Inflammation dysregulates Notch signaling in endothelial cells: Implication of Notch2 and Notch4 to endothelial dysfunction

Biochemical Pharmacology

Volumn 80, Issue 12, 2010, Pages 2032-2041

  Quillard, Thibaut ^a,b,c   Devallière, Julie ^a,b,c   Coupel, Stéphanie ^a,b,c   Charreau, Béatrice ^a,b,c  

^a INSERM   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

Author keywords

Apoptosis; Cell signaling; Endothelium; Inflammation; Notch; TNF

Indexed keywords

CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH2 RECEPTOR; NOTCH4 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CBF1; PROTEIN HEY2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULITIS;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 7; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG; MALE; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NOTCH2; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS;

EID: 78049440085     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.07.010     Document Type: Article

References (41)

1. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 1999, 284(5415):770-776.
2. Iso T., Hamamori Y., Kedes L. Notch signaling in vascular development. Arterioscler Thromb Vasc Biol 2003, 23(4):543-553.
3. Radtke F., Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor?. Nat Rev Cancer 2003, 3(10):756-767.
4. Maillard I., Adler S.H., Pear W.S. Notch and the immune system. Immunity 2003, 19(6):781-791.
5. Limbourg F.P., Takeshita K., Radtke F., Bronson R.T., Chin M.T., Liao J.K. Essential role of endothelial Notch1 in angiogenesis. Circulation 2005, 111(14):1826-1832.
6. Pober J.S. Endothelial activation: intracellular signaling pathways. Arthritis Res 2002, 4(SUPP1 3):S109-S116.
7. Mantovani A., Bussolino F., Introna M. Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today 1997, 18(5):231-240.
8. Pober J.S. Immunobiology of human vascular endothelium. Immunol Res 1999, 19(2-3):225-232.
9. Pober J.S., Cotran R.S. The role of endothelial cells in inflammation. Transplantation 1990, 50:537-544.
10. Briscoe D.M., Alexander S.I., Lichtman A.H. Interactions between T lymphocytes and endothelial cells in allograft rejection. Curr Opin Immunol 1998, 10(5):525-531.
11. Leong K.G., Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006, 107(6):2223-2233.
12. Noseda M., McLean G., Niessen K., Chang L., Pollet I., Montpetit R., et al. Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res 2004, 94(7):910-917.
13. Williams C.K., Li J.L., Murga M., Harris A.L., Tosato G. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006, 107(3):931-939.
14. MacKenzie F., Duriez P., Wong F., Noseda M., Karsan A. Notch4 inhibits endothelial apoptosis via RBP-J{kappa}-dependent and -independent pathways. J Biol Chem 2004, 279(12):11657-11663.
15. Ridgway J., Zhang G., Wu Y., Stawicki S., Liang W.C., Chanthery Y., et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006, 444(7122):1083-1087.
16. Noseda M., Chang L., McLean G., Grim J.E., Clurman B.E., Smith L.L., et al. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol 2004, 24(20):8813-8822.
17. Boulday G., Coupel S., Coulon F., Soulillou J.P., Charreau B. Antigraft antibody-mediated expression of metalloproteinases on endothelial cells. Differential expression of TIMP-1 and ADAM-10 depends on antibody specificity and isotype. Circ Res 2001, 88(4):430-437.
18. Boulday G., Coulon F., Fraser C.C., Soulillou J.P., Charreau B. Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells. Transplantation 2002, 74(9):1352-1354.
19. Coupel S., Leboeuf F., Boulday G., Soulillou J.P., Charreau B. RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy. J Am Soc Nephrol 2004, 15(9):2429-2439.
20. Fitau J., Boulday G., Coulon F., Quillard T., Charreau B. The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways. J Biol Chem 2006, 281(29):20148-20159.
21. Six E., Ndiaye D., Laabi Y., Brou C., Gupta-Rossi N., Israel A., et al. The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc Natl Acad Sci USA 2003, 100(13):7638-7643.
22. Quillard T., Coupel S., Coulon F., Fitau J., Chatelais M., Cuturi M.C., et al. Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. Arterioscler Thromb Vasc Biol 2008, 28(12):2258-2265.
23. Quillard T., Devalliere J., Chatelais M., Coulon F., Seveno C., Romagnoli M., et al. Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin. PLoS One 2009, 4(12):e8244.
24. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
25. Iso T., Kedes L., Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 2003, 194(3):237-255.
26. Madge L.A., Pober J.S. TNF signaling in vascular endothelial cells. Exp Mol Pathol 2001, 70(3):317-325.
27. Aguilera C., Hoya-Arias R., Haegeman G., Espinosa L., Bigas A. Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression. Proc Natl Acad Sci USA 2004, 101(47):16537-16542.
28. Liu Z.J., Shirakawa T., Li Y., Soma A., Oka M., Dotto G.P., et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 2003, 23(1):14-25.
29. Matsumoto T., Turesson I., Book M., Gerwins P., Claesson-Welsh L. p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol 2002, 156(1):149-160.
30. Hiratochi M., Nagase H., Kuramochi Y., Koh C.S., Ohkawara T., Nakayama K. The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway. Nucleic Acids Res 2007, 35(3):912-922.
31. Monsalve E., Perez M.A., Rubio A., Ruiz-Hidalgo M.J., Baladron V., Garcia-Ramirez J.J., et al. Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. J Immunol 2006, 176(9):5362-5373.
32. Krebs L.T., Xue Y., Norton C.R., Shutter J.R., Maguire M., Sundberg J.P., et al. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 2000, 14(11):1343-1352.
33. Henderson A.M., Wang S.J., Taylor A.C., Aitkenhead M., Hughes C.C. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation. J Biol Chem 2001, 276(9):6169-6176.
34. Liu Z.J., Xiao M., Balint K., Soma A., Pinnix C.C., Capobianco A.J., et al. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1. FASEB J 2006, 20(7):1009-1011.
35. Chi J.T., Chang H.Y., Haraldsen G., Jahnsen F.L., Troyanskaya O.G., Chang D.S., et al. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci USA 2003, 100(19):10623-10628.
36. Espinosa L., Ingles-Esteve J., Robert-Moreno A., Bigas A. IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways. Mol Biol Cell 2003, 14(2):491-502.
37. Sweeney C., Morrow D., Birney Y.A., Coyle S., Hennessy C., Scheller A., et al. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J 2004, 18(12):1421-1423.
38. Ohishi K., Varnum-Finney B., Flowers D., Anasetti C., Myerson D., Bernstein I.D. Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1. Blood 2000, 95(9):2847-2854.
39. Saito T., Chiba S., Ichikawa M., Kunisato A., Asai T., Shimizu K., et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 2003, 18(5):675-685.
40. Witt C.M., Hurez V., Swindle C.S., Hamada Y., Klug C.A. Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol Cell Biol 2003, 23(23):8637-8650.
41. Al-Lamki R.S., Wang J., Vandenabeele P., Bradley J.A., Thiru S., Luo D., et al. TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury. FASEB J 2005, 19(12):1637-1645.