Overcoming the polyethylene glycol dilemma via pathological environment-sensitive change of the surface property of nanoparticles for cellular entry

Journal of Controlled Release

Volumn 206, Issue , 2015, Pages 67-74

  Hama, Susumu ^a   Itakura, Shoko ^a   Nakai, Mayumi ^a   Nakayama, Kayoko ^a   Morimoto, Satoshi ^a   Suzuki, Satoko ^a   Kogure, Kentaro ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cancer therapy; Charge inversion; Intratumoral pH; Nanoparticles; Pathological environment sensitivity

Indexed keywords

CARDIOVASCULAR SYSTEM; CELLS; DISEASES; DRUG DELIVERY; MOBILE SECURITY; POLYETHYLENE GLYCOLS; POLYETHYLENES; SURFACE CHARGE; TISSUE; TUMORS;

ANTI-CANCER DRUG DELIVERY; CANCER THERAPY; CHARGE INVERSION; ENHANCED PERMEATION AND RETENTIONS; NEGATIVE SURFACE CHARGES; PATHOLOGICAL ENVIRONMENT-SENSITIVITY; PEGYLATED NANOPARTICLE; TUMOR MICROENVIRONMENT;

NANOPARTICLES;

MACROGOL; NANOPARTICLE; SLIGHTLY ACIDIC PH SENSITIVE PEPTIDE NANOPARTICLE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG CARRIER; MACROGOL DERIVATIVE; PEPTIDE;

ANIMAL CELL; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENVIRONMENT; MOUSE; NONHUMAN; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE; SURFACE PROPERTY; TISSUE DISTRIBUTION; TUMOR MICROENVIRONMENT; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; NANOPARTICLES; NEOPLASMS; PEPTIDES; POLYETHYLENE GLYCOLS; SURFACE PROPERTIES;

EID: 84925070692     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.03.011     Document Type: Article

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