The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

Nature

Volumn 482, Issue 7386, 2012, Pages 542-546

  Huang, Jing ^a   Gurung, Buddha ^b   Wan, Bingbing ^a   Matkar, Smita ^b   Veniaminova, Natalia A ^a   Wan, Ke ^a   Merchant, Juanita L ^a   Hua, Xianxin ^b   Lei, Ming ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; MENIN PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN 1; TRANSCRIPTION FACTOR JUND; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

BIOCHEMISTRY; CHEMICAL BINDING; CRYSTAL STRUCTURE; CYTOLOGY; ENDOCRINE SYSTEM; ENZYME ACTIVITY; GENE EXPRESSION; HERITABILITY; HOMINID; PROTEIN; TUMOR;

ARTICLE; GENETIC TRANSCRIPTION; LEUKEMOGENESIS; MISSENSE MUTATION; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; UPREGULATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; FIBROBLASTS; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 84862777931     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10806     Document Type: Article

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