-
1
-
-
0033779235
-
Molecular mechanisms of development of the gastrointestinal tract
-
D.J. Roberts Molecular mechanisms of development of the gastrointestinal tract Dev. Dyn. 219 2000 109 120
-
(2000)
Dev. Dyn.
, vol.219
, pp. 109-120
-
-
Roberts, D.J.1
-
2
-
-
8444220513
-
Signaling pathways in intestinal development and cancer
-
E. Batlle Signaling pathways in intestinal development and cancer Annu. Rev. Cell Dev. Biol. 20 2004 695 723
-
(2004)
Annu. Rev. Cell Dev. Biol.
, vol.20
, pp. 695-723
-
-
Batlle, E.1
-
3
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol. 20 2004 781 810
-
(2004)
Annu. Rev. Cell Dev. Biol.
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
4
-
-
5444243641
-
The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation
-
J. Wang, and A. Wynshaw-Boris The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation Curr. Opin. Genet. Dev. 14 2004 533 539
-
(2004)
Curr. Opin. Genet. Dev.
, vol.14
, pp. 533-539
-
-
Wang, J.1
Wynshaw-Boris, A.2
-
5
-
-
5444265502
-
The Wnt connection to tumorigenesis
-
J. Behrens, and B. Lustig The Wnt connection to tumorigenesis Int. J. Dev. Biol. 48 2004 477 487
-
(2004)
Int. J. Dev. Biol.
, vol.48
, pp. 477-487
-
-
Behrens, J.1
Lustig, B.2
-
6
-
-
0036571011
-
Axin-mediated CKI phosphorylation of β-catenin at Ser 45: A molecular switch for the Wnt pathway
-
S. Amit Axin-mediated CKI phosphorylation of β-catenin at Ser 45: A molecular switch for the Wnt pathway Genes Dev. 16 2002 1066 1076
-
(2002)
Genes Dev.
, vol.16
, pp. 1066-1076
-
-
Amit, S.1
-
7
-
-
0037155691
-
Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
-
C. Liu Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism Cell 108 2002 837 847
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
-
8
-
-
0033522491
-
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
-
M. Kitagawa An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin EMBO J. 18 1999 2401 2410
-
(1999)
EMBO J.
, vol.18
, pp. 2401-2410
-
-
Kitagawa, M.1
-
9
-
-
0033068154
-
The SCF β-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
-
J.T. Winston The SCF β-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro Genes Dev. 13 1999 270 283
-
(1999)
Genes Dev.
, vol.13
, pp. 270-283
-
-
Winston, J.T.1
-
10
-
-
0032497513
-
Drosophila Tcf and Groucho interact to repress Wingless signalling activity
-
R.A. Cavallo Drosophila Tcf and Groucho interact to repress Wingless signalling activity Nature 395 1998 604 608
-
(1998)
Nature
, vol.395
, pp. 604-608
-
-
Cavallo, R.A.1
-
11
-
-
0032497485
-
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
-
J. Roose The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors Nature 395 1998 608 612
-
(1998)
Nature
, vol.395
, pp. 608-612
-
-
Roose, J.1
-
12
-
-
0037737726
-
Wnt proteins are lipid-modified and can act as stem cell growth factors
-
K. Willert Wnt proteins are lipid-modified and can act as stem cell growth factors Nature 423 2003 448 452
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
-
13
-
-
0029781509
-
Functional interaction of β-catenin with the transcription factor LEF-1
-
J. Behrens Functional interaction of β-catenin with the transcription factor LEF-1 Nature 382 1996 638 642
-
(1996)
Nature
, vol.382
, pp. 638-642
-
-
Behrens, J.1
-
14
-
-
0001003110
-
XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
-
M. Molenaar XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos Cell 86 1996 391 399
-
(1996)
Cell
, vol.86
, pp. 391-399
-
-
Molenaar, M.1
-
15
-
-
0034678357
-
The transcriptional coactivator CBP interacts with β-catenin to activate gene expression
-
K.I. Takemaru, and R.T. Moon The transcriptional coactivator CBP interacts with β-catenin to activate gene expression J. Cell Biol. 149 2000 249 254
-
(2000)
J. Cell Biol.
, vol.149
, pp. 249-254
-
-
Takemaru, K.I.1
Moon, R.T.2
-
16
-
-
0035801499
-
The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation
-
N. Barker The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation EMBO J. 20 2001 4935 4943
-
(2001)
EMBO J.
, vol.20
, pp. 4935-4943
-
-
Barker, N.1
-
17
-
-
0037023584
-
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex
-
T. Kramps Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex Cell 109 2002 47 60
-
(2002)
Cell
, vol.109
, pp. 47-60
-
-
Kramps, T.1
-
18
-
-
0036097733
-
A new nuclear component of the Wnt signalling pathway
-
B. Thompson A new nuclear component of the Wnt signalling pathway Nat. Cell Biol. 4 2002 367 373
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 367-373
-
-
Thompson, B.1
-
19
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
T.C. He Identification of c-MYC as a target of the APC pathway Science 281 1998 1509 1512
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
-
20
-
-
0034739023
-
The APC tumour suppressor has a nuclear export function
-
R. Rosin-Arbesfeld The APC tumour suppressor has a nuclear export function Nature 406 2000 1009 1012
-
(2000)
Nature
, vol.406
, pp. 1009-1012
-
-
Rosin-Arbesfeld, R.1
-
21
-
-
23244448347
-
Expression pattern of Wnt signaling components in the adult intestine
-
A. Gregorieff Expression pattern of Wnt signaling components in the adult intestine Gastroenterology 129 2005 626 638
-
(2005)
Gastroenterology
, vol.129
, pp. 626-638
-
-
Gregorieff, A.1
-
22
-
-
18644373146
-
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
M. van de Wetering The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111 2002 241 250
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
Van De Wetering, M.1
-
23
-
-
0031848068
-
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
-
V. Korinek Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 Nat. Genet. 19 1998 379 383
-
(1998)
Nat. Genet.
, vol.19
, pp. 379-383
-
-
Korinek, V.1
-
24
-
-
0037829660
-
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
-
D. Pinto Canonical Wnt signals are essential for homeostasis of the intestinal epithelium Genes Dev. 17 2003 1709 1713
-
(2003)
Genes Dev.
, vol.17
, pp. 1709-1713
-
-
Pinto, D.1
-
25
-
-
0346458662
-
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
-
F. Kuhnert Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Proc. Natl. Acad. Sci. U. S. A. 101 2004 266 271
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 266-271
-
-
Kuhnert, F.1
-
26
-
-
18644376279
-
β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
-
E. Batlle β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB Cell 111 2002 251 263
-
(2002)
Cell
, vol.111
, pp. 251-263
-
-
Batlle, E.1
-
27
-
-
21344460054
-
EphB receptor activity suppresses colorectal cancer progression
-
E. Batlle EphB receptor activity suppresses colorectal cancer progression Nature 435 2005 1126 1130
-
(2005)
Nature
, vol.435
, pp. 1126-1130
-
-
Batlle, E.1
-
28
-
-
20244364236
-
Wnt signalling induces maturation of Paneth cells in intestinal crypts
-
J.H. van Es Wnt signalling induces maturation of Paneth cells in intestinal crypts Nat. Cell Biol. 7 2005 381 386
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 381-386
-
-
Van Es, J.H.1
-
29
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
T. Reya, and H. Clevers Wnt signalling in stem cells and cancer Nature 434 2005 843 850
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
30
-
-
8444236025
-
The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium
-
I.S. Nathke The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium Annu. Rev. Cell Dev. Biol. 20 2004 337 366
-
(2004)
Annu. Rev. Cell Dev. Biol.
, vol.20
, pp. 337-366
-
-
Nathke, I.S.1
-
31
-
-
0030949463
-
Activation of β-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
-
P.J. Morin Activation of β-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC Science 275 1997 1787 1790
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
-
32
-
-
0033780630
-
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
-
W. Liu Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling Nat. Genet. 26 2000 146 147
-
(2000)
Nat. Genet.
, vol.26
, pp. 146-147
-
-
Liu, W.1
-
33
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
E.R. Fearon, and B. Vogelstein A genetic model for colorectal tumorigenesis Cell 61 1990 759 767
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
34
-
-
0037062430
-
Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation
-
T.A. Chan Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation Proc. Natl. Acad. Sci. U. S. A. 99 2002 8265 8270
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 8265-8270
-
-
Chan, T.A.1
-
35
-
-
0034760407
-
β-catenin antisense treatment decreases β-catenin expression and tumor growth rate in colon carcinoma xenografts
-
D.W. Green β-catenin antisense treatment decreases β-catenin expression and tumor growth rate in colon carcinoma xenografts J. Surg. Res. 101 2001 16 20
-
(2001)
J. Surg. Res.
, vol.101
, pp. 16-20
-
-
Green, D.W.1
-
36
-
-
11144344179
-
Wnt β-catenin-pathway as a molecular target for future anti-cancer therapeutics
-
S. Dihlmann, and M. von Knebel Doeberitz Wnt β-catenin-pathway as a molecular target for future anti-cancer therapeutics Int. J. Cancer 113 2005 515 524
-
(2005)
Int. J. Cancer
, vol.113
, pp. 515-524
-
-
Dihlmann, S.1
Von Knebel Doeberitz, M.2
-
37
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
-
M. Lepourcelet Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex Cancer Cell 5 2004 91 102
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
-
38
-
-
20544460148
-
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
J.H. van Es Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Nature 435 2005 959 963
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
Van Es, J.H.1
-
39
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
S. Artavanis-Tsakonas Notch signaling: cell fate control and signal integration in development Science 284 1999 770 776
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
-
40
-
-
0037376416
-
An overview of the Notch signalling pathway
-
M. Baron An overview of the Notch signalling pathway Semin. Cell Dev. Biol. 14 2003 113 119
-
(2003)
Semin. Cell Dev. Biol.
, vol.14
, pp. 113-119
-
-
Baron, M.1
-
41
-
-
0030877659
-
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
-
C.M. Blaumueller Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Cell 90 1997 281 291
-
(1997)
Cell
, vol.90
, pp. 281-291
-
-
Blaumueller, C.M.1
-
42
-
-
0141922141
-
Modulation of notch-ligand binding by protein O-Fucosyltransferase 1 and fringe
-
T. Okajima Modulation of notch-ligand binding by protein O-Fucosyltransferase 1 and fringe J. Biol. Chem. 278 2003 42340 42345
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42340-42345
-
-
Okajima, T.1
-
43
-
-
14844355836
-
Chaperone activity of protein O-fucosyltransferase 1 promotes Notch receptor folding
-
T. Okajima Chaperone activity of protein O-fucosyltransferase 1 promotes Notch receptor folding Science 307 2005 1599 1603
-
(2005)
Science
, vol.307
, pp. 1599-1603
-
-
Okajima, T.1
-
44
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
-
C. Brou A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE Mol. Cell 5 2000 207 216
-
(2000)
Mol. Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
-
45
-
-
0037080699
-
Kuzbanian-mediated cleavage of Drosophila Notch
-
T. Lieber Kuzbanian-mediated cleavage of Drosophila Notch Genes Dev. 16 2002 209 221
-
(2002)
Genes Dev.
, vol.16
, pp. 209-221
-
-
Lieber, T.1
-
46
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
B. De Strooper A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain Nature 398 1999 518 522
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
-
47
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
E.H. Schroeter Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Nature 393 1998 382 386
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
-
48
-
-
0037363922
-
HES and HERP families: Multiple effectors of the Notch signaling pathway
-
T. Iso HES and HERP families: multiple effectors of the Notch signaling pathway J. Cell. Physiol. 194 2003 237 255
-
(2003)
J. Cell. Physiol.
, vol.194
, pp. 237-255
-
-
Iso, T.1
-
49
-
-
0036947013
-
Expression of Notch pathway components in fetal and adult mouse small intestine
-
N. Schroder, and A. Gossler Expression of Notch pathway components in fetal and adult mouse small intestine Gene Expr. Patterns 2 2002 247 250
-
(2002)
Gene Expr. Patterns
, vol.2
, pp. 247-250
-
-
Schroder, N.1
Gossler, A.2
-
50
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
J. Jensen Control of endodermal endocrine development by Hes-1 Nat. Genet. 24 2000 36 44
-
(2000)
Nat. Genet.
, vol.24
, pp. 36-44
-
-
Jensen, J.1
-
51
-
-
0035824487
-
Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
-
Q. Yang Requirement of Math1 for secretory cell lineage commitment in the mouse intestine Science 294 2001 2155 2158
-
(2001)
Science
, vol.294
, pp. 2155-2158
-
-
Yang, Q.1
-
52
-
-
0037011171
-
Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
-
M. Jenny Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium EMBO J. 21 2002 6338 6347
-
(2002)
EMBO J.
, vol.21
, pp. 6338-6347
-
-
Jenny, M.1
-
53
-
-
0035988246
-
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
-
H. Han Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision Int. Immunol. 14 2002 637 645
-
(2002)
Int. Immunol.
, vol.14
, pp. 637-645
-
-
Han, H.1
-
54
-
-
16844382711
-
Delta-Notch signaling controls commitment to a secretory fate in zebrafish intestine
-
C. Crosnier Delta-Notch signaling controls commitment to a secretory fate in zebrafish intestine Development 132 2005 1093 1104
-
(2005)
Development
, vol.132
, pp. 1093-1104
-
-
Crosnier, C.1
-
55
-
-
20544447734
-
Notch signals control the fate of immature progenitor cells in the intestine
-
S. Fre Notch signals control the fate of immature progenitor cells in the intestine Nature 435 2005 964 968
-
(2005)
Nature
, vol.435
, pp. 964-968
-
-
Fre, S.1
-
56
-
-
0034669031
-
A common enzyme connects Notch signaling and Alzheimer's disease
-
R. Kopan, and A. Goate A common enzyme connects Notch signaling and Alzheimer's disease Genes Dev. 14 2000 2799 2806
-
(2000)
Genes Dev.
, vol.14
, pp. 2799-2806
-
-
Kopan, R.1
Goate, A.2
-
57
-
-
11144355129
-
Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
G.T. Wong Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation J. Biol. Chem. 279 2004 12876 12882
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12876-12882
-
-
Wong, G.T.1
-
58
-
-
8444247084
-
Modulation of Notch processing by γ-secretase inhibitors causes intestinal Goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
-
Milano, J. et al. (2004) Modulation of Notch processing by γ-secretase inhibitors causes intestinal Goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol. Sci. 1, 341-258
-
(2004)
Toxicol. Sci.
, vol.1
, pp. 341-258
-
-
Milano, J.1
-
59
-
-
0242412482
-
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
-
G.H. Searfoss Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor J. Biol. Chem. 278 2003 46107 46116
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46107-46116
-
-
Searfoss, G.H.1
-
60
-
-
0026562404
-
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
-
L.K. Su Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene Science 256 1992 668 670
-
(1992)
Science
, vol.256
, pp. 668-670
-
-
Su, L.K.1
|