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Volumn 7, Issue 4, 2017, Pages

siRNA delivery strategies: A comprehensive review of recent developments

Author keywords

Cancer therapy; Delivery systems; Gene delivery; Nanoparticles; RNAi; siRNA; Targeted delivery; Tumor

Indexed keywords


EID: 85018490272     PISSN: None     EISSN: 20794991     Source Type: Journal    
DOI: 10.3390/nano7040077     Document Type: Review
Times cited : (341)

References (83)
  • 1
    • 84957634220 scopus 로고    scopus 로고
    • Nanoparticle-siRNA: A potential cancer therapy
    • [CrossRef] [PubMed]
    • Young, S.W.S.; Stenzel, M.; Yang, J.L. Nanoparticle-siRNA: A potential cancer therapy? Crit. Rev. Oncol. Hematol. 2016, 98, 159–169. [CrossRef] [PubMed]
    • (2016) Crit. Rev. Oncol. Hematol , vol.98 , pp. 159-169
    • Young, S.W.S.1    Stenzel, M.2    Yang, J.L.3
  • 3
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • [CrossRef] [PubMed]
    • Castanotto, D.; Rossi, J.J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009, 457, 426–433. [CrossRef] [PubMed]
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 4
    • 77749322701 scopus 로고    scopus 로고
    • Structural insights into RNA interference
    • [CrossRef] [PubMed]
    • Sashital, D.G.; Doudna, J.A. Structural insights into RNA interference. Curr. Opin. Struct. Biol. 2010, 20, 90–97. [CrossRef] [PubMed]
    • (2010) Curr. Opin. Struct. Biol , vol.20 , pp. 90-97
    • Sashital, D.G.1    Doudna, J.A.2
  • 5
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • [CrossRef]
    • Martinez, J.; Patkaniowska, A.; Urlaub, H.; Lührmann, R.; Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 2002, 110, 563–574. [CrossRef]
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 6
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • [CrossRef] [PubMed]
    • Meister, G.; Tuschi, T. Mechanisms of gene silencing by double-stranded RNA. Nature 2004, 431, 343–349. [CrossRef] [PubMed]
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschi, T.2
  • 7
    • 84992202251 scopus 로고    scopus 로고
    • Nanoparticle delivery systems for siRNA-based therapeutics
    • [CrossRef]
    • Li, J.; Xue, S.; Mao, Z.W. Nanoparticle delivery systems for siRNA-based therapeutics. J. Mater. Chem. B 2016, 4, 6620–6639. [CrossRef]
    • (2016) J. Mater. Chem. B , vol.4 , pp. 6620-6639
    • Li, J.1    Xue, S.2    Mao, Z.W.3
  • 8
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • [CrossRef] [PubMed]
    • Dykxhoorn, D.M.; Novina, C.D.; Sharp, P.A. Killing the messenger: Short RNAs that silence gene expression. Nat. Rev. Mol. Cell Biol. 2003, 4, 457–467. [CrossRef] [PubMed]
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 10
    • 84887032296 scopus 로고    scopus 로고
    • Synergetic regulatory networks mediated by oncogene-driven microRNAs and transcription factors in serous ovarian cancer
    • [CrossRef] [PubMed]
    • Zhao, M.; Sun, J.; Zhao, Z. Synergetic regulatory networks mediated by oncogene-driven microRNAs and transcription factors in serous ovarian cancer. Mol. Biosyst. 2013, 9, 3187–3198. [CrossRef] [PubMed]
    • (2013) Mol. Biosyst , vol.9 , pp. 3187-3198
    • Zhao, M.1    Sun, J.2    Zhao, Z.3
  • 11
    • 84903133224 scopus 로고    scopus 로고
    • RNAi Therapies: Drugging the Undruggable
    • [CrossRef] [PubMed]
    • Wu, S.Y.; Lopez-Berestein, G.; Calin, G.A.; Sood, A.K. RNAi Therapies: Drugging the Undruggable. Sci. Transl. Med. 2014, 6, 240–247. [CrossRef] [PubMed]
    • (2014) Sci. Transl. Med , vol.6 , pp. 240-247
    • Wu, S.Y.1    Lopez-Berestein, G.2    Calin, G.A.3    Sood, A.K.4
  • 12
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • [CrossRef] [PubMed]
    • Davidson, B.L.; McCray, P.B. Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 2011, 12, 329–340. [CrossRef] [PubMed]
    • (2011) Nat. Rev. Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 13
    • 84891340265 scopus 로고    scopus 로고
    • Stable RNA interference rules for silencing
    • [CrossRef] [PubMed]
    • Fellmann, C.; Lowe, S.W. Stable RNA interference rules for silencing. Nat. Cell Biol. 2014, 16, 10–18. [CrossRef] [PubMed]
    • (2014) Nat. Cell Biol , vol.16 , pp. 10-18
    • Fellmann, C.1    Lowe, S.W.2
  • 14
    • 84973527084 scopus 로고    scopus 로고
    • Delivery strategies and potential targets for siRNA in major cancer types
    • Lee, S.J.; Kim, M.J.; Kwon, I.C.; Roberts, T.M. Delivery strategies and potential targets for siRNA in major cancer types. Adv. Drug Deliv. Rev. 2015, 104, 2–15.
    • (2015) Adv. Drug Deliv. Rev , vol.104 , pp. 2-15
    • Lee, S.J.1    Kim, M.J.2    Kwon, I.C.3    Roberts, T.M.4
  • 16
    • 33645167401 scopus 로고    scopus 로고
    • Prospects of RNA interference therapy for cancer
    • [CrossRef] [PubMed]
    • Pai, S.; Lin, Y.Y.; Macaes, B.; Meneshian, A.; Hung, C.F.; Wu, T.C. Prospects of RNA interference therapy for cancer. Gene Ther. 2006, 13, 464–477. [CrossRef] [PubMed]
    • (2006) Gene Ther , vol.13 , pp. 464-477
    • Pai, S.1    Lin, Y.Y.2    Macaes, B.3    Meneshian, A.4    Hung, C.F.5    Wu, T.C.6
  • 17
    • 84879074792 scopus 로고    scopus 로고
    • A review of the current status of siRNA nanomedicines in the treatment of cancer
    • [CrossRef] [PubMed]
    • Resnier, P.; Montier, T.; Mathieu, V.; Benoit, J.P.; Passirani, C. A review of the current status of siRNA nanomedicines in the treatment of cancer. Biomaterials 2013, 34, 6429–6443. [CrossRef] [PubMed]
    • (2013) Biomaterials , vol.34 , pp. 6429-6443
    • Resnier, P.1    Montier, T.2    Mathieu, V.3    Benoit, J.P.4    Passirani, C.5
  • 19
    • 84908564426 scopus 로고    scopus 로고
    • Current issues of RNAi therapeutics delivery and development
    • [CrossRef] [PubMed]
    • Haussecker, D. Current issues of RNAi therapeutics delivery and development. J. Control. Release 2014, 195, 49–54. [CrossRef] [PubMed]
    • (2014) J. Control. Release , vol.195 , pp. 49-54
    • Haussecker, D.1
  • 20
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • [CrossRef] [PubMed]
    • Fang, J.; Nakamura, H.; Maeda, H. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 2011, 63, 136–151. [CrossRef] [PubMed]
    • (2011) Adv. Drug Deliv. Rev , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 21
    • 84896734996 scopus 로고    scopus 로고
    • Improving conventional enhanced permeability and retention (EPR) effects; What is the appropriate target?
    • [CrossRef] [PubMed]
    • Kobayashi, H.; Watanabe, R.; Choyke, P.L. Improving conventional enhanced permeability and retention (EPR) effects; What is the appropriate target? Theranostics 2014, 4, 81–89. [CrossRef] [PubMed]
    • (2014) Theranostics , vol.4 , pp. 81-89
    • Kobayashi, H.1    Watanabe, R.2    Choyke, P.L.3
  • 22
    • 67049087043 scopus 로고    scopus 로고
    • Update on the glomerular filtration barrier
    • [CrossRef] [PubMed]
    • Jarad, G.; Miner, J.H. Update on the glomerular filtration barrier. Curr. Opin. Nephrol. Hypertens. 2009, 18, 226–232. [CrossRef] [PubMed]
    • (2009) Curr. Opin. Nephrol. Hypertens , vol.18 , pp. 226-232
    • Jarad, G.1    Miner, J.H.2
  • 25
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi, S.M.; Hunter, A.C.; Murray, J.C. Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol. Rev. 2001, 53, 283–318.
    • (2001) Pharmacol. Rev , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 26
    • 85018520249 scopus 로고    scopus 로고
    • [PubMed]
    • [PubMed]
  • 27
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • [CrossRef] [PubMed]
    • Cho, K.; Wang, X.; Nie, S.; Chen, Z.; Shin, D.M. Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 2008, 14, 1310–1316. [CrossRef] [PubMed]
    • (2008) Clin. Cancer Res , vol.14 , pp. 1310-1316
    • Cho, K.1    Wang, X.2    Nie, S.3    Chen, Z.4    Shin, D.M.5
  • 28
    • 84864670257 scopus 로고    scopus 로고
    • Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo
    • [CrossRef] [PubMed]
    • Huang, K.; Ma, H.; Liu, J.; Huo, S.; Kumar, A.; Wei, T.; Zhang, X.; Jin, S.; Gan, Y.; Wang, P.C.; et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano 2012, 6, 4483–4493. [CrossRef] [PubMed]
    • (2012) ACS Nano , vol.6 , pp. 4483-4493
    • Huang, K.1    Ma, H.2    Liu, J.3    Huo, S.4    Kumar, A.5    Wei, T.6    Zhang, X.7    Jin, S.8    Gan, Y.9    Wang, P.C.10
  • 29
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P.; Kallinowski, F.; Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res. 1989, 49, 6449–6465.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 30
    • 85018495899 scopus 로고    scopus 로고
    • [PubMed]
    • [PubMed]
  • 31
    • 84863721493 scopus 로고    scopus 로고
    • Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery
    • [CrossRef] [PubMed]
    • Li, L.; Wang, R.; Wilcox, D.; Zhao, X.; Song, J.; Lin, X.; Kohlbrenner, W.M.; Fesik, S.W.; Shen, Y. Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther. 2012, 19, 775–780. [CrossRef] [PubMed]
    • (2012) Gene Ther , vol.19 , pp. 775-780
    • Li, L.1    Wang, R.2    Wilcox, D.3    Zhao, X.4    Song, J.5    Lin, X.6    Kohlbrenner, W.M.7    Fesik, S.W.8    Shen, Y.9
  • 32
    • 34248680739 scopus 로고    scopus 로고
    • Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides
    • [CrossRef] [PubMed]
    • Meade, B.R.; Dowdy, S.F. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv. Drug Deliv. Rev. 2007, 59, 134–140. [CrossRef] [PubMed]
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 134-140
    • Meade, B.R.1    Dowdy, S.F.2
  • 34
    • 46649104073 scopus 로고    scopus 로고
    • Gene transfer into guinea pig cochlea using adeno-associated virus vectors
    • [CrossRef] [PubMed]
    • Konishi, M.; Kawamoto, K.; Izumikawa, M.; Kuriyama, H.; Yamashita, T. Gene transfer into guinea pig cochlea using adeno-associated virus vectors. J. Gene Med. 2008, 10, 610–618. [CrossRef] [PubMed]
    • (2008) J. Gene Med , vol.10 , pp. 610-618
    • Konishi, M.1    Kawamoto, K.2    Izumikawa, M.3    Kuriyama, H.4    Yamashita, T.5
  • 36
    • 84857260144 scopus 로고    scopus 로고
    • Lysosomal acidification mechanisms
    • [CrossRef] [PubMed]
    • Mindell, J.A. Lysosomal acidification mechanisms. Annu. Rev. Physiol. 2012, 74, 69–86. [CrossRef] [PubMed]
    • (2012) Annu. Rev. Physiol , vol.74 , pp. 69-86
    • Mindell, J.A.1
  • 37
    • 84881565288 scopus 로고    scopus 로고
    • The lysosome: Fromwaste bag to potential therapeutic target
    • [CrossRef] [PubMed]
    • Appelqvist, H.; Wäster, P.; Kågedal, K.; Öllinger, K. The lysosome: Fromwaste bag to potential therapeutic target. J.Mol. Cell Biol. 2013, 5, 214–226. [CrossRef] [PubMed]
    • (2013) J.Mol. Cell Biol , vol.5 , pp. 214-226
    • Appelqvist, H.1    Wäster, P.2    Kågedal, K.3    Öllinger, K.4
  • 38
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • [CrossRef] [PubMed]
    • Sonawane, N.D.; Szoka, F.C.; Verkman, A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 2003, 278, 44826–44831. [CrossRef] [PubMed]
    • (2003) J. Biol. Chem , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka, F.C.2    Verkman, A.S.3
  • 40
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity
    • [CrossRef] [PubMed]
    • Jackson, A.L.; Burchard, J.; Schelter, J.; Chau, B.N.; Cleary, M.; Lim, L.; Linsley, P.S. Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity. RNA 2006, 12, 1179–1187. [CrossRef] [PubMed]
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 41
    • 17844387370 scopus 로고    scopus 로고
    • A computational study of off-target effects of RNA interference
    • [CrossRef] [PubMed]
    • Qiu, S.; Adema, C.M.; Lane, T. A computational study of off-target effects of RNA interference. Nucleic Acids Res. 2005, 33, 1834–1847. [CrossRef] [PubMed]
    • (2005) Nucleic Acids Res , vol.33 , pp. 1834-1847
    • Qiu, S.1    Adema, C.M.2    Lane, T.3
  • 43
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • [CrossRef] [PubMed]
    • Judge, A.D.; Sood, V.; Shaw, J.R.; Fang, D.; McClintock, K.; MacLachlan, I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 2005, 23, 457–462. [CrossRef] [PubMed]
    • (2005) Nat. Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    Maclachlan, I.6
  • 44
    • 84888586074 scopus 로고    scopus 로고
    • Response of C2C12 myoblasts to hypoxia: The relative roles of glucose and oxygen in adaptive cellular metabolism
    • [CrossRef] [PubMed]
    • Li, W.; Hu, Z.F.; Chen, B.; Ni, G.X. Response of C2C12 myoblasts to hypoxia: The relative roles of glucose and oxygen in adaptive cellular metabolism. BioMed Res. Int. 2013, 2013, 326346. [CrossRef] [PubMed]
    • (2013) Biomed Res. Int , vol.2013
    • Li, W.1    Hu, Z.F.2    Chen, B.3    Ni, G.X.4
  • 45
    • 84890453749 scopus 로고    scopus 로고
    • Applications of inorganic nanoparticles as therapeutic agents
    • [CrossRef] [PubMed]
    • Kim, T.; Hyeon, T. Applications of inorganic nanoparticles as therapeutic agents. Nanotechnology 2014, 25, 12001. [CrossRef] [PubMed]
    • (2014) Nanotechnology , vol.25
    • Kim, T.1    Hyeon, T.2
  • 46
    • 85059774987 scopus 로고    scopus 로고
    • Magnetic nanoparticle drug delivery systems for targeting tumor
    • [CrossRef]
    • Mody, V.V.; Cox, A.; Shah, S.; Singh, A.; Bevins, W.; Parihar, H. Magnetic nanoparticle drug delivery systems for targeting tumor. Appl. Nanosci. 2013, 4, 385–392. [CrossRef]
    • (2013) Appl. Nanosci , vol.4 , pp. 385-392
    • Mody, V.V.1    Cox, A.2    Shah, S.3    Singh, A.4    Bevins, W.5    Parihar, H.6
  • 48
    • 84891718629 scopus 로고    scopus 로고
    • Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment
    • [CrossRef]
    • Zhang, L.; Li, Y.; Yu, J.C. Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment. J. Mater. Chem. B 2014, 2, 452–470. [CrossRef]
    • (2014) J. Mater. Chem. B , vol.2 , pp. 452-470
    • Zhang, L.1    Li, Y.2    Yu, J.C.3
  • 49
    • 84906787631 scopus 로고    scopus 로고
    • Theranostic nanoparticles for future personalized medicine
    • [CrossRef] [PubMed]
    • Ryu, J.H.; Lee, S.; Son, S.; Kim, S.H.; Leary, J.F.; Choi, K.; Kwon, I.C. Theranostic nanoparticles for future personalized medicine. J. Control. Release 2014, 190, 477–484. [CrossRef] [PubMed]
    • (2014) J. Control. Release , vol.190 , pp. 477-484
    • Ryu, J.H.1    Lee, S.2    Son, S.3    Kim, S.H.4    Leary, J.F.5    Choi, K.6    Kwon, I.C.7
  • 50
    • 84902529384 scopus 로고    scopus 로고
    • Nanotheranostics-application and further development of nanomedicine strategies for advanced theranostics
    • [CrossRef] [PubMed]
    • Muthu, M.S.; Leong, D.T.; Mei, L.; Feng, S.S. Nanotheranostics-application and further development of nanomedicine strategies for advanced theranostics. Theranostics 2014, 4, 660–677. [CrossRef] [PubMed]
    • (2014) Theranostics , vol.4 , pp. 660-677
    • Muthu, M.S.1    Leong, D.T.2    Mei, L.3    Feng, S.S.4
  • 51
    • 80051548932 scopus 로고    scopus 로고
    • Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery
    • [CrossRef] [PubMed]
    • Endres, T.K.; Beck-Broichsitter, M.; Samsonova, O.; Renette, T.; Kissel, T.H. Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery. Biomaterials 2011, 32, 7721–7731. [CrossRef] [PubMed]
    • (2011) Biomaterials , vol.32 , pp. 7721-7731
    • Endres, T.K.1    Beck-Broichsitter, M.2    Samsonova, O.3    Renette, T.4    Kissel, T.H.5
  • 52
    • 79951914745 scopus 로고    scopus 로고
    • Simultaneous delivery of siRNA and paclitaxel via a “two-in-one” micelleplex promotes synergistic tumor suppression
    • [CrossRef] [PubMed]
    • Sun, T.M.; Du, J.Z.; Yao, Y.D.; Mao, C.Q.; Dou, S.; Huang, S.Y.; Zhang, P.Z.; Leong, K.W.; Song, E.W.; Wang, J. Simultaneous delivery of siRNA and paclitaxel via a “two-in-one” micelleplex promotes synergistic tumor suppression. ACS Nano 2011, 5, 1483–1494. [CrossRef] [PubMed]
    • (2011) ACS Nano , vol.5 , pp. 1483-1494
    • Sun, T.M.1    Du, J.Z.2    Yao, Y.D.3    Mao, C.Q.4    Dou, S.5    Huang, S.Y.6    Zhang, P.Z.7    Leong, K.W.8    Song, E.W.9    Wang, J.10
  • 53
    • 81855227156 scopus 로고    scopus 로고
    • Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery
    • [CrossRef] [PubMed]
    • Yu, H.; Zou, Y.; Wang, Y.; Huang, X.; Huang, G.; Sumer, B.D.; Boothman, D.A.; Gao, J. Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA-b-PDPA micelleplexes for siRNA delivery. ACS Nano 2011, 5, 9246–9255. [CrossRef] [PubMed]
    • (2011) ACS Nano , vol.5 , pp. 9246-9255
    • Yu, H.1    Zou, Y.2    Wang, Y.3    Huang, X.4    Huang, G.5    Sumer, B.D.6    Boothman, D.A.7    Gao, J.8
  • 54
    • 84908407738 scopus 로고    scopus 로고
    • Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: Current progress and advances
    • [CrossRef] [PubMed]
    • Gandhi, N.S.; Tekade, R.K.; Chougule, M.B. Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: Current progress and advances. J. Control. Release 2014, 194, 238–256. [CrossRef] [PubMed]
    • (2014) J. Control. Release , vol.194 , pp. 238-256
    • Gandhi, N.S.1    Tekade, R.K.2    Chougule, M.B.3
  • 55
    • 84884901192 scopus 로고    scopus 로고
    • Glutathione metabolism and Parkinson’s disease
    • [CrossRef] [PubMed]
    • Smeyne, M.; Smeyne, R.J. Glutathione metabolism and Parkinson’s disease. Free Radic. Biol. Med. 2013, 62, 13–25. [CrossRef] [PubMed]
    • (2013) Free Radic. Biol. Med , vol.62 , pp. 13-25
    • Smeyne, M.1    Smeyne, R.J.2
  • 56
    • 78650121491 scopus 로고    scopus 로고
    • Self-cross-linked polymer nanogels: A versatile nanoscopic drug delivery platform supporting info
    • [CrossRef] [PubMed]
    • Ryu, J.-H.; Chacko, R.T.; Jiwpanich, S.; Bickerton, S.; Babu, R.P.; Thayumanavan, S. Self-cross-linked polymer nanogels: A versatile nanoscopic drug delivery platform supporting info. J. Am. Chem. Soc. 2010, 3, 17227–17235. [CrossRef] [PubMed]
    • (2010) J. Am. Chem. Soc , vol.3 , pp. 17227-17235
    • Ryu, J.-H.1    Chacko, R.T.2    Jiwpanich, S.3    Bickerton, S.4    Babu, R.P.5    Thayumanavan, S.6
  • 57
    • 84864767887 scopus 로고    scopus 로고
    • Glutathione and modulation of cell apoptosis
    • [CrossRef] [PubMed]
    • Circu, M.L.; Aw, T.Y. Glutathione and modulation of cell apoptosis. Biochim. Biophys. Acta 2012, 1823, 1767–1777. [CrossRef] [PubMed]
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 1767-1777
    • Circu, M.L.1    Aw, T.Y.2
  • 58
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • [CrossRef] [PubMed]
    • Neri, D.; Supuran, C.T. Interfering with pH regulation in tumours as a therapeutic strategy. Nat. Rev. Drug Discov. 2011, 10, 767–777. [CrossRef] [PubMed]
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 59
    • 84920134746 scopus 로고    scopus 로고
    • A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery
    • [CrossRef] [PubMed]
    • Li, J.; Yu, X.; Wang, Y.; Yuan, Y.; Xiao, H.; Cheng, D.; Shuai, X. A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery. Adv. Mater. 2014, 26, 8217–8224. [CrossRef] [PubMed]
    • (2014) Adv. Mater , vol.26 , pp. 8217-8224
    • Li, J.1    Yu, X.2    Wang, Y.3    Yuan, Y.4    Xiao, H.5    Cheng, D.6    Shuai, X.7
  • 60
    • 84925070692 scopus 로고    scopus 로고
    • Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry
    • [CrossRef] [PubMed]
    • Hama, S.; Itakura, S.; Nakai, M.; Nakayama, K.; Morimoto, S.; Suzuki, S.; Kogure, K. Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry. J. Control. Release 2015, 206, 67–74. [CrossRef] [PubMed]
    • (2015) J. Control. Release , vol.206 , pp. 67-74
    • Hama, S.1    Itakura, S.2    Nakai, M.3    Nakayama, K.4    Morimoto, S.5    Suzuki, S.6    Kogure, K.7
  • 61
    • 84902551145 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2-responsive micelle for siRNA delivery
    • [CrossRef] [PubMed]
    • Wang, H.X.; Yang, X.Z.; Sun, C.Y.; Mao, C.Q.; Zhu, Y.H.; Wang, J. Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials 2014, 35, 7622–7634. [CrossRef] [PubMed]
    • (2014) Biomaterials , vol.35 , pp. 7622-7634
    • Wang, H.X.1    Yang, X.Z.2    Sun, C.Y.3    Mao, C.Q.4    Zhu, Y.H.5    Wang, J.6
  • 62
    • 84879233407 scopus 로고    scopus 로고
    • Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery
    • [CrossRef] [PubMed]
    • Li, H.; Yu, S.S.; Miteva, M.; Nelson, C.E.; Werfel, T.; Giorgio, T.D.; Duvall, C.L. Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery. Adv. Funct. Mater. 2013, 23, 3040–3052. [CrossRef] [PubMed]
    • (2013) Adv. Funct. Mater , vol.23 , pp. 3040-3052
    • Li, H.1    Yu, S.S.2    Miteva, M.3    Nelson, C.E.4    Werfel, T.5    Giorgio, T.D.6    Duvall, C.L.7
  • 63
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the yumor microenvironment
    • [CrossRef] [PubMed]
    • Kessenbrock, K.; Plaks, V.; Werb, Z. Matrix metalloproteinases: Regulators of the yumor microenvironment. Cell 2010, 141, 52–67. [CrossRef] [PubMed]
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 64
    • 79957651592 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Protective roles in cancer
    • [CrossRef] [PubMed]
    • Decock, J.; Thirkettle, S.; Wagstaff, L.; Edwards, D.R. Matrix metalloproteinases: Protective roles in cancer. J. Cell. Mol. Med. 2011, 15, 1254–1265. [CrossRef] [PubMed]
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 1254-1265
    • Decock, J.1    Thirkettle, S.2    Wagstaff, L.3    Edwards, D.R.4
  • 66
    • 84918578407 scopus 로고    scopus 로고
    • Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing
    • [CrossRef] [PubMed]
    • Nair, J.K.; Willoughby, J.L.S.; Chan, A.; Charisse, K.; Alam, M.R.; Wang, Q.; Hoekstra, M.; Kandasamy, P.; Kelin, A.V.; Milstein, S.; et al. Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. J. Am. Chem. Soc. 2014, 136, 16958–16961. [CrossRef] [PubMed]
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 16958-16961
    • Nair, J.K.1    Willoughby, J.L.S.2    Chan, A.3    Charisse, K.4    Alam, M.R.5    Wang, Q.6    Hoekstra, M.7    Kandasamy, P.8    Kelin, A.V.9    Milstein, S.10
  • 67
    • 79960556709 scopus 로고    scopus 로고
    • The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells
    • [CrossRef] [PubMed]
    • Cruz, L.J.; Tacken, P.J.; Fokkink, R.; Figdor, C.G. The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells. Biomaterials 2011, 32, 6791–6803. [CrossRef] [PubMed]
    • (2011) Biomaterials , vol.32 , pp. 6791-6803
    • Cruz, L.J.1    Tacken, P.J.2    Fokkink, R.3    Figdor, C.G.4
  • 68
    • 0029949266 scopus 로고    scopus 로고
    • Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
    • [CrossRef] [PubMed]
    • Xu, Y.; Szoka, F.C.J. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996, 35, 5616–5623. [CrossRef] [PubMed]
    • (1996) Biochemistry , vol.35 , pp. 5616-5623
    • Xu, Y.1    Szoka, F.C.J.2
  • 69
    • 0034882516 scopus 로고    scopus 로고
    • On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    • [CrossRef] [PubMed]
    • Hafez, I.M.; Maurer, N.; Cullis, P.R. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther. 2001, 8, 1188–1196. [CrossRef] [PubMed]
    • (2001) Gene Ther , vol.8 , pp. 1188-1196
    • Hafez, I.M.1    Maurer, N.2    Cullis, P.R.3
  • 70
    • 79953066932 scopus 로고    scopus 로고
    • A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma
    • [CrossRef] [PubMed]
    • Hatakeyama, H.; Akita, H.; Harashima, H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma. Adv. Drug Deliv. Rev. 2011, 63, 152–160. [CrossRef] [PubMed]
    • (2011) Adv. Drug Deliv. Rev , vol.63 , pp. 152-160
    • Hatakeyama, H.1    Akita, H.2    Harashima, H.3
  • 72
    • 66449127352 scopus 로고    scopus 로고
    • Layer-by-layer assembled gold nanoparticles for sirna delivery
    • [CrossRef] [PubMed]
    • Elbakry, A.; Zaky, A.; Liebl, R.; Rachel, R.; Goepferich, A.; Breunig, M. Layer-by-layer assembled gold nanoparticles for sirna delivery. Nano Lett. 2009, 9, 2059–2064. [CrossRef] [PubMed]
    • (2009) Nano Lett , vol.9 , pp. 2059-2064
    • Elbakry, A.1    Zaky, A.2    Liebl, R.3    Rachel, R.4    Goepferich, A.5    Breunig, M.6
  • 73
    • 84949772553 scopus 로고    scopus 로고
    • Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure
    • [CrossRef] [PubMed]
    • Yamaguchi, M. Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure. Biomed. Rep. 2014, 2, 303–308. [CrossRef] [PubMed]
    • (2014) Biomed. Rep , vol.2 , pp. 303-308
    • Yamaguchi, M.1
  • 74
    • 84865593616 scopus 로고    scopus 로고
    • Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG
    • [CrossRef] [PubMed]
    • Suma, T.; Miyata, K.; Anraku, Y.; Watanabe, S.; Christie, R.J.; Takemoto, H.; Shioyama, M.; Gouda, N.; Ishii, T.; Nishiyama, N.; et al. Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG. ACS Nano 2012, 6, 6693–6705. [CrossRef] [PubMed]
    • (2012) ACS Nano , vol.6 , pp. 6693-6705
    • Suma, T.1    Miyata, K.2    Anraku, Y.3    Watanabe, S.4    Christie, R.J.5    Takemoto, H.6    Shioyama, M.7    Gouda, N.8    Ishii, T.9    Nishiyama, N.10
  • 75
    • 77349109732 scopus 로고    scopus 로고
    • Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery
    • [CrossRef] [PubMed]
    • Li, J.; Chen, Y.C.; Tseng, Y.C.; Mozumdar, S.; Huang, L. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J. Control. Release 2010, 142, 416–421. [CrossRef] [PubMed]
    • (2010) J. Control. Release , vol.142 , pp. 416-421
    • Li, J.1    Chen, Y.C.2    Tseng, Y.C.3    Mozumdar, S.4    Huang, L.5
  • 76
    • 33645241767 scopus 로고    scopus 로고
    • Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer
    • [CrossRef] [PubMed]
    • Kakizawa, Y.; Furukawa, S.; Ishii, A.; Kataoka, K. Organic-inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer. J. Control. Release 2006, 111, 368–370. [CrossRef] [PubMed]
    • (2006) J. Control. Release , vol.111 , pp. 368-370
    • Kakizawa, Y.1    Furukawa, S.2    Ishii, A.3    Kataoka, K.4
  • 77
    • 79951578276 scopus 로고    scopus 로고
    • Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity
    • [CrossRef] [PubMed]
    • Pittella, F.; Zhang, M.; Lee, Y.; Kim, H.J.; Tockary, T.; Osada, K.; Ishii, T.; Miyata, K.; Nishiyama, N.; Kataoka, K. Enhanced endosomal escape of siRNA-incorporating hybrid nanoparticles from calcium phosphate and PEG-block charge-conversional polymer for efficient gene knockdown with negligible cytotoxicity. Biomaterials 2011, 32, 3106–3114. [CrossRef] [PubMed]
    • (2011) Biomaterials , vol.32 , pp. 3106-3114
    • Pittella, F.1    Zhang, M.2    Lee, Y.3    Kim, H.J.4    Tockary, T.5    Osada, K.6    Ishii, T.7    Miyata, K.8    Nishiyama, N.9    Kataoka, K.10
  • 78
    • 84924722741 scopus 로고    scopus 로고
    • Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles
    • [CrossRef] [PubMed]
    • Kim, H.J.; Takemoto, H.; Yi, Y.; Zheng, M.; Maeda, Y.; Chaya, H.; Hayashi, K.; Mi, P.; Pittella, F.; Christie, R.J.; et al. Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles. ACS Nano 2014, 8, 8979–8991. [CrossRef] [PubMed]
    • (2014) ACS Nano , vol.8 , pp. 8979-8991
    • Kim, H.J.1    Takemoto, H.2    Yi, Y.3    Zheng, M.4    Maeda, Y.5    Chaya, H.6    Hayashi, K.7    Mi, P.8    Pittella, F.9    Christie, R.J.10
  • 80
    • 77953168018 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells
    • [CrossRef] [PubMed]
    • Hom, C.; Lu, J.; Liong, M.; Luo, H.; Li, Z.; Zink, J.I.; Tamanoi, F. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. Small 2011, 6, 1185–1190. [CrossRef] [PubMed]
    • (2011) Small , vol.6 , pp. 1185-1190
    • Hom, C.1    Lu, J.2    Liong, M.3    Luo, H.4    Li, Z.5    Zink, J.I.6    Tamanoi, F.7
  • 81
    • 84857911904 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor
    • [CrossRef] [PubMed]
    • Li, J.; Yang, Y.; Huang, L. Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor. J. Control. Release 2012, 158, 108–114. [CrossRef] [PubMed]
    • (2012) J. Control. Release , vol.158 , pp. 108-114
    • Li, J.1    Yang, Y.2    Huang, L.3
  • 82
    • 84943364330 scopus 로고    scopus 로고
    • Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines?
    • [CrossRef]
    • Guo, J.; Rahme, K.; Fitzgerald, K.A.; Holmes, J.D.; O’Driscoll, C.M. Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines? Nano Res. 2015, 8, 3111–3140. [CrossRef]
    • (2015) Nano Res , vol.8 , pp. 3111-3140
    • Guo, J.1    Rahme, K.2    Fitzgerald, K.A.3    Holmes, J.D.4    O’Driscoll, C.M.5
  • 83
    • 84888865755 scopus 로고    scopus 로고
    • Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment
    • [CrossRef] [PubMed]
    • Deng, Z.J.; Morton, S.W.; Ben-Akiva, E.; Dreaden, E.C.; Shopsowitz, K.E.; Hammond, P.T. Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment. ACS Nano 2013, 7, 9571–9584. [CrossRef] [PubMed]
    • (2013) ACS Nano , vol.7 , pp. 9571-9584
    • Deng, Z.J.1    Morton, S.W.2    Ben-Akiva, E.3    Dreaden, E.C.4    Shopsowitz, K.E.5    Hammond, P.T.6


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