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Volumn 13, Issue 6, 2008, Pages 483-495

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

Author keywords

CELLCYCLE; STEMCELL

Indexed keywords

MIXED LINEAGE LEUKEMIA PROTEIN; RAC PROTEIN;

EID: 44449151168     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2008.04.020     Document Type: Article
Times cited : (274)

References (44)
  • 5
    • 34247595838 scopus 로고    scopus 로고
    • Modeling the initiation and progression of human acute leukemia in mice
    • Barabe F., Kennedy J.A., Hope K.J., and Dick J.E. Modeling the initiation and progression of human acute leukemia in mice. Science 316 (2007) 600-604
    • (2007) Science , vol.316 , pp. 600-604
    • Barabe, F.1    Kennedy, J.A.2    Hope, K.J.3    Dick, J.E.4
  • 7
    • 23844542698 scopus 로고    scopus 로고
    • Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
    • Cancelas J.A., Lee A.W., Prabhakar R., Stringer K.F., Zheng Y., and Williams D.A. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat. Med. 11 (2005) 886-891
    • (2005) Nat. Med. , vol.11 , pp. 886-891
    • Cancelas, J.A.1    Lee, A.W.2    Prabhakar, R.3    Stringer, K.F.4    Zheng, Y.5    Williams, D.A.6
  • 8
    • 33745941911 scopus 로고    scopus 로고
    • A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
    • Chen W., Li Q., Hudson W.A., Kumar A., Kirchhof N., and Kersey J.H. A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood 108 (2006) 669-677
    • (2006) Blood , vol.108 , pp. 669-677
    • Chen, W.1    Li, Q.2    Hudson, W.A.3    Kumar, A.4    Kirchhof, N.5    Kersey, J.H.6
  • 9
    • 15844394270 scopus 로고    scopus 로고
    • An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J., Lavenir I., Impey H., Warren A.J., Forster A., Larson T.A., Bell S., McKenzie A.N., King G., and Rabbitts T.H. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes. Cell 85 (1996) 853-861
    • (1996) Cell , vol.85 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3    Warren, A.J.4    Forster, A.5    Larson, T.A.6    Bell, S.7    McKenzie, A.N.8    King, G.9    Rabbitts, T.H.10
  • 10
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A., Passegue E., Ayton P.M., Karsunky H., Cleary M.L., and Weissman I.L. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 17 (2003) 3029-3035
    • (2003) Genes Dev. , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 11
    • 0026561448 scopus 로고
    • Bipotential precursors of B cells and macrophages in murine fetal liver
    • Cumano A., Paige C.J., Iscove N.N., and Brady G. Bipotential precursors of B cells and macrophages in murine fetal liver. Nature 356 (1992) 612-615
    • (1992) Nature , vol.356 , pp. 612-615
    • Cumano, A.1    Paige, C.J.2    Iscove, N.N.3    Brady, G.4
  • 12
    • 21344472782 scopus 로고    scopus 로고
    • The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia
    • De Braekeleer M., Morel F., Le Bris M.J., Herry A., and Douet-Guilbert N. The MLL gene and translocations involving chromosomal band 11q23 in acute leukemia. Anticancer Res. 25 (2005) 1931-1944
    • (2005) Anticancer Res. , vol.25 , pp. 1931-1944
    • De Braekeleer, M.1    Morel, F.2    Le Bris, M.J.3    Herry, A.4    Douet-Guilbert, N.5
  • 13
    • 0032831130 scopus 로고    scopus 로고
    • Mll rearrangements in haematological malignancies: Lessons from clinical and biological studies
    • Dimartino J.F., and Cleary M.L. Mll rearrangements in haematological malignancies: Lessons from clinical and biological studies. Br. J. Haematol. 106 (1999) 614-626
    • (1999) Br. J. Haematol. , vol.106 , pp. 614-626
    • Dimartino, J.F.1    Cleary, M.L.2
  • 14
    • 0037093081 scopus 로고    scopus 로고
    • The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10
    • DiMartino J.F., Ayton P.M., Chen E.H., Naftzger C.C., Young B.D., and Cleary M.L. The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 99 (2002) 3780-3785
    • (2002) Blood , vol.99 , pp. 3780-3785
    • DiMartino, J.F.1    Ayton, P.M.2    Chen, E.H.3    Naftzger, C.C.4    Young, B.D.5    Cleary, M.L.6
  • 15
    • 33644503560 scopus 로고    scopus 로고
    • Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein
    • DiMartino J.F., Lacayo N.J., Varadi M., Li L., Saraiya C., Ravindranath Y., Yu R., Sikic B.I., Raimondi S.C., and Dahl G.V. Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein. Leukemia 20 (2006) 426-432
    • (2006) Leukemia , vol.20 , pp. 426-432
    • DiMartino, J.F.1    Lacayo, N.J.2    Varadi, M.3    Li, L.4    Saraiya, C.5    Ravindranath, Y.6    Yu, R.7    Sikic, B.I.8    Raimondi, S.C.9    Dahl, G.V.10
  • 16
    • 0037397929 scopus 로고    scopus 로고
    • Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors
    • Feuring-Buske M., Gerhard B., Cashman J., Humphries R.K., Eaves C.J., and Hogge D.E. Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 17 (2003) 760-763
    • (2003) Leukemia , vol.17 , pp. 760-763
    • Feuring-Buske, M.1    Gerhard, B.2    Cashman, J.3    Humphries, R.K.4    Eaves, C.J.5    Hogge, D.E.6
  • 19
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y., Dickerson J.B., Guo F., Zheng J., and Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. USA 101 (2004) 7618-7623
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 21
    • 0141455931 scopus 로고    scopus 로고
    • GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages
    • Iwasaki H., Mizuno S., Wells R.A., Cantor A.B., Watanabe S., and Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity 19 (2003) 451-462
    • (2003) Immunity , vol.19 , pp. 451-462
    • Iwasaki, H.1    Mizuno, S.2    Wells, R.A.3    Cantor, A.B.4    Watanabe, S.5    Akashi, K.6
  • 24
    • 7244236503 scopus 로고    scopus 로고
    • Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes
    • Lacayo N.J., Meshinchi S., Kinnunen P., Yu R., Wang Y., Stuber C.M., Douglas L., Wahab R., Becton D.L., Weinstein H., et al. Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes. Blood 104 (2004) 2646-2654
    • (2004) Blood , vol.104 , pp. 2646-2654
    • Lacayo, N.J.1    Meshinchi, S.2    Kinnunen, P.3    Yu, R.4    Wang, Y.5    Stuber, C.M.6    Douglas, L.7    Wahab, R.8    Becton, D.L.9    Weinstein, H.10
  • 25
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • Lavau C., Szilvassy S.J., Slany R., and Cleary M.L. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J. 16 (1997) 4226-4237
    • (1997) EMBO J. , vol.16 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 26
    • 0035230221 scopus 로고    scopus 로고
    • Bipotential B-macrophage progenitors are present in adult bone marrow
    • Montecino-Rodriguez E., Leathers H., and Dorshkind K. Bipotential B-macrophage progenitors are present in adult bone marrow. Nat. Immunol. 2 (2001) 83-88
    • (2001) Nat. Immunol. , vol.2 , pp. 83-88
    • Montecino-Rodriguez, E.1    Leathers, H.2    Dorshkind, K.3
  • 27
    • 0345167904 scopus 로고    scopus 로고
    • Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    • Mulloy J.C., Cammenga J., Berguido F.J., Wu K., Zhou P., Comenzo R.L., Jhanwar S., Moore M.A., and Nimer S.D. Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood 102 (2003) 4369-4376
    • (2003) Blood , vol.102 , pp. 4369-4376
    • Mulloy, J.C.1    Cammenga, J.2    Berguido, F.J.3    Wu, K.4    Zhou, P.5    Comenzo, R.L.6    Jhanwar, S.7    Moore, M.A.8    Nimer, S.D.9
  • 30
    • 0141816710 scopus 로고    scopus 로고
    • AML with 11q23/MLL abnormalities as defined by the WHO classification: Incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
    • Schoch C., Schnittger S., Klaus M., Kern W., Hiddemann W., and Haferlach T. AML with 11q23/MLL abnormalities as defined by the WHO classification: Incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood 102 (2003) 2395-2402
    • (2003) Blood , vol.102 , pp. 2395-2402
    • Schoch, C.1    Schnittger, S.2    Klaus, M.3    Kern, W.4    Hiddemann, W.5    Haferlach, T.6
  • 31
    • 0031918022 scopus 로고    scopus 로고
    • General report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997
    • Secker-Walker L.M. General report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997. Leukemia 12 (1998) 776-778
    • (1998) Leukemia , vol.12 , pp. 776-778
    • Secker-Walker, L.M.1
  • 32
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • So C.W., Karsunky H., Passegue E., Cozzio A., Weissman I.L., and Cleary M.L. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3 (2003) 161-171
    • (2003) Cancer Cell , vol.3 , pp. 161-171
    • So, C.W.1    Karsunky, H.2    Passegue, E.3    Cozzio, A.4    Weissman, I.L.5    Cleary, M.L.6
  • 33
    • 0042885909 scopus 로고    scopus 로고
    • Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
    • So C.W., Lin M., Ayton P.M., Chen E.H., and Cleary M.L. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 4 (2003) 99-110
    • (2003) Cancer Cell , vol.4 , pp. 99-110
    • So, C.W.1    Lin, M.2    Ayton, P.M.3    Chen, E.H.4    Cleary, M.L.5
  • 34
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille T.C., and Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10 (2006) 257-268
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 36
    • 34447523378 scopus 로고    scopus 로고
    • FLT3 as a therapeutic target in childhood acute leukemia
    • Stubbs M.C., and Armstrong S.A. FLT3 as a therapeutic target in childhood acute leukemia. Curr. Drug Targets 8 (2007) 703-714
    • (2007) Curr. Drug Targets , vol.8 , pp. 703-714
    • Stubbs, M.C.1    Armstrong, S.A.2
  • 37
    • 38349177497 scopus 로고    scopus 로고
    • MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: Development of a model for rapid therapeutic assessment
    • Stubbs M.C., Kim Y.M., Krivtsov A.V., Wright R.D., Feng Z., Agarwal J., Kung A.L., and Armstrong S.A. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: Development of a model for rapid therapeutic assessment. Leukemia 22 (2008) 66-77
    • (2008) Leukemia , vol.22 , pp. 66-77
    • Stubbs, M.C.1    Kim, Y.M.2    Krivtsov, A.V.3    Wright, R.D.4    Feng, Z.5    Agarwal, J.6    Kung, A.L.7    Armstrong, S.A.8
  • 40
    • 27144477007 scopus 로고    scopus 로고
    • Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells
    • Warner J.K., Wang J.C., Takenaka K., Doulatov S., McKenzie J.L., Harrington L., and Dick J.E. Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells. Leukemia 19 (2005) 1794-1805
    • (2005) Leukemia , vol.19 , pp. 1794-1805
    • Warner, J.K.1    Wang, J.C.2    Takenaka, K.3    Doulatov, S.4    McKenzie, J.L.5    Harrington, L.6    Dick, J.E.7
  • 41
    • 33748176403 scopus 로고    scopus 로고
    • Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
    • Wunderlich M., Krejci O., Wei J., and Mulloy J.C. Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood 108 (2006) 1690-1697
    • (2006) Blood , vol.108 , pp. 1690-1697
    • Wunderlich, M.1    Krejci, O.2    Wei, J.3    Mulloy, J.C.4
  • 42
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into macrophages
    • Xie H., Ye M., Feng R., and Graf T. Stepwise reprogramming of B cells into macrophages. Cell 117 (2004) 663-676
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.1    Ye, M.2    Feng, R.3    Graf, T.4
  • 43
    • 0033678937 scopus 로고    scopus 로고
    • Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
    • Yang F.C., Kapur R., King A.J., Tao W., Kim C., Borneo J., Breese R., Marshall M., Dinauer M.C., and Williams D.A. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 12 (2000) 557-568
    • (2000) Immunity , vol.12 , pp. 557-568
    • Yang, F.C.1    Kapur, R.2    King, A.J.3    Tao, W.4    Kim, C.5    Borneo, J.6    Breese, R.7    Marshall, M.8    Dinauer, M.C.9    Williams, D.A.10
  • 44
    • 0037456994 scopus 로고    scopus 로고
    • The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell
    • Zeisig B.B., Garcia-Cuellar M.P., Winkler T.H., and Slany R.K. The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell. Oncogene 22 (2003) 1629-1637
    • (2003) Oncogene , vol.22 , pp. 1629-1637
    • Zeisig, B.B.1    Garcia-Cuellar, M.P.2    Winkler, T.H.3    Slany, R.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.