Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

Nature Chemical Biology

Volumn 8, Issue 3, 2012, Pages 277-284

  Grembecka, Jolanta ^a   He, Shihan ^a   Shi, Aibin ^a   Purohit, Trupta ^a   Muntean, Andrew G ^a   Sorenson, Roderick J ^b   Showalter, Hollis D ^b   Murai, Marcelo J ^a   Belcher, Amalia M ^c   Hartley, Thomas ^a   Hess, Jay L ^a   Cierpicki, Tomasz ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HYBRID PROTEIN; MENIN MIXED LINEAGE LEUKEMIA INHIBITOR; METHIONINE; MIXED LINEAGE LEUKEMIA PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

EID: 84857195696     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.773     Document Type: Article

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