Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ

Cell Death and Differentiation

Volumn 9, Issue 8, 2002, Pages 842-855

  Nickoloff, B J ^a   Qin, J Z ^a   Chaturvedi, V ^a   Denning, M F ^a   Bonish, B ^a   Miele, L ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cell fate; Differentiation; Jagged; NF B; Notch; PPAR; Skin

Indexed keywords

CALCIUM ION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JAGGED1; LIGAND; LORICRIN; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SYNAPTOTAGMIN; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; CELL RECEPTOR; CELL SURFACE RECEPTOR; CHUK PROTEIN, HUMAN; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; INVOLUCRIN; MEMBRANE PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; NOTCH2 PROTEIN, HUMAN; NOTCH2 RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN; PROTEIN PRECURSOR; PROTEIN SERINE THREONINE KINASE; SERRATE PROTEINS; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPIDERMIS; HUMAN; HUMAN CELL; IMMUNOLOCALIZATION; IMMUNOPRECIPITATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRATIFICATION; STRATUM CORNEUM; WESTERN BLOTTING; ADULT; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL SIZE; CYTOLOGY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; NEWBORN; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN; UPREGULATION;

ADULT; CELL COMPARTMENTATION; CELL DIFFERENTIATION; CELL SIZE; CELLS, CULTURED; EPIDERMIS; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; KERATINOCYTES; MALE; MEMBRANE PROTEINS; NF-KAPPA B; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; SKIN; TRANSCRIPTION FACTORS; UP-REGULATION; CALCIUM-BINDING PROTEINS; HUMANS; I-KAPPA B KINASE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, NOTCH;

EID: 0036024023     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401036     Document Type: Article

References (62)

1. The epidermal permeability barrier
2. The stratum corneum revisited
3. Bricks and mortar of the epidermal barrier
4. Defects in the barrier
5. The pathogenesis of squamous cell cancer: Lesons learned from studies of skin carcinogenesis
6. Localization of calcium in murine epidermis following disruption and repair of the permeability barrier
7. Terminal defferentiation of cultured human epidermal cells
8. Expression of murine epidermal defferentiation makers is highly regulated by restricted extracellular calcium concentrations in vitro
9. Notch signaling: Cell fate control and signal integration in development
10. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch 1
11. Arbiter of dilferentiation and death: Notch signaling meets apoptosis
12. Notch-1 controls the expression of acid-activated transcription factors and is require for adipognesis
13. Notch and the immune system
14. Regulation of T cell fate by Notch
15. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
16. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
17. Involvement of Notch-1 in mammalian retinal neurogenesis: Association of Notch-1 activity with both immature and terminally differentiated cells
18. Verlebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
19. Notch-1 prevents apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar drugs
20. Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation
21. Mouse Notch: Expression in hair follicles correlates with cell fate determination
22. Stimulation of human epidermal differentiation by delta-notch signaling at the boundaries of stem-cell clusters
23. Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
24. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B protiens in T cells
25. Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain
26. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-J kappa
27. Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells
28. Alterations in NF-κB function in transgenic epithelial tissue demonstrates a growth inhibitory role for NF-κB
29. Limb and skin abnormalities in mice lacking IKKα
30. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
31. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice
32. NEMO/IKKγ-deficient mice model incontinentia pigmenti
33. Female mice heterozygous for IKK-γ/ NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
34. It's got you covered; NF-κB in the epidermis
35. Differentiated expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes
36. Peroxisome proliferator-activated receptor-α enhances lipid metabolism in a skin equivalent model
37. Stimulation of PPARα promotes epedermal keratinocyte differentiation in vivo
38. Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation
39. Toward the rationale design A cell fate modifiers: Notch signaling as a target for novel biopharmaceuticals
40. Response of the EpiDerm skin model to topically applied irritants and allergens
41. Epidermal morphogenesis and induction of the 67 KD keratin polypeptide by culture of human keratinocytes at the liquid-air interface
42. Role of NF-κB in the apoptotic-resistant phenotype of KCs
43. T cell leukemia associated human Notch/translocation-associated Notch homologues has l kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
44. Positive and negative regulation Of lκB activity through lKKβ subunit phosphorylation
45. The peroxisome proliferator-activated receptors - γ is a negative regulator of macrophage activation
46. The Notch signaling pathway in hair growth
47. A new role for otch and Delta in cell fate decisions: Patterning the feather array
48. Recognition and ubiquitination of Notch by itch, a Hect-type E3 ubiquitin ligase
49. Calcium depletion disassociates and activates heterodimeric Notch receptors
50. A histone deacetylase corepressor complex regulates the Notch signal tranduction pathway
51. SKIP, a CBF-1 associated protien interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function
52. Functional interaction between the mouse notch1 intercellular region and histone acetyltransferases PCAF and GCN5
53. Notch inhibition of E47 supports the existence of a novel signaling pathway
54. Human deltex is a conserved regulator of Notch signalling
55. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
56. Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch 3 transgenic mice
57. Discordant expression of Notch-1 and -2 compared to Notch ligands (Jagged, Delta) in psoriatic epidermis
58. Protein kinase-cμ expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture
59. High level bacterial expression of uteroglobin, a dimeric eukaryotic protein with interchain disulfide bridges, in its natural quaternary structure
60. Stable, long-term bacterial production of soluble, dimeric, disulfide-bonded protein pharmaceuticals without antibiotic selection
61. Apoptosis in proliferating, senescent, and immortalized keratinocytes
62. Abnormal NF-κB signaling pathway with enhanced susceptibility to apoptosis in immortalized keratinocytes