miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11511-11516

  Chen, Ping ^a   Price, Colles ^a   Li, Zejuan ^a   Li, Yuanyuan ^a   Cao, Donglin ^a,b   Wiley, Anissa ^a   He, Chunjiang ^a   Gurbuxani, Sandeep ^a   Kunjamma, Rejani B ^a   Huang, Hao ^a   Jiang, Xi ^a   Arnovitz, Stephen ^a   Xu, Mengyi ^a   Hong, Gia Ming ^a   Elkahloun, Abdel G ^c   Neilly, Mary Beth ^a   Wunderlich, Mark ^d   Larson, Richard A ^a   Le Beau, Michelle M ^a   Mulloy, James C ^d   Liu, Paul P ^c   Rowley, Janet D ^a   Chen, Jianjun ^a   more..

^a UNIVERSITY OF CHICAGO   (United States)

^b GUANGDONG SECOND PROVINCIAL GENERAL HOSPITAL   (China)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CPEB4 PROTEIN; ENDOD1 PROTEIN; JANUS KINASE 1; KRUPPEL LIKE FACTOR 6; MICRORNA 9; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN; RAB8B PROTEIN; RHAG PROTEIN; RHOH PROTEIN; RYBP PROTEIN; SERPINB9 PROTEIN; TFRC PROTEIN; TRANSCRIPTION FACTOR HOXA9; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; VAMP5 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

APOPTOSIS; CELL SURVIVAL; DNA-BINDING PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICRORNAS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROTO-ONCOGENES; TRANSCRIPTION FACTORS;

EID: 84879932160     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310144110     Document Type: Article

References (42)

1. He L, Hannon GJ (2004) MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet 5(7):522-531. (Pubitemid 38868508)
2. Chen J, Odenike O, Rowley JD (2010) Leukaemogenesis: More than mutant genes. Nat Rev Cancer 10(1):23-36.
3. Guo H, Ingolia NT, Weissman JS, Bartel DP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466(7308):835-840.
4. Xiao C, Rajewsky K (2009) MicroRNA control in the immune system: Basic principles. Cell 136(1):26-36.
5. Löwenberg B, Downing JR, Burnett A (1999) Acute myeloid leukemia. N Engl J Med 341(14):1051-1062. (Pubitemid 29451802)
6. Krivtsov AV, Armstrong SA (2007) MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 7(11):823-833. (Pubitemid 350006257)
7. Muntean AG, Hess JL (2012) The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 7:283-301.
8. Li Z, et al. (2008) Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 105(40):15535-15540.
9. Popovic R, et al. (2009) Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood 113(14):3314-3322.
10. Li Z, et al. (2012) miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun 3:688.
11. Li Z, et al. (2009) Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. Cancer Res 69(3):1109-1116.
12. Wong P, et al. (2010) The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res 70(9):3833-3842.
13. Mi S, et al. (2010) Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci USA 107(8):3710-3715.
14. Jiang X, et al. (2012) MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci USA 109(47):19397-19402.
15. Wei J, et al. (2008) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell 13(6):483-495. (Pubitemid 351763903)
16. Zeisig BB, et al. (2004) Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol Cell Biol 24(2):617-628. (Pubitemid 38057914)
17. Wong P, Iwasaki M, Somervaille TC, So CW, Cleary ML (2007) Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev 21(21):2762-2774. (Pubitemid 350070722)
18. Faber J, et al. (2009) HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood 113(11):2375-2385.
19. Milne TA, et al. (2005) MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci USA 102(41):14765-14770. (Pubitemid 41457130)
20. Bernt KM, et al. (2011) MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 20(1):66-78.
21. Jiang X, et al. (2012) Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell 22(4):524-535.
22. Ma L, et al. (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12(3):247-256.
23. Mueller D, et al. (2009) Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol 7(11):e1000249.
24. Tsuchiya S, et al. (1982) Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res 42(4):1530-1536. (Pubitemid 12148801)
25. Senyuk V, et al. (2013) Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc Natl Acad Sci USA 110(14):5594-5599.
26. Arai S, et al. (2011) Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells. Blood 117(23):6304-6314.
27. Gröschel S, et al. (2013) Deregulated expression of EVI1 defines a poor prognostic subset of MLL-rearranged acute myeloid leukemias: A study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON/SAKK Cooperative Group. J Clin Oncol 31(1):95-103.
28. Li Z, et al. (2013) PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood 121(8):1422-1431.
29. Hsiao CH, et al. (2002) High incidence of CD56 expression and relapse rate in acute myeloid leukemia patients with t(8;21) in Taiwan. J Formos Med Assoc 101(6):393-398.
30. Gharib TG, et al. (2002) Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma. Neoplasia 4(5):440-448. (Pubitemid 34976960)
31. Schwartz DR, et al. (2002) Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res 62(16):4722-4729.
32. Chen D, et al. (2009) RYBP stabilizes p53 by modulating MDM2. EMBO Rep 10(2):166-172.
33. Dallery E, et al. (1995) TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 10 (11):2171-2178.
34. Sanchez-Aguilera A, et al. (2010) Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia 24(1):97-104.
35. Iwasaki T, et al. (2008) Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Eur J Haematol 81(6):454-460.
36. Begley CG, Green AR (1999) The SCL gene: From case report to critical hematopoietic regulator. Blood 93(9):2760-2770. (Pubitemid 29200765)
37. Larson RA, Le Beau MM (2005) Therapy-related myeloid leukaemia: A model for leukemogenesis in humans. Chem Biol Interact 153-154:187-195. (Pubitemid 40797810)
38. Whitman SP, et al. (2010) FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. Blood 116(18):3622-3626.
39. Klinakis A, et al. (2011) A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473(7346):230-233.
40. Yao CJ, Works K, Romagnoli PA, Austin GE (2005) Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells. Leukemia 19(11):1958-1968. (Pubitemid 41554005)
41. Humbert M, et al. (2011) Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Leuk Res 35(7):909-913.
42. Stirewalt DL, et al. (2008) Identification of genes with abnormal expression changes in acute myeloid leukemia. Genes Chromosomes Cancer 47(1):8-20. (Pubitemid 350191459)