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Volumn , Issue , 2015, Pages 223-250

Cellular and molecular basis of KMT2A/MLL leukaemias: From transformation mechanisms to novel therapeutic strategies

Author keywords

Acute leukaemia; Cell of origin; Epigenetics; KMT2A MLL leukaemia stem cells; Targeted therapy

Indexed keywords


EID: 85016821680     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-19983-2_11     Document Type: Chapter
Times cited : (5)

References (142)
  • 1
    • 79952460280 scopus 로고    scopus 로고
    • 11q23/MLL acute leukemia: Update of clinical aspects
    • Tamai H, Inokuchi K (2010) 11q23/MLL acute leukemia: update of clinical aspects. J Clin Exp Hematopathol: JCEH 50(2): 91-98
    • (2010) J Clin Exp Hematopathol: JCEH , vol.50 , Issue.2 , pp. 91-98
    • Tamai, H.1    Inokuchi, K.2
  • 2
    • 84869065611 scopus 로고    scopus 로고
    • SnapShot: Acute myeloid leukemia
    • Zeisig BB et al (2012) SnapShot: acute myeloid leukemia. Cancer Cell 22(5): 698-698, e1
    • (2012) Cancer Cell , vol.22 , Issue.5
    • Zeisig, B.B.1
  • 3
    • 84884205814 scopus 로고    scopus 로고
    • Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: An overview
    • Manola KN (2013) Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview. Br J Haematol 163: 24-39
    • (2013) Br J Haematol , vol.163 , pp. 24-39
    • Manola, K.N.1
  • 4
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • Pui C, Robison L, Look A (2008) Acute lymphoblastic leukaemia. Lancet 371: 1030-1043
    • (2008) Lancet , vol.371 , pp. 1030-1043
    • Pui, C.1    Robison, L.2    Look, A.3
  • 5
    • 0141634051 scopus 로고    scopus 로고
    • Origins of chromosome translocations in childhood leukaemia
    • Greaves M, Wiemels J (2003) Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer 3(9): 639-649
    • (2003) Nat Rev Cancer , vol.3 , Issue.9 , pp. 639-649
    • Greaves, M.1    Wiemels, J.2
  • 6
    • 0026597560 scopus 로고
    • Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood: Report of three cases and review of the literature
    • Hunger S, Sklar J, Link M (1992) Acute lymphoblastic leukemia occurring as a second malignant neoplasm in childhood: report of three cases and review of the literature. J Clin Oncol: Off J Am Soc Clin Oncol 10(1): 156-163
    • (1992) J Clin Oncol: Off J Am Soc Clin Oncol , vol.10 , Issue.1 , pp. 156-163
    • Hunger, S.1    Sklar, J.2    Link, M.3
  • 7
    • 84887320453 scopus 로고    scopus 로고
    • The MLL recombinome of acute leukemias in 2013
    • Meyer C et al (2013) The MLL recombinome of acute leukemias in 2013. Leukemia 27(11): 2165-2176
    • (2013) Leukemia , vol.27 , Issue.11 , pp. 2165-2176
    • Meyer, C.1
  • 8
    • 24644514410 scopus 로고    scopus 로고
    • The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin
    • Zeisig DT et al (2005) The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene 24(35): 5525-5532
    • (2005) Oncogene , vol.24 , Issue.35 , pp. 5525-5532
    • Zeisig, D.T.1
  • 9
    • 33846522525 scopus 로고    scopus 로고
    • The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
    • Bitoun E, Oliver P, Davies K (2007) The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet 16(1): 92-106
    • (2007) Hum Mol Genet , vol.16 , Issue.1 , pp. 92-106
    • Bitoun, E.1    Oliver, P.2    Davies, K.3
  • 10
    • 39649084473 scopus 로고    scopus 로고
    • A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
    • Mueller D et al (2007) A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood 110(13): 4445-4454
    • (2007) Blood , vol.110 , Issue.13 , pp. 4445-4454
    • Mueller, D.1
  • 11
    • 75949126139 scopus 로고    scopus 로고
    • AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
    • Lin C et al (2010) AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell 37(3): 429-437
    • (2010) Mol Cell , vol.37 , Issue.3 , pp. 429-437
    • Lin, C.1
  • 12
    • 76349118080 scopus 로고    scopus 로고
    • A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
    • Yokoyama A et al (2010) A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell 17(2): 198-212
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 198-212
    • Yokoyama, A.1
  • 13
    • 77949409084 scopus 로고    scopus 로고
    • Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
    • Mohan M et al (2010) Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev 24(6): 574-589
    • (2010) Genes Dev , vol.24 , Issue.6 , pp. 574-589
    • Mohan, M.1
  • 14
    • 0141680407 scopus 로고    scopus 로고
    • Dimerization of MLL fusion proteins immortalizes hematopoietic cells
    • Martin M et al (2003) Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell 4(3): 197-207
    • (2003) Cancer Cell , vol.4 , Issue.3 , pp. 197-207
    • Martin, M.1
  • 15
    • 84892879433 scopus 로고    scopus 로고
    • Eradicating acute myeloid leukemia in a Mll(PTD/wt): Flt3(ITD/wt) murine model: A path to novel therapeutic approaches for human disease
    • Bernot KM et al (2013) Eradicating acute myeloid leukemia in a Mll(PTD/wt): Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease. Blood 122(23): 3778-3783
    • (2013) Blood , vol.122 , Issue.23 , pp. 3778-3783
    • Bernot, K.M.1
  • 16
    • 84864565435 scopus 로고    scopus 로고
    • Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias
    • Zorko NA et al (2012) Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias. Blood 120(5): 1130-1136
    • (2012) Blood , vol.120 , Issue.5 , pp. 1130-1136
    • Zorko, N.A.1
  • 17
    • 84864548794 scopus 로고    scopus 로고
    • Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells
    • Zhang Y et al (2012) Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood 120(5): 1118-1129
    • (2012) Blood , vol.120 , Issue.5 , pp. 1118-1129
    • Zhang, Y.1
  • 18
    • 0036682174 scopus 로고    scopus 로고
    • Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: A study of the Acute Myeloid Leukemia Study Group Ulm
    • Dohner K (2002) Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J Clin Oncol 20: 3254-3261
    • (2002) J Clin Oncol , vol.20 , pp. 3254-3261
    • Dohner, K.1
  • 19
    • 84877676204 scopus 로고    scopus 로고
    • Mixed lineage leukemia protein in normal and leukemic stem cells
    • Yip B, So C (2013) Mixed lineage leukemia protein in normal and leukemic stem cells. Exp Biol Med (Maywood) 238(3): 315-323
    • (2013) Exp Biol Med (Maywood) , vol.238 , Issue.3 , pp. 315-323
    • Yip, B.1    So, C.2
  • 20
    • 0037608704 scopus 로고    scopus 로고
    • MLL intrachromosomal amplification in a pre-B acute lymphoblastic leukemia
    • Espinet B et al (2003) MLL intrachromosomal amplification in a pre-B acute lymphoblastic leukemia. Haematologica 88(2): 28-29
    • (2003) Haematologica , vol.88 , Issue.2 , pp. 28-29
    • Espinet, B.1
  • 21
    • 0025833975 scopus 로고
    • Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias
    • Ziemin-van der Poel S et al (1991) Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A 88(23): 10735-10739
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.23 , pp. 10735-10739
    • Ziemin-Van der Poel, S.1
  • 22
    • 0026496887 scopus 로고
    • The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
    • Gu Y et al (1992) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71(4): 701-708
    • (1992) Cell , vol.71 , Issue.4 , pp. 701-708
    • Gu, Y.1
  • 23
    • 0026936328 scopus 로고
    • A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
    • Djabali M et al (1992) A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet 2(2): 113-118
    • (1992) Nat Genet , vol.2 , Issue.2 , pp. 113-118
    • Djabali, M.1
  • 24
    • 15844394270 scopus 로고    scopus 로고
    • An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J et al (1996) An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell 85(6): 853-861
    • (1996) Cell , vol.85 , Issue.6 , pp. 853-861
    • Corral, J.1
  • 25
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • Lavau C et al (1997) Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J 16(14): 4226-4237
    • (1997) EMBO J , vol.16 , Issue.14 , pp. 4226-4237
    • Lavau, C.1
  • 26
    • 78650003931 scopus 로고    scopus 로고
    • β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells
    • Yeung J et al (2010) β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell 18: 606-618
    • (2010) Cancer Cell , vol.18 , pp. 606-618
    • Yeung, J.1
  • 27
    • 0034252206 scopus 로고    scopus 로고
    • Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development
    • Collins E et al (2000) Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep 1(2): 127-132
    • (2000) EMBO Rep , vol.1 , Issue.2 , pp. 127-132
    • Collins, E.1
  • 28
    • 27144493049 scopus 로고    scopus 로고
    • Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis
    • Drynan L et al (2005) Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J 24(17): 3136-3146
    • (2005) EMBO J , vol.24 , Issue.17 , pp. 3136-3146
    • Drynan, L.1
  • 29
    • 0345582392 scopus 로고    scopus 로고
    • Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
    • Forster A et al (2003) Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell 3(5): 449-458
    • (2003) Cancer Cell , vol.3 , Issue.5 , pp. 449-458
    • Forster, A.1
  • 30
    • 9144236224 scopus 로고    scopus 로고
    • Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
    • Zeisig BB et al (2004) Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 24(2): 617-628
    • (2004) Mol Cell Biol , vol.24 , Issue.2 , pp. 617-628
    • Zeisig, B.B.1
  • 31
    • 27144505698 scopus 로고    scopus 로고
    • Continuous MLL-ENL expression is necessary to establish a “Hox Code” and maintain immortalization of hematopoietic progenitor cells
    • Horton S et al (2005) Continuous MLL-ENL expression is necessary to establish a “Hox Code” and maintain immortalization of hematopoietic progenitor cells. Cancer Res 65(20): 9245-9252
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9245-9252
    • Horton, S.1
  • 32
    • 44449151168 scopus 로고    scopus 로고
    • Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
    • Wei J et al (2008) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6): 483-495
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 483-495
    • Wei, J.1
  • 33
    • 34247595838 scopus 로고    scopus 로고
    • Modeling the initiation and progression of human acute leukemia in mice
    • Barabé F et al (2007) Modeling the initiation and progression of human acute leukemia in mice. Science (New York) 316(5824): 600-604
    • (2007) Science (New York) , vol.316 , Issue.5824 , pp. 600-604
    • Barabé, F.1
  • 34
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • So C et al (2003) MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3(2): 161-171
    • (2003) Cancer Cell , vol.3 , Issue.2 , pp. 161-171
    • So, C.1
  • 35
    • 33745941911 scopus 로고    scopus 로고
    • A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
    • Chen W (2006) A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood 108: 669-677
    • (2006) Blood , vol.108 , pp. 669-677
    • Chen, W.1
  • 36
    • 33745103352 scopus 로고    scopus 로고
    • A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology
    • Metzler M et al (2006) A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene 25(22): 3093-3103
    • (2006) Oncogene , vol.25 , Issue.22 , pp. 3093-3103
    • Metzler, M.1
  • 37
    • 33745968731 scopus 로고    scopus 로고
    • Alert and sniffy-nosed about Mll-AF4?
    • Greaves MF, So CW (2006) Alert and sniffy-nosed about Mll-AF4? Blood 108: 416-417
    • (2006) Blood , vol.108 , pp. 416-417
    • Greaves, M.F.1    So, C.W.2
  • 38
    • 54549083228 scopus 로고    scopus 로고
    • H3K79 methylation profiles define murine and human MLL-AF4 leukemias
    • Krivtsov AV et al (2008) H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14(5): 355-368
    • (2008) Cancer Cell , vol.14 , Issue.5 , pp. 355-368
    • Krivtsov, A.V.1
  • 39
    • 54549127171 scopus 로고    scopus 로고
    • Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia
    • Zeisig BB et al (2008) Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia. Cancer Cell 14(5): 345-347
    • (2008) Cancer Cell , vol.14 , Issue.5 , pp. 345-347
    • Zeisig, B.B.1
  • 40
    • 77951749557 scopus 로고    scopus 로고
    • The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4
    • Bursen A et al (2010) The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 115(17): 3570-3579
    • (2010) Blood , vol.115 , Issue.17 , pp. 3570-3579
    • Bursen, A.1
  • 41
    • 79954613955 scopus 로고    scopus 로고
    • Authors’ comments: T(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL
    • Kumar AR et al (2011) Authors’ comments: t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL. Leuk Res 35(5): 697
    • (2011) Leuk Res , vol.35 , Issue.5 , pp. 697
    • Kumar, A.R.1
  • 42
    • 34249651279 scopus 로고    scopus 로고
    • Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele
    • Kowarz E et al (2007) Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4.MLL fusion allele. Leukemia 21(6): 1232-1238
    • (2007) Leukemia , vol.21 , Issue.6 , pp. 1232-1238
    • Kowarz, E.1
  • 43
    • 0037456994 scopus 로고    scopus 로고
    • The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell
    • Zeisig BB et al (2003) The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell. Oncogene 22(11): 1629-1637
    • (2003) Oncogene , vol.22 , Issue.11 , pp. 1629-1637
    • Zeisig, B.B.1
  • 44
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from selfrenewing stem cells and short-lived myeloid progenitors
    • Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL (2003) Similar MLL-associated leukemias arising from selfrenewing stem cells and short-lived myeloid progenitors. Genes Dev 17: 3029-3035
    • (2003) Genes Dev , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 45
    • 33746498580 scopus 로고    scopus 로고
    • Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
    • Krivtsov AV et al (2006) Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442(7104): 818-822
    • (2006) Nature , vol.442 , Issue.7104 , pp. 818-822
    • Krivtsov, A.V.1
  • 46
    • 58949102947 scopus 로고    scopus 로고
    • Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
    • Somervaille T et al (2009) Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4(2): 129-140
    • (2009) Cell Stem Cell , vol.4 , Issue.2 , pp. 129-140
    • Somervaille, T.1
  • 47
    • 42949097515 scopus 로고    scopus 로고
    • Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells
    • Chen W et al (2008) Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell 13(5): 432-440
    • (2008) Cancer Cell , vol.13 , Issue.5 , pp. 432-440
    • Chen, W.1
  • 48
    • 18944373328 scopus 로고    scopus 로고
    • Highly efficient endogenous human gene correction using designed zinc-finger nucleases
    • Urnov F et al (2005) Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435(7042): 646-651
    • (2005) Nature , vol.435 , Issue.7042 , pp. 646-651
    • Urnov, F.1
  • 49
    • 79551685675 scopus 로고    scopus 로고
    • A TALE nuclease architecture for efficient genome editing
    • Miller J et al (2011) A TALE nuclease architecture for efficient genome editing. Nat Biotechnol 29(2): 143-148
    • (2011) Nat Biotechnol , vol.29 , Issue.2 , pp. 143-148
    • Miller, J.1
  • 50
    • 0028580104 scopus 로고
    • Spreading the silence: Epigenetic transcriptional regulation during Drosophila development
    • Moehrle A, Paro R (1994) Spreading the silence: epigenetic transcriptional regulation during Drosophila development. Dev Genet 15: 478-484
    • (1994) Dev Genet , vol.15 , pp. 478-484
    • Moehrle, A.1    Paro, R.2
  • 51
    • 0028869112 scopus 로고
    • Altered hox expression and segmental identity in Mll-mutant mice
    • Yu B et al (1995) Altered hox expression and segmental identity in Mll-mutant mice. Nature 378(6556): 505-508
    • (1995) Nature , vol.378 , Issue.6556 , pp. 505-508
    • Yu, B.1
  • 52
    • 0030668324 scopus 로고    scopus 로고
    • SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes
    • Nislow C, Ray E, Pillus L (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12): 2421-2436
    • (1997) Mol Biol Cell , vol.8 , Issue.12 , pp. 2421-2436
    • Nislow, C.1    Ray, E.2    Pillus, L.3
  • 53
    • 0037126594 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
    • Roguev A et al (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24): 7137-7148
    • (2001) EMBO J , vol.20 , Issue.24 , pp. 7137-7148
    • Roguev, A.1
  • 54
    • 18744373853 scopus 로고    scopus 로고
    • MLL targets SET domain methyltransferase activity to hox gene promoters
    • Milne T et al (2002) MLL targets SET domain methyltransferase activity to hox gene promoters. Mol Cell 10(5): 1107-1117
    • (2002) Mol Cell , vol.10 , Issue.5 , pp. 1107-1117
    • Milne, T.1
  • 55
    • 1642618325 scopus 로고    scopus 로고
    • Modulation of heat shock gene expression by the TAC1 chromatinmodifying complex
    • Smith ST et al (2004) Modulation of heat shock gene expression by the TAC1 chromatinmodifying complex. Nat Cell Biol 6: 162-167
    • (2004) Nat Cell Biol , vol.6 , pp. 162-167
    • Smith, S.T.1
  • 56
    • 33646230318 scopus 로고    scopus 로고
    • Histone and DNA methylation defects at hox genes in mice expressing a SET domain-truncated form of Mll
    • Terranova R et al (2006) Histone and DNA methylation defects at hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A 103(17): 6629-6634
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.17 , pp. 6629-6634
    • Terranova, R.1
  • 57
    • 77957128551 scopus 로고    scopus 로고
    • Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis
    • Mohan M et al (2010) Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer 10(10): 721-728
    • (2010) Nat Rev Cancer , vol.10 , Issue.10 , pp. 721-728
    • Mohan, M.1
  • 58
    • 81855195123 scopus 로고    scopus 로고
    • The COMPASS family of H3K4 methylases in Drosophila
    • Mohan M et al (2011) The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol 31(21): 4310-4318
    • (2011) Mol Cell Biol , vol.31 , Issue.21 , pp. 4310-4318
    • Mohan, M.1
  • 59
    • 77953246813 scopus 로고    scopus 로고
    • The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
    • Muntean A et al (2010) The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17(6): 609-621
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 609-621
    • Muntean, A.1
  • 60
    • 80054984945 scopus 로고    scopus 로고
    • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    • Dawson M et al (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478(7370): 529-533
    • (2011) Nature , vol.478 , Issue.7370 , pp. 529-533
    • Dawson, M.1
  • 61
    • 26844555530 scopus 로고    scopus 로고
    • The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
    • Yokoyama A et al (2005) The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell 123(2): 207-218
    • (2005) Cell , vol.123 , Issue.2 , pp. 207-218
    • Yokoyama, A.1
  • 62
    • 0042885909 scopus 로고    scopus 로고
    • Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
    • So C et al (2003) Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 4: 99-110
    • (2003) Cancer Cell , vol.4 , pp. 99-110
    • So, C.1
  • 63
    • 2342484341 scopus 로고    scopus 로고
    • The small oligomerization domain of gephyrin converts MLL to an oncogene
    • Eguchi M, Eguchi-Ishimae M, Greaves M (2004) The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood 103(10): 3876-3882
    • (2004) Blood , vol.103 , Issue.10 , pp. 3876-3882
    • Eguchi, M.1    Eguchi-Ishimae, M.2    Greaves, M.3
  • 64
    • 34848865728 scopus 로고    scopus 로고
    • Protein arginine-methyltransferase-dependent oncogenesis
    • Cheung N et al (2007) Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol 9(10): 1208-1215
    • (2007) Nat Cell Biol , vol.9 , Issue.10 , pp. 1208-1215
    • Cheung, N.1
  • 65
    • 79959514392 scopus 로고    scopus 로고
    • MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
    • Wang Q-F et al (2011) MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood 117(25): 6895-6905
    • (2011) Blood , vol.117 , Issue.25 , pp. 6895-6905
    • Wang, Q.-F.1
  • 66
    • 79960044951 scopus 로고    scopus 로고
    • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • Bernt K et al (2011) MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20(1): 66-78
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 66-78
    • Bernt, K.1
  • 67
    • 58049220979 scopus 로고    scopus 로고
    • Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
    • Guenther M et al (2008) Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev 22(24): 3403-3408
    • (2008) Genes Dev , vol.22 , Issue.24 , pp. 3403-3408
    • Guenther, M.1
  • 68
    • 77953913196 scopus 로고    scopus 로고
    • Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
    • Milne T et al (2010) Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell 38(6): 853-863
    • (2010) Mol Cell , vol.38 , Issue.6 , pp. 853-863
    • Milne, T.1
  • 69
    • 76549105779 scopus 로고    scopus 로고
    • MLL-AF9-induced leukemogenesis requires coexpression of the wildtype Mll allele
    • Thiel A et al (2010) MLL-AF9-induced leukemogenesis requires coexpression of the wildtype Mll allele. Cancer Cell 17(2): 148-159
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 148-159
    • Thiel, A.1
  • 70
    • 34548462072 scopus 로고    scopus 로고
    • Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    • Jude C et al (2007) Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3): 324-337
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 324-337
    • Jude, C.1
  • 71
    • 34548413178 scopus 로고    scopus 로고
    • Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal
    • McMahon K et al (2007) Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal. Cell Stem Cell 1(3): 338-345
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 338-345
    • McMahon, K.1
  • 72
    • 84901281295 scopus 로고    scopus 로고
    • The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis
    • Mishra BP et al (2014) The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Rep 7: 1239-1247
    • (2014) Cell Rep , vol.7 , pp. 1239-1247
    • Mishra, B.P.1
  • 73
    • 0029926378 scopus 로고    scopus 로고
    • Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line
    • Tanabe S et al (1996) Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line. Genes Chromosomes Cancer 15(4): 206-216
    • (1996) Genes Chromosomes Cancer , vol.15 , Issue.4 , pp. 206-216
    • Tanabe, S.1
  • 74
    • 16844380787 scopus 로고    scopus 로고
    • Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis
    • Ono R et al (2005) Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis. J Clin Invest 115(4): 919-929
    • (2005) J Clin Invest , vol.115 , Issue.4 , pp. 919-929
    • Ono, R.1
  • 75
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong S et al (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 30(1): 41-47
    • (2002) Nat Genet , vol.30 , Issue.1 , pp. 41-47
    • Armstrong, S.1
  • 76
    • 0013312329 scopus 로고    scopus 로고
    • Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
    • Armstrong S et al (2003) Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell 3(2): 173-183
    • (2003) Cancer Cell , vol.3 , Issue.2 , pp. 173-183
    • Armstrong, S.1
  • 77
    • 80052713073 scopus 로고    scopus 로고
    • The clinical development of FLT3 inhibitors in acute myeloid leukemia
    • Knapper S (2011) The clinical development of FLT3 inhibitors in acute myeloid leukemia. Expert Opin Investig Drugs 20(10): 1377-1395
    • (2011) Expert Opin Investig Drugs , vol.20 , Issue.10 , pp. 1377-1395
    • Knapper, S.1
  • 78
    • 84881599676 scopus 로고    scopus 로고
    • Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes
    • Albouhair S, Morgado E, Lavau C (2013) Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes. PLoS One 8(8): e72261
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e72261
    • Albouhair, S.1    Morgado, E.2    Lavau, C.3
  • 79
    • 84895823849 scopus 로고    scopus 로고
    • Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells
    • Montes R et al (2013) Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells. Leukemia 28: 666-674
    • (2013) Leukemia , vol.28 , pp. 666-674
    • Montes, R.1
  • 80
    • 33745595058 scopus 로고    scopus 로고
    • C-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells
    • Hess JL et al (2006) c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood 108(1): 297-304
    • (2006) Blood , vol.108 , Issue.1 , pp. 297-304
    • Hess, J.L.1
  • 81
    • 35948964020 scopus 로고    scopus 로고
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
    • Wong P et al (2007) Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 21(21): 2762-2774
    • (2007) Genes Dev , vol.21 , Issue.21 , pp. 2762-2774
    • Wong, P.1
  • 82
    • 70350495169 scopus 로고    scopus 로고
    • Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C
    • Schwieger M et al (2009) Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C. Blood 114(12): 2476-2488
    • (2009) Blood , vol.114 , Issue.12 , pp. 2476-2488
    • Schwieger, M.1
  • 83
    • 64049095814 scopus 로고    scopus 로고
    • HOXA9 is required for survival in human MLL-rearranged acute leukemias
    • Faber J et al (2009) HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood 113(11): 2375-2385
    • (2009) Blood , vol.113 , Issue.11 , pp. 2375-2385
    • Faber, J.1
  • 84
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton P, Cleary M (2003) Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 17(18): 2298-2307
    • (2003) Genes Dev , vol.17 , Issue.18 , pp. 2298-2307
    • Ayton, P.1    Cleary, M.2
  • 85
    • 1842579481 scopus 로고    scopus 로고
    • Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    • So C et al (2004) Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood 103(8): 3192-3199
    • (2004) Blood , vol.103 , Issue.8 , pp. 3192-3199
    • So, C.1
  • 86
    • 1442356858 scopus 로고    scopus 로고
    • Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
    • Kumar AR et al (2004) Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia. Blood 103(5): 1823-1828
    • (2004) Blood , vol.103 , Issue.5 , pp. 1823-1828
    • Kumar, A.R.1
  • 87
    • 84869835580 scopus 로고    scopus 로고
    • MiR-495 is a tumor-suppressor microRNA down-regulated in MLLrearranged leukemia
    • Jiang X et al (2012) MiR-495 is a tumor-suppressor microRNA down-regulated in MLLrearranged leukemia. Proc Natl Acad Sci U S A 109(47): 19397-19402
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.47 , pp. 19397-19402
    • Jiang, X.1
  • 88
    • 84880366679 scopus 로고    scopus 로고
    • TET1 plays an essential oncogenic role in MLL-rearranged leukemia
    • Huang H et al (2013) TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A 110(29): 11994-11999
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.29 , pp. 11994-11999
    • Huang, H.1
  • 89
    • 84879932160 scopus 로고    scopus 로고
    • Mir-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia
    • Chen P et al (2013) miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proc Natl Acad Sci U S A 110(28): 11511-11516
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.28 , pp. 11511-11516
    • Chen, P.1
  • 90
    • 84862497497 scopus 로고    scopus 로고
    • EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs
    • Bindels E et al (2012) EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood 119(24): 5838-5849
    • (2012) Blood , vol.119 , Issue.24 , pp. 5838-5849
    • Bindels, E.1
  • 91
    • 34447641262 scopus 로고    scopus 로고
    • The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia
    • Mikesch JH et al (2007) The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. Leukemia 21: 1638-1647
    • (2007) Leukemia , vol.21 , pp. 1638-1647
    • Mikesch, J.H.1
  • 92
    • 77950287628 scopus 로고    scopus 로고
    • The Wnt/β catenin pathway is required for the development of leukemia stem cells in AML
    • Wang Y et al (2010) The Wnt/β catenin pathway is required for the development of leukemia stem cells in AML. Science 327: 1650-1653
    • (2010) Science , vol.327 , pp. 1650-1653
    • Wang, Y.1
  • 93
    • 38049105637 scopus 로고    scopus 로고
    • Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin
    • Jeannet G et al (2008) Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood 111(1): 142-149
    • (2008) Blood , vol.111 , Issue.1 , pp. 142-149
    • Jeannet, G.1
  • 94
    • 38049139201 scopus 로고    scopus 로고
    • Simultaneous loss of beta-and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    • Koch U et al (2008) Simultaneous loss of beta-and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood 111(1): 160-164
    • (2008) Blood , vol.111 , Issue.1 , pp. 160-164
    • Koch, U.1
  • 95
    • 84862137376 scopus 로고    scopus 로고
    • Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/β-catenin pathway
    • Fung T, Gandillet A, So C (2012) Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/β-catenin pathway. Curr Opin Hematol 19(4): 280-286
    • (2012) Curr Opin Hematol , vol.19 , Issue.4 , pp. 280-286
    • Fung, T.1    Gandillet, A.2    So, C.3
  • 96
    • 84859523707 scopus 로고    scopus 로고
    • Genetic and pharmacologic inhibition of β-catenin targets imatinibresistant leukemia stem cells in CML
    • Heidel F et al (2012) Genetic and pharmacologic inhibition of β-catenin targets imatinibresistant leukemia stem cells in CML. Cell Stem Cell 10(4): 412-424
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 412-424
    • Heidel, F.1
  • 97
    • 36649002031 scopus 로고    scopus 로고
    • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    • Zhao C et al (2007) Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12(6): 528-541
    • (2007) Cancer Cell , vol.12 , Issue.6 , pp. 528-541
    • Zhao, C.1
  • 98
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson CH et al (2004) Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351(7): 657-667
    • (2004) N Engl J Med , vol.351 , Issue.7 , pp. 657-667
    • Jamieson, C.H.1
  • 99
    • 84880011146 scopus 로고    scopus 로고
    • In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
    • Miller P et al (2013) In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell 24(1): 45-58
    • (2013) Cancer Cell , vol.24 , Issue.1 , pp. 45-58
    • Miller, P.1
  • 100
    • 84879995987 scopus 로고    scopus 로고
    • Linking MLL leukemia with integrin signaling
    • Zeisig BB, So CW (2013) Linking MLL leukemia with integrin signaling. Cancer Cell 24(1): 5-7
    • (2013) Cancer Cell , vol.24 , Issue.1 , pp. 5-7
    • Zeisig, B.B.1    So, C.W.2
  • 101
    • 77952887713 scopus 로고    scopus 로고
    • The SYK tyrosine kinase: A crucial player in diverse biological functions
    • Mócsai A, Ruland J, Tybulewicz V (2010) The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 10(6): 387-402
    • (2010) Nat Rev Immunol , vol.10 , Issue.6 , pp. 387-402
    • Mócsai, A.1    Ruland, J.2    Tybulewicz, V.3
  • 102
    • 81255189533 scopus 로고    scopus 로고
    • Collaboration between PcG proteins and MLL fusions in leukemogenesis: An emerging paradigm
    • Zeisig BB et al (2011) Collaboration between PcG proteins and MLL fusions in leukemogenesis: an emerging paradigm. Cancer Cell 20(5): 551-553
    • (2011) Cancer Cell , vol.20 , Issue.5 , pp. 551-553
    • Zeisig, B.B.1
  • 103
    • 79957839752 scopus 로고    scopus 로고
    • Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells
    • Smith LL et al (2011) Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells. Cell Stem Cell 8(6): 649-662
    • (2011) Cell Stem Cell , vol.8 , Issue.6 , pp. 649-662
    • Smith, L.L.1
  • 104
    • 0035945657 scopus 로고    scopus 로고
    • The ENL moiety of the childhood leukemia-associated MLLENL oncoprotein recruits human Polycomb 3
    • García-Cuéllar M et al (2001) The ENL moiety of the childhood leukemia-associated MLLENL oncoprotein recruits human Polycomb 3. Oncogene 20(4): 411-419
    • (2001) Oncogene , vol.20 , Issue.4 , pp. 411-419
    • García-Cuéllar, M.1
  • 105
    • 81255192170 scopus 로고    scopus 로고
    • CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
    • Tan J et al (2011) CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell 20(5): 563-575
    • (2011) Cancer Cell , vol.20 , Issue.5 , pp. 563-575
    • Tan, J.1
  • 106
    • 84878547644 scopus 로고    scopus 로고
    • MLL-ENL inhibits polycomb repressive complex 1 to achieve effi-cient transformation of hematopoietic cells
    • Maethner E et al (2013) MLL-ENL inhibits polycomb repressive complex 1 to achieve effi-cient transformation of hematopoietic cells. Cell Rep 3(5): 1553-1566
    • (2013) Cell Rep , vol.3 , Issue.5 , pp. 1553-1566
    • Maethner, E.1
  • 107
    • 84859475727 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 is required for MLL-AF9 leukemia
    • Neff T et al (2012) Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A 109(13): 5028-5033
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.13 , pp. 5028-5033
    • Neff, T.1
  • 108
    • 84864567410 scopus 로고    scopus 로고
    • Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
    • Tanaka S et al (2012) Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood 120(5): 1107-1117
    • (2012) Blood , vol.120 , Issue.5 , pp. 1107-1117
    • Tanaka, S.1
  • 109
    • 84055223081 scopus 로고    scopus 로고
    • The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
    • Huang G et al (2011) The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood 118(25): 6544-6552
    • (2011) Blood , vol.118 , Issue.25 , pp. 6544-6552
    • Huang, G.1
  • 110
    • 84883534738 scopus 로고    scopus 로고
    • Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
    • Goyama S et al (2013) Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. J Clin Invest 123(9): 3876-3888
    • (2013) J Clin Invest , vol.123 , Issue.9 , pp. 3876-3888
    • Goyama, S.1
  • 111
    • 84873133035 scopus 로고    scopus 로고
    • RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction
    • Wilkinson A et al (2013) RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep 3(1): 116-127
    • (2013) Cell Rep , vol.3 , Issue.1 , pp. 116-127
    • Wilkinson, A.1
  • 112
    • 84897486848 scopus 로고    scopus 로고
    • Down-regulation of RUNX1/CBFβ by MLL fusion proteins enhances HSC self-renewal
    • Zhao X et al (2014) Down-regulation of RUNX1/CBFβ by MLL fusion proteins enhances HSC self-renewal. Blood 123: 1729-1738
    • (2014) Blood , vol.123 , pp. 1729-1738
    • Zhao, X.1
  • 113
    • 84892504696 scopus 로고    scopus 로고
    • Initiation of MLL-rearranged AML is dependent on C/EBPα
    • Ohlsson E et al (2014) Initiation of MLL-rearranged AML is dependent on C/EBPα. J Exp Med 211(1): 5-13
    • (2014) J Exp Med , vol.211 , Issue.1 , pp. 5-13
    • Ohlsson, E.1
  • 114
    • 84904040001 scopus 로고    scopus 로고
    • PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/ HOX pathway
    • Zhou J et al (2013) PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/ HOX pathway. Leukemia 28(7): 1436-1438
    • (2013) Leukemia , vol.28 , Issue.7 , pp. 1436-1438
    • Zhou, J.1
  • 115
    • 84885344977 scopus 로고    scopus 로고
    • Epigenetic roles of MLL oncoproteins are dependent on NF-κB
    • Kuo H-P et al (2013) Epigenetic roles of MLL oncoproteins are dependent on NF-κB. Cancer Cell 24(4): 423-437
    • (2013) Cancer Cell , vol.24 , Issue.4 , pp. 423-437
    • Kuo, H.-P.1
  • 116
    • 84874638746 scopus 로고    scopus 로고
    • Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
    • Wang E et al (2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A 110(10): 3901-3906
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.10 , pp. 3901-3906
    • Wang, E.1
  • 117
    • 84893858504 scopus 로고    scopus 로고
    • Positive feedback between NF-κB and TNF-α promotes leukemiainitiating cell capacity
    • Kagoya Y et al (2014) Positive feedback between NF-κB and TNF-α promotes leukemiainitiating cell capacity. J Clin Invest 124(2): 528-542
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 528-542
    • Kagoya, Y.1
  • 118
    • 79951999971 scopus 로고    scopus 로고
    • Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: A report from the Children’s Oncology Group
    • Dreyer Z et al (2011) Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children’s Oncology Group. J Clin Oncol: Off J Am Soc Clin Oncol 29(2): 214-222
    • (2011) J Clin Oncol: Off J Am Soc Clin Oncol , vol.29 , Issue.2 , pp. 214-222
    • Dreyer, Z.1
  • 119
    • 77957949594 scopus 로고    scopus 로고
    • Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: Results from the Interfant-99 study
    • Mann G et al (2010) Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 study. Blood 116(15): 2644-2650
    • (2010) Blood , vol.116 , Issue.15 , pp. 2644-2650
    • Mann, G.1
  • 120
    • 79955948524 scopus 로고    scopus 로고
    • Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
    • Jo S et al (2011) Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood 117(18): 4759-4768
    • (2011) Blood , vol.117 , Issue.18 , pp. 4759-4768
    • Jo, S.1
  • 121
    • 79959493965 scopus 로고    scopus 로고
    • DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
    • Nguyen A et al (2011) DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood 117(25): 6912-6922
    • (2011) Blood , vol.117 , Issue.25 , pp. 6912-6922
    • Nguyen, A.1
  • 122
    • 80052480322 scopus 로고    scopus 로고
    • Essential role of DOT1L in maintaining normal adult hematopoiesis
    • Nguyen A et al (2011) Essential role of DOT1L in maintaining normal adult hematopoiesis. Cell Res 21(9): 1370-1373
    • (2011) Cell Res , vol.21 , Issue.9 , pp. 1370-1373
    • Nguyen, A.1
  • 123
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent smallmolecule DOT1L inhibitor
    • Daigle S et al (2011) Selective killing of mixed lineage leukemia cells by a potent smallmolecule DOT1L inhibitor. Cancer Cell 20(1): 53-65
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 53-65
    • Daigle, S.1
  • 124
    • 84871737742 scopus 로고    scopus 로고
    • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
    • Yu W et al (2012) Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 3: 1288
    • (2012) Nat Commun , vol.3 , pp. 1288
    • Yu, W.1
  • 125
    • 84886864184 scopus 로고    scopus 로고
    • Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
    • Daigle S et al (2013) Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 122(6): 1017-1025
    • (2013) Blood , vol.122 , Issue.6 , pp. 1017-1025
    • Daigle, S.1
  • 126
    • 84859837026 scopus 로고    scopus 로고
    • The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
    • Harris W et al (2012) The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4): 473-487
    • (2012) Cancer Cell , vol.21 , Issue.4 , pp. 473-487
    • Harris, W.1
  • 127
    • 84862777766 scopus 로고    scopus 로고
    • Inhibition of the LSD1 (KDM1A) demethylase reactivates the alltrans-retinoic acid differentiation pathway in acute myeloid leukemia
    • Schenk T et al (2012) Inhibition of the LSD1 (KDM1A) demethylase reactivates the alltrans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 18(4): 605-611
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 605-611
    • Schenk, T.1
  • 128
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J et al (2011) RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478(7370): 524-528
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1
  • 129
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • Filippakopoulos P et al (2010) Selective inhibition of BET bromodomains. Nature 468(7327): 1067-1073
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1067-1073
    • Filippakopoulos, P.1
  • 130
    • 78650806593 scopus 로고    scopus 로고
    • Suppression of inflammation by a synthetic histone mimic
    • Nicodeme E et al (2010) Suppression of inflammation by a synthetic histone mimic. Nature 468(7327): 1119-1123
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1119-1123
    • Nicodeme, E.1
  • 131
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • Kim J et al (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143(2): 313-324
    • (2010) Cell , vol.143 , Issue.2 , pp. 313-324
    • Kim, J.1
  • 132
    • 84893735484 scopus 로고    scopus 로고
    • Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia
    • Dawson M et al (2014) Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia. Leukemia 28(2): 311-320
    • (2014) Leukemia , vol.28 , Issue.2 , pp. 311-320
    • Dawson, M.1
  • 133
    • 84891879120 scopus 로고    scopus 로고
    • BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms
    • Wyspiańska B et al (2014) BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms. Leukemia 28(1): 88-97
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 88-97
    • Wyspiańska, B.1
  • 134
    • 0038695861 scopus 로고    scopus 로고
    • Functional studies of the MEN1 gene
    • Chandrasekharappa S, Teh B (2003) Functional studies of the MEN1 gene. J Intern Med 253(6): 606-615
    • (2003) J Intern Med , vol.253 , Issue.6 , pp. 606-615
    • Chandrasekharappa, S.1    Teh, B.2
  • 135
    • 84862777931 scopus 로고    scopus 로고
    • The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
    • Huang J et al (2012) The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 482(7386): 542-546
    • (2012) Nature , vol.482 , Issue.7386 , pp. 542-546
    • Huang, J.1
  • 136
    • 84857195696 scopus 로고    scopus 로고
    • Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    • Grembecka J et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol 8(3): 277-284
    • (2012) Nat Chem Biol , vol.8 , Issue.3 , pp. 277-284
    • Grembecka, J.1
  • 137
    • 84870486815 scopus 로고    scopus 로고
    • Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    • Shi A et al (2012) Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood 120(23): 4461-4469
    • (2012) Blood , vol.120 , Issue.23 , pp. 4461-4469
    • Shi, A.1
  • 138
    • 33746849256 scopus 로고    scopus 로고
    • Regulation of MLL1 H3K4 methyltransferase activity by its core components
    • Dou Y et al (2006) Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13(8): 713-719
    • (2006) Nat Struct Mol Biol , vol.13 , Issue.8 , pp. 713-719
    • Dou, Y.1
  • 139
    • 84892841527 scopus 로고    scopus 로고
    • Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia
    • Cao F et al (2014) Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell 53(2): 247-261
    • (2014) Mol Cell , vol.53 , Issue.2 , pp. 247-261
    • Cao, F.1
  • 140
    • 84887346920 scopus 로고    scopus 로고
    • MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
    • Muntean A et al (2013) MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction. Blood 122(11): 1914-1922
    • (2013) Blood , vol.122 , Issue.11 , pp. 1914-1922
    • Muntean, A.1
  • 141
    • 84937764878 scopus 로고    scopus 로고
    • Targeting the MLL complex in castration-resistant prostate cancer
    • Malik R et al (2015) Targeting the MLL complex in castration-resistant prostate cancer. Nat Med 21(4): 344-352
    • (2015) Nat Med , vol.21 , Issue.4 , pp. 344-352
    • Malik, R.1
  • 142
    • 84928037867 scopus 로고    scopus 로고
    • Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo
    • Borkin D et al (2015) Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo. Cancer Cell 27: 589-602
    • (2015) Cancer Cell , vol.27 , pp. 589-602
    • Borkin, D.1


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