Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by γ-secretase inhibition

DMM Disease Models and Mechanisms

Volumn 3, Issue 1-2, 2010, Pages 104-110

  Menke, Vivianda ^a   Van Es, Johan H ^b,c   De Lau, Wim ^b,c   Van Den Born, Maaike ^b,c   Kuipers, Ernst J ^a   Siersema, Peter D ^a,c   De Bruin, Ron W F ^a   Kusters, Johannes G ^a,d   Clevers, Hans ^b,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b HUBRECHT INSTITUTE   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d University Medical Centre Utrecht ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; CELL PROTEIN; DIBENZAZEPINE DERIVATIVE; GAMMA SECRETASE; JAGGED1; MESSENGER RNA; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN ATONAL HOMOLOG 1; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARRETT ESOPHAGUS; CANCER CELL CULTURE; CELL DIFFERENTIATION; COLON; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; EPITHELIUM CELL; ESOPHAGEAL ADENOCARCINOMA; GENE EXPRESSION; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BARRETT ESOPHAGUS; BIOPSY; CELL LINE, TUMOR; CELL PROLIFERATION; COLON; DIBENZAZEPINES; DISEASE MODELS, ANIMAL; EPITHELIUM; GENE EXPRESSION REGULATION; GOBLET CELLS; HUMANS; METAPLASIA; MITOSIS; RATS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

RODENTIA;

EID: 77649199102     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.003012     Document Type: Article

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