-
1
-
-
8644278033
-
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein
-
Ayton, P.M., E.H. Chen, and M.L. Cleary. 2004. Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol. Cell. Biol. 24:10470-10478. http://dx.doi.org/10.1128/MCB.24.23.10470-10478.2004.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10470-10478
-
-
Ayton, P.M.1
Chen, E.H.2
Cleary, M.L.3
-
2
-
-
33751267902
-
Acute myeloid leukaemia
-
Estey, E., and H. Döhner. 2006. Acute myeloid leukaemia. Lancet. 368:1894-1907. http://dx.doi.org/10.1016/S0140-6736(06)69780-8.
-
(2006)
Lancet.
, vol.368
, pp. 1894-1907
-
-
Estey, E.1
Döhner, H.2
-
3
-
-
78650444882
-
Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
-
Gentles, A.J., S.K. Plevritis, R. Majeti, and A.A. Alizadeh. 2010. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA. 304:2706-2715. http://dx.doi.org/10 .1001/jama.2010.1862.
-
(2010)
JAMA.
, vol.304
, pp. 2706-2715
-
-
Gentles, A.J.1
Plevritis, S.K.2
Majeti, R.3
Alizadeh, A.A.4
-
4
-
-
77955134007
-
Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group
-
Haferlach, T., A. Kohlmann, L. Wieczorek, G. Basso, G.T. Kronnie, M.C. Béné, J. De Vos, J.M. Hernández, W.K. Hofmann, K.I. Mills, et al. 2010. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J. Clin. Oncol. 28:2529-2537. http://dx.doi.org/10.1200/JCO.2009.23.4732.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2529-2537
-
-
Haferlach, T.1
Kohlmann, A.2
Wieczorek, L.3
Basso, G.4
Kronnie, G.T.5
Béné, M.C.6
De Vos, J.7
Hernández, J.M.8
Hofmann, W.K.9
Mills, K.I.10
-
5
-
-
84862015400
-
Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency
-
Hasemann, M.S., M.B. Schuster, A.K. Frank, K. Theilgaard-Mönch, T.A. Pedersen, C. Nerlov, and B.T. Porse. 2012. Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency. PLoS ONE. 7:e38841. http://dx.doi.org/10.1371/journal.pone.0038841.
-
(2012)
PLoS ONE.
, vol.7
-
-
Hasemann, M.S.1
Schuster, M.B.2
Frank, A.K.3
Theilgaard-Mönch, K.4
Pedersen, T.A.5
Nerlov, C.6
Porse, B.T.7
-
6
-
-
73449134439
-
Gene set enrichment analysis made simple
-
Irizarry, R.A., C. Wang, Y. Zhou, and T.P. Speed. 2009. Gene set enrichment analysis made simple. Stat. Methods Med. Res. 18:565-575. http://dx.doi.org/10.1177/0962280209351908.
-
(2009)
Stat. Methods Med. Res.
, vol.18
, pp. 565-575
-
-
Irizarry, R.A.1
Wang, C.2
Zhou, Y.3
Speed, T.P.4
-
7
-
-
35548934558
-
MLL translocations, histone modifications and leukaemia stem-cell development
-
Krivtsov, A.V., and S.A. Armstrong. 2007. MLL translocations, histone modifications and leukaemia stem-cell development. Nat. Rev. Cancer. 7:823-833. http://dx.doi.org/10.1038/nrc2253.
-
(2007)
Nat. Rev. Cancer.
, vol.7
, pp. 823-833
-
-
Krivtsov, A.V.1
Armstrong, S.A.2
-
8
-
-
0032126633
-
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
-
Kroon, E., J. Krosl, U. Thorsteinsdottir, S. Baban, A.M. Buchberg, and G. Sauvageau. 1998. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 17:3714-3725. http://dx.doi.org/10.1093/emboj/17.13.3714.
-
(1998)
EMBO J.
, vol.17
, pp. 3714-3725
-
-
Kroon, E.1
Krosl, J.2
Thorsteinsdottir, U.3
Baban, S.4
Buchberg, A.M.5
Sauvageau, G.6
-
9
-
-
0029155706
-
Inducible gene targeting in mice
-
Kühn, R., F. Schwenk, M. Aguet, and K. Rajewsky. 1995. Inducible gene targeting in mice. Science. 269:1427-1429. http://dx.doi.org/10.1126/science.7660125.
-
(1995)
Science.
, vol.269
, pp. 1427-1429
-
-
Kühn, R.1
Schwenk, F.2
Aguet, M.3
Rajewsky, K.4
-
10
-
-
62349130698
-
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
-
Langmead, B., C. Trapnell, M. Pop, and S.L. Salzberg. 2009. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10:R25. http://dx.doi.org/10.1186/gb-2009-10-3-r25.
-
(2009)
Genome Biol.
, vol.10
-
-
Langmead, B.1
Trapnell, C.2
Pop, M.3
Salzberg, S.L.4
-
11
-
-
0030765649
-
Disruption of the c/ebp alpha gene in adult mouse liver
-
Lee, Y.H., B. Sauer, P.F. Johnson, and F.J. Gonzalez. 1997. Disruption of the c/ebp alpha gene in adult mouse liver. Mol. Cell. Biol. 17:6014-6022.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6014-6022
-
-
Lee, Y.H.1
Sauer, B.2
Johnson, P.F.3
Gonzalez, F.J.4
-
12
-
-
84856916060
-
The pathogenesis of mixed-lineage leukemia
-
Muntean, A.G., and J.L. Hess. 2012. The pathogenesis of mixed-lineage leukemia. Annu. Rev. Pathol. 7:283-301. http://dx.doi.org/10.1146/annurev-pathol-011811-132434.
-
(2012)
Annu. Rev. Pathol.
, vol.7
, pp. 283-301
-
-
Muntean, A.G.1
Hess, J.L.2
-
13
-
-
2342544921
-
C/EBPalpha mutations in acute myeloid leukaemias
-
Nerlov, C. 2004. C/EBPalpha mutations in acute myeloid leukaemias. Nat. Rev. Cancer. 4:394-400. http://dx.doi.org/10.1038/nrc1363.
-
(2004)
Nat. Rev. Cancer.
, vol.4
, pp. 394-400
-
-
Nerlov, C.1
-
14
-
-
79959960773
-
The diverse functions of Dot1 and H3K79 methylation
-
Nguyen, A.T., and Y. Zhang. 2011. The diverse functions of Dot1 and H3K79 methylation. Genes Dev. 25:1345-1358. http://dx.doi.org/10.1101/gad .2057811.
-
(2011)
Genes Dev.
, vol.25
, pp. 1345-1358
-
-
Nguyen, A.T.1
Zhang, Y.2
-
15
-
-
85027927682
-
Molecular mechanisms underlying deregulation of C/EBPalpha in acute myeloid leukemia
-
Reckzeh, K., and J. Cammenga. 2010. Molecular mechanisms underlying deregulation of C/EBPalpha in acute myeloid leukemia. Int. J. Hematol. 91:557-568. http://dx.doi.org/10.1007/s12185-010-0573-1.
-
(2010)
Int. J. Hematol.
, vol.91
, pp. 557-568
-
-
Reckzeh, K.1
Cammenga, J.2
-
16
-
-
67650770689
-
The molecular biology of mixed lineage leukemia
-
Slany, R.K. 2009. The molecular biology of mixed lineage leukemia. Haematologica. 94:984-993. http://dx.doi.org/10.3324/haematol.2008.002436.
-
(2009)
Haematologica.
, vol.94
, pp. 984-993
-
-
Slany, R.K.1
-
17
-
-
4544341015
-
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
-
Smyth, G.K. 2004. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3:3.
-
(2004)
Stat. Appl. Genet. Mol. Biol.
, vol.3
, pp. 3
-
-
Smyth, G.K.1
-
18
-
-
33749440584
-
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
-
Somervaille, T.C., and M.L. Cleary. 2006. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 10:257-268. http://dx.doi.org/10.1016/j.ccr.2006 .08.020.
-
(2006)
Cancer Cell.
, vol.10
, pp. 257-268
-
-
Somervaille, T.C.1
Cleary, M.L.2
-
19
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A., P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, and J.P. Mesirov. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA. 102:15545-15550. http://dx.doi.org/10.1073/pnas.0506580102.
-
(2005)
Proc. Natl. Acad. Sci. USA.
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
20
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura, A., D.G. Kirsch, M.E. McLaughlin, D.A. Tuveson, J. Grimm, L. Lintault, J. Newman, E.E. Reczek, R. Weissleder, and T. Jacks. 2007. Restoration of p53 function leads to tumour regression in vivo. Nature. 445:661-665. http://dx.doi.org/10.1038/nature05541.
-
(2007)
Nature.
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
21
-
-
33646589342
-
Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy
-
Wagner, K., P. Zhang, F. Rosenbauer, B. Drescher, S. Kobayashi, H.S. Radomska, J.L. Kutok, D.G. Gilliland, J. Krauter, and D.G. Tenen. 2006. Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy. Proc. Natl. Acad. Sci. USA. 103:6338-6343. http://dx.doi.org/10.1073/pnas.0508143103.
-
(2006)
Proc. Natl. Acad. Sci. USA.
, vol.103
, pp. 6338-6343
-
-
Wagner, K.1
Zhang, P.2
Rosenbauer, F.3
Drescher, B.4
Kobayashi, S.5
Radomska, H.S.6
Kutok, J.L.7
Gilliland, D.G.8
Krauter, J.9
Tenen, D.G.10
-
22
-
-
79959514392
-
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
-
Wang, Q.F., G. Wu, S. Mi, F. He, J. Wu, J. Dong, R.T. Luo, R. Mattison, J.J. Kaberlein, S. Prabhakar, H. Ji, and M.J. Thirman. 2011. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood. 117:6895-6905.
-
(2011)
Blood.
, vol.117
, pp. 6895-6905
-
-
Wang, Q.F.1
Wu, G.2
Mi, S.3
He, F.4
Wu, J.5
Dong, J.6
Luo, R.T.7
Mattison, R.8
Kaberlein, J.J.9
Prabhakar, S.10
Ji, H.11
Thirman, M.J.12
-
23
-
-
44149104364
-
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements
-
Weischenfeldt, J., I. Damgaard, D. Bryder, K. Theilgaard-Mönch, L.A. Thoren, F.C. Nielsen, S.E. Jacobsen, C. Nerlov, and B.T. Porse. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev. 22:1381-1396. http://dx.doi.org/10.1101/gad.468808.
-
(2008)
Genes Dev.
, vol.22
, pp. 1381-1396
-
-
Weischenfeldt, J.1
Damgaard, I.2
Bryder, D.3
Theilgaard-Mönch, K.4
Thoren, L.A.5
Nielsen, F.C.6
Jacobsen, S.E.7
Nerlov, C.8
Porse, B.T.9
-
24
-
-
78751483481
-
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity
-
Wilhelm, B.T., M. Briau, P. Austin, A. Faubert, G. Boucher, P. Chagnon, K. Hope, S. Girard, N. Mayotte, J.R. Landry, et al. 2011. RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity. Blood. 117:e27-e38. http://dx.doi.org/10.1182/blood-2010-07-293332.
-
(2011)
Blood.
, vol.117
-
-
Wilhelm, B.T.1
Briau, M.2
Austin, P.3
Faubert, A.4
Boucher, G.5
Chagnon, P.6
Hope, K.7
Girard, S.8
Mayotte, N.9
Landry, J.R.10
-
25
-
-
63849241865
-
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
-
Wouters, B.J., B. Löwenberg, C.A. Erpelinck-Verschueren, W.L. van Putten, P.J. Valk, and R. Delwel. 2009. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. 113:3088-3091. http://dx.doi.org/10.1182/blood-2008-09-179895.
-
(2009)
Blood.
, vol.113
, pp. 3088-3091
-
-
Wouters, B.J.1
Löwenberg, B.2
Erpelinck-Verschueren, C.A.3
van Putten, W.L.4
Valk, P.J.5
Delwel, R.6
-
26
-
-
9144236224
-
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
-
Zeisig, B.B., T. Milne, M.P. García-Cuéllar, S. Schreiner, M.E. Martin, U. Fuchs, A. Borkhardt, S.K. Chanda, J. Walker, R. Soden, et al. 2003. Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol. Cell. Biol. 24:617-628. http://dx.doi.org/10.1128/MCB.24.2.617-628.2004.
-
(2003)
Mol. Cell. Biol.
, vol.24
, pp. 617-628
-
-
Zeisig, B.B.1
Milne, T.2
García-Cuéllar, M.P.3
Schreiner, S.4
Martin, M.E.5
Fuchs, U.6
Borkhardt, A.7
Chanda, S.K.8
Walker, J.9
Soden, R.10
-
27
-
-
10344230611
-
Enhancement of hematopoietic stem cell repopulating capacity and selfrenewal in the absence of the transcription factor C/EBP alpha
-
Zhang, P., J. Iwasaki-Arai, H. Iwasaki, M.L. Fenyus, T. Dayaram, B.M. Owens, H. Shigematsu, E. Levantini, C.S. Huettner, J.A. Lekstrom-Himes, et al. 2004. Enhancement of hematopoietic stem cell repopulating capacity and selfrenewal in the absence of the transcription factor C/EBP alpha. Immunity. 21:853-863. http://dx.doi.org/10.1016/j.immuni.2004.11.006.
-
(2004)
Immunity.
, vol.21
, pp. 853-863
-
-
Zhang, P.1
Iwasaki-Arai, J.2
Iwasaki, H.3
Fenyus, M.L.4
Dayaram, T.5
Owens, B.M.6
Shigematsu, H.7
Levantini, E.8
Huettner, C.S.9
Lekstrom-Himes, J.A.10
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