Functional studies of the MEN1 gene

Journal of Internal Medicine

Volumn 253, Issue 6, 2003, Pages 606-615

  Chandrasekharappa, Settara C ^a   Teh, B T ^b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b VAN ANDEL RESEARCH INSTITUTE   (United States)

Author keywords

Jun D; Menin; Multiple endocrine neoplasia type 1 (MEN1); Nuclear localization; Protein interaction; Tumour suppressor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MENIN PROTEIN; PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR JUND; UNCLASSIFIED DRUG;

CARCINOGENESIS; CONFERENCE PAPER; GENETIC ANALYSIS; HUMAN; KNOCKOUT MOUSE; MEN1 GENE; MULTIPLE ENDOCRINE NEOPLASIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CELL NUCLEUS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; GENES, TUMOR SUPPRESSOR; HUMANS; LYMPHOCYTES; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; NEOPLASM PROTEINS; NF-KAPPA B; PROTEIN INTERACTION MAPPING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; SEQUENCE ALIGNMENT; SMAD3 PROTEIN; TRANS-ACTIVATORS;

EID: 0038695861     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2003.01165.x     Document Type: Conference Paper

References (40)

1. Brandi M, Marx S, Aurbach G. Fitzpatrick L. Familial multiple endocrine neoplasia type 1: a new look at pathophysiology. Endocr Rev 1987: 8: 391-405.
2. Larsson C. Skogsied B. Oberg K, Naramura Y. Nordenskjold M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature 1988; 332: 85-7.
3. Chandrasekharappa S, Guru S, Manickam P et al. Positional cloning of the gene for multiple endocrine neoplasia type 1. Science 1997: 276: 404-7.
4. The European Consortium on MEN1. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Hum Mol Genet 1997; 6: 1177-83.
5. Cavaco BM, Domingues R, Bacelar MC et al. Mutational analysis of Portuguese families with multiple endocrine neoplasia type 1 reveals large germline deletions. Clin Endocrinol 2002; 56: 465-73.
6. Villablanca A. Hoog A. Larsson C. Teh BT. Molecular genetics of familial hyperparathyroidism. J Endocrinol Genet 2001; 2: 3-12.
7. Simonds WF, James-Newton LA, Agarwal SK et al. Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36 kindreds. Medicine 2002; 81: 1-26
8. Chandrasekharappa S. Teh BT. Clinical and molecular aspects of multiple endocrine neoplasia Type 1 - for the book "Genetic Disorders of Endocrine Neoplasia". Front Horm Res 2001; 28: 50-80
9. Teh BT. Multiple Endocrine Neoplasta Type 1. Molecular Genetics of Cancer. 2nd edn. BIOS Scientific Publishers, 2001; 149-69.
10. Kim Y, Burns A, Goldsmith P et al. Stable overexpression of MEN 1 suppresses tumorigenicity of RAS. Oncogene 1999; 18: 5936-42.
11. Guru SC, Prasad NB, Shin EJ et al. Characterization of a MEN1 ortholog from Drosophila melanogaster. Gene 2001; 263: 31-8.
12. van Kesteren RE, Syed NI, Munno DW et al. Synapse formation between central neurons requires postsynaptic expression of the MEN1 tumor suppressor gene. J Neurosci 2001; 21: RC161: 1-5.
13. Manickam P. Vogel A. Agarwal S et al. Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1. Mamm Genome 2000: 11: 448-54.
14. Guru S, Crabtree J, Brown K et al. Isolation, genomic organization and expression analysis of Men1, the murine homolog of the MEN1 gene. Mamm Genome 1999: 10: 592-6.
15. Stewart C. Parente F. Piehl F et al. Characterization of the mouse Men1 gene and its expression during development. Oncogene 1998; 17: 2485-93.
16. Karges W, Maier S. Wissmann A, Dralle H, Dosch HM, Boehm BO. Primary structure, gene expression and chromosomal mapping of rodent homologues of the MEN1 tumor suppressor gene. Biochim Biophys Acta 1999; 1446: 286-94.
17. Maruyama K, Tsukada T, Hosono T et al. Structure and distribution of rat menin mRNA. Mol Cell Endocrinol 1999; 156: 25-33.
18. Bassett JH. Rashbass P. Harding B. Forbes SA. Pannett AA. Thakker RV. Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1. J Bone Miner Res 1999; 14: 3-10
19. Ikeo Y. Sakurai A. Suzuki R et al. Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage. Lab Invest 2000; 80: 797-804.
20. Iyer V, Eisen M, Ross D et al. The transcriptional program in the response of human fibroblasts to serum. Science 1999: 283: 83-8.
21. Wautot V, Khodaei S. Frappart L et al. Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues. Int J Cancer 2000: 85: 877-81.
22. Kaji H, Canaff L. Goltzman D, Hendy G. Cell cycle regulation of menin expression. Cancer Res 1999; 59: 5097-101.
23. Guru S. Goldsmith P. Burns A et al. Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci USA 1998; 95: 1630-34.
24. Ikeo Y, Sakurai A, Hashizume K. Characterization of the MEN1 gene produce, menin, by site-specific polyclonal antibodies. Jpn J Cancer Res 1999: 90: 1088-95.
25. Chellapan S. Hiebert S. Mudrvi M. Horowitz J. Nevins J. The E2F transcription factor is a cellular target for the RB protein. Cell 1991; 65: 1053-61.
26. Momand J, Zambetti G. Olson D, George D. Levine A. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992: 69: 1237-45.
27. Scully R, Chen J, Plug A. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 1997; 88: 265-75.
28. Agarwal S, Guru S, Heppner C et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 1999; 96: 143-52.
29. Gobl AE, Berg M, Lopez-Egido JR, Oberg K, Skogseid B, Westin G. Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. Biochim Biophys Acta 1999; 1447: 51-6.
30. Ohkura N, Kishi M, Tsukada T, Yamaguchi K. Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23. Biochem Biophys Res Commun 2001: 282: 1206-10.
31. Lemmens IH. Forsberg L, Pannett AA et al. Menin interacts directly with the homeobox-containing protein Pem. Biochem Biophys Res Commun 2001: 286; 426-31.
32. Sukhodolets KE, Hickman AB, Agarwal SK et al. The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol 2003; 23: 493-509.
33. Lopez-Egido J, Cunningham J. Berg M, Oberg K. Bongcam-Rudloff E. Gobl A. Menin's interaction with glial fibrillary acidic protein and vimentin suggest a role for the intermediate filament network in regulating menin activity. Exp Cell Res 2002: 278: 175-83
34. Heppner C. Bilimoria KY, Agarwal SK et al. The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 2001; 20: 4917-25.
35. Kaji H, Canaff L, Lebrun JJ. Goltzman D, Hendy GN. Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc Natl Acad Sci USA 2001; 98: 3837-42.
36. Knapp JI, Heppner C, Hickman AB et al. Identification and characterization of JunD missense mutants that lack menin binding. Oncogene 2000; 19: 4706-12.
37. Yazgan O, Pfarr CM. Differential binding of the Menin tumor suppressor protein to JunD isoforms. Cancer Res 2001; 61; 912-20.
38. Wayne CM, MacLean II JA. Cornwall G, Wilkinson MF. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Gene 2002; 301: 1-11.
39. Yaguchi H, Ohkura N, Tsukada T, Yamaguchi K. Menin, the multiple endocrine neoplasia type 1 gene product, exhibits CTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23. J Biol Chem 2002; 277: 38197-9204.
40. Crabtree JS, Scacheri PC, Ward JM et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci USA 2001; 98: 1118-23.