-
1
-
-
0033569406
-
Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
-
Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999;286:531-7.
-
(1999)
Science
, vol.286
, pp. 531-537
-
-
Golub, T.R.1
Slonim, D.K.2
Tamayo, P.3
Huard, C.4
Gaasenbeek, M.5
Mesirov, J.P.6
-
2
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sørlie, T.2
Eisen, M.B.3
Van De Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
-
3
-
-
79953756460
-
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
-
Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Gu S, et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2011;17:500-3.
-
(2011)
Nat Med
, vol.17
, pp. 500-503
-
-
Collisson, E.A.1
Sadanandam, A.2
Olson, P.3
Gibb, W.J.4
Truitt, M.5
Gu, S.6
-
4
-
-
84877619075
-
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
-
Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med 2013;19:619-25.
-
(2013)
Nat Med
, vol.19
, pp. 619-625
-
-
Sadanandam, A.1
Lyssiotis, C.A.2
Homicsko, K.3
Collisson, E.A.4
Gibb, W.J.5
Wullschleger, S.6
-
5
-
-
84960109620
-
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics
-
Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discov 2015;5:1296-313.
-
(2015)
Cancer Discov
, vol.5
, pp. 1296-1313
-
-
Sadanandam, A.1
Wullschleger, S.2
Lyssiotis, C.A.3
Grotzinger, C.4
Barbi, S.5
Bersani, S.6
-
6
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak RGW, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17:98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.W.1
Hoadley, K.A.2
Purdom, E.3
Wang, V.4
Qi, Y.5
Wilkerson, M.D.6
-
7
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multi-region sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multi-region sequencing. N Engl J Med 2012;366:883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
8
-
-
84938940583
-
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
-
Daemen A, Peterson D, Sahu N, McCord R, Du X, Liu B, et al. Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors. Proc Natl Acad Sci U S A 2015;112:E4410-E7.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. E4410-E4417
-
-
Daemen, A.1
Peterson, D.2
Sahu, N.3
McCord, R.4
Du, X.5
Liu, B.6
-
9
-
-
84860512005
-
Links between metabolism and cancer
-
Dang CV.Links between metabolism and cancer. Genes Dev 2012;26:877-90.
-
(2012)
Genes Dev
, vol.26
, pp. 877-890
-
-
Dang, C.V.1
-
10
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O.On the origin of cancer cells. Science 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
11
-
-
0000277858
-
Mémoire sur la fermentation alcoolique
-
Pasteur L.Mémoire sur la fermentation alcoolique. C R Seances Acad Sci 1857;45:1032-6.
-
(1857)
C R Seances Acad Sci
, vol.45
, pp. 1032-1036
-
-
Pasteur, L.1
-
12
-
-
69249202478
-
Hypoxia and the metabolic phenotype of prostate cancer cells
-
Higgins LH, Withers HG, Garbens A, Love HD, Magnoni L, Hayward SW, et al. Hypoxia and the metabolic phenotype of prostate cancer cells. Biochimica et Biophysica Acta 2009;1787:1433-43.
-
(2009)
Biochimica et Biophysica Acta
, vol.1787
, pp. 1433-1443
-
-
Higgins, L.H.1
Withers, H.G.2
Garbens, A.3
Love, H.D.4
Magnoni, L.5
Hayward, S.W.6
-
13
-
-
26944452745
-
Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
-
Griguer C, Oliva C, Gillespie GY. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J Neurooncol 2005;74:123-33.
-
(2005)
J Neurooncol
, vol.74
, pp. 123-133
-
-
Griguer, C.1
Oliva, C.2
Gillespie, G.Y.3
-
14
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008;452:230-3.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
-
15
-
-
84867140008
-
Emerging roles of PKM2 in cell metabolism and cancer progression
-
Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab 2012;23:560-6.
-
(2012)
Trends Endocrinol Metab
, vol.23
, pp. 560-566
-
-
Luo, W.1
Semenza, G.L.2
-
16
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462:739-44.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
-
17
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009;360:765-73.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
-
18
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009;361:1058-66.
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
-
19
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, Wortham NC, et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 2005;14:2231-9.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
-
20
-
-
84920639883
-
Succinate dehydrogenase-deficient renal cell carcinoma: Detailed characterization of 11 tumors definingaunique subtype of renalcell carcinoma
-
Williamson SR, Eble JN, Amin MB, Gupta NS, Smith SC, Sholl LM, et al. Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors definingaunique subtype of renalcell carcinoma. Mod Pathol 2015;28:80-94.
-
(2015)
Mod Pathol
, vol.28
, pp. 80-94
-
-
Williamson, S.R.1
Eble, J.N.2
Amin, M.B.3
Gupta, N.S.4
Smith, S.C.5
Sholl, L.M.6
-
21
-
-
84904256040
-
SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma
-
Hadoux J, Favier J, Scoazec JY, Leboulleux S, Ghuzlan AA, Caramella C, et al. SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma. Int J Cancer 2014;135:2711-20.
-
(2014)
Int J Cancer
, vol.135
, pp. 2711-2720
-
-
Hadoux, J.1
Favier, J.2
Scoazec, J.Y.3
Leboulleux, S.4
Ghuzlan, A.A.5
Caramella, C.6
-
22
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, et al. Mutational landscape and significance across 12 major cancer types. Nature 2013;502:333-9.
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
-
23
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
24
-
-
84860321700
-
Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, et al. Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012;149:656-70.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
-
25
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013;496:101-5.
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
-
26
-
-
65649108558
-
A gene expression signature associated with "K-Ras Addiction" reveals regulators of EMT and tumor cell survival
-
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, et al. A gene expression signature associated with "K-Ras Addiction" reveals regulators of EMT and tumor cell survival. Cancer Cell 2009;15:489-500.
-
(2009)
Cancer Cell
, vol.15
, pp. 489-500
-
-
Singh, A.1
Greninger, P.2
Rhodes, D.3
Koopman, L.4
Violette, S.5
Bardeesy, N.6
-
27
-
-
78751676408
-
Cells of origin in cancer
-
Visvader JE.Cells of origin in cancer. Nature 2011;469:314-22.
-
(2011)
Nature
, vol.469
, pp. 314-322
-
-
Visvader, J.E.1
-
28
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
Kaelin WG, McKnight SL. Influence of metabolism on epigenetics and disease. Cell 2013;153:56-69.
-
(2013)
Cell
, vol.153
, pp. 56-69
-
-
Kaelin, W.G.1
McKnight, S.L.2
-
30
-
-
84942885357
-
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
-
Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SGH, Hoadley KA, et al. Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet 2015;47:1168-78.
-
(2015)
Nat Genet
, vol.47
, pp. 1168-1178
-
-
Moffitt, R.A.1
Marayati, R.2
Flate, E.L.3
Volmar, K.E.4
Loeza, S.G.H.5
Hoadley, K.A.6
-
31
-
-
33748963738
-
Gata6 is an important regulator of mouse pancreas development
-
Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol 2006;298:415-29.
-
(2006)
Dev Biol
, vol.298
, pp. 415-429
-
-
Decker, K.1
Goldman, D.C.2
Grasch, C.L.3
Sussel, L.4
-
32
-
-
84957640649
-
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma
-
Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, et al. CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma. Nat Med 2016;22:278-87.
-
(2016)
Nat Med
, vol.22
, pp. 278-287
-
-
Noll, E.M.1
Eisen, C.2
Stenzinger, A.3
Espinet, E.4
Muckenhuber, A.5
Klein, C.6
-
33
-
-
84960194345
-
Genomic analyses identify molecular subtypes of pancreatic cancer
-
Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016;531:47-52.
-
(2016)
Nature
, vol.531
, pp. 47-52
-
-
Bailey, P.1
Chang, D.K.2
Nones, K.3
Johns, A.L.4
Patch, A.M.5
Gingras, M.C.6
-
34
-
-
84903984143
-
Yap1 activation enables bypass of oncogenic KRAS addiction in pancreatic cancer
-
Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, et al. Yap1 activation enables bypass of oncogenic KRAS addiction in pancreatic cancer. Cell 2014;158:185-97.
-
(2014)
Cell
, vol.158
, pp. 185-197
-
-
Kapoor, A.1
Yao, W.2
Ying, H.3
Hua, S.4
Liewen, A.5
Wang, Q.6
-
35
-
-
84928811801
-
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets
-
Medico E, Russo M, Picco G, Cancelliere C, Valtorta E, Corti G, et al. The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. Nat commun 2015;6:7002.
-
(2015)
Nat Commun
, vol.6
, pp. 7002
-
-
Medico, E.1
Russo, M.2
Picco, G.3
Cancelliere, C.4
Valtorta, E.5
Corti, G.6
-
36
-
-
84946571753
-
The consensus molecular subtypes of colorectal cancer
-
Guinney J, Dienstmann R, Wang X, de Reynies A, Schlicker A, Soneson C, et al. The consensus molecular subtypes of colorectal cancer. Nat Med 2015;21:1350-6.
-
(2015)
Nat Med
, vol.21
, pp. 1350-1356
-
-
Guinney, J.1
Dienstmann, R.2
Wang, X.3
De Reynies, A.4
Schlicker, A.5
Soneson, C.6
-
37
-
-
84939981489
-
Epithelial-mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation
-
Li L, Li W. Epithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation. Pharmacol Ther 2015;150:33-46.
-
(2015)
Pharmacol Ther
, vol.150
, pp. 33-46
-
-
Li, L.1
Li, W.2
-
38
-
-
84880321156
-
Heterogeneity of tumor-induced gene expression changes in the human metabolic network
-
Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, et al. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat Biotechnol 2013;31:522-9.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 522-529
-
-
Hu, J.1
Locasale, J.W.2
Bielas, J.H.3
O'Sullivan, J.4
Sheahan, K.5
Cantley, L.C.6
-
39
-
-
30444434216
-
Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer
-
Jordan VC. Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. Br J Pharmacol 2006;147:S269-76.
-
(2006)
Br J Pharmacol
, vol.147
, pp. S269-S276
-
-
Jordan, V.C.1
-
40
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
-
41
-
-
84877600884
-
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
-
De Sousa E, Melo F, Wang X, Jansen M, Fessler E, Trinh A, de Rooij LPMH, et al. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med 2013;19:614-8.
-
(2013)
Nat Med
, vol.19
, pp. 614-618
-
-
De Sousa, E.1
Melo, F.2
Wang, X.3
Jansen, M.4
Fessler, E.5
Trinh, A.6
De Rooij, L.7
-
42
-
-
84863115693
-
Subtype and pathway specific responses to anticancer compounds in breast cancer
-
Heiser LM, Sadanandam A, Kuo W-L, Benz SC, Goldstein TC, Ng S, et al. Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc Natl Acad Sci U S A 2012;109:2724-9.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2724-2729
-
-
Heiser, L.M.1
Sadanandam, A.2
Kuo, W.-L.3
Benz, S.C.4
Goldstein, T.C.5
Ng, S.6
|