Modeling the initiation and progression of human acute leukemia in mice

Science

Volumn 316, Issue 5824, 2007, Pages 600-604

  Barabé, Frédéric ^a,b,c,d   Kennedy, James A ^a,e   Hope, Kristin J ^a,e   Dick, John E ^a,e  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c LAVAL UNIVERSITY   (Canada)

^d LAVAL UNIVERSITY   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANTIBODY; CANCER; DISEASE SEVERITY; GENE EXPRESSION; GENETICALLY MODIFIED ORGANISM; IMMUNE RESPONSE; IMMUNOASSAY; PROTEIN; RODENT;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER MODEL; CELL LINEAGE; CELL TYPE; GENE FUSION; GERM LINE; HEMATOPOIETIC CELL; IMMUNOGLOBULIN GENE; IN VIVO STUDY; LEUKEMIA CELL; MICROENVIRONMENT; MLL GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LEUKEMIA, LYMPHOCYTIC; LEUKEMIA, MYELOID; MICE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

MUS;

EID: 34247595838     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1139851     Document Type: Article

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28. We thank M. Doedens for technical assistance; the University Health Network Pathology Research Program for tissue sectioning and immunohistochemistry; P. Marrano for karyotyping; members of the Dick lab, J. Hitzler, and M. Minden for critical comments on the manuscript; and M. Greaves for inspiring this study. This work was supported by a Canadian Institute of Health Research (CIHR) clinician-scientist award (to F.B.), an MD/PhD studentship (to J.A.K.), and grants from the CIHR, the Ontario Cancer Research Network, Genome Canada through the Ontario Genomics Institute, a Canada Research Chair, the Leukemia and Lymphoma Society, and the National Cancer Institute of Canada, with funds from the Canadian Cancer Society and the Terry Fox Foundation (to J.E.D.).