage S, Yu J, Kurtovic J and Riordan SM. Gut flora and bacterial translocation in chronic liver disease. World J Gastroenterol 2006; 12: 1493-1502.
32. Lin RS, Lee FY, Lee SD, Tsai YT, Lin HC, Lu RH, Hsu WC, Huang CC, Wang SS and Lo KJ. Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophageal varices, and hyperdynamic circulation. J Hepatol 1995; 22: 165-172.
33. Varol C, Zigmond E and Jung S. Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol 2010; 10: 415-426.
34. Forster C. Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol 2008; 130: 55-70.
35. Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M and Schulzke JD. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007; 56: 61-72.
36. Nahidi L, Day AS, Lemberg DA and Leach ST. Differential effects of nutritional and non-nutritional therapies on intestinal barrier function in an in vitro model. J Gastroenterol 2012; 47: 107-117.
37. Edelblum KL and Turner JR. The tight junction in inflammatory disease: communication breakdown. Curr Opin Pharmacol 2009; 9: 715-720.
38. Montalto M, Maggiano N, Ricci R, Curigliano V, Santoro L, Di Nicuolo F, Vecchio FM and Gasbarrini A. Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells. Digestion 2004; 69: 225-228.
39. Marques TM, Wall R, Ross RP, Fitzgerald GF, Fitzgerald GF, Fitzgerald GF, Ryan CA and Stanton C. Programming infant gut microbiota: influence of dietary and environmental factors. Curr Opin Biotechnol 2010; 21: 149-156.
40. Othman M, Aguero R, Lin HC. Alterations in intestinal microbial flora and human disease. Curr Opin Gastroenterol 2008; 24: 11-16.
41. French SW. Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease. J Biomed Sci 2001; 8: 20-27.