Evolutionary history and metabolic insights of ancient mammalian uricases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 10, 2014, Pages 3763-3768

  Kratzer, James T ^a,b   Lanaspa, Miguel A ^c   Murphy, Michael N ^d   Cicerchi, Christina ^c   Graves, Christina L ^a   Tipton, Peter A ^e   Ortlund, Eric A ^d   Johnson, Richard J ^c   Gaucher, Eric A ^a,b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b General Genomics   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of Missouri   (United States)

Author keywords

Evolution; Hyperuricemia; Pseudogene

Indexed keywords

FAT; FRUCTOSE; URATE; URATE OXIDASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; APE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME METABOLISM; FRUCTOSE METABOLISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LAST COMMON ANCESTOR; MAMMAL; MOLECULAR EVOLUTION; MULTIGENE FAMILY; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PSEUDOGENE; SWINE;

EVOLUTION; HYPERURICEMIA; PSEUDOGENE;

ADAPTATION, BIOLOGICAL; ADIPOSE TISSUE; ANIMALS; BAYES THEOREM; COMPUTATIONAL BIOLOGY; DNA PRIMERS; EVOLUTION, MOLECULAR; FRUIT; HEP G2 CELLS; HOMINIDAE; HUMANS; MODELS, BIOLOGICAL; MODELS, GENETIC; MODELS, MOLECULAR; PHYLOGENY; PROTEIN CONFORMATION; PSEUDOGENES; RATS; RATS, SPRAGUE-DAWLEY; URATE OXIDASE;

EID: 84896306029     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320393111     Document Type: Article

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