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Volumn 104, Issue , 2016, Pages 44-60

Imaging-guided delivery of RNAi for anticancer treatment

Author keywords

Cancer; Gene delivery; Molecular imaging; Nanocarrier; RNA interference; siRNA; Theranostics

Indexed keywords

DISEASES; DRUG PRODUCTS; GENE TRANSFER; IMAGE PROCESSING; IMAGING TECHNIQUES; RNA;

EID: 84956666000     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2016.01.008     Document Type: Review
Times cited : (95)

References (178)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • [1] Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., Mello, C.C., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998), 806–811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • [2] Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., Tuschl, T., Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001), 494–498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 6
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • [6] O'Connell, R.M., Rao, D.S., Chaudhuri, A.A., Baltimore, D., Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10 (2010), 111–122.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 7
    • 84868475728 scopus 로고    scopus 로고
    • MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
    • [7] van Rooij, E., Olson, E.N., MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat. Rev. Drug Discov. 11 (2012), 860–872.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 860-872
    • van Rooij, E.1    Olson, E.N.2
  • 10
    • 84861194242 scopus 로고    scopus 로고
    • Nanovector delivery of siRNA for cancer therapy
    • [10] Shen, H., Sun, T., Ferrari, M., Nanovector delivery of siRNA for cancer therapy. Cancer Gene Ther. 19 (2012), 367–373.
    • (2012) Cancer Gene Ther. , vol.19 , pp. 367-373
    • Shen, H.1    Sun, T.2    Ferrari, M.3
  • 12
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • [12] Alexis, F., Pridgen, E., Molnar, L.K., Farokhzad, O.C., Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5 (2008), 505–515.
    • (2008) Mol. Pharm. , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 14
    • 33847099637 scopus 로고    scopus 로고
    • Lipid-based nanoparticles for nucleic acid delivery
    • [14] Li, W., Szoka, F.C. Jr., Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24 (2007), 438–449.
    • (2007) Pharm. Res. , vol.24 , pp. 438-449
    • Li, W.1    Szoka, F.C.2
  • 15
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • [15] Mintzer, M.A., Simanek, E.E., Nonviral vectors for gene delivery. Chem. Rev. 109 (2009), 259–302.
    • (2009) Chem. Rev. , vol.109 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 18
  • 20
    • 0038574350 scopus 로고    scopus 로고
    • Non-viral gene therapy: polycation-mediated DNA delivery
    • [20] Thomas, M., Klibanov, A.M., Non-viral gene therapy: polycation-mediated DNA delivery. Appl. Microbiol. Biotechnol. 62 (2003), 27–34.
    • (2003) Appl. Microbiol. Biotechnol. , vol.62 , pp. 27-34
    • Thomas, M.1    Klibanov, A.M.2
  • 21
    • 84856917252 scopus 로고    scopus 로고
    • Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy
    • [21] Mo, R.H., Zaro, J.L., Shen, W.C., Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy. Mol. Pharm. 9 (2012), 299–309.
    • (2012) Mol. Pharm. , vol.9 , pp. 299-309
    • Mo, R.H.1    Zaro, J.L.2    Shen, W.C.3
  • 22
    • 33847192134 scopus 로고    scopus 로고
    • Peptide-guided gene delivery
    • [22] Martin, M.E., Rice, K.G., Peptide-guided gene delivery. AAPS J. 9 (2007), E18–E29.
    • (2007) AAPS J. , vol.9 , pp. E18-E29
    • Martin, M.E.1    Rice, K.G.2
  • 28
    • 39849106393 scopus 로고    scopus 로고
    • Inorganic nanoparticles as carriers of nucleic acids into cells
    • [28] Sokolova, V., Epple, M., Inorganic nanoparticles as carriers of nucleic acids into cells. Angew. Chem. Int. Ed. Engl. 47 (2008), 1382–1395.
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , pp. 1382-1395
    • Sokolova, V.1    Epple, M.2
  • 33
    • 84946054162 scopus 로고    scopus 로고
    • Systemic delivery of anti-miRNA for suppression of triple negative breast cancer utilizing RNA nanotechnology
    • [33] Shu, D., Li, H., Shu, Y., Xiong, G., Carson, W.E. 3rd, Haque, F., Xu, R., Guo, P., Systemic delivery of anti-miRNA for suppression of triple negative breast cancer utilizing RNA nanotechnology. ACS Nano 9 (2015), 9731–9740.
    • (2015) ACS Nano , vol.9 , pp. 9731-9740
    • Shu, D.1    Li, H.2    Shu, Y.3    Xiong, G.4    Carson, W.E.5    Haque, F.6    Xu, R.7    Guo, P.8
  • 34
    • 84908564426 scopus 로고    scopus 로고
    • Current issues of RNAi therapeutics delivery and development
    • [34] Haussecker, D., Current issues of RNAi therapeutics delivery and development. J. Control. Release 195 (2014), 49–54.
    • (2014) J. Control. Release , vol.195 , pp. 49-54
    • Haussecker, D.1
  • 35
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of siRNA therapeutics: barriers and carriers
    • [35] Wang, J., Lu, Z., Wientjes, M.G., Au, J.L.S., Delivery of siRNA therapeutics: barriers and carriers. AAPS J. 12 (2010), 492–503.
    • (2010) AAPS J. , vol.12 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.S.4
  • 37
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • [37] Judge, A.D., Sood, V., Shaw, J.R., Fang, D., McClintock, K., MacLachlan, I., Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23 (2005), 457–462.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 38
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity
    • [38] Jackson, A.L., Burchard, J., Schelter, J., Chau, B.N., Cleary, M., Lim, L., Linsley, P.S., Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity. RNA 12 (2006), 1179–1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 39
    • 75749154476 scopus 로고    scopus 로고
    • In vivo imaging of RNA Interference
    • [39] Hong, H., Zhang, Y., Cai, W.B., In vivo imaging of RNA Interference. J. Nucl. Med. 51 (2010), 169–172.
    • (2010) J. Nucl. Med. , vol.51 , pp. 169-172
    • Hong, H.1    Zhang, Y.2    Cai, W.B.3
  • 42
    • 0036405345 scopus 로고    scopus 로고
    • Advances in in vivo bioluminescence imaging of gene expression
    • [42] Contag, C.H., Bachmann, M.H., Advances in in vivo bioluminescence imaging of gene expression. Annu. Rev. Biomed. Eng. 4 (2002), 235–260.
    • (2002) Annu. Rev. Biomed. Eng. , vol.4 , pp. 235-260
    • Contag, C.H.1    Bachmann, M.H.2
  • 43
    • 84876274984 scopus 로고    scopus 로고
    • Noninvasive visualization of microRNA-16 in the chemoresistance of gastric cancer using a dual reporter gene imaging system
    • [43] Wang, F., Song, X., Li, X., Xin, J., Wang, S., Yang, W., Wang, J., Wu, K., Chen, X., Liang, J., Tian, J., Cao, F., Noninvasive visualization of microRNA-16 in the chemoresistance of gastric cancer using a dual reporter gene imaging system. PLoS ONE, 8, 2013, e61792.
    • (2013) PLoS ONE , vol.8
    • Wang, F.1    Song, X.2    Li, X.3    Xin, J.4    Wang, S.5    Yang, W.6    Wang, J.7    Wu, K.8    Chen, X.9    Liang, J.10    Tian, J.11    Cao, F.12
  • 44
    • 84862533366 scopus 로고    scopus 로고
    • Design of “smart” probes for optical imaging of apoptosis
    • [44] Huang, X., Lee, S., Chen, X., Design of “smart” probes for optical imaging of apoptosis. Am. J. Nucl. Med. Mol Imaging 1 (2011), 3–17.
    • (2011) Am. J. Nucl. Med. Mol Imaging , vol.1 , pp. 3-17
    • Huang, X.1    Lee, S.2    Chen, X.3
  • 46
    • 84858017151 scopus 로고    scopus 로고
    • Positron emission tomography (PET) imaging with (18)F-based radiotracers
    • [46] Alauddin, M.M., Positron emission tomography (PET) imaging with (18)F-based radiotracers. Am. J. Nucl. Med. Mol Imaging. 2 (2012), 55–76.
    • (2012) Am. J. Nucl. Med. Mol Imaging. , vol.2 , pp. 55-76
    • Alauddin, M.M.1
  • 47
  • 48
    • 34547693063 scopus 로고    scopus 로고
    • Molecular ultrasound imaging using microbubble contrast agents
    • [48] Dayton, P.A., Rychak, J.J., Molecular ultrasound imaging using microbubble contrast agents. Front. Biosci. 12 (2007), 5124–5142.
    • (2007) Front. Biosci. , vol.12 , pp. 5124-5142
    • Dayton, P.A.1    Rychak, J.J.2
  • 50
    • 84882253822 scopus 로고    scopus 로고
    • RNA Interference and personalized cancer therapy
    • [50] Rao, D.D., Wang, Z.H., Senzer, N., Nemunaitis, J., RNA Interference and personalized cancer therapy. Discov. Med. 81 (2013), 101–110.
    • (2013) Discov. Med. , vol.81 , pp. 101-110
    • Rao, D.D.1    Wang, Z.H.2    Senzer, N.3    Nemunaitis, J.4
  • 51
    • 85015603642 scopus 로고    scopus 로고
    • EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery (IND# 72924): A Phase I Clinical Trial
    • [51] M.D.A.C. Center, EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery (IND# 72924): A Phase I Clinical Trial. https://clinicaltrials.gov/ct2/show/NCT01591356?term=NCT01591356, 2012.
    • (2012)
    • M.D.A.C. Center1
  • 52
    • 85015596649 scopus 로고    scopus 로고
    • A Phase 1, Open-Label, Dose-Ranging Study to Assess the Safety and Immunologic Activity of APN401
    • [52] C.C.C.o.W.F. University, A Phase 1, Open-Label, Dose-Ranging Study to Assess the Safety and Immunologic Activity of APN401. https://clinicaltrials.gov/ct2/show/NCT02166255, 2014.
    • (2014)
    • C.C.C.o.W.F. University1
  • 53
    • 85015586546 scopus 로고    scopus 로고
    • Phase I Study of Active Immunotherapy of Metastatic Melanoma with Mature Autologous Dendritic Cells Transfected with Tumor Antigen RNA and Small Inhibitory RNAs to Alter Proteasomal Antigen Processing
    • [53] S. Pruitt, Phase I Study of Active Immunotherapy of Metastatic Melanoma with Mature Autologous Dendritic Cells Transfected with Tumor Antigen RNA and Small Inhibitory RNAs to Alter Proteasomal Antigen Processing. https://clinicaltrials.gov/ct2/show/NCT00672542, 2008.
    • (2008)
    • S. Pruitt1
  • 54
    • 85015602859 scopus 로고    scopus 로고
    • A Prospective, Open-label, Single Center, Dose Finding Phase I-Study with Atu027 (an siRNA Formulation) in Subjects with Advanced Solid Cancer
    • [54] S.T. GmbH, A Prospective, Open-label, Single Center, Dose Finding Phase I-Study with Atu027 (an siRNA Formulation) in Subjects with Advanced Solid Cancer. https://clinicaltrials.gov/ct2/show/NCT00938574, 2009.
    • (2009)
    • S.T. GmbH1
  • 55
    • 85015600827 scopus 로고    scopus 로고
    • Phase I—Escalating Dose Study of siG12D LODER (Local Drug EluteR) in Patients With Locally Advanced Adenocarcinoma of the Pancreas, and a Single Dose Study of siG12D LODER (Local Drug EluteR) in Patients With Non-operable Adenocarcinoma of the Pancreas
    • [55] S. Ltd, Phase I—Escalating Dose Study of siG12D LODER (Local Drug EluteR) in Patients With Locally Advanced Adenocarcinoma of the Pancreas, and a Single Dose Study of siG12D LODER (Local Drug EluteR) in Patients With Non-operable Adenocarcinoma of the Pancreas. https://clinicaltrials.gov/ct2/show/NCT01188785, 2010.
    • (2010)
    • S. Ltd1
  • 56
    • 85015585439 scopus 로고    scopus 로고
    • A Phase 1 Dose Escalation Study of Hepatic Intra-Arterial Administration of TKM 080301 (Lipid Nanoparticles Containing siRNA Against the PLK1 Gene Product) in Patients with Colorectal, Pancreas, Gastric, Breast, Ovarian and Esophageal Cancers with Hepatic
    • [56] N.C.I. (NCI), A Phase 1 Dose Escalation Study of Hepatic Intra-Arterial Administration of TKM 080301 (Lipid Nanoparticles Containing siRNA Against the PLK1 Gene Product) in Patients with Colorectal, Pancreas, Gastric, Breast, Ovarian and Esophageal Cancers with Hepatic. https://clinicaltrials.gov/ct2/show/NCT01437007, 2011.
    • (2011)
    • N.C.I. (NCI)1
  • 57
    • 85015604677 scopus 로고    scopus 로고
    • A Phase 1b/2, Open Label, Randomized, Repeat Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Biological Activity, and Pharmacokinetics of ND-L02-s0201 Injection, a Vitamin A-coupled Lipid Nanoparticle Containing siRNA Against HSP47, in Subjects with Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4)
    • [57] N.D. Corporation, A Phase 1b/2, Open Label, Randomized, Repeat Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Biological Activity, and Pharmacokinetics of ND-L02-s0201 Injection, a Vitamin A-coupled Lipid Nanoparticle Containing siRNA Against HSP47, in Subjects with Moderate to Extensive Hepatic Fibrosis (METAVIR F3-4). https://clinicaltrials.gov/ct2/show/NCT02227459, 2014.
    • (2014)
    • N.D. Corporation1
  • 58
    • 85015606584 scopus 로고    scopus 로고
    • Phase I, Multicenter, Cohort Dose Escalation Trial to Determine the Safety, Tolerance, and Maximum Tolerated Dose of DCR-MYC, a Lipid Nanoparticle (LNP)-Formulated Small Inhibitory RNA (siRNA) Oligonucleotide Targeting MYC, in Patients with Refractory Locally Advanced or Metastatic Solid Tumor Malignancies, Multiple Myeloma, or Lymphoma
    • [58] I. Dicerna Pharmaceuticals, Phase I, Multicenter, Cohort Dose Escalation Trial to Determine the Safety, Tolerance, and Maximum Tolerated Dose of DCR-MYC, a Lipid Nanoparticle (LNP)-Formulated Small Inhibitory RNA (siRNA) Oligonucleotide Targeting MYC, in Patients with Refractory Locally Advanced or Metastatic Solid Tumor Malignancies, Multiple Myeloma, or Lymphoma. https://clinicaltrials.gov/ct2/show/NCT02110563, 2014.
    • (2014)
    • I. Dicerna Pharmaceuticals1
  • 59
    • 85015598883 scopus 로고    scopus 로고
    • A Phase I, Dose-Escalating Study of the Safety of Intravenous CALAA-01 in Adults with Solid Tumors Refractory to Standard-of-Care Therapies
    • [59] C. Pharmaceuticals, A Phase I, Dose-Escalating Study of the Safety of Intravenous CALAA-01 in Adults with Solid Tumors Refractory to Standard-of-Care Therapies. https://clinicaltrials.gov/ct2/show/NCT00689065, 2008.
    • (2008)
    • C. Pharmaceuticals1
  • 60
    • 85015603208 scopus 로고    scopus 로고
    • A Phase 1/2 Dose Escalation Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous TKM-080301 in Patients with Advanced Solid Tumors
    • [60] T.P. Corporation, A Phase 1/2 Dose Escalation Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of Intravenous TKM-080301 in Patients with Advanced Solid Tumors. https://clinicaltrials.gov/ct2/show/NCT01262235, 2010.
    • (2010)
    • T.P. Corporation1
  • 61
    • 85015602799 scopus 로고    scopus 로고
    • A Multi-Center, Open Label, Phase 1 Dose-Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 in Patients with Advanced Solid Tumors with Liver Involvement
    • [61] A. Pharmaceuticals, A Multi-Center, Open Label, Phase 1 Dose-Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 in Patients with Advanced Solid Tumors with Liver Involvement. https://clinicaltrials.gov/ct2/show/NCT00882180, 2009.
    • (2009)
    • A. Pharmaceuticals1
  • 62
    • 85015591759 scopus 로고    scopus 로고
    • A Multi-center, Open-Label, Extension Study of ALN-VSP02 in Cancer Patients Who Have Responded to ALN-VSP02 Treatment
    • [62] A. Pharmaceuticals, A Multi-center, Open-Label, Extension Study of ALN-VSP02 in Cancer Patients Who Have Responded to ALN-VSP02 Treatment. https://clinicaltrials.gov/ct2/show/NCT01158079, 2009.
    • (2009)
    • A. Pharmaceuticals1
  • 68
    • 0029417238 scopus 로고
    • Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
    • [68] Blangy, A., Lane, H.A., d'Herin, P., Harper, M., Kress, M., Nigg, E.A., Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83 (1995), 1159–1169.
    • (1995) Cell , vol.83 , pp. 1159-1169
    • Blangy, A.1    Lane, H.A.2    d'Herin, P.3    Harper, M.4    Kress, M.5    Nigg, E.A.6
  • 69
    • 0033991167 scopus 로고    scopus 로고
    • Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer
    • [69] Itakura, J., Ishiwata, T., Shen, B., Kornmann, M., Korc, M., Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int. J. Cancer 85 (2000), 27–34.
    • (2000) Int. J. Cancer , vol.85 , pp. 27-34
    • Itakura, J.1    Ishiwata, T.2    Shen, B.3    Kornmann, M.4    Korc, M.5
  • 71
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • [71] Ferrara, N., Gerber, H.P., LeCouter, J., The biology of VEGF and its receptors. Nat. Med. 9 (2003), 669–676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 72
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • [72] Duxbury, M.S., Ito, H., Zinner, M.J., Ashley, S.W., Whang, E.E., RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 23 (2004), 1539–1548.
    • (2004) Oncogene , vol.23 , pp. 1539-1548
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 73
    • 84869506983 scopus 로고    scopus 로고
    • The impact of quantitative imaging in medicine and surgery: charting our course for the future
    • [73] Wang, Y.X., Ng, C.K., The impact of quantitative imaging in medicine and surgery: charting our course for the future. Quant. Imaging. Med. Surg. 1 (2011), 1–3.
    • (2011) Quant. Imaging. Med. Surg. , vol.1 , pp. 1-3
    • Wang, Y.X.1    Ng, C.K.2
  • 74
    • 85015607355 scopus 로고    scopus 로고
    • Phase I First-in-Human Trial of ALN-TTRsc, a Novel RNA Interference Therapeutic for the Treatment of Familial Amyloidotic Cardiomyopathy (FAC)
    • [74] Tracy Zimmermann, V.K., Harrop, Jamie, Chan, Amy, Chiesa, Joseph, Peters, Gary, Falzone, Rick, Cehelsky, Jeffrey, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared, Phase I First-in-Human Trial of ALN-TTRsc, a Novel RNA Interference Therapeutic for the Treatment of Familial Amyloidotic Cardiomyopathy (FAC). http://www.alnylam.com/web/wp-content/uploads/2013/09/ALN-TTRsc-PhI-HFSA-Poster-Sep2013.pdf, 2013.
    • (2013)
    • Tracy Zimmermann, V.K.1    Harrop, J.2    Chan, A.3    Chiesa, J.4    Peters, G.5    Falzone, R.6    Cehelsky, J.7    Nochur, S.8    Vaishnaw, A.9    Gollob, J.10
  • 76
  • 77
    • 67649295505 scopus 로고    scopus 로고
    • siRNA delivery systems for cancer treatment
    • [77] Oh, Y.K., Park, T.G., siRNA delivery systems for cancer treatment. Adv. Drug Deliv. Rev. 61 (2009), 850–862.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 850-862
    • Oh, Y.K.1    Park, T.G.2
  • 80
    • 84896734996 scopus 로고    scopus 로고
    • Improving conventional enhanced permeability and retention (EPR) effects; what Is the appropriate Target?
    • [80] Kobayashi, H., Watanabe, R., Choyke, P.L., Improving conventional enhanced permeability and retention (EPR) effects; what Is the appropriate Target?. Theranostics. 4 (2014), 81–89.
    • (2014) Theranostics. , vol.4 , pp. 81-89
    • Kobayashi, H.1    Watanabe, R.2    Choyke, P.L.3
  • 81
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer-chemotherapy—mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs
    • [81] Matsumura, Y., Maeda, H., A new concept for macromolecular therapeutics in cancer-chemotherapy—mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs. Cancer Res. 46 (1986), 6387–6392.
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 82
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: theory to practice
    • [82] Moghimi, S.M., Hunter, A.C., Murray, J.C., Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53 (2001), 283–318.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 83
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • [83] Cho, K.J., Wang, X., Nie, S.M., Chen, Z., Shin, D.M., Therapeutic nanoparticles for drug delivery in cancer. Clin. Cancer Res. 14 (2008), 1310–1316.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1310-1316
    • Cho, K.J.1    Wang, X.2    Nie, S.M.3    Chen, Z.4    Shin, D.M.5
  • 84
    • 34250819325 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery
    • [84] van Vlerken, L.E., Vyas, T.K., Amiji, M.M., Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery. Pharm. Res. 24 (2007), 1405–1414.
    • (2007) Pharm. Res. , vol.24 , pp. 1405-1414
    • van Vlerken, L.E.1    Vyas, T.K.2    Amiji, M.M.3
  • 85
    • 33645235714 scopus 로고    scopus 로고
    • Diffusible-PEG-lipid stabilized plasmid lipid particles
    • 53pa
    • [85] Maclachlan, I., Cullis, P., Diffusible-PEG-lipid stabilized plasmid lipid particles. Adv. Genet., 2005, 157–188 53pa.
    • (2005) Adv. Genet. , pp. 157-188
    • Maclachlan, I.1    Cullis, P.2
  • 86
    • 0024408986 scopus 로고
    • Blood-flow, oxygen and nutrient supply, and metabolic microenvironment of human-tumors—a review
    • [86] Vaupel, P., Kallinowski, F., Okunieff, P., Blood-flow, oxygen and nutrient supply, and metabolic microenvironment of human-tumors—a review. Cancer Res. 49 (1989), 6449–6465.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 87
    • 84863721493 scopus 로고    scopus 로고
    • Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery
    • [87] Li, L., Wang, R., Wilcox, D., Zhao, X., Song, J., Lin, X., Kohlbrenner, W.M., Fesik, S.W., Shen, Y., Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery. Gene Ther. 19 (2012), 775–780.
    • (2012) Gene Ther. , vol.19 , pp. 775-780
    • Li, L.1    Wang, R.2    Wilcox, D.3    Zhao, X.4    Song, J.5    Lin, X.6    Kohlbrenner, W.M.7    Fesik, S.W.8    Shen, Y.9
  • 88
    • 84864670257 scopus 로고    scopus 로고
    • Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo
    • [88] Huang, K., Ma, H., Liu, J., Huo, S., Kumar, A., Wei, T., Zhang, X., Jin, S., Gan, Y., Wang, P.C., He, S., Zhang, X., Liang, X.J., Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano 6 (2012), 4483–4493.
    • (2012) ACS Nano , vol.6 , pp. 4483-4493
    • Huang, K.1    Ma, H.2    Liu, J.3    Huo, S.4    Kumar, A.5    Wei, T.6    Zhang, X.7    Jin, S.8    Gan, Y.9    Wang, P.C.10    He, S.11    Zhang, X.12    Liang, X.J.13
  • 89
    • 84903748665 scopus 로고    scopus 로고
    • The role of molecular imaging in modern drug development
    • [89] Cunha, L., Szigeti, K., Mathe, D., Metello, L.F., The role of molecular imaging in modern drug development. Drug Discov. Today 19 (2014), 936–948.
    • (2014) Drug Discov. Today , vol.19 , pp. 936-948
    • Cunha, L.1    Szigeti, K.2    Mathe, D.3    Metello, L.F.4
  • 90
    • 34248680739 scopus 로고    scopus 로고
    • Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides
    • [90] Meade, B.R., Dowdy, S.F., Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv. Drug Deliv. Rev. 59 (2007), 134–140.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 134-140
    • Meade, B.R.1    Dowdy, S.F.2
  • 92
  • 94
    • 84922724331 scopus 로고    scopus 로고
    • Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics
    • [94] Lorenzer, C., Dirin, M., Winkler, A.M., Baumann, V., Winkler, J., Going beyond the liver: progress and challenges of targeted delivery of siRNA therapeutics. J. Control. Release 203 (2015), 1–15.
    • (2015) J. Control. Release , vol.203 , pp. 1-15
    • Lorenzer, C.1    Dirin, M.2    Winkler, A.M.3    Baumann, V.4    Winkler, J.5
  • 95
    • 33745859044 scopus 로고    scopus 로고
    • Mechanisms of pathogen entry through the endosomal compartments
    • [95] Gruenberg, J., van der Goot, F.G., Mechanisms of pathogen entry through the endosomal compartments. Nat. Rev. Mol. Cell Biol. 7 (2006), 495–504.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 495-504
    • Gruenberg, J.1    van der Goot, F.G.2
  • 96
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • [96] Sonawane, N.D., Szoka, F.C. Jr., Verkman, A.S., Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278 (2003), 44826–44831.
    • (2003) J. Biol. Chem. , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka, F.C.2    Verkman, A.S.3
  • 98
    • 17844387370 scopus 로고    scopus 로고
    • A computational study of off-target effects of RNA interference
    • [98] Qiu, S., Adema, C.M., Lane, T., A computational study of off-target effects of RNA interference. Nucleic Acids Res. 33 (2005), 1834–1847.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 1834-1847
    • Qiu, S.1    Adema, C.M.2    Lane, T.3
  • 100
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • [100] Judge, A.D., Sood, V., Shaw, J.R., Fang, D., McClintock, K., MacLachlan, I., Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23 (2005), 457–462.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 101
    • 42649103333 scopus 로고    scopus 로고
    • Does the understanding of immune activation by RNA predict the design of safe siRNAs?
    • [101] Sioud, M., Does the understanding of immune activation by RNA predict the design of safe siRNAs?. Front. Biosci. 13 (2008), 4379–4392.
    • (2008) Front. Biosci. , vol.13 , pp. 4379-4392
    • Sioud, M.1
  • 102
    • 0036802915 scopus 로고    scopus 로고
    • Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents
    • [102] Sevick-Muraca, E.M., Houston, J.P., Gurfinkel, M., Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents. Curr. Opin. Chem. Biol. 6 (2002), 642–650.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 642-650
    • Sevick-Muraca, E.M.1    Houston, J.P.2    Gurfinkel, M.3
  • 103
    • 0142230995 scopus 로고    scopus 로고
    • In vivo near-infrared fluorescence imaging
    • [103] Frangioni, J.V., In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol. 7 (2003), 626–634.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 626-634
    • Frangioni, J.V.1
  • 105
    • 73249116830 scopus 로고    scopus 로고
    • Pre-clinical whole-body fluorescence imaging: review of instruments, methods and applications
    • [105] Leblond, F., Davis, S.C., Valdés, P.A., Pogue, B.W., Pre-clinical whole-body fluorescence imaging: review of instruments, methods and applications. J. Photochem. Photobiol., B 98 (2010), 77–94.
    • (2010) J. Photochem. Photobiol., B , vol.98 , pp. 77-94
    • Leblond, F.1    Davis, S.C.2    Valdés, P.A.3    Pogue, B.W.4
  • 106
    • 84889050211 scopus 로고    scopus 로고
    • Recent progress in the development of near-infrared fluorescent probes for bioimaging applications
    • [106] Guo, Z., Park, S., Yoon, J., Shin, I., Recent progress in the development of near-infrared fluorescent probes for bioimaging applications. Chem. Soc. Rev. 43 (2014), 16–29.
    • (2014) Chem. Soc. Rev. , vol.43 , pp. 16-29
    • Guo, Z.1    Park, S.2    Yoon, J.3    Shin, I.4
  • 107
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • [107] Kim, S.H., Jeong, J.H., Lee, S.H., Kim, S.W., Park, T.G., Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 129 (2008), 107–116.
    • (2008) J. Control. Release , vol.129 , pp. 107-116
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 109
    • 34248353867 scopus 로고    scopus 로고
    • Novel siRNA-based molecular beacons for dual imaging and therapy
    • [109] Chang, E., Zhu, M.Q., Drezek, R., Novel siRNA-based molecular beacons for dual imaging and therapy. Biotechnol. J. 2 (2007), 422–425.
    • (2007) Biotechnol. J. , vol.2 , pp. 422-425
    • Chang, E.1    Zhu, M.Q.2    Drezek, R.3
  • 112
    • 84903488678 scopus 로고    scopus 로고
    • Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors
    • [112] Oe, Y., Christie, R.J., Naito, M., Low, S.A., Fukushima, S., Toh, K., Miura, Y., Matsumoto, Y., Nishiyama, N., Miyata, K., Kataoka, K., Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors. Biomaterials 35 (2014), 7887–7895.
    • (2014) Biomaterials , vol.35 , pp. 7887-7895
    • Oe, Y.1    Christie, R.J.2    Naito, M.3    Low, S.A.4    Fukushima, S.5    Toh, K.6    Miura, Y.7    Matsumoto, Y.8    Nishiyama, N.9    Miyata, K.10    Kataoka, K.11
  • 113
  • 114
    • 84937862485 scopus 로고    scopus 로고
    • High performance photoluminescent carbon dots for In Vitro and In vivo bioimaging: effect of nitrogen doping ratios
    • [114] Wang, J., Zhang, P., Huang, C., Liu, G., Leung, K.C., Wang, Y.X., High performance photoluminescent carbon dots for In Vitro and In vivo bioimaging: effect of nitrogen doping ratios. Langmuir 31 (2015), 8063–8073.
    • (2015) Langmuir , vol.31 , pp. 8063-8073
    • Wang, J.1    Zhang, P.2    Huang, C.3    Liu, G.4    Leung, K.C.5    Wang, Y.X.6
  • 115
    • 65549126819 scopus 로고    scopus 로고
    • NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA
    • [115] Jiang, S., Zhang, Y., Lim, K.M., Sim, E.K.W., Ye, L., NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA. Nanotechnology, 20, 2009, e155101.
    • (2009) Nanotechnology , vol.20
    • Jiang, S.1    Zhang, Y.2    Lim, K.M.3    Sim, E.K.W.4    Ye, L.5
  • 117
    • 84947967937 scopus 로고    scopus 로고
    • Opportunities and challenges of fluorescent carbon dots in translational optical imaging
    • [117] Wang, J., Liu, G., Leung, K.C., Loffroy, R., Lu, P.X., Wang, Y.X., Opportunities and challenges of fluorescent carbon dots in translational optical imaging. Curr. Pharm. Des. 21 (2015), 5401–5416.
    • (2015) Curr. Pharm. Des. , vol.21 , pp. 5401-5416
    • Wang, J.1    Liu, G.2    Leung, K.C.3    Loffroy, R.4    Lu, P.X.5    Wang, Y.X.6
  • 118
    • 84906100483 scopus 로고    scopus 로고
    • Carbon-dot-based two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA
    • [118] Wang, L., Wang, X., Bhirde, A., Cao, J., Zeng, Y., Huang, X., Sun, Y., Liu, G., Chen, X., Carbon-dot-based two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA. Adv. Healthc. Mater. 3 (2014), 1203–1209.
    • (2014) Adv. Healthc. Mater. , vol.3 , pp. 1203-1209
    • Wang, L.1    Wang, X.2    Bhirde, A.3    Cao, J.4    Zeng, Y.5    Huang, X.6    Sun, Y.7    Liu, G.8    Chen, X.9
  • 119
    • 78650348625 scopus 로고    scopus 로고
    • Small upconverting fluorescent nanoparticles for biomedical applications
    • [119] Chatterjee, D.K., Gnanasammandhan, Y., Fau-Zhang, Mk, Zhang, Y., Small upconverting fluorescent nanoparticles for biomedical applications. Small 6 (2010), 2781–2795.
    • (2010) Small , vol.6 , pp. 2781-2795
    • Chatterjee, D.K.1    Gnanasammandhan, Y.2    Fau-Zhang, M.3    Zhang, Y.4
  • 120
    • 84908671507 scopus 로고    scopus 로고
    • Efficient gene delivery and multimodal imaging by lanthanide-based upconversion nanoparticles
    • [120] Wang, L., Liu, J., Dai, Y., Yang, Q., Zhang, Y., Yang, P., Cheng, Z., Lian, H., Li, C., Hou, Z., Ma, P., Lin, J., Efficient gene delivery and multimodal imaging by lanthanide-based upconversion nanoparticles. Langmuir 30 (2014), 13042–13051.
    • (2014) Langmuir , vol.30 , pp. 13042-13051
    • Wang, L.1    Liu, J.2    Dai, Y.3    Yang, Q.4    Zhang, Y.5    Yang, P.6    Cheng, Z.7    Lian, H.8    Li, C.9    Hou, Z.10    Ma, P.11    Lin, J.12
  • 121
    • 84883244353 scopus 로고    scopus 로고
    • Multimodality imaging of RNA Interference
    • [121] Nayak, T.R., Krasteva, L.K., Cai, W., Multimodality imaging of RNA Interference. Curr. Med. Chem. 20 (2013), 3664–3675.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 3664-3675
    • Nayak, T.R.1    Krasteva, L.K.2    Cai, W.3
  • 123
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • [123] Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A., Herweijer, H., Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 32 (2002), 107–108.
    • (2002) Nat. Genet. , vol.32 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 126
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • [126] Bartlett, D.W., Davis, M.E., Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 34 (2006), 322–333.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 322-333
    • Bartlett, D.W.1    Davis, M.E.2
  • 127
    • 31544448890 scopus 로고    scopus 로고
    • Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate
    • [127] Kim, S.H., Mok, H., Jeong, J.H., Kim, S.W., Park, T.G., Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate. Bioconjug. Chem. 17 (2006), 241–244.
    • (2006) Bioconjug. Chem. , vol.17 , pp. 241-244
    • Kim, S.H.1    Mok, H.2    Jeong, J.H.3    Kim, S.W.4    Park, T.G.5
  • 128
    • 84866676318 scopus 로고    scopus 로고
    • Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA
    • [128] Huschka, R., Barhoumi, A., Liu, Q., Roth, J.A., Ji, L., Halas, N.J., Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA. ACS Nano 6 (2012), 7681–7691.
    • (2012) ACS Nano , vol.6 , pp. 7681-7691
    • Huschka, R.1    Barhoumi, A.2    Liu, Q.3    Roth, J.A.4    Ji, L.5    Halas, N.J.6
  • 129
    • 84860190466 scopus 로고    scopus 로고
    • A molecular imaging primer: modalities, imaging agents, and applications
    • [129] James, M.L., Gambhir, S.S., A molecular imaging primer: modalities, imaging agents, and applications. Physiol. Rev. 92 (2012), 897–965.
    • (2012) Physiol. Rev. , vol.92 , pp. 897-965
    • James, M.L.1    Gambhir, S.S.2
  • 130
    • 0034241796 scopus 로고    scopus 로고
    • Positron emission tomography provides molecular imaging of biological processes
    • [130] Phelps, M.E., Positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. U. S. A. 97 (2000), 9226–9233.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 9226-9233
    • Phelps, M.E.1
  • 131
    • 15844420860 scopus 로고    scopus 로고
    • Positron emission tomography: principles, technology, and recent developments
    • [131] Ziegler, S.I., Positron emission tomography: principles, technology, and recent developments. Nucl. Phys. A. 752 (2005), 679c–687c.
    • (2005) Nucl. Phys. A. , vol.752 , pp. 679c-687c
    • Ziegler, S.I.1
  • 133
    • 77951053004 scopus 로고    scopus 로고
    • Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection
    • [133] Lu, W., Zhang, G., Zhang, R., Flores, L.G. 2nd, Huang, Q., Gelovani, J.G., Li, C., Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Res. 70 (2010), 3177–3188.
    • (2010) Cancer Res. , vol.70 , pp. 3177-3188
    • Lu, W.1    Zhang, G.2    Zhang, R.3    Flores, L.G.4    Huang, Q.5    Gelovani, J.G.6    Li, C.7
  • 134
    • 84883244353 scopus 로고    scopus 로고
    • Multimodality imaging of RNA interference
    • [134] Nayak, T.R., Krasteva, L.K., Cai, W., Multimodality imaging of RNA interference. Curr. Med. Chem. 20 (2013), 3664–3675.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 3664-3675
    • Nayak, T.R.1    Krasteva, L.K.2    Cai, W.3
  • 135
    • 77951260189 scopus 로고    scopus 로고
    • Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography
    • [135] Hatanaka, K., Asai, T., Koide, H., Kenjo, E., Tsuzuku, T., Harada, N., Tsukada, H., Oku, N., Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography. Bioconjug. Chem. 21 (2010), 756–763.
    • (2010) Bioconjug. Chem. , vol.21 , pp. 756-763
    • Hatanaka, K.1    Asai, T.2    Koide, H.3    Kenjo, E.4    Tsuzuku, T.5    Harada, N.6    Tsukada, H.7    Oku, N.8
  • 136
    • 85010072902 scopus 로고    scopus 로고
    • PET/SPECT molecular imaging in clinical neuroscience: recent advances in the investigation of CNS diseases
    • [136] Lu, F.M., Yuan, Z., PET/SPECT molecular imaging in clinical neuroscience: recent advances in the investigation of CNS diseases. Quant. Imaging. Med. Surg. 5 (2015), 433–447.
    • (2015) Quant. Imaging. Med. Surg. , vol.5 , pp. 433-447
    • Lu, F.M.1    Yuan, Z.2
  • 137
    • 34248188676 scopus 로고    scopus 로고
    • Radiolabeling small RNA with technetium-99 m for visualizing cellular delivery and mouse biodistribution
    • [137] Liu, N., Ding, H., Vanderheyden, J.L., Zhu, Z., Zhang, Y., Radiolabeling small RNA with technetium-99 m for visualizing cellular delivery and mouse biodistribution. Nucl. Med. Biol. 34 (2007), 399–404.
    • (2007) Nucl. Med. Biol. , vol.34 , pp. 399-404
    • Liu, N.1    Ding, H.2    Vanderheyden, J.L.3    Zhu, Z.4    Zhang, Y.5
  • 138
    • 61849179561 scopus 로고    scopus 로고
    • In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure
    • [138] Merkel, O.M., Librizzi, D., Pfestroff, A., Schurrat, T., Behe, M., Kissel, T., In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure. Bioconjug. Chem. 20 (2009), 174–182.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 174-182
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Behe, M.5    Kissel, T.6
  • 139
    • 33846132148 scopus 로고    scopus 로고
    • Basic Principles of MRI
    • OutSource
    • [139] Faulkner, W., Basic Principles of MRI. OutSource, 1996.
    • (1996)
    • Faulkner, W.1
  • 140
    • 84857619411 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application
    • [140] Wang, Y.X., Superparamagnetic iron oxide based MRI contrast agents: current status of clinical application. Quant. Imaging. Med. Surg. 1 (2011), 35–40.
    • (2011) Quant. Imaging. Med. Surg. , vol.1 , pp. 35-40
    • Wang, Y.X.1
  • 141
    • 78649962007 scopus 로고    scopus 로고
    • pH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells
    • [141] Mok, H., Veiseh, O., Fang, C., Kievit, F.M., Wang, F.Y., Park, J.O., Zhang, M., pH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells. Mol. Pharm. 7 (2010), 1930–1939.
    • (2010) Mol. Pharm. , vol.7 , pp. 1930-1939
    • Mok, H.1    Veiseh, O.2    Fang, C.3    Kievit, F.M.4    Wang, F.Y.5    Park, J.O.6    Zhang, M.7
  • 142
  • 143
    • 78649614246 scopus 로고    scopus 로고
    • Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy
    • [143] Li, C., Penet, M.F., Wildes, F., Takagi, T., Chen, Z.H., Winnard, P.T., Artemov, D., Bhujwalla, Z.M., Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy. ACS Nano 4 (2010), 6707–6716.
    • (2010) ACS Nano , vol.4 , pp. 6707-6716
    • Li, C.1    Penet, M.F.2    Wildes, F.3    Takagi, T.4    Chen, Z.H.5    Winnard, P.T.6    Artemov, D.7    Bhujwalla, Z.M.8
  • 144
    • 78349306448 scopus 로고    scopus 로고
    • Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging
    • [144] Bae, K.H., Lee, K., Kim, C., Park, T.G., Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. Biomaterials 32 (2011), 176–184.
    • (2011) Biomaterials , vol.32 , pp. 176-184
    • Bae, K.H.1    Lee, K.2    Kim, C.3    Park, T.G.4
  • 145
    • 84870567279 scopus 로고    scopus 로고
    • A synergistically enhanced T(1)–T(2) dual-modal contrast agent
    • [145] Zhou, Z., Huang, D., Bao, J., Chen, Q., Liu, G., Chen, Z., Chen, X., Gao, J., A synergistically enhanced T(1)–T(2) dual-modal contrast agent. Adv. Mater. 24 (2012), 6223–6228.
    • (2012) Adv. Mater. , vol.24 , pp. 6223-6228
    • Zhou, Z.1    Huang, D.2    Bao, J.3    Chen, Q.4    Liu, G.5    Chen, Z.6    Chen, X.7    Gao, J.8
  • 146
    • 84881526268 scopus 로고    scopus 로고
    • Gadolinium embedded iron oxide nanoclusters as T1–T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery
    • [146] Wang, X., Zhou, Z., Wang, Z., Xue, Y., Zeng, Y., Gao, J., Zhu, L., Zhang, X., Liu, G., Chen, X., Gadolinium embedded iron oxide nanoclusters as T1–T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery. Nanoscale. 5 (2013), 8098–8104.
    • (2013) Nanoscale. , vol.5 , pp. 8098-8104
    • Wang, X.1    Zhou, Z.2    Wang, Z.3    Xue, Y.4    Zeng, Y.5    Gao, J.6    Zhu, L.7    Zhang, X.8    Liu, G.9    Chen, X.10
  • 147
    • 8844285146 scopus 로고    scopus 로고
    • The role of ultrasound in molecular imaging
    • [147] Liang, H.D., Blomley, M.J.K., The role of ultrasound in molecular imaging. Br. J. Radiol. 76 (2003), S140–S150.
    • (2003) Br. J. Radiol. , vol.76 , pp. S140-S150
    • Liang, H.D.1    Blomley, M.J.K.2
  • 148
    • 84864508341 scopus 로고    scopus 로고
    • Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
    • [148] Shim, M.S., Kwon, Y.J., Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Adv. Drug Deliv. Rev. 64 (2012), 1046–1059.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 1046-1059
    • Shim, M.S.1    Kwon, Y.J.2
  • 149
    • 84901633696 scopus 로고    scopus 로고
    • Cardiovascular drug delivery with ultrasound and microbubbles
    • [149] Unger, E., Porter, T., Lindner, J., Grayburn, P., Cardiovascular drug delivery with ultrasound and microbubbles. Adv. Drug Deliv. Rev. 72 (2014), 110–126.
    • (2014) Adv. Drug Deliv. Rev. , vol.72 , pp. 110-126
    • Unger, E.1    Porter, T.2    Lindner, J.3    Grayburn, P.4
  • 150
    • 84879203847 scopus 로고    scopus 로고
    • Current status and prospects for microbubbles in ultrasound theranostics
    • [150] Martin, K.H., Dayton, P.A., Current status and prospects for microbubbles in ultrasound theranostics. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 5 (2013), 329–345.
    • (2013) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. , vol.5 , pp. 329-345
    • Martin, K.H.1    Dayton, P.A.2
  • 151
    • 84897539059 scopus 로고    scopus 로고
    • Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment
    • [151] Florinas, S., Kim, J., Nam, K., Janat-Amsbury, M.M., Kim, S.W., Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment. J. Control. Release 183 (2014), 1–8.
    • (2014) J. Control. Release , vol.183 , pp. 1-8
    • Florinas, S.1    Kim, J.2    Nam, K.3    Janat-Amsbury, M.M.4    Kim, S.W.5
  • 153
    • 33746457788 scopus 로고    scopus 로고
    • Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery
    • [153] Liu, Y., Miyoshi, H., Nakamura, M., Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. J. Control. Release 114 (2006), 89–99.
    • (2006) J. Control. Release , vol.114 , pp. 89-99
    • Liu, Y.1    Miyoshi, H.2    Nakamura, M.3
  • 154
    • 84887136058 scopus 로고    scopus 로고
    • Targeted drug delivery with focused ultrasound-induced blood–brain barrier opening using acoustically-activated nanodroplets
    • [154] Chen, C.C., Sheeran, P.S., Wu, S.Y., Olumolade, O.O., Dayton, P.A., Konofagou, E.E., Targeted drug delivery with focused ultrasound-induced blood–brain barrier opening using acoustically-activated nanodroplets. J. Control. Release 172 (2013), 795–804.
    • (2013) J. Control. Release , vol.172 , pp. 795-804
    • Chen, C.C.1    Sheeran, P.S.2    Wu, S.Y.3    Olumolade, O.O.4    Dayton, P.A.5    Konofagou, E.E.6
  • 155
    • 84894058190 scopus 로고    scopus 로고
    • Ultrasound-triggered phase transition sensitive magnetic fluorescent nanodroplets as a multimodal imaging contrast agent in rat and mouse model
    • [155] Cheng, X., Li, H., Chen, Y., Luo, B., Liu, X., Liu, W., Xu, H., Yang, X., Ultrasound-triggered phase transition sensitive magnetic fluorescent nanodroplets as a multimodal imaging contrast agent in rat and mouse model. PLoS ONE, 8, 2013, e85003.
    • (2013) PLoS ONE , vol.8
    • Cheng, X.1    Li, H.2    Chen, Y.3    Luo, B.4    Liu, X.5    Liu, W.6    Xu, H.7    Yang, X.8
  • 157
    • 84906849493 scopus 로고    scopus 로고
    • India ink incorporated multifunctional phase-transition nanodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy
    • [157] Jian, J., Liu, C., Gong, Y., Su, L., Zhang, B., Wang, Z., Wang, D., Zhou, Y., Xu, F., Li, P., Zheng, Y., Song, L., Zhou, X., India ink incorporated multifunctional phase-transition nanodroplets for photoacoustic/ultrasound dual-modality imaging and photoacoustic effect based tumor therapy. Theranostics. 4 (2014), 1026–1038.
    • (2014) Theranostics. , vol.4 , pp. 1026-1038
    • Jian, J.1    Liu, C.2    Gong, Y.3    Su, L.4    Zhang, B.5    Wang, Z.6    Wang, D.7    Zhou, Y.8    Xu, F.9    Li, P.10    Zheng, Y.11    Song, L.12    Zhou, X.13
  • 158
    • 80054992145 scopus 로고    scopus 로고
    • Evaluation of antitumor effects following tumor necrosis factor-alpha gene delivery using nanobubbles and ultrasound
    • [158] Horie, S., Watanabe, Y., Ono, M., Mori, S., Kodama, T., Evaluation of antitumor effects following tumor necrosis factor-alpha gene delivery using nanobubbles and ultrasound. Cancer Sci. 102 (2011), 2082–2089.
    • (2011) Cancer Sci. , vol.102 , pp. 2082-2089
    • Horie, S.1    Watanabe, Y.2    Ono, M.3    Mori, S.4    Kodama, T.5
  • 159
    • 79958012143 scopus 로고    scopus 로고
    • Aptamer-conjugated nanobubbles for targeted ultrasound molecular imaging
    • [159] Wang, C.H., Huang, Y.F., Yeh, C.K., Aptamer-conjugated nanobubbles for targeted ultrasound molecular imaging. Langmuir 27 (2011), 6971–6976.
    • (2011) Langmuir , vol.27 , pp. 6971-6976
    • Wang, C.H.1    Huang, Y.F.2    Yeh, C.K.3
  • 160
    • 84899988976 scopus 로고    scopus 로고
    • Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes
    • [160] Yin, T., Wang, P., Li, J., Wang, Y., Zheng, B., Zheng, R., Cheng, D., Shuai, X., Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes. Biomaterials 35 (2014), 5932–5943.
    • (2014) Biomaterials , vol.35 , pp. 5932-5943
    • Yin, T.1    Wang, P.2    Li, J.3    Wang, Y.4    Zheng, B.5    Zheng, R.6    Cheng, D.7    Shuai, X.8
  • 161
    • 70350644382 scopus 로고    scopus 로고
    • Enhancement of survivin gene downregulation and cell apoptosis by a novel combination: liposome microbubbles and ultrasound exposure
    • [161] Chen, Z., Liang, K., Liu, J., Xie, M., Wang, X., Lu, Q., Zhang, J., Fang, L., Enhancement of survivin gene downregulation and cell apoptosis by a novel combination: liposome microbubbles and ultrasound exposure. Med. Oncol. 26 (2009), 491–500.
    • (2009) Med. Oncol. , vol.26 , pp. 491-500
    • Chen, Z.1    Liang, K.2    Liu, J.3    Xie, M.4    Wang, X.5    Lu, Q.6    Zhang, J.7    Fang, L.8
  • 163
    • 84870531968 scopus 로고    scopus 로고
    • Ultrasound for molecular imaging and therapy in cancer
    • [163] Kaneko, O.F., Willmann, J.K., Ultrasound for molecular imaging and therapy in cancer. Quant. Imaging. Med. Surg. 2 (2012), 87–97.
    • (2012) Quant. Imaging. Med. Surg. , vol.2 , pp. 87-97
    • Kaneko, O.F.1    Willmann, J.K.2
  • 164
    • 84927804717 scopus 로고    scopus 로고
    • Echogenic nanoparticles for ultrasound technologies: evolution from diagnostic imaging modality to multimodal theranostic agent
    • [164] Son, S., Min, H.S., You, D.G., Kim, B.S., Kwon, I.C., Echogenic nanoparticles for ultrasound technologies: evolution from diagnostic imaging modality to multimodal theranostic agent. Nano Today 9 (2014), 525–540.
    • (2014) Nano Today , vol.9 , pp. 525-540
    • Son, S.1    Min, H.S.2    You, D.G.3    Kim, B.S.4    Kwon, I.C.5
  • 165
    • 44149124040 scopus 로고    scopus 로고
    • Response of contrast agents to ultrasound
    • [165] Sboros, V., Response of contrast agents to ultrasound. Adv. Drug Deliv. Rev. 60 (2008), 1117–1136.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1117-1136
    • Sboros, V.1
  • 168
    • 84875615823 scopus 로고    scopus 로고
    • Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas
    • [168] Yin, T., Wang, P., Li, J., Zheng, R., Zheng, B., Cheng, D., Li, R., Lai, J., Shuai, X., Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. Biomaterials 34 (2013), 4532–4543.
    • (2013) Biomaterials , vol.34 , pp. 4532-4543
    • Yin, T.1    Wang, P.2    Li, J.3    Zheng, R.4    Zheng, B.5    Cheng, D.6    Li, R.7    Lai, J.8    Shuai, X.9
  • 169
    • 84863338346 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for multimodal imaging and theragnosis
    • [169] Lee, D.E., Koo, H., Sun, I.C., Ryu, J.H., Kim, K., Kwon, I.C., Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem. Soc. Rev. 41 (2012), 2656–2672.
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 2656-2672
    • Lee, D.E.1    Koo, H.2    Sun, I.C.3    Ryu, J.H.4    Kim, K.5    Kwon, I.C.6
  • 170
    • 78649739683 scopus 로고    scopus 로고
    • Nanoparticles for biomedical imaging: fundamentals of clinical translation
    • [170] Choi, H.S., Frangioni, J.V., Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol. Imaging 9 (2010), 291–310.
    • (2010) Mol. Imaging , vol.9 , pp. 291-310
    • Choi, H.S.1    Frangioni, J.V.2
  • 171
    • 77952537647 scopus 로고    scopus 로고
    • Multimodality imaging probes: design and challenges
    • [171] Louie, A.Y., Multimodality imaging probes: design and challenges. Chem. Rev. 110 (2010), 3146–3195.
    • (2010) Chem. Rev. , vol.110 , pp. 3146-3195
    • Louie, A.Y.1
  • 172
    • 48749108533 scopus 로고    scopus 로고
    • Multimodality probes: amphibian cars for molecular imaging
    • [172] Boerman, O.C., Oyen, W.J.G., Multimodality probes: amphibian cars for molecular imaging. J. Nucl. Med. 49 (2008), 1213–1214.
    • (2008) J. Nucl. Med. , vol.49 , pp. 1213-1214
    • Boerman, O.C.1    Oyen, W.J.G.2
  • 173
    • 84905920762 scopus 로고    scopus 로고
    • Theranostics and contrast-agents for medical imaging: a pharmaceutical company viewpoint
    • [173] Idee, J.M., Louguet, S., Ballet, S., Corot, C., Theranostics and contrast-agents for medical imaging: a pharmaceutical company viewpoint. Quant. Imaging. Med. Surg. 3 (2013), 292–297.
    • (2013) Quant. Imaging. Med. Surg. , vol.3 , pp. 292-297
    • Idee, J.M.1    Louguet, S.2    Ballet, S.3    Corot, C.4
  • 174
    • 84940210316 scopus 로고    scopus 로고
    • Physical scientists research biomedicine: a call for caution
    • [174] Wang, Y.X., Physical scientists research biomedicine: a call for caution. Chin. J. Cancer Res. 27 (2015), 94–95.
    • (2015) Chin. J. Cancer Res. , vol.27 , pp. 94-95
    • Wang, Y.X.1
  • 175
    • 33847720312 scopus 로고    scopus 로고
    • In vivo imaging of siRNA delivery and silencing in tumors
    • [175] Medarova, Z., Pham, W., Farrar, C., Petkova, V., Moore, A., In vivo imaging of siRNA delivery and silencing in tumors. Nat. Med. 13 (2007), 372–377.
    • (2007) Nat. Med. , vol.13 , pp. 372-377
    • Medarova, Z.1    Pham, W.2    Farrar, C.3    Petkova, V.4    Moore, A.5
  • 177
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • [177] Bartlett, D.W., Su, H., Hildebrandt, I.J., Weber, W.A., Davis, M.E., Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 15549–15554.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5


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