-
1
-
-
50449116079
-
Electron microscopy of the glomerular capillary wall
-
Rhodin J. Electron microscopy of the glomerular capillary wall. Exp Cell Res 1955; 8:572-574.
-
(1955)
Exp Cell Res
, vol.8
, pp. 572-574
-
-
Rhodin, J.1
-
3
-
-
85047693347
-
What determines glomerular capillary permeability?
-
Deen WM. What determines glomerular capillary permeability? J Clin Invest 2004; 114:1412-1414.
-
(2004)
J Clin Invest
, vol.114
, pp. 1412-1414
-
-
Deen, W.M.1
-
4
-
-
40449110084
-
Resolved: Normal glomeruli filter nephrotic levels of albumin
-
A point-counterpoint style review of the competing hypotheses of the glomerular versus tubular origin of proteinuria
-
Comper WD, Haraldsson B, Deen WM. Resolved: normal glomeruli filter nephrotic levels of albumin. J Am Soc Nephrol 2008; 19:427-432. A point-counterpoint style review of the competing hypotheses of the glomerular versus tubular origin of proteinuria.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 427-432
-
-
Comper, W.D.1
Haraldsson, B.2
Deen, W.M.3
-
5
-
-
33645403170
-
Hereditary proteinuria syndromes and mechanisms of proteinuria
-
Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006; 354: 1387-1401.
-
(2006)
N Engl J Med
, vol.354
, pp. 1387-1401
-
-
Tryggvason, K.1
Patrakka, J.2
Wartiovaara, J.3
-
6
-
-
0037389827
-
Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function
-
Smithies O. Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function. Proc Natl Acad Sci USA 2003; 100:4108-4113.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4108-4113
-
-
Smithies, O.1
-
7
-
-
42149122041
-
Properties of the glomerular barrier and mechanisms of proteinuria
-
An outstanding extensive review of the physiology of the GFB and the mechanisms of proteinuria
-
Haraldsson B, Nystrom J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008; 88:451-487. An outstanding extensive review of the physiology of the GFB and the mechanisms of proteinuria.
-
(2008)
Physiol Rev
, vol.88
, pp. 451-487
-
-
Haraldsson, B.1
Nystrom, J.2
Deen, W.M.3
-
8
-
-
0028527844
-
a landmark in nephrology: Carl Ludwig's revolutionary concept of renal function
-
Ludwig CF. 1842: a landmark in nephrology: Carl Ludwig's revolutionary concept of renal function. Kidney Int Suppl 1994; 46:1-23.
-
(1842)
Kidney Int Suppl
, vol.46
, pp. 1-23
-
-
Ludwig, C.F.1
-
9
-
-
0009909699
-
Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in renal tubules
-
Wearn JT, Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in renal tubules. Am J Physiol 1924; 71:209-227.
-
(1924)
Am J Physiol
, vol.71
, pp. 209-227
-
-
Wearn, J.T.1
Richards, A.N.2
-
10
-
-
0016563163
-
Editorial: The primary glomerular filtration barrier: basement membrane or epithelial slits?
-
Farquhar MG. Editorial: the primary glomerular filtration barrier: basement membrane or epithelial slits? Kidney Int 1975; 8:197-211.
-
(1975)
Kidney Int
, vol.8
, pp. 197-211
-
-
Farquhar, M.G.1
-
11
-
-
0141941392
-
Effect of rennin on proteinuria and PAH clearance at low plasma levels
-
Brandt JL, Gruhn JG. Effect of rennin on proteinuria and PAH clearance at low plasma levels. Am J Physiol 1948; 153:458-464.
-
(1948)
Am J Physiol
, vol.153
, pp. 458-464
-
-
Brandt, J.L.1
Gruhn, J.G.2
-
12
-
-
67849115384
-
Renin proteinuria in the rat: Evidence that renin does not interfere with the tubular resorption of purified human hemoglobin or bovine albumin
-
Rather LJ, Addis T. Renin proteinuria in the rat: evidence that renin does not interfere with the tubular resorption of purified human hemoglobin or bovine albumin. J Exp Med 1950; 91:567-572.
-
(1950)
J Exp Med
, vol.91
, pp. 567-572
-
-
Rather, L.J.1
Addis, T.2
-
13
-
-
0015089156
-
Micropuncture studies of proximal tubule albumin concentrations in normal and nephrotic rats
-
Oken DE, Flamenbaum W. Micropuncture studies of proximal tubule albumin concentrations in normal and nephrotic rats. J Clin Invest 1971; 50:1498-1505.
-
(1971)
J Clin Invest
, vol.50
, pp. 1498-1505
-
-
Oken, D.E.1
Flamenbaum, W.2
-
14
-
-
0026445848
-
Intrarenal handling of proteins in rats using fractional micropuncture technique
-
Tojo A, Endou H. Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol 1992; 263:F601-F606.
-
(1992)
Am J Physiol
, vol.263
-
-
Tojo, A.1
Endou, H.2
-
15
-
-
0345703582
-
Fractional clearance of high molecular weight proteins in conscious rats using a continuous infusion method
-
Burne MJ, Osicka TM, Comper WD. Fractional clearance of high molecular weight proteins in conscious rats using a continuous infusion method. Kidney Int 1999; 55:261-270.
-
(1999)
Kidney Int
, vol.55
, pp. 261-270
-
-
Burne, M.J.1
Osicka, T.M.2
Comper, W.D.3
-
16
-
-
0032895573
-
The return of glomerular-filtered albumin to the rat renal vein
-
Eppel GA, Osicka TM, Pratt LM, et al. The return of glomerular-filtered albumin to the rat renal vein. Kidney Int 1999; 55:1861-1870.
-
(1999)
Kidney Int
, vol.55
, pp. 1861-1870
-
-
Eppel, G.A.1
Osicka, T.M.2
Pratt, L.M.3
-
17
-
-
20444403781
-
Puromycin aminonucleoside nephrosis results in a marked increase in fractional clearance of albumin
-
Osicka TM, Hankin AR, Comper WD. Puromycin aminonucleoside nephrosis results in a marked increase in fractional clearance of albumin. Am J Physiol 1999; 277:F139-F145.
-
(1999)
Am J Physiol
, vol.277
-
-
Osicka, T.M.1
Hankin, A.R.2
Comper, W.D.3
-
18
-
-
0034000504
-
Characteristics of albumin processing during renal passage in anti-Thy1 and antiglomerular basement membrane glomerulonephritis
-
Eppel GA, Takazoe K, Nikolic-Paterson DJ, et al. Characteristics of albumin processing during renal passage in anti-Thy1 and antiglomerular basement membrane glomerulonephritis. Am J Kidney Dis 2000; 35:418-426.
-
(2000)
Am J Kidney Dis
, vol.35
, pp. 418-426
-
-
Eppel, G.A.1
Takazoe, K.2
Nikolic-Paterson, D.J.3
-
19
-
-
0034843154
-
Glomerular permselectivity factors are not responsible for the increase in fractional clearance of albumin in rat glomerulonephritis
-
Greive KA, Nikolic-Paterson DJ, Guimaraes MA, et al. Glomerular permselectivity factors are not responsible for the increase in fractional clearance of albumin in rat glomerulonephritis. Am J Pathol 2001; 159:1159-1170.
-
(2001)
Am J Pathol
, vol.159
, pp. 1159-1170
-
-
Greive, K.A.1
Nikolic-Paterson, D.J.2
Guimaraes, M.A.3
-
20
-
-
0037255145
-
Renal processing of albumin in diabetes and hypertension in rats: Possible role of TGF-beta1
-
Russo LM, Osicka TM, Brammar GC, et al. Renal processing of albumin in diabetes and hypertension in rats: possible role of TGF-beta1. Am J Nephrol 2003; 23:61-70.
-
(2003)
Am J Nephrol
, vol.23
, pp. 61-70
-
-
Russo, L.M.1
Osicka, T.M.2
Brammar, G.C.3
-
21
-
-
1042280356
-
Renal processing of serum proteins in an albumin-deficient environment: An in vivo study of glomerulonephritis in the Nagase analbuminaemic rat
-
Osicka TM, Strong KJ, Nikolic-Paterson DJ, et al. Renal processing of serum proteins in an albumin-deficient environment: an in vivo study of glomerulonephritis in the Nagase analbuminaemic rat. Nephrol Dial Transplant 2004; 19:320-328.
-
(2004)
Nephrol Dial Transplant
, vol.19
, pp. 320-328
-
-
Osicka, T.M.1
Strong, K.J.2
Nikolic-Paterson, D.J.3
-
22
-
-
33947181051
-
The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states
-
One report in a series of papers suggesting that the normal glomerulus filters a high level of albumin, which is then reclaimed by proximal tubules and returned intact to the circulation. They argue for a tubular origin of proteinuria
-
Russo LM, Sandoval RM, McKee M, et al. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int 2007; 71:504-513. One report in a series of papers suggesting that the normal glomerulus filters a high level of albumin, which is then reclaimed by proximal tubules and returned intact to the circulation. They argue for a tubular origin of proteinuria.
-
(2007)
Kidney Int
, vol.71
, pp. 504-513
-
-
Russo, L.M.1
Sandoval, R.M.2
McKee, M.3
-
23
-
-
0033868831
-
Glomerular size and charge selectivity in the rat as revealed by FITC-ficoll and albumin
-
Ohlson M, Sorensson J, Haraldsson B. Glomerular size and charge selectivity in the rat as revealed by FITC-ficoll and albumin. Am J Physiol Renal Physiol 2000; 279:F84-F91.
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
Ohlson, M.1
Sorensson, J.2
Haraldsson, B.3
-
24
-
-
0016824003
-
Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran
-
Chang RL, Ueki IF, Troy JL, et al. Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran. Biophys J 1975; 15:887-906.
-
(1975)
Biophys J
, vol.15
, pp. 887-906
-
-
Chang, R.L.1
Ueki, I.F.2
Troy, J.L.3
-
25
-
-
0017195018
-
Permselectivity of the glomerular capillary wall. Studies of experimental glomerulonephritis in the rat using neutral dextran
-
Chang RL, Deen WM, Robertson CR, et al. Permselectivity of the glomerular capillary wall. Studies of experimental glomerulonephritis in the rat using neutral dextran. J Clin Invest 1976; 57:1272-1286.
-
(1976)
J Clin Invest
, vol.57
, pp. 1272-1286
-
-
Chang, R.L.1
Deen, W.M.2
Robertson, C.R.3
-
26
-
-
0016753740
-
Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions
-
Chang RL, Deen WM, Robertson CR, Brenner BM. Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions. Kidney Int 1975; 8:212-218.
-
(1975)
Kidney Int
, vol.8
, pp. 212-218
-
-
Chang, R.L.1
Deen, W.M.2
Robertson, C.R.3
Brenner, B.M.4
-
27
-
-
0017838170
-
Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations
-
Bohrer MP, Baylis C, Humes HD, et al. Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations. J Clin Invest 1978; 61:72-78.
-
(1978)
J Clin Invest
, vol.61
, pp. 72-78
-
-
Bohrer, M.P.1
Baylis, C.2
Humes, H.D.3
-
28
-
-
0037530611
-
Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes
-
Jeansson M, Haraldsson B. Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes. J Am Soc Nephrol 2003; 14:1756-1765.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 1756-1765
-
-
Jeansson, M.1
Haraldsson, B.2
-
30
-
-
15044362503
-
Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: Effects of molecular size, shape, charge, and deformability
-
Venturoli D, Rippe B. Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability. Am J Physiol Renal Physiol 2005; 288:F605-F613.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Venturoli, D.1
Rippe, B.2
-
31
-
-
33750937902
-
Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats
-
Asgeirsson D, Venturoli D, Rippe B, Rippe C. Increased glomerular permeability to negatively charged Ficoll relative to neutral Ficoll in rats. Am J Physiol Renal Physiol 2006; 291:F1083-F1089.
-
(2006)
Am J Physiol Renal Physiol
, vol.291
-
-
Asgeirsson, D.1
Venturoli, D.2
Rippe, B.3
Rippe, C.4
-
32
-
-
35348878790
-
Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation
-
Asgeirsson D, Venturoli D, Fries E, et al. Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation. Acta Physiol (Oxf) 2007; 191:237-246.
-
(2007)
Acta Physiol (Oxf)
, vol.191
, pp. 237-246
-
-
Asgeirsson, D.1
Venturoli, D.2
Fries, E.3
-
33
-
-
34547680445
-
Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity
-
Harvey SJ, Jarad G, Cunningham J, et al. Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. Am J Pathol 2007; 171:139-152.
-
(2007)
Am J Pathol
, vol.171
, pp. 139-152
-
-
Harvey, S.J.1
Jarad, G.2
Cunningham, J.3
-
34
-
-
55249098128
-
Revisiting the glomerular charge barrier in the molecular era
-
Harvey SJ, Miner JH. Revisiting the glomerular charge barrier in the molecular era. Curr Opin Nephrol Hypertens 2008; 17:393-398.
-
(2008)
Curr Opin Nephrol Hypertens
, vol.17
, pp. 393-398
-
-
Harvey, S.J.1
Miner, J.H.2
-
35
-
-
34249874096
-
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine
-
Galeano B, Klootwijk R, Manoli I, et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest 2007; 117:1585-1594.
-
(2007)
J Clin Invest
, vol.117
, pp. 1585-1594
-
-
Galeano, B.1
Klootwijk, R.2
Manoli, I.3
-
36
-
-
33644806727
-
Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier
-
Jeansson M, Haraldsson B. Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier. Am J Physiol Renal Physiol 2006; 290:F111-F116.
-
(2006)
Am J Physiol Renal Physiol
, vol.290
-
-
Jeansson, M.1
Haraldsson, B.2
-
37
-
-
0346728703
-
Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries
-
Hjalmarsson C, Johansson BR, Haraldsson B. Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries. Microvasc Res 2004; 67:9-17.
-
(2004)
Microvasc Res
, vol.67
, pp. 9-17
-
-
Hjalmarsson, C.1
Johansson, B.R.2
Haraldsson, B.3
-
38
-
-
34248377676
-
The endothelial glycocalyx: Composition, functions, and visualization
-
A study discussing the endothelilal glycocalyx in general, its importance, and the methods used to visualize it
-
Reitsma S, Slaaf DW, Vink H, et al. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 2007; 454:345-359. A study discussing the endothelilal glycocalyx in general, its importance, and the methods used to visualize it.
-
(2007)
Pflugers Arch
, vol.454
, pp. 345-359
-
-
Reitsma, S.1
Slaaf, D.W.2
Vink, H.3
-
39
-
-
0021783936
-
Dose-dependent movement of cationic molecules across the glomerular wall
-
Andrews PM, Bates SB. Dose-dependent movement of cationic molecules across the glomerular wall. Anat Rec 1985; 212:223-231.
-
(1985)
Anat Rec
, vol.212
, pp. 223-231
-
-
Andrews, P.M.1
Bates, S.B.2
-
40
-
-
0008454513
-
Interaction of serum proteins with lung endothelial glycocalyx: Its effect on endothelial permeability
-
Schneeberger EE, Hamelin M. Interaction of serum proteins with lung endothelial glycocalyx: its effect on endothelial permeability. Am J Physiol 1984; 247:H206-H217.
-
(1984)
Am J Physiol
, vol.247
-
-
Schneeberger, E.E.1
Hamelin, M.2
-
41
-
-
0031658440
-
Nature of glomerular dysfunction in preeclampsia
-
Lafayette RA, Druzin M, Sibley R, et al. Nature of glomerular dysfunction in preeclampsia. Kidney Int 1998; 54:1240-1249.
-
(1998)
Kidney Int
, vol.54
, pp. 1240-1249
-
-
Lafayette, R.A.1
Druzin, M.2
Sibley, R.3
-
43
-
-
40849130173
-
VEGF inhibition and renal thrombotic microangiopathy
-
This study shows that antitumor therapy in humans with avastin, an anti-VEGF antibody, or podocyte-specific knockout of VEGF in adult mice causes glomerular endothelial cell defects similar to those observed in preeclampsia
-
Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358:1129-1136. This study shows that antitumor therapy in humans with avastin, an anti-VEGF antibody, or podocyte-specific knockout of VEGF in adult mice causes glomerular endothelial cell defects similar to those observed in preeclampsia.
-
(2008)
N Engl J Med
, vol.358
, pp. 1129-1136
-
-
Eremina, V.1
Jefferson, J.A.2
Kowalewska, J.3
-
44
-
-
0037370325
-
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
-
Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003; 111:707-716.
-
(2003)
J Clin Invest
, vol.111
, pp. 707-716
-
-
Eremina, V.1
Sood, M.2
Haigh, J.3
-
45
-
-
0037631361
-
Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
-
Sugimoto H, Hamano Y, Charytan D, et al. Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003; 278:12605-12608.
-
(2003)
J Biol Chem
, vol.278
, pp. 12605-12608
-
-
Sugimoto, H.1
Hamano, Y.2
Charytan, D.3
-
46
-
-
36048938456
-
A breakthrough in diabetic nephropathy: The role of endothelial dysfunction
-
Nakagawa T, Segal M, Croker B, Johnson RJ. A breakthrough in diabetic nephropathy: the role of endothelial dysfunction. Nephrol Dial Transplant 2007; 22:2775-2777.
-
(2007)
Nephrol Dial Transplant
, vol.22
, pp. 2775-2777
-
-
Nakagawa, T.1
Segal, M.2
Croker, B.3
Johnson, R.J.4
-
47
-
-
0016282517
-
The permeability of glomerular capillaries to graded dextrans. Identification of the basement membrane as the primary filtration barrier
-
Caulfield JP, Farquhar MG. The permeability of glomerular capillaries to graded dextrans. Identification of the basement membrane as the primary filtration barrier. J Cell Biol 1974; 63:883-903.
-
(1974)
J Cell Biol
, vol.63
, pp. 883-903
-
-
Caulfield, J.P.1
Farquhar, M.G.2
-
48
-
-
0347670074
-
Segregation of ferritin in glomerular protein absorption droplets
-
Farquhar MG, Palade GE. Segregation of ferritin in glomerular protein absorption droplets. J Biophys Biochem Cytol 1960; 7:297-304.
-
(1960)
J Biophys Biochem Cytol
, vol.7
, pp. 297-304
-
-
Farquhar, M.G.1
Palade, G.E.2
-
49
-
-
0017196977
-
Glomerular permeability to proteins. Effects of hemodynamic factors on the distribution of endogenous immunoglobulin G and exogenous catalase in the rat glomerulus
-
Ryan GB, Hein SJ, Karnovsky MJ. Glomerular permeability to proteins. Effects of hemodynamic factors on the distribution of endogenous immunoglobulin G and exogenous catalase in the rat glomerulus. Lab Invest 1976; 34:415-427.
-
(1976)
Lab Invest
, vol.34
, pp. 415-427
-
-
Ryan, G.B.1
Hein, S.J.2
Karnovsky, M.J.3
-
50
-
-
0016799620
-
The permeability of glomerular capillaries of aminonucleoside nephrotic rats to graded dextrans
-
Caulfield JP, Farquhar MG. The permeability of glomerular capillaries of aminonucleoside nephrotic rats to graded dextrans. J Exp Med 1975; 142:61-83.
-
(1975)
J Exp Med
, vol.142
, pp. 61-83
-
-
Caulfield, J.P.1
Farquhar, M.G.2
-
51
-
-
0017653463
-
An ultrastructural study of the mechanisms of proteinuria in rat nephrotoxic nephritis
-
Kuhn K, Ryan GB, Hein SJ, et al. An ultrastructural study of the mechanisms of proteinuria in rat nephrotoxic nephritis. Lab Invest 1977; 36:375-387.
-
(1977)
Lab Invest
, vol.36
, pp. 375-387
-
-
Kuhn, K.1
Ryan, G.B.2
Hein, S.J.3
-
52
-
-
0016809348
-
An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis
-
Ryan GB, Karnovsky MJ. An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis. Kidney Int 1975; 8:219-232.
-
(1975)
Kidney Int
, vol.8
, pp. 219-232
-
-
Ryan, G.B.1
Karnovsky, M.J.2
-
53
-
-
0014558749
-
Glomerular permeability. Ultrastructural studies in experimental nephrosis using horseradish peroxidase as a tracer
-
Venkatachalam MA, Karnovsky MJ, Cotran RS. Glomerular permeability. Ultrastructural studies in experimental nephrosis using horseradish peroxidase as a tracer. J Exp Med 1969; 130:381-399.
-
(1969)
J Exp Med
, vol.130
, pp. 381-399
-
-
Venkatachalam, M.A.1
Karnovsky, M.J.2
Cotran, R.S.3
-
54
-
-
0029127384
-
The renal glomerulus of mice lacking slaminin/laminin beta 2: Nephrosis despite molecular compensation by laminin beta 1
-
Noakes PG, Miner JH, Gautam M, et al. The renal glomerulus of mice lacking slaminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. Nat Genet 1995; 10:400-406.
-
(1995)
Nat Genet
, vol.10
, pp. 400-406
-
-
Noakes, P.G.1
Miner, J.H.2
Gautam, M.3
-
55
-
-
33645548140
-
Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: Implications for Pierson syndrome
-
Miner JH, Go G, Cunningham J, et al. Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome. Development 2006; 133:967-975.
-
(2006)
Development
, vol.133
, pp. 967-975
-
-
Miner, J.H.1
Go, G.2
Cunningham, J.3
-
56
-
-
8444221929
-
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities
-
Zenker M, Aigner T, Wendler O, et al. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 2004; 13:2625-2632.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2625-2632
-
-
Zenker, M.1
Aigner, T.2
Wendler, O.3
-
57
-
-
42649132827
-
Variable phenotype of Pierson syndrome
-
This study describes patients carrying laminin b2 mutations with very different clinical presentations
-
Choi HJ, Lee BH, Kang JH, et al. Variable phenotype of Pierson syndrome. Pediatr Nephrol 2008; 23:995-1000. This study describes patients carrying laminin b2 mutations with very different clinical presentations.
-
(2008)
Pediatr Nephrol
, vol.23
, pp. 995-1000
-
-
Choi, H.J.1
Lee, B.H.2
Kang, J.H.3
-
58
-
-
33746730496
-
Proteinuria precedes podocyte abnormalities in Lamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier
-
Jarad G, Cunningham J, Shaw AS, Miner JH. Proteinuria precedes podocyte abnormalities in Lamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest 2006; 116:2272-2279.
-
(2006)
J Clin Invest
, vol.116
, pp. 2272-2279
-
-
Jarad, G.1
Cunningham, J.2
Shaw, A.S.3
Miner, J.H.4
-
59
-
-
0030457613
-
Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): Implications for Alport syndrome
-
Miner JH, Sanes JR. Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome. J Cell Biol 1996; 135:1403-1413.
-
(1996)
J Cell Biol
, vol.135
, pp. 1403-1413
-
-
Miner, J.H.1
Sanes, J.R.2
-
60
-
-
34548510567
-
-
Abrahamson DR, Isom K, Roach E, et al. Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects. J Am Soc Nephrol 2007; 18:2465-2472. A report showing the GBM changes associated with Alport syndrome in mice and the associated increased premeability to ferritin.
-
Abrahamson DR, Isom K, Roach E, et al. Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects. J Am Soc Nephrol 2007; 18:2465-2472. A report showing the GBM changes associated with Alport syndrome in mice and the associated increased premeability to ferritin.
-
-
-
-
61
-
-
0032015551
-
Positionally cloned gene for a novel glomerular protein-nephrin - is mutated in congenital nephrotic syndrome
-
Kestila M, Lenkkeri U, Mannikko M, et al. Positionally cloned gene for a novel glomerular protein-nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1:575-582.
-
(1998)
Mol Cell
, vol.1
, pp. 575-582
-
-
Kestila, M.1
Lenkkeri, U.2
Mannikko, M.3
-
62
-
-
0033529312
-
Nephrin is specifically located at the slit diaphragm of glomerular podocytes
-
Ruotsalainen V, Ljungberg P, Wartiovaara J, et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci USA 1999; 96:7962-7967.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7962-7967
-
-
Ruotsalainen, V.1
Ljungberg, P.2
Wartiovaara, J.3
-
63
-
-
0034948819
-
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN
-
Donoviel DB, Freed DD, Vogel H, et al. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol 2001; 21:4829-4836.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4829-4836
-
-
Donoviel, D.B.1
Freed, D.D.2
Vogel, H.3
-
64
-
-
0034034757
-
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
-
Boute N, Gribouval O, Roselli S, et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 2000; 24:349-354.
-
(2000)
Nat Genet
, vol.24
, pp. 349-354
-
-
Boute, N.1
Gribouval, O.2
Roselli, S.3
-
65
-
-
0033680171
-
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere
-
Li C, Ruotsalainen V, Tryggvason K, et al. CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. Am J Physiol Renal Physiol 2000; 279:F785-F792.
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
Li, C.1
Ruotsalainen, V.2
Tryggvason, K.3
-
66
-
-
0015953201
-
Porous substructure of the glomerular slit diaphragm in the rat and mouse
-
Rodewald R, Karnovsky MJ. Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 1974; 60:423-433.
-
(1974)
J Cell Biol
, vol.60
, pp. 423-433
-
-
Rodewald, R.1
Karnovsky, M.J.2
-
67
-
-
33645749205
-
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography
-
Wartiovaara J, Ofverstedt LG, Khoshnoodi J, et al. Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. J Clin Invest 2004; 114:1475-1483.
-
(2004)
J Clin Invest
, vol.114
, pp. 1475-1483
-
-
Wartiovaara, J.1
Ofverstedt, L.G.2
Khoshnoodi, J.3
-
68
-
-
15944419514
-
Is loss of podocyte foot processes necessary for the induction of proteinuria?
-
Karumanchi SA, Epstein FH, Stillman IE. Is loss of podocyte foot processes necessary for the induction of proteinuria? Am J Kidney Dis 2005; 45:436.
-
(2005)
Am J Kidney Dis
, vol.45
, pp. 436
-
-
Karumanchi, S.A.1
Epstein, F.H.2
Stillman, I.E.3
-
69
-
-
15944387124
-
Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies
-
van den Berg JG, van den Bergh Weerman MA, Assmann KJ, et al. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int 2004; 66:1901-1906.
-
(2004)
Kidney Int
, vol.66
, pp. 1901-1906
-
-
van den Berg, J.G.1
van den Bergh Weerman, M.A.2
Assmann, K.J.3
-
70
-
-
42549105123
-
-
Yoshida S, Nagase M, Shibata S, Fujita T. Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK. Nephron Exp Nephrol 2008; 108:e57-e68. This study suggests that albumin overload in vitro and in vivo is podocyte toxic. Albumin overload was associated with increased podocyte apoptosis and increased transforming growth factor-β1 levels and activity.
-
Yoshida S, Nagase M, Shibata S, Fujita T. Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK. Nephron Exp Nephrol 2008; 108:e57-e68. This study suggests that albumin overload in vitro and in vivo is podocyte toxic. Albumin overload was associated with increased podocyte apoptosis and increased transforming growth factor-β1 levels and activity.
-
-
-
-
71
-
-
46249119601
-
Glomerular albumin filtration through podocyte cell body in puromycin aminonucleoside nephrotic rat
-
This study recapitulated the conclusion of older studies, by showing that in the setting of PAN nephrosis, albumin is taken and transported through podocyte cell body
-
Tojo A, Onozato ML, Kitiyakara C, et al. Glomerular albumin filtration through podocyte cell body in puromycin aminonucleoside nephrotic rat. Med Mol Morphol 2008; 41:92-98. This study recapitulated the conclusion of older studies, by showing that in the setting of PAN nephrosis, albumin is taken and transported through podocyte cell body.
-
(2008)
Med Mol Morphol
, vol.41
, pp. 92-98
-
-
Tojo, A.1
Onozato, M.L.2
Kitiyakara, C.3
-
72
-
-
44949182711
-
-
Ijpelaar DH, Schulz A, Koop K, et al. Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fromter rats. Am J Physiol Renal Physiol 2008; 294:F758-F767. This study showed that in Munich-Wistar-Fromter rats, which develop focal segmental glomerulosclerosis, albuminuria was preceded by glomerular hypertrophy and is accompanied by signs of podocyte injury and entrapment of albumin in the injured podocytes. The authors did not elaborate whether albumin can induce or contribute to podocyte injury.
-
Ijpelaar DH, Schulz A, Koop K, et al. Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fromter rats. Am J Physiol Renal Physiol 2008; 294:F758-F767. This study showed that in Munich-Wistar-Fromter rats, which develop focal segmental glomerulosclerosis, albuminuria was preceded by glomerular hypertrophy and is accompanied by signs of podocyte injury and entrapment of albumin in the injured podocytes. The authors did not elaborate whether albumin can induce or contribute to podocyte injury.
-
-
-
-
73
-
-
20944437139
-
In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: Implication for permselective dysfunction of chronic nephropathies
-
Morigi M, Buelli S, Angioletti S, et al. In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies. Am J Pathol 2005; 166:1309-1320.
-
(2005)
Am J Pathol
, vol.166
, pp. 1309-1320
-
-
Morigi, M.1
Buelli, S.2
Angioletti, S.3
-
74
-
-
33646150223
-
Effects of glomerular filtration rate on Ficoll sieving coefficients (theta) in rats
-
Rippe C, Asgeirsson D, Venturoli D, et al. Effects of glomerular filtration rate on Ficoll sieving coefficients (theta) in rats. Kidney Int 2006; 69:1326-1332.
-
(2006)
Kidney Int
, vol.69
, pp. 1326-1332
-
-
Rippe, C.1
Asgeirsson, D.2
Venturoli, D.3
-
75
-
-
0024410191
-
Glomerular basement membrane as a compressible ultrafilter
-
Robinson GB, Walton HA. Glomerular basement membrane as a compressible ultrafilter. Microvasc Res 1989; 38:36-48.
-
(1989)
Microvasc Res
, vol.38
, pp. 36-48
-
-
Robinson, G.B.1
Walton, H.A.2
-
76
-
-
0026625490
-
Glomerular basement membrane: In vitro studies of water and protein permeability
-
Daniels BS, Hauser EB, Deen WM, Hostetter TH. Glomerular basement membrane: in vitro studies of water and protein permeability. Am J Physiol 1992; 262:F919-F926.
-
(1992)
Am J Physiol
, vol.262
-
-
Daniels, B.S.1
Hauser, E.B.2
Deen, W.M.3
Hostetter, T.H.4
-
77
-
-
33846223928
-
Model of albumin reabsorption in the proximal tubule
-
Lazzara MJ, Deen WM. Model of albumin reabsorption in the proximal tubule. Am J Physiol Renal Physiol 2007; 292:F430-F439.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Lazzara, M.J.1
Deen, W.M.2
-
78
-
-
47349084411
-
Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria
-
This study shows that mutation of Ext1, encoding an enzyme required for heparan sulfate glycosaminoglycan biosynthesis, specifically in podocytes results in only mild foot process effacement but no significant albuminuria, despite loss of anionic charge
-
Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y, et al. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria. Kidney Int 2008; 74:289-299. This study shows that mutation of Ext1, encoding an enzyme required for heparan sulfate glycosaminoglycan biosynthesis, specifically in podocytes results in only mild foot process effacement but no significant albuminuria, despite loss of anionic charge.
-
(2008)
Kidney Int
, vol.74
, pp. 289-299
-
-
Chen, S.1
Wassenhove-McCarthy, D.J.2
Yamaguchi, Y.3
-
79
-
-
0021328801
-
Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit
-
Park CH, Maack T. Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. J Clin Invest 1984; 73:767-777.
-
(1984)
J Clin Invest
, vol.73
, pp. 767-777
-
-
Park, C.H.1
Maack, T.2
-
80
-
-
0033850378
-
Albuminuria in patients with type 1 diabetes is directly linked to changes in the lysosome-mediated degradation of albumin during renal passage
-
Osicka TM, Houlihan CA, Chan JG, et al. Albuminuria in patients with type 1 diabetes is directly linked to changes in the lysosome-mediated degradation of albumin during renal passage. Diabetes 2000; 49:1579-1584.
-
(2000)
Diabetes
, vol.49
, pp. 1579-1584
-
-
Osicka, T.M.1
Houlihan, C.A.2
Chan, J.G.3
-
81
-
-
56549090675
-
In vivo visualization of albumin degradation in the proximal tubule
-
This study shows that some of the albumin taken up by proximal tubule cells is degraded
-
Slattery C, Lee A, Zhang Y, et al. In vivo visualization of albumin degradation in the proximal tubule. Kidney Int 2008; 74:1480-1486. This study shows that some of the albumin taken up by proximal tubule cells is degraded.
-
(2008)
Kidney Int
, vol.74
, pp. 1480-1486
-
-
Slattery, C.1
Lee, A.2
Zhang, Y.3
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