MLL fusion protein–driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction

Blood

Volumn 122, Issue 11, 2013, Pages 1914-1922

  Muntean, Andrew G ^a   Chen, Wei ^a   Jones, Morgan ^a   Granowicz, Eric M ^a   Maillard, Ivan ^a   Hess, Jay L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MEIS1 PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; PEPTIDES AND PROTEINS; POLYMERASE ASSOCIATED FACTOR COMPLEX; PROTEIN BCL 2; PROTEIN CDC73; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; HRPT2 PROTEIN, MOUSE; MLL AF9 FUSION PROTEIN, MOUSE; MLL-AF9 FUSION PROTEIN, MOUSE; MYELOID ECOTROPIC VIRAL INTEGRATION SITE 1 PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PAF1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR HOXA9; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ACUTE MYELOID LEUKEMIA; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPIGENETICS; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; CELL STRAIN HEK293; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PROTEIN SUBUNIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM PROTEINS; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; PROTEIN BINDING; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84887346920     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-02-486977     Document Type: Article

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