-
2
-
-
0026086474
-
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
-
Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell 1991; 67: 687–699.
-
(1991)
Cell
, vol.67
, pp. 687-699
-
-
Rebay, I.1
Fleming, R.J.2
Fehon, R.G.3
Cherbas, L.4
Cherbas, P.5
Artavanis-Tsakonas, S.6
-
3
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas S Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770–776.
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
-
4
-
-
80051531363
-
Notch signaling: Simplicity in design, versatility in function
-
Andersson ER, Sandberg R, Lendahl U Notch signaling: simplicity in design, versatility in function. Development 2011; 138: 3593–3612.
-
(2011)
Development
, vol.138
, pp. 3593-3612
-
-
Andersson, E.R.1
Sandberg, R.2
Lendahl, U.3
-
6
-
-
84953283022
-
Mini-review: Does Notch promote or suppress cancer? New findings and old controversies
-
Grishina IB. Mini-review: Does Notch promote or suppress cancer? New findings and old controversies. Am J Clin Exp Urol 2015; 3: 24–27.
-
(2015)
Am J Clin Exp Urol
, vol.3
, pp. 24-27
-
-
Grishina, I.B.1
-
7
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883–899.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
8
-
-
0037180757
-
Inflammation and cancer
-
Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420: 860–867.
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
10
-
-
84868204453
-
Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells
-
Debeb BG, Cohen EN, Boley K, Freiter EM, Li L, Robertson FM et al. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat 2012; 134: 495–510.
-
(2012)
Breast Cancer Res Treat
, vol.134
, pp. 495-510
-
-
Debeb, B.G.1
Cohen, E.N.2
Boley, K.3
Freiter, E.M.4
Li, L.5
Robertson, F.M.6
-
11
-
-
84916899853
-
Notch signaling drives multiple myeloma induced osteoclastogenesis
-
Colombo M, Thümmler K, Mirandola L, Garavelli S, Todoerti K, Apicella L et al. Notch signaling drives multiple myeloma induced osteoclastogenesis. Oncotarget 2014; 5: 10393–10406.
-
(2014)
Oncotarget
, vol.5
, pp. 10393-10406
-
-
Colombo, M.1
Thümmler, K.2
Mirandola, L.3
Garavelli, S.4
Todoerti, K.5
Apicella, L.6
-
12
-
-
84920997369
-
Emerging roles of Notch signaling in liver disease
-
Geisler F, Strazzabosco M. Emerging roles of Notch signaling in liver disease. Hepatology 2015; 61: 382–392.
-
(2015)
Hepatology
, vol.61
, pp. 382-392
-
-
Geisler, F.1
Strazzabosco, M.2
-
13
-
-
73949094187
-
Role of Notch signaling in colorectal cancer
-
Qiao L, Wong BCY. Role of Notch signaling in colorectal cancer. Carcinogenesis 2009; 30: 1979–1986.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1979-1986
-
-
Qiao, L.1
Wong, B.C.Y.2
-
14
-
-
77955714153
-
Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice
-
Shinoda M, Shin-Ya M, Naito Y, Kishida T, Ito R, Suzuki N et al. Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice. J Gastroenterol 2010; 45: 608–617.
-
(2010)
J Gastroenterol
, vol.45
, pp. 608-617
-
-
Shinoda, M.1
Shin-Ya, M.2
Naito, Y.3
Kishida, T.4
Ito, R.5
Suzuki, N.6
-
15
-
-
58249123433
-
Requirement of Notch activation during regeneration of the intestinal epithelia
-
Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T et al. Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 2009; 296: G23–G35.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
, pp. G23-G35
-
-
Okamoto, R.1
Tsuchiya, K.2
Nemoto, Y.3
Akiyama, J.4
Nakamura, T.5
Kanai, T.6
-
16
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006; 7: 678–689.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
18
-
-
84922465297
-
Non-canonical notch signaling in cancer and immunity
-
Ayaz F, Osborne BA. Non-canonical notch signaling in cancer and immunity. Front Oncol 2014; 4: 345.
-
(2014)
Front Oncol
, vol.4
, pp. 345
-
-
Ayaz, F.1
Osborne, B.A.2
-
20
-
-
0037326023
-
IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: Cross-talk between Notch and NF-κB pathways
-
Espinosa L, Inglés-Esteve J, Robert-Moreno A, Bigas A. IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NF-κB pathways. Mol Biol Cell 2003; 14: 491–502.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 491-502
-
-
Espinosa, L.1
Inglés-Esteve, J.2
Robert-Moreno, A.3
Bigas, A.4
-
21
-
-
84883097117
-
NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype
-
Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N, Inoue J. NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. Nat Commun 2013; 4: 2299.
-
(2013)
Nat Commun
, vol.4
, pp. 2299
-
-
Yamamoto, M.1
Taguchi, Y.2
Ito-Kureha, T.3
Semba, K.4
Yamaguchi, N.5
Inoue, J.6
-
22
-
-
42149117769
-
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
-
Zheng X, Linke S, Dias JM, Gradin K, Wallis TP, Hamilton BR et al. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci 2008; 105: 3368–3373.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 3368-3373
-
-
Zheng, X.1
Linke, S.2
Dias, J.M.3
Gradin, K.4
Wallis, T.P.5
Hamilton, B.R.6
-
23
-
-
55849139852
-
Notch1 is an effector of Akt and hypoxia in melanoma development
-
Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB. Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest 2008; 118: 3660–3670.
-
(2008)
J Clin Invest
, vol.118
, pp. 3660-3670
-
-
Bedogni, B.1
Warneke, J.A.2
Nickoloff, B.J.3
Giaccia, A.J.4
Powell, M.B.5
-
24
-
-
84871821947
-
Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
-
Zou J, Li P, Lu F, Liu N, Dai J, Ye J et al. Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells. J Hematol Oncol 2013; 6: 3.
-
(2013)
J Hematol Oncol
, vol.6
, pp. 3
-
-
Zou, J.1
Li, P.2
Lu, F.3
Liu, N.4
Dai, J.5
Ye, J.6
-
25
-
-
33847637262
-
66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/ progenitor cells of the mammary gland expanded in vitro as mammospheres
-
Sansone P, Storci G, Giovannini C, Pandolfi S, Pianetti S, Taffurelli M et al. p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/ progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells 2007; 25: 807–815.
-
(2007)
Stem Cells
, vol.25
, pp. 807-815
-
-
Sansone, P.1
Storci, G.2
Giovannini, C.3
Pandolfi, S.4
Pianetti, S.5
Taffurelli, M.6
-
26
-
-
44049090235
-
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
-
Sahlgren C, Gustafsson MV, Jin S, Poellinger L, Lendahl U. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 2008; 105: 6392–6397.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6392-6397
-
-
Sahlgren, C.1
Gustafsson, M.V.2
Jin, S.3
Poellinger, L.4
Lendahl, U.5
-
27
-
-
75549083984
-
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
-
Chen J, Imanaka N, Griffin JD. Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. BR J Cancer 2010; 102: 351–360.
-
(2010)
BR J Cancer
, vol.102
, pp. 351-360
-
-
Chen, J.1
Imanaka, N.2
Griffin, J.D.3
-
28
-
-
1842524153
-
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
-
Zavadil J, Cermak L, Soto-Nieves N, Böttinger EP. Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO 2004; 23: 1155–1165.
-
(2004)
EMBO
, vol.23
, pp. 1155-1165
-
-
Zavadil, J.1
Cermak, L.2
Soto-Nieves, N.3
Böttinger, E.P.4
-
29
-
-
84958581411
-
Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells
-
Fazio C, Piazzi G, Vitaglione P, Fogliano V, Munarini A, Prossomariti A et al. Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells. Sci Rep 2016; 6: 20670.
-
(2016)
Sci Rep
, vol.6
-
-
Fazio, C.1
Piazzi, G.2
Vitaglione, P.3
Fogliano, V.4
Munarini, A.5
Prossomariti, A.6
-
30
-
-
65549140672
-
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
-
Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fernández-Majada V, Grilli A et al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci USA 2009; 106: 6315–6320.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6315-6320
-
-
Rodilla, V.1
Villanueva, A.2
Obrador-Hevia, A.3
Robert-Moreno, A.4
Fernández-Majada, V.5
Grilli, A.6
-
31
-
-
33845609555
-
Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1
-
Liu Z-J, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ et al. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J 2006; 20: 1009–1011.
-
(2006)
FASEB J
, vol.20
, pp. 1009-1011
-
-
Liu, Z.-J.1
Xiao, M.2
Balint, K.3
Soma, A.4
Pinnix, C.C.5
Capobianco, A.J.6
-
32
-
-
59049088446
-
Activation of Notch signaling in human colon adenocarcinoma
-
Reedijk M, Odorcic S, Zhang H, Chetty R, Tennert C, Dickson BC et al. Activation of Notch signaling in human colon adenocarcinoma. Int J Oncol 2008; 33: 1223–1229.
-
(2008)
Int J Oncol
, vol.33
, pp. 1223-1229
-
-
Reedijk, M.1
Odorcic, S.2
Zhang, H.3
Chetty, R.4
Tennert, C.5
Dickson, B.C.6
-
33
-
-
50849104230
-
Notch tumor suppressor function
-
Dotto GP. Notch tumor suppressor function. Oncogene 2008; 27: 5115–5123.
-
(2008)
Oncogene
, vol.27
, pp. 5115-5123
-
-
Dotto, G.P.1
-
34
-
-
11244304299
-
Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (H-Int3sh)
-
Raafat A, Bargo S, Anver MR, Callahan R. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Oncogene 2004; 23: 9401–9407.
-
(2004)
Oncogene
, vol.23
, pp. 9401-9407
-
-
Raafat, A.1
Bargo, S.2
Anver, M.R.3
Callahan, R.4
-
35
-
-
0036734148
-
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
-
Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med. 2002; 8: 979–986.
-
(2002)
Nat Med
, vol.8
, pp. 979-986
-
-
Weijzen, S.1
Rizzo, P.2
Braid, M.3
Vaishnav, R.4
Jonkheer, S.M.5
Zlobin, A.6
-
36
-
-
33644670028
-
Notch and NOXA-related pathways in melanoma cells
-
Nickoloff BJ, Hendrix MJC, Pollock PM, Trent JM, Miele L, Qin J-Z. Notch and NOXA-related pathways in melanoma cells. J Investig Dermatol Symp Proc 2005; 10: 95–104.
-
(2005)
J Investig Dermatol Symp Proc
, vol.10
, pp. 95-104
-
-
Nickoloff, B.J.1
Hendrix, M.J.C.2
Pollock, P.M.3
Trent, J.M.4
Miele, L.5
Qin, J.-Z.6
-
37
-
-
27644490306
-
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression
-
Balint K, Xiao M, Pinnix CC, Soma A, Veres I, Juhasz I et al. Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest 2005; 115: 3166–3176.
-
(2005)
J Clin Invest
, vol.115
, pp. 3166-3176
-
-
Balint, K.1
Xiao, M.2
Pinnix, C.C.3
Soma, A.4
Veres, I.5
Juhasz, I.6
-
38
-
-
0035300448
-
Notch signaling induces cell cycle arrest in small cell lung cancer cells
-
Sriuranpong V, Borges MW, Ravi RK, Arnold DR, Nelkin BD, Baylin SB et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001; 61: 3200–3205.
-
(2001)
Cancer Res
, vol.61
, pp. 3200-3205
-
-
Sriuranpong, V.1
Borges, M.W.2
Ravi, R.K.3
Arnold, D.R.4
Nelkin, B.D.5
Baylin, S.B.6
-
39
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M et al. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 2003; 33: 416–421.
-
(2003)
Nat Genet
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
Kummer, J.A.4
Mill, P.5
van Noort, M.6
-
40
-
-
2942528798
-
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing
-
Thélu J, Rossio P, Favier B. Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. BMC Dermatol 2002; 2: 7.
-
(2002)
BMC Dermatol
, vol.2
, pp. 7
-
-
Thélu, J.1
Rossio, P.2
Favier, B.3
-
42
-
-
84897561550
-
IL-6 R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
-
Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D et al. IL-6 R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest 2014; 124: 1853–1867.
-
(2014)
J Clin Invest
, vol.124
, pp. 1853-1867
-
-
Rokavec, M.1
Oner, M.G.2
Li, H.3
Jackstadt, R.4
Jiang, L.5
Lodygin, D.6
-
43
-
-
84861440163
-
Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis
-
Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D et al. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer 2012; 106: 1833–1841.
-
(2012)
Br J Cancer
, vol.106
, pp. 1833-1841
-
-
Lee, Y.S.1
Choi, I.2
Ning, Y.3
Kim, N.Y.4
Khatchadourian, V.5
Yang, D.6
-
44
-
-
11144358653
-
Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
-
Jundt F, Pröbsting KS, Anagnostopoulos I, Muehlinghaus G, Chatterjee M, Mathas S et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood 2004; 103: 3511–3515.
-
(2004)
Blood
, vol.103
, pp. 3511-3515
-
-
Jundt, F.1
Pröbsting, K.S.2
Anagnostopoulos, I.3
Muehlinghaus, G.4
Chatterjee, M.5
Mathas, S.6
-
45
-
-
84984873609
-
Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche
-
(e-pub ahead of print
-
Colombo M, Galletti S, Bulfamante G, Falleni M, Tosi D, Todoerti K et al. Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche. Oncotarget 2016 (e-pub ahead of print).
-
(2016)
Oncotarget
-
-
Colombo, M.1
Galletti, S.2
Bulfamante, G.3
Falleni, M.4
Tosi, D.5
Todoerti, K.6
-
46
-
-
84055217307
-
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
-
Maniati E, Bossard M, Cook N, Candido JB, Emami-Shahri N, Nedospasov SA et al. Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest 2011; 121: 4685–4699.
-
(2011)
J Clin Invest
, vol.121
, pp. 4685-4699
-
-
Maniati, E.1
Bossard, M.2
Cook, N.3
Candido, J.B.4
Emami-Shahri, N.5
Nedospasov, S.A.6
-
47
-
-
84856264859
-
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression
-
Liu M, Lee D-F, Chen C-T, Yen C-J, Li L-Y, Lee H-J et al. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell 2012; 45: 171–184.
-
(2012)
Mol Cell
, vol.45
, pp. 171-184
-
-
Liu, M.1
Lee, D.-F.2
Chen, C.-T.3
Yen, C.-J.4
Li, L.-Y.5
Lee, H.-J.6
-
48
-
-
36849039660
-
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
-
Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007; 117: 3988–4002.
-
(2007)
J Clin Invest
, vol.117
, pp. 3988-4002
-
-
Sansone, P.1
Storci, G.2
Tavolari, S.3
Guarnieri, T.4
Giovannini, C.5
Taffurelli, M.6
-
49
-
-
79959570695
-
Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
-
Guo S, Gonzalez-Perez RR. Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer. PLOS One 2011; 6: e21467.
-
(2011)
PLOS One
, vol.6
-
-
Guo, S.1
Gonzalez-Perez, R.R.2
-
50
-
-
84941370131
-
Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma
-
Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X et al. Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma. PLOS One 2015; 10: e0132677.
-
(2015)
PLOS One
, vol.10
-
-
Sun, Y.1
Zhu, D.2
Wang, G.3
Wang, D.4
Zhou, H.5
Liu, X.6
-
51
-
-
38549148417
-
Notch and cancer: A double-edged sword
-
Internet
-
Koch U, Radtke F. Notch and cancer: a double-edged sword. Cell Mol Life Sci [Internet] 2007; 64: 2746–2762.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2746-2762
-
-
Koch, U.1
Radtke, F.2
-
52
-
-
0036713311
-
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
-
Talora C, Sgroi DC, Crum CP, Dotto GP. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev 2002; 16: 2252–2263.
-
(2002)
Genes Dev
, vol.16
, pp. 2252-2263
-
-
Talora, C.1
Sgroi, D.C.2
Crum, C.P.3
Dotto, G.P.4
-
53
-
-
0037421484
-
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
-
Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ et al. NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 2003; 421: 639–643.
-
(2003)
Nature
, vol.421
, pp. 639-643
-
-
Dajee, M.1
Lazarov, M.2
Zhang, J.Y.3
Cai, T.4
Green, C.L.5
Russell, A.J.6
-
54
-
-
0036024023
-
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
-
Nickoloff BJ, Qin J-Z, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 2002; 9: 842–855.
-
(2002)
Cell Death Differ
, vol.9
, pp. 842-855
-
-
Nickoloff, B.J.1
Qin, J.-Z.2
Chaturvedi, V.3
Denning, M.F.4
Bonish, B.5
Miele, L.6
-
55
-
-
84875459250
-
Impact of notch signaling on inflammatory responses in cardiovascular disorders
-
Quillard T, Charreau B. Impact of notch signaling on inflammatory responses in cardiovascular disorders. Int J Mol Sci 2013; 14: 6863–6888.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 6863-6888
-
-
Quillard, T.1
Charreau, B.2
-
56
-
-
81555209757
-
The many faces of interleukin-6: The role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis
-
Barnes TC, Anderson ME, Moots RJ. The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis. Int J Rheumatol 2011; 2011: 721608.
-
(2011)
Int J Rheumatol
, vol.2011
-
-
Barnes, T.C.1
Anderson, M.E.2
Moots, R.J.3
-
57
-
-
33644782668
-
Recent insights into the role of Notch signaling in tumorigenesis
-
Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006; 107: 2223–2233.
-
(2006)
Blood
, vol.107
, pp. 2223-2233
-
-
Leong, K.G.1
Karsan, A.2
-
58
-
-
78049440085
-
Inflammation dysregulates Notch signaling in endothelial cells: Implication of Notch2 and Notch4 to endothelial dysfunction
-
Quillard T, Devallière J, Coupel S, Charreau B. Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction. Biochem Pharmacol 2010; 80: 2032–2041.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 2032-2041
-
-
Quillard, T.1
Devallière, J.2
Coupel, S.3
Charreau, B.4
-
59
-
-
84942871336
-
Interleukin-6 stimulates defective angiogenesis
-
Gopinathan G, Milagre C, Pearce OM, Reynolds LE, Hodivala-Dilke K, Leinster DA et al. Interleukin-6 stimulates defective angiogenesis. Cancer Res 2015; 75: 3098–3107.
-
(2015)
Cancer Res
, vol.75
, pp. 3098-3107
-
-
Gopinathan, G.1
Milagre, C.2
Pearce, O.M.3
Reynolds, L.E.4
Hodivala-Dilke, K.5
Leinster, D.A.6
-
60
-
-
80055009326
-
Role of Notch signaling in colon homeostasis and carcinogenesis
-
Miyamoto S, Rosenberg DW. Role of Notch signaling in colon homeostasis and carcinogenesis. Cancer Sci 2011; 102: 1938–1942.
-
(2011)
Cancer Sci
, vol.102
, pp. 1938-1942
-
-
Miyamoto, S.1
Rosenberg, D.W.2
-
61
-
-
34249987090
-
Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis
-
Shroyer NF, Helmrath MA, Wang VY-C, Antalffy B, Henning SJ, Zoghbi HY. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 2007; 132: 2478–2488.
-
(2007)
Gastroenterology
, vol.132
, pp. 2478-2488
-
-
Shroyer, N.F.1
Helmrath, M.A.2
Wang, V.-C.3
Antalffy, B.4
Henning, S.J.5
Zoghbi, H.Y.6
-
62
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
Van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005; 435: 959–963.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
van den Born, M.4
Vooijs, M.5
Begthel, H.6
-
63
-
-
84865988309
-
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer
-
Kim H-A, Koo B-K, Cho J-H, Kim Y-Y, Seong J, Chang HJ et al. Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. J Clin Investig 2012; 122: 3248–3259.
-
(2012)
J Clin Investig
, vol.122
, pp. 3248-3259
-
-
Kim, H.-A.1
Koo, B.-K.2
Cho, J.-H.3
Kim, Y.-Y.4
Seong, J.5
Chang, H.J.6
-
64
-
-
84906266448
-
Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota
-
Piazzi G, D’Argenio G, Prossomariti A, Lembo V, Mazzone G, Candela M et al. Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota. Int J Cancer 2014; 135: 2004–2013.
-
(2014)
Int J Cancer
, vol.135
, pp. 2004-2013
-
-
Piazzi, G.1
D’Argenio, G.2
Prossomariti, A.3
Lembo, V.4
Mazzone, G.5
Candela, M.6
-
65
-
-
84924328294
-
A gp130–Src–YAP module links inflammation to epithelial regeneration
-
Taniguchi K, Wu L-W, Grivennikov SI, de Jong PR, Lian I, Yu F-X et al. A gp130–Src–YAP module links inflammation to epithelial regeneration. Nature 2015; 519: 57–62.
-
(2015)
Nature
, vol.519
, pp. 57-62
-
-
Taniguchi, K.1
Wu, L.-W.2
Grivennikov, S.I.3
de Jong, P.R.4
Lian, I.5
Yu, F.-X.6
-
66
-
-
76549092128
-
Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer
-
Garg P, Sarma D, Jeppsson S, Patel NR, Gewirtz AT, Merlin D et al. Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res 2010; 70: 792–801.
-
(2010)
Cancer Res
, vol.70
, pp. 792-801
-
-
Garg, P.1
Sarma, D.2
Jeppsson, S.3
Patel, N.R.4
Gewirtz, A.T.5
Merlin, D.6
-
67
-
-
84895443233
-
Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling
-
Pope JL, Bhat AA, Sharma A, Ahmad R, Krishnan M, Washington MK et al. Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Gut 2014; 63: 622–634.
-
(2014)
Gut
, vol.63
, pp. 622-634
-
-
Pope, J.L.1
Bhat, A.A.2
Sharma, A.3
Ahmad, R.4
Krishnan, M.5
Washington, M.K.6
-
68
-
-
84880740785
-
Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6
-
Lin J-T, Wang J-Y, Chen M-K, Chen H-C, Chang T-H, Su B-W et al. Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6. Exp Cell Res 2013; 319: 2216–2229.
-
(2013)
Exp Cell Res
, vol.319
, pp. 2216-2229
-
-
Lin, J.-T.1
Wang, J.-Y.2
Chen, M.-K.3
Chen, H.-C.4
Chang, T.-H.5
Su, B.-W.6
-
70
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958–969.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
-
71
-
-
66149137296
-
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
-
Alex P, Zachos NC, Nguyen T, Gonzales L, Chen T-E, Conklin LS et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis 2009; 15: 341–352.
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 341-352
-
-
Alex, P.1
Zachos, N.C.2
Nguyen, T.3
Gonzales, L.4
Chen, T.-E.5
Conklin, L.S.6
-
72
-
-
77958128428
-
Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages
-
Outtz HH, Wu JK, Wang X, Kitajewski J. Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol 2010; 185: 4363–4373.
-
(2010)
J Immunol
, vol.185
, pp. 4363-4373
-
-
Outtz, H.H.1
Wu, J.K.2
Wang, X.3
Kitajewski, J.4
-
73
-
-
84862591151
-
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
-
Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol 2012; 13: 642–650.
-
(2012)
Nat Immunol
, vol.13
, pp. 642-650
-
-
Xu, H.1
Zhu, J.2
Smith, S.3
Foldi, J.4
Zhao, B.5
Chung, A.Y.6
-
74
-
-
84938787447
-
A novel role of Numb as a regulator of proinflammatory cytokine production in macrophages in response to toll-like receptor 4
-
Kueanjinda P, Roytrakul S, Palaga T. A novel role of Numb as a regulator of proinflammatory cytokine production in macrophages in response to toll-like receptor 4. Sci Rep 2015; 5: 12784.
-
(2015)
Sci Rep
, vol.5
-
-
Kueanjinda, P.1
Roytrakul, S.2
Palaga, T.3
-
75
-
-
84863605556
-
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders
-
Fukuda D, Aikawa E, Swirski FK, Novobrantseva TI, Kotelianski V, Gorgun CZ et al. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci USA 2012; 109: E1868–E1877.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. E1868-E1877
-
-
Fukuda, D.1
Aikawa, E.2
Swirski, F.K.3
Novobrantseva, T.I.4
Kotelianski, V.5
Gorgun, C.Z.6
-
76
-
-
77649199102
-
Conversion of metaplastic Barrett’s epithelium into post-mitotic goblet cells by gamma-secretase inhibition
-
Menke V, van Es JH, de Lau W, van den Born M, Kuipers EJ, Siersema PD et al. Conversion of metaplastic Barrett’s epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Dis Model Mech 2010; 3: 104–110.
-
(2010)
Dis Model Mech
, vol.3
, pp. 104-110
-
-
Menke, V.1
van Es, J.H.2
de Lau, W.3
van den Born, M.4
Kuipers, E.J.5
Siersema, P.D.6
-
77
-
-
27844485675
-
Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease
-
Van Es JH, Clevers H. Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends Mol Med 2005; 11: 496–502.
-
(2005)
Trends Mol Med
, vol.11
, pp. 496-502
-
-
van Es, J.H.1
Clevers, H.2
-
78
-
-
77956144348
-
Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells
-
Kazanjian A, Noah T, Brown D, Burkart J, Shroyer NF. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology 2010; 139: 918–928.
-
(2010)
Gastroenterology
, vol.139
, pp. 918-928
-
-
Kazanjian, A.1
Noah, T.2
Brown, D.3
Burkart, J.4
Shroyer, N.F.5
-
79
-
-
84888013612
-
Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (Cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer
-
Moon CM, Kwon J-H, Kim JS, Oh S-H, Jin Lee K, Park JJ et al. Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. Int J Cancer 2014; 134: 519–529.
-
(2014)
Int J Cancer
, vol.134
, pp. 519-529
-
-
Moon, C.M.1
Kwon, J.-H.2
Kim, J.S.3
Oh, S.-H.4
Jin Lee, K.5
Park, J.J.6
-
80
-
-
0029818546
-
Nutrition and cancer among American Indians and Alaska natives
-
Byers T. Nutrition and cancer among American Indians and Alaska natives. Cancer 1996; 78: 1612–1616.
-
(1996)
Cancer
, vol.78
, pp. 1612-1616
-
-
Byers, T.1
-
81
-
-
78650364506
-
Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice
-
Fini L, Piazzi G, Ceccarelli C, Daoud Y, Belluzzi A, Munarini A et al. Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice. Clin Cancer Res 2010; 16: 5703–5711.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5703-5711
-
-
Fini, L.1
Piazzi, G.2
Ceccarelli, C.3
Daoud, Y.4
Belluzzi, A.5
Munarini, A.6
|