Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor

Journal of Controlled Release

Volumn 158, Issue 1, 2012, Pages 108-114

  Li, Jun ^a   Yang, Yang ^a   Huang, Leaf ^a  

^a University of North Carolina   (United States)

Author keywords

Asymmetric lipid bilayer; Calcium phosphate; Nanoparticle; siRNA delivery

Indexed keywords

ANIONIC LIPIDS; BI-LAYER STRUCTURE; BILAYER COATINGS; BIODISTRIBUTIONS; CALCIUM PHOSPHATE NANOPARTICLES; CATIONIC LIPIDS; HOLLOW CORES; IN-VITRO; IN-VIVO; INNER LEAFLETS; LIPID MIXTURES; LUNG CANCER CELLS; NANO-SIZE; PEGYLATION; SIGMA RECEPTORS; SIRNA DELIVERY; SUB-CELLULAR; SURFACE CURVATURES; TARGETED DELIVERY;

CALCIUM PHOSPHATE; CELLS; COATINGS; CYTOLOGY; NANOPARTICLES; ORGANIC SOLVENTS; PHOSPHOLIPIDS; RNA; TUMORS; ZETA POTENTIAL;

LIPID BILAYERS;

AMPHOPHILE; CALCIUM PHOSPHATE; CATION; DNA; FIREFLY LUCIFERASE; LIGAND; LIPID; NANOCOATING; NANOPARTICLE; ORGANIC SOLVENT; PROTAMINE; RHODAMINE; SIGMA OPIATE RECEPTOR; SMALL INTERFERING RNA;

AQUEOUS SOLUTION; ARTICLE; CANCER CELL; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONJUGATE; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LIPID BILAYER; LUNG CANCER; MEASUREMENT; NANOENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; SOLUBILITY; TISSUE DISTRIBUTION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR; ZETA POTENTIAL;

ANIMALS; CALCIUM PHOSPHATES; CELL LINE, TUMOR; FATTY ACIDS, MONOUNSATURATED; FEMALE; GENE SILENCING; GENE TRANSFER TECHNIQUES; HUMANS; LIPID BILAYERS; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLCHOLINES; QUATERNARY AMMONIUM COMPOUNDS; RNA, SMALL INTERFERING;

EID: 84857911904     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.020     Document Type: Article

References (60)

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32. K.A. Whitehead, R. Langer, and D.G. Anderson Knocking down barriers: advances in siRNA delivery Nat. Rev. Drug Discov. 8 2 2009 129 138
33. S.D. Li, and L. Huang Nanoparticles evading the reticuloendothelial system: role of the supported bilayer Biochim. Biophys. Acta 1788 10 2009 2259 2266
34. M.E. Davis The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic Mol. Pharm. 6 3 2009 659 668
35. S.C. Semple, A. Akinc, J. Chen, A.P. Sandhu, B.L. Mui, C.K. Cho, D.W. Sah, D. Stebbing, E.J. Crosley, E. Yaworski, I. Hafez, J.R. Dorkin, J. Qin, K. Lam, K.G. Rajeev, K.F. Wong, L.B. Jeffs, L. Nechev, M.L. Eisenhardt, M. Jayaraman, M. Kazem, M.A. Maier, M. Srinivasulu, M.J. Weinstein, Q. Chen, R. Alvarez, S.A. Barros, S. De, S.K. Klimuk, T. Borland, V. Kosovrasti, W.L. Cantley, Y.K. Tam, M. Manoharan, M.A. Ciufolini, M.A. Tracy, A. de Fougerolles, I. MacLachlan, P.R. Cullis, T.D. Madden, and M.J. Hope Rational design of cationic lipids for siRNA delivery Nat. Biotechnol. 28 2 2010 172 176
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37. A. Akinc, W. Querbes, S. De, J. Qin, M. Frank-Kamenetsky, K.N. Jayaprakash, M. Jayaraman, K.G. Rajeev, W.L. Cantley, J.R. Dorkin, J.S. Butler, L. Qin, T. Racie, A. Sprague, E. Fava, A. Zeigerer, M.J. Hope, M. Zerial, D.W. Sah, K. Fitzgerald, M.A. Tracy, M. Manoharan, V. Koteliansky, A. Fougerolles, and M.A. Maier Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms Mol. Ther. 18 7 2010 1357 1364
38. A. Akinc, M. Goldberg, J. Qin, J.R. Dorkin, C. Gamba-Vitalo, M. Maier, K.N. Jayaprakash, M. Jayaraman, K.G. Rajeev, M. Manoharan, V. Koteliansky, I. Röhl, E.S. Leshchiner, R. Langer, and D.G. Anderson Development of lipidoid-siRNA formulations for systemic delivery to the liver Mol. Ther. 17 5 2009 872 879
39. S. Chono, S.D. Li, C.C. Conwell, and L. Huang An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor J. Control. Release 131 1 2008 64 69
40. S.D. Li, Y.C. Chen, M.J. Hackett, and L. Huang Tumor-targeted delivery of siRNA by self-assembled nanoparticles Mol. Ther. 16 1 2008 163 169
41. S.D. Li, S. Chono, and L. Huang Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA Mol. Ther. 16 5 2008 942 946 (Pubitemid 351587105)
42. M.E. Davis, J.E. Zuckerman, C.H. Choi, D. Seligson, A. Tolcher, C.A. Alabi, Y. Yen, J.D. Heidel, and A. Ribas Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Nature 464 7291 2010 1067 1070
43. S.R. Popielarski, S.H. Pun, and M.E. Davis A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 1. Synthesis and characterization Bioconjug. Chem. 16 5 2005 1063 1070 (Pubitemid 41368106)
44. S. Hu-Lieskovan, J.D. Heidel, D.W. Bartlett, M.E. Davis, and T.J. Triche Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma Cancer Res. 65 19 2005 8984 8992 (Pubitemid 41377390)
45. J. Li, Y.C. Chen, Y.C. Tseng, S. Mozumdar, and L. Huang Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery J. Control. Release 142 3 2010 416 421
46. F. Alexis, E. Pridgen, L.K. Molnar, and O.C. Farokhzad Factors affecting the clearance and biodistribution of polymeric nanoparticles Mol. Pharm. 5 4 2008 505 515
47. P.S. Uster, T.M. Allen, B.E. Daniel, C.J. Mendez, M.S. Newman, and G.Z. Zhu Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time FEBS Lett. 386 2-3 1996 243 246 (Pubitemid 26173078)
48. J.M. Cotmore, G. Nichols Jr., and R.E. Wuthier Phospholipid-calcium phosphate complex: enhanced calcium migration in the presence of phosphate Science 172 990 1971 1339 1341
49. J. Whittenton, S. Harendra, R. Pitchumani, K. Mohanty, C. Vipulanandan, and S. Thevananther Evaluation of asymmetric liposomal nanoparticles for encapsulation of polynucleotides Langmuir 24 16 2008 8533 8540
50. T.P. Frederic Duconge, Pestourie Carine, Herin Laurence, Theze Benoît, Gombert Karine, Mahler Benoît, Hinnen Françoise, Kühnast Bertrand, Dolle Frederic, Dubertret Benoît, and Tavitian Bertrand Fluorine-18-labeled phospholipid quantum dot micelles for in vivo multimodal imaging from whole body to cellular scales Bioconjug. Chem. 19 9 2008 1921 1926
51. P.S. Benoit Dubertret, David J. Norris, Noireaux Vincent, Ali H. Brivanlou, and Libchaber Albert In vivo imaging of quantum dots encapsulated in phospholipid micelles Science 298 5599 2002 1759 1762 (Pubitemid 35404113)
52. M.C. Woodle, and D.D. Lasic Sterically stabilized liposomes Biochim. Biophys. Acta 1113 2 1992 171 199
53. A.L. Klibanov, K. Maruyama, V.P. Torchilin, and L. Huang Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett. 268 1 1990 235 237 (Pubitemid 20233874)
54. R. Banerjee, P. Tyagi, S. Li, and L. Huang Anisamide-targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells Int. J. Cancer 112 4 2004 693 700 (Pubitemid 39425952)
55. O. Garbuzenko, Y. Barenholz, and A. Priev Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer Chem. Phys. Lipids 135 2 2005 117 129 (Pubitemid 40744733)
56. Y. Tan, M. Whitmore, S. Li, P. Frederik, and L. Huang LPD nanoparticles-novel nonviral vector for efficient gene delivery Methods Mol. Med. 69 2002 73 81
57. A.D. Judge, M. Robbins, I. Tavakoli, J. Levi, L. Hu, A. Fronda, E. Ambegia, K. McClintock, and I. MacLachlan Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice J. Clin. Invest. 119 3 2009 661 673
58. O. Boussif, F. Lezoualc'h, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U. S. A. 92 16 1995 7297 7301
59. Y. Xu, and F.C. Szoka Jr. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection Biochemistry 35 18 1996 5616 5623 (Pubitemid 26143656)
60. I.M. Hafez, N. Maurer, and P.R. Cullis On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids Gene Ther. 8 15 2001 1188 1196 (Pubitemid 32776393)